Published in Science on October 03, 2003
Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol (2010) 3.97
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Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol (2009) 2.37
The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure (2011) 2.19
Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol Rev (2011) 2.06
Cryo-electron microscopy of vitreous sections. EMBO J (2004) 2.03
Subnanometre single-molecule localization, registration and distance measurements. Nature (2010) 1.98
Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harb Perspect Biol (2010) 1.96
How to build a central synapse: clues from cell culture. Trends Neurosci (2005) 1.94
Characterizing the initial encounter complex in cadherin adhesion. Structure (2009) 1.90
Resolving cadherin interactions and binding cooperativity at the single-molecule level. Proc Natl Acad Sci U S A (2008) 1.81
Thinking outside the cell: how cadherins drive adhesion. Trends Cell Biol (2012) 1.72
The allosteric role of the Ca2+ switch in adhesion and elasticity of C-cadherin. Biophys J (2008) 1.72
Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography. EMBO J (2004) 1.69
Two-step adhesive binding by classical cadherins. Nat Struct Mol Biol (2010) 1.67
The desmosome and pemphigus. Histochem Cell Biol (2008) 1.54
Trans-bonded pairs of E-cadherin exhibit a remarkable hierarchy of mechanical strengths. Proc Natl Acad Sci U S A (2004) 1.53
Cooperativity between trans and cis interactions in cadherin-mediated junction formation. Proc Natl Acad Sci U S A (2010) 1.46
Electron microscopy of high pressure frozen samples: bridging the gap between cellular ultrastructure and atomic resolution. Histochem Cell Biol (2008) 1.44
The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism. J Mol Biol (2007) 1.32
Sequence and structural determinants of strand swapping in cadherin domains: do all cadherins bind through the same adhesive interface? J Mol Biol (2008) 1.31
Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling. Mol Biol Cell (2005) 1.29
Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins. Structure (2008) 1.24
Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton. J Mol Histol (2004) 1.17
Mechanistic basis of desmosome-targeted diseases. J Mol Biol (2013) 1.16
The assay that defines desmosome hyper-adhesion. J Invest Dermatol (2012) 1.14
Lifetime measurements reveal kinetic differences between homophilic cadherin bonds. Biophys J (2005) 1.14
The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium. Int Rev Cell Mol Biol (2011) 1.12
Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem (2008) 1.09
Gene structure and mutant alleles of PCDH15: nonsyndromic deafness DFNB23 and type 1 Usher syndrome. Hum Genet (2008) 1.07
Disruption of desmosome assembly by monovalent human pemphigus vulgaris monoclonal antibodies. J Invest Dermatol (2008) 1.05
Monte Carlo electron-trajectory simulations in bright-field and dark-field STEM: implications for tomography of thick biological sections. Ultramicroscopy (2008) 1.04
Two stage cadherin kinetics require multiple extracellular domains but not the cytoplasmic region. J Biol Chem (2007) 1.03
Supported bilayers at the vanguard of immune cell activation studies. J Struct Biol (2009) 1.01
Desmosomes from a structural perspective. Curr Opin Cell Biol (2007) 1.00
Structure, function, and regulation of desmosomes. Prog Mol Biol Transl Sci (2013) 1.00
Membrane-impermeable cross-linking provides evidence for homophilic, isoform-specific binding of desmosomal cadherins in epithelial cells. J Biol Chem (2010) 0.99
Calcium-dependent dynamics of cadherin interactions at cell-cell junctions. Proc Natl Acad Sci U S A (2011) 0.98
Sorting out a promiscuous superfamily: towards cadherin connectomics. Trends Cell Biol (2014) 0.97
Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin. Am J Pathol (2008) 0.96
Local refinement: an attempt to correct for shrinkage and distortion in electron tomography. J Struct Biol (2006) 0.96
A freeze substitution fixation-based gold enlarging technique for EM studies of endocytosed Nanogold-labeled molecules. J Struct Biol (2007) 0.96
The three-dimensional molecular structure of the desmosomal plaque. Proc Natl Acad Sci U S A (2011) 0.95
Re-evaluation of a bacterial antifreeze protein as an adhesin with ice-binding activity. PLoS One (2012) 0.94
Methods for generating high-resolution structural models from electron microscope tomography data. Structure (2004) 0.94
Correlative light- and electron microscopy with chemical tags. J Struct Biol (2014) 0.94
Water at the surfaces of aligned phospholipid multibilayer model membranes probed with ultrafast vibrational spectroscopy. J Am Chem Soc (2008) 0.93
Three-dimensional architecture of hair-bundle linkages revealed by electron-microscopic tomography. J Assoc Res Otolaryngol (2008) 0.93
Dynamics and stability of E-cadherin dimers. Biophys J (2006) 0.92
Desmoglein 2 mutant mice develop cardiac fibrosis and dilation. Basic Res Cardiol (2011) 0.91
Desmosomes in vivo. Dermatol Res Pract (2010) 0.89
JUST (Java User Segmentation Tool) for semi-automatic segmentation of tomographic maps. J Struct Biol (2007) 0.89
Quantitative analysis of human keratinocyte cell elasticity using atomic force microscopy (AFM). IEEE Trans Nanobioscience (2011) 0.88
The formation of ordered nanoclusters controls cadherin anchoring to actin and cell-cell contact fluidity. J Cell Biol (2015) 0.87
Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus. J Biol Chem (2009) 0.86
Imaging and force spectroscopy on desmoglein 1 using atomic force microscopy reveal multivalent Ca(2+)-dependent, low-affinity trans-interaction. J Membr Biol (2007) 0.86
Nanomechanics of the cadherin ectodomain: "canalization" by Ca2+ binding results in a new mechanical element. J Biol Chem (2010) 0.86
Electron tomography of paranodal septate-like junctions and the associated axonal and glial cytoskeletons in the central nervous system. J Neurosci Res (2010) 0.85
The C-terminal unique region of desmoglein 2 inhibits its internalization via tail-tail interactions. J Cell Biol (2012) 0.84
Structure of artificial and natural VE-cadherin-based adherens junctions. Biochem Soc Trans (2008) 0.84
Desmosomes in acquired disease. Cell Tissue Res (2015) 0.83
The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin. J Pharm Sci (2009) 0.81
Characterization of multiple stable conformers of the EC5 domain of E-cadherin and the interaction of EC5 with E-cadherin peptides. Chem Biol Drug Des (2009) 0.79
Different roles of cadherins in the assembly and structural integrity of the desmosome complex. J Cell Sci (2014) 0.78
Exploring the Nature of Desmosomal Cadherin Associations in 3D. Dermatol Res Pract (2010) 0.78
CDH3-Related Syndromes: Report on a New Mutation and Overview of the Genotype-Phenotype Correlations. Mol Syndromol (2011) 0.77
LI-cadherin cis-dimerizes in the plasma membrane Ca(2+) independently and forms highly dynamic trans-contacts. Cell Mol Life Sci (2012) 0.77
Structural basis of adhesive binding by desmocollins and desmogleins. Proc Natl Acad Sci U S A (2016) 0.77
The X-ray structure of human P-cadherin EC1-EC2 in a closed conformation provides insight into the type I cadherin dimerization pathway. Acta Crystallogr F Struct Biol Commun (2015) 0.75
Cis and Trans Cooperativity of E-Cadherin Mediates Adhesion in Biomimetic Lipid Droplets. Biophys J (2016) 0.75
Extending the knowledge in histochemistry and cell biology. Histochem Cell Biol (2009) 0.75
Outcome of the first electron microscopy validation task force meeting. Structure (2012) 4.35
Structure of a copper pump suggests a regulatory role for its metal-binding domain. Structure (2008) 1.74
Beta-catenin and Tcfs in mammary development and cancer. J Mammary Gland Biol Neoplasia (2003) 1.68
Membrane invagination in Rhodobacter sphaeroides is initiated at curved regions of the cytoplasmic membrane, then forms both budded and fully detached spherical vesicles. Mol Microbiol (2010) 1.62
Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria. Biophys J (2011) 1.57
Normal mode-based fitting of atomic structure into electron density maps: application to sarcoplasmic reticulum Ca-ATPase. Biophys J (2004) 1.46
Structure-function mapping of a heptameric module in the nuclear pore complex. J Cell Biol (2012) 1.44
MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors. PLoS One (2009) 1.33
Comparison of lymphoblast mitochondria from normal subjects and patients with Barth syndrome using electron microscopic tomography. Lab Invest (2006) 1.32
Key signaling nodes in mammary gland development and cancer: β-catenin. Breast Cancer Res (2010) 1.24
Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development (2006) 1.23
A structural model for the catalytic cycle of Ca(2+)-ATPase. J Mol Biol (2002) 1.22
A hyperspectral imaging system for in vivo optical diagnostics. Hyperspectral imaging basic principles, instrumental systems, and applications of biomedical interest. IEEE Eng Med Biol Mag (2004) 1.16
The physical state of lipid substrates provides transacylation specificity for tafazzin. Nat Chem Biol (2012) 1.15
A high-throughput strategy to screen 2D crystallization trials of membrane proteins. J Struct Biol (2007) 1.15
Native ultrastructure of the red cell cytoskeleton by cryo-electron tomography. Biophys J (2011) 1.11
Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. Mitochondrion (2008) 1.10
Spatial and dynamic interactions between phospholamban and the canine cardiac Ca2+ pump revealed with use of heterobifunctional cross-linking agents. J Biol Chem (2003) 1.09
Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem (2008) 1.09
Biodiversity conservation in local planning. Conserv Biol (2008) 1.08
Cross-linking of C-terminal residues of phospholamban to the Ca2+ pump of cardiac sarcoplasmic reticulum to probe spatial and functional interactions within the transmembrane domain. J Biol Chem (2006) 1.08
Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia. Proc Natl Acad Sci U S A (2003) 1.08
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nat Struct Mol Biol (2013) 1.05
Role of metal-binding domains of the copper pump from Archaeoglobus fulgidus. Biochem Biophys Res Commun (2006) 1.01
A systematic screen for micro-RNAs regulating the canonical Wnt pathway. PLoS One (2011) 1.00
Structure, dynamics, evolution, and function of a major scaffold component in the nuclear pore complex. Structure (2013) 1.00
Fourier-Bessel reconstruction of helical assemblies. Methods Enzymol (2010) 0.99
Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy. Proc Natl Acad Sci U S A (2013) 0.99
Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling. Am J Pathol (2004) 0.98
Tafazzin knockdown in mice leads to a developmental cardiomyopathy with early diastolic dysfunction preceding myocardial noncompaction. J Am Heart Assoc (2012) 0.98
Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump. J Mol Biol (2010) 0.98
Plakoglobin is required for effective intermediate filament anchorage to desmosomes. J Invest Dermatol (2008) 0.97
Application of a miniature biochip using the molecular beacon probe in breast cancer gene BRCA1 detection. Biosens Bioelectron (2004) 0.97
Role of leucine 31 of phospholamban in structural and functional interactions with the Ca2+ pump of cardiac sarcoplasmic reticulum. J Biol Chem (2005) 0.97
Three-dimensional reconstruction of intact human integrin αIIbβ3: new implications for activation-dependent ligand binding. Blood (2013) 0.96
Real-space processing of helical filaments in SPARX. J Struct Biol (2012) 0.95
Beta-catenin and cyclin D1: connecting development to breast cancer. Cell Cycle (2004) 0.94
Plakoglobin is O-glycosylated close to the N-terminal destruction box. J Biol Chem (2003) 0.93
An automated pipeline to screen membrane protein 2D crystallization. J Struct Funct Genomics (2010) 0.93
Three-dimensional structure of the enveloped bacteriophage phi12: an incomplete T = 13 lattice is superposed on an enclosed T = 1 shell. PLoS One (2009) 0.92
Choreographing metastasis to the tune of LTBP. J Mammary Gland Biol Neoplasia (2011) 0.90
Application of the iterative helical real-space reconstruction method to large membranous tubular crystals of P-type ATPases. J Struct Biol (2006) 0.86
The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor. Development (2007) 0.85
Present and future of membrane protein structure determination by electron crystallography. Adv Protein Chem Struct Biol (2010) 0.85
Electron tomography of paranodal septate-like junctions and the associated axonal and glial cytoskeletons in the central nervous system. J Neurosci Res (2010) 0.85
Electron cryo-tomographic structure of cystovirus phi 12. Virology (2007) 0.82
Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms. Gene (2003) 0.82
Plasmonics-based nanostructures for surface-enhanced Raman scattering bioanalysis. Methods Mol Biol (2005) 0.82
The architecture of CopA from Archeaoglobus fulgidus studied by cryo-electron microscopy and computational docking. Structure (2011) 0.81
Toroidal surface complexes of bacteriophage ϕ12 are responsible for host-cell attachment. Virology (2011) 0.80
A mouse transgenic approach to induce β-catenin signaling in a temporally controlled manner. Transgenic Res (2010) 0.80
Cryoelectron tomography of isolated desmosomes. Biochem Soc Trans (2008) 0.79
Membrane protein structure determination by electron crystallography. Curr Opin Struct Biol (2012) 0.79
Exploring the Nature of Desmosomal Cadherin Associations in 3D. Dermatol Res Pract (2010) 0.78
Distinct function of androgen receptor coactivator ARA70α and ARA70β in mammary gland development, and in breast cancer. Breast Cancer Res Treat (2010) 0.77
Modeling, docking, and fitting of atomic structures to 3D maps from cryo-electron microscopy. Methods Mol Biol (2013) 0.77
Screening for the breast cancer gene (BRCA1) using a biochip system and molecular beacon probes immobilized on solid surfaces. J Biomed Opt (2004) 0.77
Gli activity is critical at multiple stages of embryonic mammary and nipple development. PLoS One (2013) 0.76
Links between transforming growth factor-beta and canonical Wnt signaling yield new insights into breast cancer susceptibility, suppression and tumor heterogeneity. Breast Cancer Res (2009) 0.76
Three-dimensional structure of the KdpFABC complex of Escherichia coli by electron tomography of two-dimensional crystals. J Struct Biol (2007) 0.76
Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution. Breast Cancer Res (2013) 0.75
Adhesion G-protein-coupled receptors: elusive hybrids come of age. Cell Commun Adhes (2013) 0.75
Highlights from special issue: junctional targets of skin and heart diseases. Cell Commun Adhes (2014) 0.75
Effect of orthophosphate, nucleotide analogues, ADP, and phosphorylation on the cytoplasmic domains of Ca(2+)-ATPase from scallop sarcoplasmic reticulum. J Biol Chem (2003) 0.75