Published in J Biol Chem on September 23, 2003
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell (2004) 5.94
Evaluation of fluorophores for optimal performance in localization-based super-resolution imaging. Nat Methods (2011) 5.25
A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell (2009) 3.88
Homotypic fusion of ER membranes requires the dynamin-like GTPase atlastin. Nature (2009) 3.31
Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network. J Clin Invest (2010) 2.59
Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. Hum Mol Genet (2008) 2.28
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion. Traffic (2008) 2.16
Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners. Hum Mol Genet (2005) 2.01
Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A. Proc Natl Acad Sci U S A (2011) 1.93
Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance. Proc Natl Acad Sci U S A (2006) 1.56
Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Nat Neurosci (2010) 1.52
Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proc Natl Acad Sci U S A (2012) 1.46
Mechanisms of disease in hereditary sensory and autonomic neuropathies. Nat Rev Neurol (2012) 1.44
Further assembly required: construction and dynamics of the endoplasmic reticulum network. EMBO Rep (2010) 1.35
Untangling the web: mechanisms underlying ER network formation. Biochim Biophys Acta (2013) 1.23
SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell (2010) 1.20
Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein. Neurogenetics (2006) 1.15
The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii. J Biol Chem (2012) 0.98
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation. J Clin Invest (2014) 0.96
Fusing a lasting relationship between ER tubules. Trends Cell Biol (2011) 0.96
An intramolecular salt bridge drives the soluble domain of GTP-bound atlastin into the postfusion conformation. J Cell Biol (2011) 0.95
Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11. Ann Clin Transl Neurol (2014) 0.94
GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusion. Proc Natl Acad Sci U S A (2011) 0.94
Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2. Biochem Biophys Res Commun (2010) 0.93
Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Hum Mol Genet (2012) 0.92
Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. Proc Natl Acad Sci U S A (2013) 0.91
A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep (2013) 0.91
The R495W mutation in SPG3A causes spastic paraplegia associated with axonal neuropathy. J Neurol (2005) 0.89
MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. Mol Biol Cell (2012) 0.89
Balancing ER dynamics: shaping, bending, severing, and mending membranes. Curr Opin Cell Biol (2011) 0.89
Early onset autosomal dominant spastic paraplegia caused by novel mutations in SPG3A. Neurogenetics (2004) 0.88
Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A. Hum Mol Genet (2014) 0.88
The effect of HSP-causing mutations in SPG3A and NIPA1 on the assembly, trafficking, and interaction between atlastin-1 and NIPA1. Mol Cell Neurosci (2010) 0.86
Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network. Elife (2016) 0.84
Hereditary spastic paraplegia-causing mutations in atlastin-1 interfere with BMPRII trafficking. Mol Cell Neurosci (2012) 0.84
STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking. Traffic (2008) 0.83
Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons. Neurogenetics (2010) 0.82
Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly. Viruses (2016) 0.81
Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis. Brain Res (2008) 0.81
FAM21 directs SNX27-retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus. Nat Commun (2016) 0.80
A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function. Nat Struct Mol Biol (2017) 0.78
A novel mutation in the SPG3A gene (atlastin) in hereditary spastic paraplegia. J Neurol (2007) 0.78
N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress. Brain Res (2012) 0.78
Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia. J Neurogenet (2008) 0.78
Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9. Infect Immun (2015) 0.77
A newly discovered member of the Atlastin family, BmAtlastin-n, has an antiviral effect against BmNPV in Bombyx mori. Sci Rep (2016) 0.77
Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development. PLoS One (2014) 0.76
Modeling Axonal Defects in Hereditary Spastic Paraplegia with Human Pluripotent Stem Cells. Front Biol (Beijing) (2016) 0.75
Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae. Elife (2017) 0.75
The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin. FASEB J (2016) 0.75
Metadata matters: access to image data in the real world. J Cell Biol (2010) 12.49
A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell (2009) 3.88
Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. J Biol Chem (2007) 3.86
OMERO: flexible, model-driven data management for experimental biology. Nat Methods (2012) 3.72
Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis. CMAJ (2004) 2.76
Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network. J Clin Invest (2010) 2.59
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin. Nat Chem Biol (2007) 2.30
Atlastin GTPases are required for Golgi apparatus and ER morphogenesis. Hum Mol Genet (2008) 2.28
Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1. Ann N Y Acad Sci (2010) 2.20
Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1. J Biol Chem (2004) 2.19
Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat Struct Mol Biol (2008) 2.18
L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. J Biol Chem (2003) 2.12
Comparison of porcine epidemic diarrhea viruses from Germany and the United States, 2014. Emerg Infect Dis (2015) 2.08
The remediation challenge: theoretical and methodological insights from a systematic review. Med Educ (2013) 2.02
Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation. J Biol Chem (2005) 2.02
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death. Curr Biol (2005) 1.87
SPG3A protein atlastin-1 is enriched in growth cones and promotes axon elongation during neuronal development. Hum Mol Genet (2006) 1.59
A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division. J Biol Chem (2010) 1.56
Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases. PLoS Genet (2011) 1.54
Sexual behaviors and procreational intentions of adolescents and young adults with perinatally acquired human immunodeficiency virus infection: experience of an urban tertiary center. J Adolesc Health (2006) 1.52
SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle. FASEB J (2009) 1.45
Quality assurance of treatment plans for interstitial and intracavitary high-dose-rate brachytherapy. Brachytherapy (2006) 1.43
Targeted high-throughput sequencing identifies mutations in atlastin-1 as a cause of hereditary sensory neuropathy type I. Am J Hum Genet (2010) 1.42
Mutations in TPM3 are a common cause of congenital fiber type disproportion. Ann Neurol (2008) 1.39
Traffic accidents: molecular genetic insights into the pathogenesis of the hereditary spastic paraplegias. Pharmacol Ther (2005) 1.36
Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor trafficking. Mol Biol Cell (2007) 1.36
Further assembly required: construction and dynamics of the endoplasmic reticulum network. EMBO Rep (2010) 1.35
Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential. Biol Cell (2008) 1.33
Untangling the web: mechanisms underlying ER network formation. Biochim Biophys Acta (2013) 1.23
Influenza vaccine: immunization rates, knowledge, and attitudes of resident physicians in an urban teaching hospital. Infect Control Hosp Epidemiol (2005) 1.21
SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell (2010) 1.20
3D CT-based high-dose-rate breast brachytherapy implants: treatment planning and quality assurance. Int J Radiat Oncol Biol Phys (2004) 1.19
Exome sequencing and SNP analysis detect novel compound heterozygosity in fatty acid hydroxylase-associated neurodegeneration. Eur J Hum Genet (2011) 1.18
African-American women have a higher risk for developing peripartum cardiomyopathy. J Am Coll Cardiol (2010) 1.16
Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice. Am J Physiol Heart Circ Physiol (2002) 1.12
Lack of spartin protein in Troyer syndrome: a loss-of-function disease mechanism? Arch Neurol (2008) 1.10
The Troyer syndrome (SPG20) protein spartin interacts with Eps15. Biochem Biophys Res Commun (2005) 1.05
Synergistic antioxidant activity of green tea with some herbs. J Adv Pharm Technol Res (2011) 1.03
Drp1 phosphorylation and mitochondrial regulation. EMBO Rep (2007) 1.03
Emerging themes of ER organization in the development and maintenance of axons. Curr Opin Neurobiol (2010) 1.00
Multi-institutional experience using the MammoSite radiation therapy system in the treatment of early-stage breast cancer: 2-year results. Int J Radiat Oncol Biol Phys (2007) 1.00
O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice. PLoS One (2010) 1.00
Characterization of a novel SPG3A deletion in a French-Canadian family. Ann Neurol (2007) 0.99
Mitochondria unite to survive. Nat Cell Biol (2011) 0.96
Medical emergency teams at The Ottawa Hospital: the first two years. Can J Anaesth (2008) 0.96
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation. J Clin Invest (2014) 0.96
Incidence of and risk factors for superior facet violation in minimally invasive versus open pedicle screw placement during transforaminal lumbar interbody fusion: a comparative analysis. J Neurosurg Spine (2013) 0.96
The New Zealand Neuromuscular Disease Registry. J Clin Neurosci (2012) 0.95
Cervical disc arthroplasty compared with fusion in a workers' compensation population. Neurosurgery (2008) 0.95
The apolipoprotein A-I mimetic peptide 4F prevents defects in vascular function in endotoxemic rats. J Lipid Res (2010) 0.93
Megavoltage computed tomography imaging: a potential tool to guide and improve the delivery of thoracic radiation therapy. Clin Lung Cancer (2004) 0.93
Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Hum Mol Genet (2012) 0.92
Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia. Stem Cells (2014) 0.92
Platelet dense-granule secretion plays a critical role in thrombosis and subsequent vascular remodeling in atherosclerotic mice. Circulation (2009) 0.92
A conserved role for atlastin GTPases in regulating lipid droplet size. Cell Rep (2013) 0.91
Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy. AJNR Am J Neuroradiol (2005) 0.91
Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation. Proc Natl Acad Sci U S A (2013) 0.91
Hereditary spastic paraplegia type 43 (SPG43) is caused by mutation in C19orf12. Hum Mutat (2013) 0.90
Detection of point mutations associated with antibiotic resistance in Pseudomonas aeruginosa. Int J Antimicrob Agents (2009) 0.90
Developmental student support in undergraduate medical education: AMEE Guide No. 92. Med Teach (2014) 0.89
MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis. Mol Biol Cell (2012) 0.89
Polyphenols, inflammatory response, and cancer prevention: chlorination of isoflavones by human neutrophils. J Nutr (2003) 0.89
Cement augmentation of refractory osteoporotic vertebral compression fractures: survivorship analysis. Spine (Phila Pa 1976) (2011) 0.89
The musculoskeletal effects of cigarette smoking. J Bone Joint Surg Am (2013) 0.88
A rare pitfall in the diagnosis of oesophageal atresia. Pediatr Radiol (2010) 0.88
An ex vivo study exploring the diagnostic potential of 1H magnetic resonance spectroscopy in squamous cell carcinoma of the head and neck region. Head Neck (2002) 0.88
Impaired gastrointestinal transit and its associated morbidity in the intensive care unit. J Crit Care (2013) 0.88
Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver. Toxicol Sci (2012) 0.88
3D-ultrasound guided radiation therapy in the post-prostatectomy setting. Technol Cancer Res Treat (2003) 0.87
Interaction of the SPG21 protein ACP33/maspardin with the aldehyde dehydrogenase ALDH16A1. Neurogenetics (2009) 0.86
Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions optical and terahertz skin cancers imaging. J Biophotonics (2012) 0.86
Global health hospitalists: the fastest growing specialty's newest niche. J Hosp Med (2013) 0.85
Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency. Eur J Pediatr (2006) 0.85
Simultaneous determination of itraconazole and hydroxyitraconazole in human plasma by high-performance liquid chromatography. J Chromatogr A (2004) 0.84
Helical tomotherapy as a means of delivering accelerated partial breast irradiation. Technol Cancer Res Treat (2004) 0.84
STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking. Traffic (2008) 0.83
Comparison of the effects of four suicide prevention programs for family and friends of high-risk suicidal men who do not seek help themselves. Suicide Life Threat Behav (2005) 0.83
A preliminary study on pro- and anti-inflammatory cytokine profiles in Plasmodium vivax malaria patients from central zone of India. Acta Trop (2009) 0.83
Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons. Neurogenetics (2010) 0.82
Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: a novel class of biological metabolites. J Mass Spectrom (2003) 0.82
A progressive, fatal dystonia-Parkinsonism syndrome in a patient with primary immunodeficiency receiving chronic IVIG therapy. Mov Disord (2007) 0.81
Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient. Crit Care Med (2016) 0.81
Potential for radiation therapy technology innovations to permit dose escalation for non-small-cell lung cancer. Clin Lung Cancer (2005) 0.81
Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis. Brain Res (2008) 0.81
Advantages of focused helical computed tomographic scanning with rectal contrast only vs triple contrast in the diagnosis of clinically uncertain acute appendicitis: a prospective randomized study. Arch Surg (2004) 0.81
Validated ultra-performance liquid chromatography tandem mass spectrometry method for the determination of pramipexole in human plasma. J Chromatogr Sci (2010) 0.81
Multicatheter hybrid breast brachytherapy: a potential alternative for patients with inadequate skin distance. Brachytherapy (2008) 0.80
Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid. Rheumatol Int (2007) 0.80
High-contrast mapping of basal cell carcinomas. Opt Lett (2012) 0.80
Diabetes insipidus as a consequence of neurologic involvement in Behcet's syndrome. Endocr Pract (2003) 0.78