Published in Science on October 31, 2003
Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet (2008) 15.51
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A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell (2010) 7.51
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron (2006) 6.50
Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature (2011) 5.62
Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am J Hum Genet (2008) 5.44
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell (2007) 4.76
Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron (2011) 4.66
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15
MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number. Neuron (2007) 4.15
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet (2009) 3.42
De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proc Natl Acad Sci U S A (2010) 3.13
Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proc Natl Acad Sci U S A (2005) 2.90
Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum Mol Genet (2004) 2.89
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci U S A (2004) 2.87
A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci U S A (2004) 2.84
Genetics of autism spectrum disorders. Trends Cogn Sci (2011) 2.61
Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord (2009) 2.61
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci (2010) 2.57
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Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J Neurosci (2009) 2.35
Ube3a is required for experience-dependent maturation of the neocortex. Nat Neurosci (2009) 2.28
Protein interactome reveals converging molecular pathways among autism disorders. Sci Transl Med (2011) 2.04
Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years. Arch Gen Psychiatry (2011) 2.04
Autism and brain development. Cell (2008) 2.01
15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders. Hum Mol Genet (2007) 1.99
Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development. J Anat (2005) 1.93
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis (2007) 1.90
SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature (2013) 1.86
Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron (2008) 1.80
Unreliable evoked responses in autism. Neuron (2012) 1.75
Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons. J Neurosci (2009) 1.74
Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysia. Neuron (2011) 1.70
Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. Mol Psychiatry (2010) 1.69
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. J Neurosci (2010) 1.69
The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders. J Clin Invest (2009) 1.66
Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron (2014) 1.66
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching. Mol Brain (2009) 1.65
Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex. Proc Natl Acad Sci U S A (2011) 1.65
Modeling autism by SHANK gene mutations in mice. Neuron (2013) 1.64
Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther (2009) 1.63
Gene hunting in autism spectrum disorder: on the path to precision medicine. Lancet Neurol (2015) 1.62
The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits. J Neurosci (2009) 1.60
Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function. J Neurosci (2009) 1.58
Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. J Neurosci (2009) 1.55
Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals. Proc Natl Acad Sci U S A (2008) 1.54
Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol (2011) 1.49
Intact long-term potentiation but reduced connectivity between neocortical layer 5 pyramidal neurons in a mouse model of Rett syndrome. J Neurosci (2009) 1.47
Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders. Trends Mol Med (2010) 1.46
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet (2011) 1.43
Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism. J Neurodev Disord (2009) 1.42
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1. Nat Neurosci (2009) 1.42
Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis. Neuron (2013) 1.37
Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet (2006) 1.37
Rare structural variation of synapse and neurotransmission genes in autism. Mol Psychiatry (2011) 1.36
NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2. Neuron (2012) 1.35
Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity. Dis Model Mech (2010) 1.33
Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations. Neurobiol Dis (2009) 1.31
Synaptic cell adhesion. Cold Spring Harb Perspect Biol (2012) 1.30
Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a. Proc Natl Acad Sci U S A (2010) 1.27
Ionotropic glutamate receptors & CNS disorders. CNS Neurol Disord Drug Targets (2008) 1.27
Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environ Health Perspect (2008) 1.27
Current developments in the genetics of autism: from phenome to genome. J Neuropathol Exp Neurol (2008) 1.26
Unusually rapid evolution of Neuroligin-4 in mice. Proc Natl Acad Sci U S A (2008) 1.25
Experience-dependent retinogeniculate synapse remodeling is abnormal in MeCP2-deficient mice. Neuron (2011) 1.23
Fragmentation and unpredictability of early-life experience in mental disorders. Am J Psychiatry (2012) 1.23
Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase. J Neurosci (2011) 1.22
SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning. Neuron (2010) 1.22
The impact of MeCP2 loss- or gain-of-function on synaptic plasticity. Neuropsychopharmacology (2012) 1.22
Cell-type-specific repression by methyl-CpG-binding protein 2 is biased toward long genes. J Neurosci (2014) 1.20
Developmental trajectories in children with and without autism spectrum disorders: the first 3 years. Child Dev (2012) 1.19
Fragile X syndrome: the GABAergic system and circuit dysfunction. Dev Neurosci (2011) 1.18
Convulsing toward the pathophysiology of autism. Brain Dev (2008) 1.15
Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism. Cereb Cortex (2011) 1.14
Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol (2009) 1.14
Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met. Curr Opin Neurobiol (2011) 1.12
Resistance to change and vulnerability to stress: autistic-like features of GAP43-deficient mice. Genes Brain Behav (2010) 1.11
The cerebellum in autism: pathogenic or an anatomical beacon? Cerebellum (2013) 1.10
Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism. PLoS One (2012) 1.10
Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate. Proc Natl Acad Sci U S A (2012) 1.08
The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches. Hum Mol Genet (2008) 1.08
Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism. Hum Mol Genet (2008) 1.06
Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering. J Physiol (2009) 1.05
Dynamic changes in Histone H3 lysine 9 acetylation localization patterns during neuronal maturation require MeCP2. Epigenetics (2007) 1.05
Targeted treatment trials for tuberous sclerosis and autism: no longer a dream. Curr Opin Neurobiol (2012) 1.05
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Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in a mutant mouse model of Rett syndrome. Neurobiol Dis (2010) 1.05
Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission. J Neurosci (2012) 1.05
Dendritic spine formation and synaptic function require neurobeachin. Nat Commun (2011) 1.05
Breathing challenges in Rett syndrome: lessons learned from humans and animal models. Respir Physiol Neurobiol (2013) 1.04
NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway. J Neurosci (2009) 1.04
The role of BAF (mSWI/SNF) complexes in mammalian neural development. Am J Med Genet C Semin Med Genet (2014) 1.03
A critical period of sleep for development of courtship circuitry and behavior in Drosophila. Science (2014) 1.03
Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J Cell Mol Med (2006) 1.03
Changing the perspective on early development of Rett syndrome. Res Dev Disabil (2013) 1.02
Paralemmin-1, a modulator of filopodia induction is required for spine maturation. Mol Biol Cell (2008) 1.01