Published in J Neurosci on December 14, 2005
The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl) (2006) 9.18
Dissecting components of reward: 'liking', 'wanting', and learning. Curr Opin Pharmacol (2009) 4.46
Reconsidering anhedonia in depression: lessons from translational neuroscience. Neurosci Biobehav Rev (2010) 3.46
Affective neuroscience of pleasure: reward in humans and animals. Psychopharmacology (Berl) (2008) 3.26
'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders. Physiol Behav (2009) 2.94
The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res (2010) 2.68
Reward processing by the opioid system in the brain. Physiol Rev (2009) 2.46
Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding. Psychopharmacology (Berl) (2007) 2.33
Reward mechanisms in obesity: new insights and future directions. Neuron (2011) 2.21
Ventral pallidum roles in reward and motivation. Behav Brain Res (2008) 2.12
Disentangling pleasure from incentive salience and learning signals in brain reward circuitry. Proc Natl Acad Sci U S A (2011) 2.09
Instant transformation of learned repulsion into motivational "wanting". Curr Biol (2013) 1.96
Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue. J Neurosci (2009) 1.81
Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats. J Neurosci (2012) 1.79
Mesolimbic dopamine in desire and dread: enabling motivation to be generated by localized glutamate disruptions in nucleus accumbens. J Neurosci (2008) 1.76
Enkephalin surges in dorsal neostriatum as a signal to eat. Curr Biol (2012) 1.74
Hypothesis-driven structural connectivity analysis supports network over hierarchical model of brain architecture. Proc Natl Acad Sci U S A (2010) 1.66
Neuroscience of affect: brain mechanisms of pleasure and displeasure. Curr Opin Neurobiol (2013) 1.56
Activation in the VTA and nucleus accumbens increases in anticipation of both gains and losses. Front Behav Neurosci (2009) 1.53
The structural basis for mapping behavior onto the ventral striatum and its subdivisions. Brain Struct Funct (2008) 1.52
Distinct opioid circuits determine the palatability and the desirability of rewarding events. Proc Natl Acad Sci U S A (2009) 1.51
Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress? BMC Biol (2006) 1.49
Gustatory reward and the nucleus accumbens. Physiol Behav (2006) 1.48
Roux-en-Y gastric bypass surgery changes food reward in rats. Int J Obes (Lond) (2010) 1.41
Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum. Eur J Neurosci (2011) 1.36
An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiol Behav (2009) 1.35
Pleasure systems in the brain. Neuron (2015) 1.34
The nucleus accumbens and Pavlovian reward learning. Neuroscientist (2007) 1.33
Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression. BMC Biol (2007) 1.31
Food reward, hyperphagia, and obesity. Am J Physiol Regul Integr Comp Physiol (2011) 1.31
Serotonergic neurons signal reward and punishment on multiple timescales. Elife (2015) 1.30
Licking-induced synchrony in the taste-reward circuit improves cue discrimination during learning. J Neurosci (2010) 1.29
Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in rats. Am J Physiol Regul Integr Comp Physiol (2008) 1.28
Dissociation of hedonic reaction to reward and incentive motivation in an animal model of the negative symptoms of schizophrenia. Neuropsychopharmacology (2012) 1.26
Roles of nucleus accumbens and basolateral amygdala in autoshaped lever pressing. Neurobiol Learn Mem (2012) 1.22
Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue-triggered 'wanting' for reward: entire core and medial shell mapped as substrates for PIT enhancement. Eur J Neurosci (2013) 1.19
Sweet preferences and analgesia during childhood: effects of family history of alcoholism and depression. Addiction (2010) 1.17
Dissecting motivational circuitry to understand substance abuse. Neuropharmacology (2008) 1.14
Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression. Transl Psychiatry (2014) 1.14
Encoding of aversion by dopamine and the nucleus accumbens. Front Neurosci (2012) 1.13
Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus. Br J Pharmacol (2007) 1.13
Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the rat. PLoS One (2010) 1.12
Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward. J Neurosci (2011) 1.12
What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex. Psychopharmacology (Berl) (2011) 1.08
Mapping brain circuits of reward and motivation: in the footsteps of Ann Kelley. Neurosci Biobehav Rev (2012) 1.07
Functional interaction of medial mediodorsal thalamic nucleus but not nucleus accumbens with amygdala and orbital prefrontal cortex is essential for adaptive response selection after reinforcer devaluation. J Neurosci (2010) 1.06
Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects. Mol Psychiatry (2012) 1.06
Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans. Mol Psychiatry (2011) 1.06
Dysregulation of brain reward systems in eating disorders: neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa. Neuropharmacology (2011) 1.05
Greater effort boosts the affective taste properties of food. Proc Biol Sci (2010) 1.05
Opioids in the hypothalamic paraventricular nucleus stimulate ethanol intake. Alcohol Clin Exp Res (2009) 1.04
Hedonic and incentive signals for body weight control. Rev Endocr Metab Disord (2011) 1.02
Inhibition of opioid transmission at the μ-opioid receptor prevents both food seeking and binge-like eating. Neuropsychopharmacology (2012) 1.02
Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis. Biol Mood Anxiety Disord (2013) 1.02
Convergent, not serial, striatal and pallidal circuits regulate opioid-induced food intake. Neuroscience (2009) 1.02
μ- and δ-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice. J Neurosci (2012) 1.01
Neural basis of reward and craving--a homeostatic point of view. Dialogues Clin Neurosci (2007) 1.01
Opioid hedonic hotspot in nucleus accumbens shell: mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting". J Neurosci (2014) 1.01
Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats. J Neurosci (2012) 1.00
On lateral septum-like characteristics of outputs from the accumbal hedonic "hotspot" of Peciña and Berridge with commentary on the transitional nature of basal forebrain "boundaries". J Comp Neurol (2013) 1.00
Hedonic and nucleus accumbens neural responses to a natural reward are regulated by aversive conditioning. Learn Mem (2010) 1.00
Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans. Arch Gen Psychiatry (2009) 1.00
Schizophrenia in translation: dissecting motivation in schizophrenia and rodents. Schizophr Bull (2012) 0.99
Role of nucleus accumbens in neuropathic pain: linked multi-scale evidence in the rat transitioning to neuropathic pain. Pain (2014) 0.98
The rostral subcommissural ventral pallidum is a mix of ventral pallidal neurons and neurons from adjacent areas: an electrophysiological study. Brain Struct Funct (2012) 0.98
DECISION UTILITY, THE BRAIN, AND PURSUIT OF HEDONIC GOALS. Soc Cogn (2008) 0.98
An orexin hotspot in ventral pallidum amplifies hedonic 'liking' for sweetness. Neuropsychopharmacology (2013) 0.98
Sweet liking phenotype, alcohol craving and response to naltrexone treatment in alcohol dependence. Alcohol Alcohol (2009) 0.97
Reversible suppression of food reward behavior by chronic mu-opioid receptor antagonism in the nucleus accumbens. Neuroscience (2010) 0.96
Building a neuroscience of pleasure and well-being. Psychol Well Being (2011) 0.95
Effects of nucleus accumbens core and shell lesions on autoshaped lever-pressing. Behav Brain Res (2013) 0.95
The neural substrates of enhanced salt appetite after repeated sodium depletions. Brain Res (2007) 0.95
Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward. Neuropsychopharmacology (2012) 0.94
Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior. Neurosci Biobehav Rev (2013) 0.93
Unipolar depression does not moderate responses to the Sweet Taste Test. Depress Anxiety (2010) 0.93
Sweetened-fat intake sensitizes gamma-aminobutyric acid-mediated feeding responses elicited from the nucleus accumbens shell. Biol Psychiatry (2013) 0.92
Nicotinic regulation of energy homeostasis. Nicotine Tob Res (2012) 0.92
Nucleus accumbens shell, but not core, tracks motivational value of salt. J Neurophysiol (2011) 0.91
Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain. Front Behav Neurosci (2015) 0.91
Differential role of mu, delta and kappa opioid receptors in ethanol-mediated locomotor activation and ethanol intake in preweanling rats. Physiol Behav (2009) 0.91
Advances in the neurobiological bases for food 'liking' versus 'wanting'. Physiol Behav (2014) 0.90
Striatal direct and indirect pathways control decision-making behavior. Front Psychol (2014) 0.90
Opioids in the nucleus accumbens stimulate ethanol intake. Physiol Behav (2009) 0.90
Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. Addict Biol (2012) 0.89
Behavioral characterization of amygdala involvement in mediating intra-accumbens opioid-driven feeding behavior. Behav Neurosci (2009) 0.89
High-fat intake induced by mu-opioid activation of the nucleus accumbens is inhibited by Y1R-blockade and MC3/4R- stimulation. Brain Res (2010) 0.89
Chronic suppression of μ-opioid receptor signaling in the nucleus accumbens attenuates development of diet-induced obesity in rats. Int J Obes (Lond) (2010) 0.88
Increased adiposity on normal diet, but decreased susceptibility to diet-induced obesity in mu-opioid receptor-deficient mice. Eur J Pharmacol (2008) 0.88
Lateral hypothalamus contains two types of palatability-related taste responses with distinct dynamics. J Neurosci (2013) 0.88
Excessive disgust caused by brain lesions or temporary inactivations: mapping hotspots of the nucleus accumbens and ventral pallidum. Eur J Neurosci (2014) 0.87
The influence of leptin on the dopamine system and implications for ingestive behavior. Int J Obes (Lond) (2009) 0.87
Obesity and the neurocognitive basis of food reward and the control of intake. Adv Nutr (2015) 0.86
mu-Opioid receptor stimulation in the nucleus accumbens elevates fatty tastant intake by increasing palatability and suppressing satiety signals. Am J Physiol Regul Integr Comp Physiol (2011) 0.86
Pathological Overeating: Emerging Evidence for a Compulsivity Construct. Neuropsychopharmacology (2016) 0.86
Altered neural reward and loss processing and prediction error signalling in depression. Soc Cogn Affect Neurosci (2015) 0.86
Chemical gradients within brain extracellular space measured using low flow push-pull perfusion sampling in vivo. ACS Chem Neurosci (2012) 0.86
Attenuated beta endorphin response to acute stress is associated with smoking relapse. Pharmacol Biochem Behav (2008) 0.85
Dorsal and ventral streams: the distinct role of striatal subregions in the acquisition and performance of goal-directed actions. Neurobiol Learn Mem (2013) 0.85
Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry. Front Syst Neurosci (2015) 0.84
The hormonal signature of energy deficit: Increasing the value of food reward. Mol Metab (2013) 0.83
Addiction. Annu Rev Psychol (2002) 6.70
Review. The incentive sensitization theory of addiction: some current issues. Philos Trans R Soc Lond B Biol Sci (2008) 5.54
The neuroscience of natural rewards: relevance to addictive drugs. J Neurosci (2002) 4.70
Ventral pallidum firing codes hedonic reward: when a bad taste turns good. J Neurophysiol (2006) 2.62
Unconscious affective reactions to masked happy versus angry faces influence consumption behavior and judgments of value. Pers Soc Psychol Bull (2005) 2.42
Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste "liking"/"disliking" reactions, place preference/avoidance, and fear. J Neurosci (2002) 2.30
Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. J Neurosci (2007) 2.18
Ventral pallidum roles in reward and motivation. Behav Brain Res (2008) 2.12
The ventral pallidum and hedonic reward: neurochemical maps of sucrose "liking" and food intake. J Neurosci (2005) 2.10
Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. Neuropsychopharmacology (2007) 2.09
Disentangling pleasure from incentive salience and learning signals in brain reward circuitry. Proc Natl Acad Sci U S A (2011) 2.09
Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards. J Neurosci (2003) 2.00
Towards a functional neuroanatomy of pleasure and happiness. Trends Cogn Sci (2009) 1.98
Hedonic hot spots in the brain. Neuroscientist (2006) 1.96
Instant transformation of learned repulsion into motivational "wanting". Curr Biol (2013) 1.96
Neural correlates of social and nonsocial emotions: An fMRI study. Neuroimage (2006) 1.82
Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue. J Neurosci (2009) 1.81
Emotional environments retune the valence of appetitive versus fearful functions in nucleus accumbens. Nat Neurosci (2008) 1.80
Mesolimbic dopamine in desire and dread: enabling motivation to be generated by localized glutamate disruptions in nucleus accumbens. J Neurosci (2008) 1.76
Enkephalin surges in dorsal neostriatum as a signal to eat. Curr Biol (2012) 1.74
Ventral pallidal neurons code incentive motivation: amplification by mesolimbic sensitization and amphetamine. Eur J Neurosci (2005) 1.64
Glutamate motivational ensembles in nucleus accumbens: rostrocaudal shell gradients of fear and feeding. Eur J Neurosci (2003) 1.62
Dynamic computation of incentive salience: "wanting" what was never "liked". J Neurosci (2009) 1.55
Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress? BMC Biol (2006) 1.49
A neural computational model of incentive salience. PLoS Comput Biol (2009) 1.48
Model-based and model-free Pavlovian reward learning: revaluation, revision, and revelation. Cogn Affect Behav Neurosci (2014) 1.22
Ventral pallidal representation of pavlovian cues and reward: population and rate codes. J Neurosci (2004) 1.21
Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue-triggered 'wanting' for reward: entire core and medial shell mapped as substrates for PIT enhancement. Eur J Neurosci (2013) 1.19
Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the rat. PLoS One (2010) 1.12
Reward uncertainty enhances incentive salience attribution as sign-tracking. Behav Brain Res (2012) 1.10
Nucleus accumbens dopamine/glutamate interaction switches modes to generate desire versus dread: D(1) alone for appetitive eating but D(1) and D(2) together for fear. J Neurosci (2011) 1.10
Which cue to 'want'? Opioid stimulation of central amygdala makes goal-trackers show stronger goal-tracking, just as sign-trackers show stronger sign-tracking. Behav Brain Res (2012) 1.09
What and when to "want"? Amygdala-based focusing of incentive salience upon sugar and sex. Psychopharmacology (Berl) (2011) 1.08
Mapping brain circuits of reward and motivation: in the footsteps of Ann Kelley. Neurosci Biobehav Rev (2012) 1.07
Dopamine receptor modulation of repetitive grooming actions in the rat: potential relevance for Tourette syndrome. Brain Res (2010) 1.06
Basal ganglia neural mechanisms of natural movement sequences. Can J Physiol Pharmacol (2004) 1.04
Opioid hedonic hotspot in nucleus accumbens shell: mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting". J Neurosci (2014) 1.01
An orexin hotspot in ventral pallidum amplifies hedonic 'liking' for sweetness. Neuropsychopharmacology (2013) 0.98
Prefrontal cortex modulates desire and dread generated by nucleus accumbens glutamate disruption. Biol Psychiatry (2012) 0.98
The functional neuroanatomy of pleasure and happiness. Discov Med (2010) 0.92
Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disorders. Eur J Neurosci (2002) 0.92
Endogenous opioids are necessary for benzodiazepine palatability enhancement: naltrexone blocks diazepam-induced increase of sucrose-'liking'. Pharmacol Biochem Behav (2005) 0.88
Excessive disgust caused by brain lesions or temporary inactivations: mapping hotspots of the nucleus accumbens and ventral pallidum. Eur J Neurosci (2014) 0.87
Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust. Eur J Neurosci (2010) 0.83
Dopamine D1 activation shortens the duration of phases in stereotyped grooming sequences. Behav Processes (2005) 0.82
Differential subjective and psychophysiological responses to socially and nonsocially generated emotional stimuli. Emotion (2006) 0.82
Nucleus accumbens GABAergic inhibition generates intense eating and fear that resists environmental retuning and needs no local dopamine. Eur J Neurosci (2013) 0.81
The Neuroscience of Happiness and Pleasure. Soc Res (New York) (2010) 0.79
The joyful mind. Sci Am (2012) 0.78
Decision Utility, Incentive Salience, and Cue-Triggered "Wanting" Oxf Ser Soc Cogn Soc Neurosci (2009) 0.76