Published in Biochemistry on October 21, 2003
Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria. Microbiol Mol Biol Rev (2008) 1.88
Drug targets in mycobacterial sulfur metabolism. Infect Disord Drug Targets (2007) 1.45
A mycothiol synthase mutant of Mycobacterium tuberculosis has an altered thiol-disulfide content and limited tolerance to stress. J Bacteriol (2006) 1.21
Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry (2010) 1.20
Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein. J Bacteriol (2004) 1.06
A mycothiol synthase mutant of Mycobacterium smegmatis produces novel thiols and has an altered thiol redox status. J Bacteriol (2005) 1.02
Detoxification of toxins by bacillithiol in Staphylococcus aureus. Microbiology (2012) 0.95
Analysis of mutants disrupted in bacillithiol metabolism in Staphylococcus aureus. Biochem Biophys Res Commun (2013) 0.86
Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production. J Bacteriol (2007) 0.86
New targets and inhibitors of mycobacterial sulfur metabolism. Infect Disord Drug Targets (2013) 0.83
The activity and cofactor preferences of N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) change depending on environmental conditions. J Biol Chem (2011) 0.83
Functional characterization of Corynebacterium glutamicum mycothiol S-conjugate amidase. PLoS One (2014) 0.81
Intramolecular alpha-glucosaminidation: synthesis of mycothiol. Org Lett (2010) 0.81
An N-acyl homolog of mycothiol is produced in marine actinomycetes. Arch Microbiol (2008) 0.80
Antibacterial activity of rifamycins for M. smegmatis with comparison of oxidation and binding to tear lipocalin. Biochim Biophys Acta (2014) 0.80
Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA. Biochim Biophys Acta (2014) 0.78
Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis. Bioorg Med Chem (2011) 0.78
Bacillithiol: a key protective thiol in Staphylococcus aureus. Expert Rev Anti Infect Ther (2015) 0.75
Structure and function of the LmbE-like superfamily. Biomolecules (2014) 0.75
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A (2010) 2.09
Bacillithiol is an antioxidant thiol produced in Bacilli. Nat Chem Biol (2009) 2.00
The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo. Mol Microbiol (2004) 1.89
Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria. Microbiol Mol Biol Rev (2008) 1.88
Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics. Antimicrob Agents Chemother (2002) 1.85
Mycothiol biochemistry. Arch Microbiol (2002) 1.83
Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast. Genome Res (2002) 1.72
Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics. Mol Microbiol (2003) 1.65
ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Biochemistry (2002) 1.61
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis. Mol Microbiol (2008) 1.52
Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. Cell Host Microbe (2008) 1.48
Comparative efficacy of commercially available and emerging antimicrobial urinary catheters against bacteriuria caused by E. coli in vitro. Urology (2011) 1.45
Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman. J Bacteriol (2003) 1.45
Mycobacterial manipulation of the host cell. FEMS Microbiol Rev (2005) 1.37
Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification. Proc Natl Acad Sci U S A (2011) 1.35
Mycothiol-dependent proteins in actinomycetes. FEMS Microbiol Rev (2007) 1.35
The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol Microbiol (2004) 1.34
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. Arch Microbiol (2002) 1.31
Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. J Bacteriol (2005) 1.31
The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). J Bacteriol (2003) 1.29
Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles. Nanomedicine (2010) 1.26
A mycothiol synthase mutant of Mycobacterium tuberculosis has an altered thiol-disulfide content and limited tolerance to stress. J Bacteriol (2006) 1.21
Biochemistry of the initial steps of mycothiol biosynthesis. J Biol Chem (2006) 1.21
Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry (2010) 1.20
Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology. Biochemistry (2007) 1.19
Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis. Biochim Biophys Acta (2009) 1.18
Mycobacterium bovis bacillus Calmette-Guérin secreting active cathepsin S stimulates expression of mature MHC class II molecules and antigen presentation in human macrophages. J Immunol (2007) 1.16
Thiol specific oxidative stress response in Mycobacteria. FEMS Microbiol Lett (2005) 1.11
Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation. J Cell Sci (2007) 1.11
Chemical and Chemoenzymatic syntheses of bacillithiol: a unique low-molecular-weight thiol amongst low G + C Gram-positive bacteria. Angew Chem Int Ed Engl (2011) 1.10
The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J Biol Chem (2003) 1.09
The mshA gene encoding the glycosyltransferase of mycothiol biosynthesis is essential in Mycobacterium tuberculosis Erdman. FEMS Microbiol Lett (2006) 1.09
Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis. Microbiology (2003) 1.09
Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles. Nanomedicine (2011) 1.08
Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors. Bioorg Med Chem (2003) 1.08
The mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance. J Biol Chem (2011) 1.06
Functional requirements for bacteriophage growth: gene essentiality and expression in mycobacteriophage Giles. Mol Microbiol (2013) 1.06
Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein. J Bacteriol (2004) 1.06
Slow release of nitric oxide from charged catheters and its effect on biofilm formation by Escherichia coli. Antimicrob Agents Chemother (2009) 1.06
Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis. PLoS Pathog (2012) 1.05
Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD. Biochem Biophys Res Commun (2006) 1.04
Mycobacterium bovis BCG attenuates surface expression of mature class II molecules through IL-10-dependent inhibition of cathepsin S. J Immunol (2005) 1.03
Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis. Biochem Biophys Res Commun (2007) 1.03
MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis. Mol Microbiol (2010) 1.03
Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis. Immunol Rev (2015) 1.03
A mycothiol synthase mutant of Mycobacterium smegmatis produces novel thiols and has an altered thiol redox status. J Bacteriol (2005) 1.02
Mycothiol-dependent mycobacterial response to oxidative stress. FEBS Lett (2006) 1.01
Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants. J Bacteriol (2011) 1.01
The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases. Biochemistry (2011) 1.01
Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen. Antimicrob Agents Chemother (2011) 1.00
Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis. J Biol Chem (2010) 0.99
Expression and localization of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Res Microbiol (2002) 0.99
Microbial protein-tyrosine kinases. J Biol Chem (2014) 0.98
Detoxification of toxins by bacillithiol in Staphylococcus aureus. Microbiology (2012) 0.95
Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme. Protein Expr Purif (2006) 0.94
Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum. J Ethnopharmacol (2011) 0.93
Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA. Biochem J (2009) 0.93
The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection. FEMS Microbiol Lett (2009) 0.92
Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity. PLoS Pathog (2013) 0.92
Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem Biophys Res Commun (2007) 0.91
Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure. Nitric Oxide (2008) 0.90
A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening. Anal Biochem (2006) 0.90
Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development. Trends Microbiol (2012) 0.89
Mycobacterium smegmatis biofilm formation and sliding motility are affected by the serine/threonine protein kinase PknF. FEMS Microbiol Lett (2007) 0.88
Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol. Antimicrob Agents Chemother (2007) 0.87
Mycobacterium avium subsp. paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection. Infect Immun (2006) 0.87
Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis. FEBS Lett (2012) 0.86
The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett (2011) 0.86
Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production. J Bacteriol (2007) 0.86
In vitro properties of antimicrobial bromotyrosine alkaloids. J Med Microbiol (2006) 0.86
Antimycobacterial activity of UDP-galactopyranose mutase inhibitors. Int J Antimicrob Agents (2010) 0.85
Precise null deletion mutations of the mycothiol synthesis genes reveal their role in isoniazid and ethionamide resistance in Mycobacterium smegmatis. Antimicrob Agents Chemother (2011) 0.85
Cloning, expression and rapid purification of active recombinant mycothiol ligase as B1 immunoglobulin binding domain of streptococcal protein G, glutathione-S-transferase and maltose binding protein fusion proteins in Mycobacterium smegmatis. Protein Expr Purif (2006) 0.85
Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis. BMC Microbiol (2010) 0.84
Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis. Antimicrob Agents Chemother (2011) 0.84
Kinome analysis of host response to mycobacterial infection: a novel technique in proteomics. Infect Immun (2003) 0.84
Mycobacterium tuberculosis modulators of the macrophage's cellular events. Microbes Infect (2012) 0.83
Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA. Mol Microbiol (2008) 0.82
Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles. Future Microbiol (2013) 0.82
Molecular cloning and biochemical characterization of a serine threonine protein kinase, PknL, from Mycobacterium tuberculosis. Protein Expr Purif (2008) 0.82
Glutathione disulfide and S-nitrosoglutathione detoxification by Mycobacterium tuberculosis thioredoxin system. FEBS Lett (2009) 0.81