Published in J Biol Chem on October 21, 2003
VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy. Front Biosci (2006) 1.65
The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. Mol Biol Cell (2005) 1.36
SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med (2012) 1.18
Vascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials. Exp Eye Res (2006) 1.14
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A (2007) 1.08
Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation. Oncogene (2004) 1.05
The ubiquitin-proteasome system meets angiogenesis. Mol Cancer Ther (2012) 0.94
Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2. J Biol Chem (2013) 0.84
Emerging roles of post-translational modifications in signal transduction and angiogenesis. Proteomics (2014) 0.81
Leucine motif-dependent tyrosine autophosphorylation of type III receptor tyrosine kinases. J Biol Chem (2006) 0.80
TMIGD1 Is a Novel Adhesion Molecule That Protects Epithelial Cells from Oxidative Cell Injury. Am J Pathol (2015) 0.79
Angiogenesis in cancer and other diseases. Nature (2000) 28.28
Cell signaling by receptor tyrosine kinases. Cell (2000) 18.16
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature (1995) 15.15
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A (1996) 8.53
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science (1992) 7.49
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature (1995) 6.16
Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol (2002) 5.05
Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J (1997) 4.59
The endocytic pathway: a mosaic of domains. Nat Rev Mol Cell Biol (2001) 4.57
Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Cell (1996) 2.75
Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo. Cancer Res (1996) 2.58
Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat Struct Biol (2001) 2.45
The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling. EMBO J (2000) 2.31
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates. J Biol Chem (1990) 2.13
Activation of the feline c-fms proto-oncogene: multiple alterations are required to generate a fully transformed phenotype. Cell (1988) 1.91
Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. J Biol Chem (2000) 1.78
Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation. J Biol Chem (2001) 1.77
Autoregulatory mechanisms in protein-tyrosine kinases. J Biol Chem (1998) 1.75
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene (1999) 1.71
Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors. Mol Cell Biol (2000) 1.47
The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain. Mol Cell Biol (1991) 1.46
Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Mol Cell Biol (2003) 1.40
Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. Structure (1999) 1.36
Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail. Structure (2000) 1.32
Recruitment and activation of phospholipase Cgamma1 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells. J Biol Chem (2003) 1.26
The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules. J Biol Chem (2002) 1.20
Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor. J Biol Chem (1997) 1.17
Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism. J Biol Chem (2002) 1.15
Src autoinhibition: let us count the ways. Nat Struct Biol (1999) 1.13
Ligand-induced phosphorylation of the colony-stimulating factor 1 receptor can occur through an intermolecular reaction that triggers receptor down modulation. Mol Cell Biol (1990) 1.11
Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal growth factor receptor. Arch Biochem Biophys (1992) 1.04
Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism. J Biol Chem (2000) 1.02
Autoinhibitory mechanisms in receptor tyrosine kinases. Front Biosci (2002) 1.01
Analysis of platelet-derived growth factor receptor domain function using a novel chimeric receptor approach. J Biol Chem (1991) 1.00
A peptide representing the carboxyl-terminal tail of the met receptor inhibits kinase activity and invasive growth. J Biol Chem (1999) 0.89
A function-structure model for NGF-activated TRK. EMBO J (1998) 0.88
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem (2004) 1.75
The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. Mol Biol Cell (2005) 1.36
Recruitment and activation of phospholipase Cgamma1 by vascular endothelial growth factor receptor-2 are required for tubulogenesis and differentiation of endothelial cells. J Biol Chem (2003) 1.26
PEST motif serine and tyrosine phosphorylation controls vascular endothelial growth factor receptor 2 stability and downregulation. Mol Cell Biol (2011) 1.26
IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. PLoS One (2008) 1.22
The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules. J Biol Chem (2002) 1.20
Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2. Circ Res (2003) 1.13
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis. Proc Natl Acad Sci U S A (2007) 1.08
A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1. J Biol Chem (2005) 1.07
Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation. Oncogene (2004) 1.05
Comparative structure-function analysis of VEGFR-1 and VEGFR-2: What have we learned from chimeric systems? Ann N Y Acad Sci (2003) 0.98
Role of c-Cbl-dependent regulation of phospholipase Cgamma1 activation in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2010) 0.92
c-Cbl, a ubiquitin E3 ligase that targets active β-catenin: a novel layer of Wnt signaling regulation. J Biol Chem (2013) 0.92
Distinct activation of epidermal growth factor receptor by UTP contributes to epithelial cell wound repair. Am J Pathol (2011) 0.87
Lysine methylation promotes VEGFR-2 activation and angiogenesis. Sci Signal (2013) 0.86
Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2. J Biol Chem (2013) 0.84
Leucine motif-dependent tyrosine autophosphorylation of type III receptor tyrosine kinases. J Biol Chem (2006) 0.80
Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. J Biol Chem (2013) 0.79
Targeting receptor tyrosine kinases and their downstream signaling with cell-penetrating peptides in human pulmonary artery smooth muscle and endothelial cells. Chem Biol Drug Des (2014) 0.79