Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion.

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Published in J Cell Biol on October 01, 1992

Authors

S Ganesan1, R Calle, K Zawalich, K Greenawalt, W Zawalich, G I Shulman, H Rasmussen

Author Affiliations

1: Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut.

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Physiology and pathophysiology of insulin secretion. Diabetes Care (1990) 1.21

Immediate and time-dependent effects of glucose on insulin release from rat pancreatic tissue. Evidence for different mechanisms of action. J Clin Invest (1978) 1.13

Perspectives in diabetes. Is protein kinase C required for physiologic insulin release? Diabetes (1988) 1.09

Control of insulin secretion: a model involving Ca2+, cAMP and diacylglycerol. Mol Cell Endocrinol (1990) 1.08

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Different expression of protein kinase C isozymes in pancreatic islet cells. Endocrinology (1990) 0.90

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Further studies on the isolation and charcterization of parathyroid polypeptides. Biochemistry (1966) 1.72

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Insulin secretion: combined effects of phorbol ester and A23187. Biochem Biophys Res Commun (1983) 1.64

A rapidly acting metabolite of vitamin D3. Proc Natl Acad Sci U S A (1971) 1.63

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Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose. J Neurochem (1994) 1.60

Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. J Clin Invest (1996) 1.58

Liver glycogen turnover in fed and fasted humans. Am J Physiol (1994) 1.57

Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest (1996) 1.57

The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways. J Biol Chem (1984) 1.55

Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion. Proc Natl Acad Sci U S A (1972) 1.51

Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magn Reson Med (1992) 1.51

Phosphorylation of an endogenous membrane protein by an endogenous, membrane-associated cyclic adenosine 3',5'-monophosphate-dependent protein kinase in human erythrocyte ghosts. J Biol Chem (1972) 1.51

The calcium messenger system (1). N Engl J Med (1986) 1.51

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In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism. J Biol Chem (2001) 1.49

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Induction of intestinal brush border alkaline phosphatase by vitamin D and identity with ca-ATPase. Nature (1970) 1.48

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Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance. J Clin Invest (2001) 1.45

TPA-induced contraction of isolated rabbit vascular smooth muscle. Biochem Biophys Res Commun (1984) 1.45

RELATION OF CHEMICAL ATTACHMENT TO PHYSIOLOGICAL ACTION OF VASOPRESSIN. Proc Natl Acad Sci U S A (1960) 1.45

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The small heat shock-related protein, HSP20, is phosphorylated on serine 16 during cyclic nucleotide-dependent relaxation. J Biol Chem (1999) 1.40

Glucose-induced translocation of protein kinase C in rat pancreatic islets. Proc Natl Acad Sci U S A (1990) 1.39

The role of cyclic AMP and calcium in cell activation. CRC Crit Rev Biochem (1972) 1.38

Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. Am J Physiol (1996) 1.37

Mechanism of troglitazone action in type 2 diabetes. Diabetes (2000) 1.36

The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells. J Biol Chem (1987) 1.35

Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 A resolution. Nat Struct Biol (1997) 1.35