Published in Nature on August 25, 1988
Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J (1990) 6.23
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14
Problems related to the interpretation of autoradiographic data on gene expression using common constitutive transcripts as controls. Nucleic Acids Res (1993) 4.81
Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. EMBO J (1994) 4.23
The C2 domain calcium-binding motif: structural and functional diversity. Protein Sci (1996) 4.20
Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect. J Cell Biol (1992) 4.14
Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog. Mol Cell Biol (1992) 4.02
Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proc Natl Acad Sci U S A (1994) 3.95
Protein kinase C isoenzymes: divergence in signal transduction? Biochem J (1993) 3.86
Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J (1997) 3.74
MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol (1993) 3.54
The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J (1990) 3.44
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties. Proc Natl Acad Sci U S A (1989) 3.21
A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids. Proc Natl Acad Sci U S A (1995) 3.02
A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc Natl Acad Sci U S A (1996) 2.95
Soluble receptors for cytokines and growth factors: generation and biological function. Biochem J (1994) 2.83
The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. EMBO J (1990) 2.74
Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence. Proc Natl Acad Sci U S A (1989) 2.72
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Proc Natl Acad Sci U S A (1991) 2.65
Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells. J Cell Biol (1998) 2.65
Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts. J Cell Biol (1989) 2.63
Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J Cell Biol (1991) 2.57
Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A (1992) 2.48
The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc Natl Acad Sci U S A (1994) 2.48
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A (1989) 2.48
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Mol Cell Biol (1993) 2.48
How does PKMζ maintain long-term memory? Nat Rev Neurosci (2010) 2.47
Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest (1992) 2.45
Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J (1993) 2.44
Cross-talk unfolded: MARCKS proteins. Biochem J (2002) 2.41
Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal (2013) 2.34
Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest (2001) 2.29
Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. Proc Natl Acad Sci U S A (1989) 2.16
A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity. EMBO J (1989) 2.14
Molecular mechanisms of cell proliferation induced by low power laser irradiation. J Biomed Sci (2009) 2.13
Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids. Proc Natl Acad Sci U S A (1994) 2.12
EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. EMBO J (1996) 2.11
A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway. Mol Cell Biol (1993) 2.06
Microspectroscopic imaging tracks the intracellular processing of a signal transduction protein: fluorescent-labeled protein kinase C beta I. Proc Natl Acad Sci U S A (1996) 2.01
MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc Natl Acad Sci U S A (1995) 2.01
A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol (1992) 1.97
The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner. Proc Natl Acad Sci U S A (1991) 1.96
Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol (1989) 1.96
Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies. Proc Natl Acad Sci U S A (1992) 1.91
hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. EMBO J (1995) 1.89
Volume-regulatory Cl- channel currents in cultured human epithelial cells. J Physiol (1992) 1.87
Influence of polyamines on membrane functions. Biochem J (1989) 1.82
Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs. Proc Natl Acad Sci U S A (1992) 1.79
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest (1997) 1.75
Coordinate viral induction of tumor necrosis factor alpha and interferon beta in human B cells and monocytes. Proc Natl Acad Sci U S A (1989) 1.72
Calcium signalling in bacteria. J Bacteriol (1996) 1.70
Brain proteins in plants: an Arabidopsis homolog to neurotransmitter pathway activators is part of a DNA binding complex. Proc Natl Acad Sci U S A (1992) 1.70
Race-specific elicitors of Cladosporium fulvum promote translocation of cytosolic components of NADPH oxidase to the plasma membrane of tomato cells. Plant Cell (1997) 1.70
Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein. J Cell Biol (1997) 1.69
A protein kinase C isozyme is translocated to cytoskeletal elements on activation. Cell Regul (1990) 1.69
Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol (1992) 1.69
Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. Mol Cell Biol (1992) 1.63
Molecular cloning of a second form of rac protein kinase. Cell Regul (1991) 1.63
A serine residue in ClC-3 links phosphorylation-dephosphorylation to chloride channel regulation by cell volume. J Gen Physiol (1999) 1.61
Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. Mol Cell Biol (2002) 1.60
Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes. Biophys J (1991) 1.60
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Mol Cell Biol (1993) 1.60
ras-induced neuronal differentiation of PC12 cells: possible involvement of fos and jun. Mol Cell Biol (1989) 1.59
Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. J Clin Invest (1993) 1.58
The plant phosphoinositide system. Biochem J (1992) 1.58
Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process. Proc Natl Acad Sci U S A (1991) 1.53
Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. EMBO J (1990) 1.51
Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the eta and delta isoforms of protein kinase C. Mol Cell Biol (1998) 1.50
Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2. J Cell Biol (1993) 1.49
Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells. J Cell Biol (1989) 1.48
Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart. Mol Cell Biol (1991) 1.47
Dual modulation of renal ATP-sensitive K+ channel by protein kinases A and C. Proc Natl Acad Sci U S A (1991) 1.47
PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus. EMBO J (1994) 1.45
Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control. EMBO J (1993) 1.45
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Mol Cell Biol (1993) 1.43
Electrostatics of phosphoinositide bilayer membranes. Theoretical and experimental results. Biophys J (1990) 1.42
Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. Pharmacol Res (2007) 1.42
A serum factor that activates the phosphatidylinositol phosphate signaling system in Xenopus oocytes. Proc Natl Acad Sci U S A (1990) 1.40
Rhabdomeric phototransduction initiated by the vertebrate photopigment melanopsin. Proc Natl Acad Sci U S A (2005) 1.39
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways. Proc Natl Acad Sci U S A (1989) 1.39
Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes. PLoS One (2015) 1.39
Glucose-induced translocation of protein kinase C in rat pancreatic islets. Proc Natl Acad Sci U S A (1990) 1.39
Mutation of the gene encoding protein kinase C 1 stimulates mitotic recombination in Saccharomyces cerevisiae. Mol Cell Biol (1994) 1.38
MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J Clin Invest (1995) 1.36
Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium. J Cancer Res Clin Oncol (2007) 1.36
Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors. Proc Natl Acad Sci U S A (1995) 1.34
Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. Am J Pathol (1999) 1.34
The SV40 TC-II(kappa B) enhanson binds ubiquitous and cell type specifically inducible nuclear proteins from lymphoid and non-lymphoid cell lines. EMBO J (1989) 1.34
Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma. EMBO J (1991) 1.33
Cellular protein kinase C isoform zeta regulates human parainfluenza virus type 3 replication. Proc Natl Acad Sci U S A (1995) 1.33
Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells. Cancer Res (2005) 1.33
C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity. Biochemistry (2001) 1.33
Three distinct mechanisms for translocation and activation of the delta subspecies of protein kinase C. Mol Cell Biol (1998) 1.32
Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor. Biochem J (1990) 1.32
Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta. EMBO J (1994) 1.30
The Caenorhabditis elegans unc-13 gene product is a phospholipid-dependent high-affinity phorbol ester receptor. Biochem J (1992) 1.29
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (1992) 12.18
The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction. JAMA (1989) 1.55
Membrane phospholipid degradation and protein kinase C for cell signalling. Neurosci Res (1992) 0.85
The heterogeneity and differential expression of multiple species of the protein kinase C family. Biofactors (1988) 0.82
Protein kinase C family and nervous function. Prog Brain Res (1991) 0.79
Lipid mediators and protein kinase C for intracellular signalling. Clin Exp Pharmacol Physiol Suppl (1995) 0.76