Published in J Neurosci on October 15, 2003
The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl) (2006) 9.18
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The adolescent brain. Dev Rev (2008) 4.21
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest (2006) 3.81
Affective neuroscience of pleasure: reward in humans and animals. Psychopharmacology (Berl) (2008) 3.26
The mysterious motivational functions of mesolimbic dopamine. Neuron (2012) 3.22
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Ventral pallidum roles in reward and motivation. Behav Brain Res (2008) 2.12
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Relation of obesity to consummatory and anticipatory food reward. Physiol Behav (2009) 1.52
Opioids for hedonic experience and dopamine to get ready for it. Psychopharmacology (Berl) (2006) 1.52
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Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse. Curr Top Behav Neurosci (2010) 1.46
Roux-en-Y gastric bypass surgery changes food reward in rats. Int J Obes (Lond) (2010) 1.41
Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling. Learn Mem (2011) 1.36
Attention-Deficit Hyperactivity Disorder in the post-genomic era. Eur Child Adolesc Psychiatry (2004) 1.36
An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiol Behav (2009) 1.35
Pleasure systems in the brain. Neuron (2015) 1.34
The nucleus accumbens and Pavlovian reward learning. Neuroscientist (2007) 1.33
Leptin signaling in brain: A link between nutrition and cognition? Biochim Biophys Acta (2008) 1.31
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Phasic dopamine release in appetitive behaviors and drug addiction. Curr Drug Abuse Rev (2009) 1.30
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Dissociation of hedonic reaction to reward and incentive motivation in an animal model of the negative symptoms of schizophrenia. Neuropsychopharmacology (2012) 1.26
Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia. J Psychiatry Neurosci (2016) 1.21
Palatable foods, stress, and energy stores sculpt corticotropin-releasing factor, adrenocorticotropin, and corticosterone concentrations after restraint. Endocrinology (2008) 1.21
Tonic dopamine modulates exploitation of reward learning. Front Behav Neurosci (2010) 1.17
"Liking" and "wanting" of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition. Am J Physiol Regul Integr Comp Physiol (2011) 1.13
Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward. J Neurosci (2011) 1.12
Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression. BMC Neurosci (2007) 1.09
Pain and suicidality: insights from reward and addiction neuroscience. Prog Neurobiol (2013) 1.08
Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation. Mol Psychiatry (2013) 1.08
Viral restoration of dopamine signaling to the dorsal striatum restores instrumental conditioning to dopamine-deficient mice. Psychopharmacology (Berl) (2006) 1.06
An imperfect dopaminergic error signal can drive temporal-difference learning. PLoS Comput Biol (2011) 1.04
Hedonic and incentive signals for body weight control. Rev Endocr Metab Disord (2011) 1.02
Taste does not determine daily intake of dilute sugar solutions in mice. Am J Physiol Regul Integr Comp Physiol (2010) 1.02
Taste uncoupled from nutrition fails to sustain the reinforcing properties of food. Eur J Neurosci (2012) 1.02
Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. Front Integr Neurosci (2012) 1.00
Regulation of dietary choice by the decision-making circuitry. Nat Neurosci (2013) 1.00
Schizophrenia in translation: dissecting motivation in schizophrenia and rodents. Schizophr Bull (2012) 0.99
Structure, production and signaling of leptin. Metabolism (2014) 0.98
Dopamine transporter mutant mice in experimental neuropharmacology. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.97
Diet-induced obesity: dopamine transporter function, impulsivity and motivation. Int J Obes (Lond) (2012) 0.96
Appetite and body weight regulation after bariatric surgery. Obes Rev (2015) 0.96
Reversible suppression of food reward behavior by chronic mu-opioid receptor antagonism in the nucleus accumbens. Neuroscience (2010) 0.96
Assessing the validity of current mouse genetic models of obsessive-compulsive disorder. Behav Pharmacol (2009) 0.96
Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia. Neurosci Biobehav Rev (2013) 0.95
Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder. Curr Chem Genomics (2008) 0.95
Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation. J Am Soc Nephrol (2011) 0.93
Conjunctive encoding of movement and reward by ventral tegmental area neurons in the freely navigating rodent. Behav Neurosci (2010) 0.93
Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior. Neurosci Biobehav Rev (2013) 0.93
Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain. Front Behav Neurosci (2015) 0.91
Advances in the neurobiological bases for food 'liking' versus 'wanting'. Physiol Behav (2014) 0.90
Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson's disease. Mol Psychiatry (2013) 0.90
Lateral thinking about leptin: a review of leptin action via the lateral hypothalamus. Physiol Behav (2011) 0.88
Monoamine transporters: vulnerable and vital doorkeepers. Prog Mol Biol Transl Sci (2011) 0.87
The influence of leptin on the dopamine system and implications for ingestive behavior. Int J Obes (Lond) (2009) 0.87
Obesity and the neurocognitive basis of food reward and the control of intake. Adv Nutr (2015) 0.86
Depot naltrexone decreases rewarding properties of sugar in patients with opioid dependence. Psychopharmacology (Berl) (2011) 0.86
Alterations in blood glucose levels under hyperinsulinemia affect accumbens dopamine. Physiol Behav (2006) 0.86
Dopaminergic enhancement of local food-seeking is under global homeostatic control. Eur J Neurosci (2011) 0.85
Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry. Front Syst Neurosci (2015) 0.84
Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders. J Child Psychol Psychiatry (2011) 0.84
Attention-deficit/hyperactivity disorder: is it time to reappraise the role of sugar consumption? Postgrad Med (2011) 0.84
Feed efficiency, food choice, and food reward behaviors in young and old Fischer rats. Neurobiol Aging (2010) 0.83
Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet. PLoS One (2014) 0.83
Food reward in the obese and after weight loss induced by calorie restriction and bariatric surgery. Ann N Y Acad Sci (2012) 0.83
Differential effects of dopamine receptor D1-type and D2-type antagonists and phase of the estrous cycle on social learning of food preferences, feeding, and social interactions in mice. Neuropsychopharmacology (2011) 0.83
Spared and impaired aspects of motivated cognitive control in schizophrenia. J Abnorm Psychol (2013) 0.83
Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust. Eur J Neurosci (2010) 0.83
What motivates gambling behavior? Insight into dopamine's role. Front Behav Neurosci (2013) 0.81
Dopamine and pain sensitivity: neither sulpiride nor acute phenylalanine and tyrosine depletion have effects on thermal pain sensations in healthy volunteers. PLoS One (2013) 0.81
Keep focussing: striatal dopamine multiple functions resolved in a single mechanism tested in a simulated humanoid robot. Front Psychol (2014) 0.81
Dopamine D5 receptor modulates male and female sexual behavior in mice. Psychopharmacology (Berl) (2005) 0.81
Nucleus accumbens GABAergic inhibition generates intense eating and fear that resists environmental retuning and needs no local dopamine. Eur J Neurosci (2013) 0.81
Neural correlates of motor vigour and motor urgency during exercise. Sports Med (2013) 0.80
Central melanocortins regulate the motivation for sucrose reward. PLoS One (2015) 0.79
Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice. Genes Brain Behav (2013) 0.79
Human dopamine transporter gene: differential regulation of 18-kb haplotypes. Pharmacogenomics (2013) 0.79
Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample. Appetite (2011) 0.79
Homeostatic regulation of memory systems and adaptive decisions. Hippocampus (2013) 0.79
Can We Selectively Reduce Appetite for Energy-Dense Foods? An Overview of Pharmacological Strategies for Modification of Food Preference Behavior. Curr Neuropharmacol (2016) 0.78
A role for the lateral dorsal tegmentum in memory and decision neural circuitry. Neurobiol Learn Mem (2014) 0.78
The motivational drive to natural rewards is modulated by prenatal glucocorticoid exposure. Transl Psychiatry (2014) 0.78
Deep Brain Stimulation for Obesity: From a Theoretical Framework to Practical Application. Neural Plast (2015) 0.77
Trait Anticipatory Pleasure Predicts Effort Expenditure for Reward. PLoS One (2015) 0.77
Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons. Mol Metab (2015) 0.77
Dopamine D1/D2 receptors do not mediate the expression of conditioned place preference induced by the aftereffect of wheel running. BMC Neurosci (2014) 0.76
Compromised NMDA/Glutamate Receptor Expression in Dopaminergic Neurons Impairs Instrumental Learning, But Not Pavlovian Goal Tracking or Sign Tracking(1,2,3). eNeuro (2015) 0.76
Measuring anhedonia: impaired ability to pursue, experience, and learn about reward. Front Psychol (2015) 0.76
Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice. Psychopharmacology (Berl) (2015) 0.76
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. Nat Commun (2016) 0.76
The effects of reduced dopamine transporter function and chronic lithium on motivation, probabilistic learning, and neurochemistry in mice: Modeling bipolar mania. Neuropharmacology (2016) 0.76
Addiction. Annu Rev Psychol (2002) 6.70
Review. The incentive sensitization theory of addiction: some current issues. Philos Trans R Soc Lond B Biol Sci (2008) 5.54
The neuroscience of natural rewards: relevance to addictive drugs. J Neurosci (2002) 4.70
Dissecting components of reward: 'liking', 'wanting', and learning. Curr Opin Pharmacol (2009) 4.46
Retracted Expression of concern: Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med (2008) 3.93
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature (2002) 3.92
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17
Hedonic hot spot in nucleus accumbens shell: where do mu-opioids cause increased hedonic impact of sweetness? J Neurosci (2005) 3.10
Ventral pallidum firing codes hedonic reward: when a bad taste turns good. J Neurophysiol (2006) 2.62
Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses. J Neurosci (2004) 2.45
Unconscious affective reactions to masked happy versus angry faces influence consumption behavior and judgments of value. Pers Soc Psychol Bull (2005) 2.42
Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste "liking"/"disliking" reactions, place preference/avoidance, and fear. J Neurosci (2002) 2.30
Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. J Neurosci (2007) 2.18
Ventral pallidum roles in reward and motivation. Behav Brain Res (2008) 2.12
The ventral pallidum and hedonic reward: neurochemical maps of sucrose "liking" and food intake. J Neurosci (2005) 2.10
Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. Neuropsychopharmacology (2007) 2.09
Disentangling pleasure from incentive salience and learning signals in brain reward circuitry. Proc Natl Acad Sci U S A (2011) 2.09
Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats. Behav Brain Res (2006) 2.02
Towards a functional neuroanatomy of pleasure and happiness. Trends Cogn Sci (2009) 1.98
Hedonic hot spots in the brain. Neuroscientist (2006) 1.96
Instant transformation of learned repulsion into motivational "wanting". Curr Biol (2013) 1.96
Neural correlates of social and nonsocial emotions: An fMRI study. Neuroimage (2006) 1.82
Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue. J Neurosci (2009) 1.81
Emotional environments retune the valence of appetitive versus fearful functions in nucleus accumbens. Nat Neurosci (2008) 1.80
Mesolimbic dopamine in desire and dread: enabling motivation to be generated by localized glutamate disruptions in nucleus accumbens. J Neurosci (2008) 1.76
Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J Biol Chem (2005) 1.75
Enkephalin surges in dorsal neostriatum as a signal to eat. Curr Biol (2012) 1.74
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biol (2007) 1.72
A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. Arch Gen Psychiatry (2009) 1.69
Ventral pallidal neurons code incentive motivation: amplification by mesolimbic sensitization and amphetamine. Eur J Neurosci (2005) 1.64
Glutamate motivational ensembles in nucleus accumbens: rostrocaudal shell gradients of fear and feeding. Eur J Neurosci (2003) 1.62
Mice with chronically elevated dopamine exhibit enhanced motivation, but not learning, for a food reward. Neuropsychopharmacology (2005) 1.60
Dynamic computation of incentive salience: "wanting" what was never "liked". J Neurosci (2009) 1.55
Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress? BMC Biol (2006) 1.49
Identification of the subthalamic nucleus in deep brain stimulation surgery with a novel wavelet-derived measure of neural background activity. J Neurosurg (2009) 1.49
A neural computational model of incentive salience. PLoS Comput Biol (2009) 1.48
Transgenic mouse models of dopamine deficiency. Ann Neurol (2003) 1.45
Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. J Neurosci (2008) 1.43
Dopamine scales performance in the absence of new learning. Neuron (2006) 1.35
Sequential super-stereotypy of an instinctive fixed action pattern in hyper-dopaminergic mutant mice: a model of obsessive compulsive disorder and Tourette's. BMC Biol (2005) 1.30
Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system. Biol Psychiatry (2003) 1.28
Model-based and model-free Pavlovian reward learning: revaluation, revision, and revelation. Cogn Affect Behav Neurosci (2014) 1.22
Instrumental learning in hyperdopaminergic mice. Neurobiol Learn Mem (2006) 1.22
Ventral pallidal representation of pavlovian cues and reward: population and rate codes. J Neurosci (2004) 1.21
Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue-triggered 'wanting' for reward: entire core and medial shell mapped as substrates for PIT enhancement. Eur J Neurosci (2013) 1.19
Analyzing grooming microstructure in neurobehavioral experiments. Nat Protoc (2007) 1.18
Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs). Neuropharmacology (2008) 1.18
Tonic dopamine modulates exploitation of reward learning. Front Behav Neurosci (2010) 1.17
Dopamine-dependent motor learning: insight into levodopa's long-duration response. Ann Neurol (2010) 1.12
Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the rat. PLoS One (2010) 1.12
Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. J Neurosci (2009) 1.11
Reward uncertainty enhances incentive salience attribution as sign-tracking. Behav Brain Res (2012) 1.10
Nucleus accumbens dopamine/glutamate interaction switches modes to generate desire versus dread: D(1) alone for appetitive eating but D(1) and D(2) together for fear. J Neurosci (2011) 1.10
Which cue to 'want'? Opioid stimulation of central amygdala makes goal-trackers show stronger goal-tracking, just as sign-trackers show stronger sign-tracking. Behav Brain Res (2012) 1.09
Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression. BMC Neurosci (2007) 1.09
What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex. Psychopharmacology (Berl) (2011) 1.08
Mapping brain circuits of reward and motivation: in the footsteps of Ann Kelley. Neurosci Biobehav Rev (2012) 1.07
Dopamine receptor modulation of repetitive grooming actions in the rat: potential relevance for Tourette syndrome. Brain Res (2010) 1.06
Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice. Hum Mol Genet (2007) 1.05
Low amplitude entrainment of mice and the impact of circadian phase on behavior tests. Physiol Behav (2006) 1.04
Basal ganglia neural mechanisms of natural movement sequences. Can J Physiol Pharmacol (2004) 1.04
Taste uncoupled from nutrition fails to sustain the reinforcing properties of food. Eur J Neurosci (2012) 1.02
Opioid hedonic hotspot in nucleus accumbens shell: mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting". J Neurosci (2014) 1.01
Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources. Front Integr Neurosci (2012) 1.00
Chronic blockade or constitutive deletion of the serotonin transporter reduces operant responding for food reward. Neuropsychopharmacology (2007) 1.00
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An orexin hotspot in ventral pallidum amplifies hedonic 'liking' for sweetness. Neuropsychopharmacology (2013) 0.98
Prefrontal cortex modulates desire and dread generated by nucleus accumbens glutamate disruption. Biol Psychiatry (2012) 0.98
A cAMP pathway underlying reward prediction in associative learning. J Neurosci (2008) 0.95
Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila. J Biol Chem (2013) 0.94
The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. Mitochondrion (2011) 0.94
Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice. J Neurophysiol (2007) 0.93
The functional neuroanatomy of pleasure and happiness. Discov Med (2010) 0.92
Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disorders. Eur J Neurosci (2002) 0.92
Altered locus coeruleus-norepinephrine function following single prolonged stress. Eur J Neurosci (2012) 0.92
Sucrose exposure in early life alters adult motivation and weight gain. PLoS One (2008) 0.89
Loss of cocaine locomotor response in Pitx3-deficient mice lacking a nigrostriatal pathway. Neuropsychopharmacology (2008) 0.88
A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease. Cell Rep (2012) 0.88
Endogenous opioids are necessary for benzodiazepine palatability enhancement: naltrexone blocks diazepam-induced increase of sucrose-'liking'. Pharmacol Biochem Behav (2005) 0.88
Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. J Neurosci (2014) 0.87
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Endogenous nociceptin modulates diet preference independent of motivation and reward. Physiol Behav (2008) 0.86
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Improved signal and reduced noise in neural recordings from close-spaced electrode arrays using independent component analysis as a preprocessor. J Neurosci Methods (2006) 0.85
Motivational effects on interval timing in dopamine transporter (DAT) knockdown mice. Brain Res (2010) 0.83
The dopamine transporter expression level differentially affects responses to cocaine and amphetamine. J Neurogenet (2014) 0.83