Expression of the thioredoxin system in interstitial lung disease.

Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy. Am J Respir Crit Care Med (2005) 2.29

Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48

Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases. Thorax (2005) 1.35

Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis. Antioxid Redox Signal (2008) 1.31

Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease. Respir Res (2006) 1.22

Extracellular superoxide dismutase has a highly specific localization in idiopathic pulmonary fibrosis/usual interstitial pneumonia. Histopathology (2006) 1.02

PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells. Br J Pharmacol (2008) 0.87

Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease. Expert Rev Clin Pharmacol (2012) 0.82

Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis. J Histochem Cytochem (2008) 0.80

Toward a chemical marker for inflammatory disease: a fluorescent probe for membrane-localized thioredoxin. J Am Chem Soc (2014) 0.79

Redox mechanisms in age-related lung fibrosis. Redox Biol (2016) 0.75

Antiinflammation and Antioxidant Effects of Thalidomide on Pulmonary Fibrosis in Mice and Human Lung Fibroblasts. Inflammation (2017) 0.75

A recurrent mutation in PALB2 in Finnish cancer families. Nature (2007) 4.64

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst (2010) 4.54

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation (2002) 3.57

Thioredoxin and related molecules--from biology to health and disease. Antioxid Redox Signal (2007) 3.50

From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal (2007) 3.49

Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system. Antioxid Redox Signal (2004) 3.04

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 2.72

Glutaredoxin systems. Biochim Biophys Acta (2008) 2.65

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 2.49

The thioredoxin system in cancer. Semin Cancer Biol (2006) 2.42

Probing the chemistry of thioredoxin catalysis with force. Nature (2007) 2.17

Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis. Hum Pathol (2012) 2.13

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A (2007) 2.11

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD (2012) 2.07

Selenoproteins. J Biol Chem (2008) 2.02

Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems. Proc Natl Acad Sci U S A (2002) 2.00

Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system. Am J Physiol Heart Circ Physiol (2006) 1.99

Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J Biol Chem (2006) 1.98

Identification of cell cycle regulatory and inflammatory genes as predominant targets of p38 mitogen-activated protein kinase in the heart. Circ Res (2006) 1.92

Folding of human superoxide dismutase: disulfide reduction prevents dimerization and produces marginally stable monomers. Proc Natl Acad Sci U S A (2004) 1.89

Thioredoxins and glutaredoxins as facilitators of protein folding. Biochim Biophys Acta (2008) 1.85

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82

19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res (2012) 1.81

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues. Am J Pathol (2005) 1.79

Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis. Arch Biochem Biophys (2002) 1.78

Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor. Proc Natl Acad Sci U S A (2005) 1.68

Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma (2011) 1.65

Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. J Biol Chem (2005) 1.64

Diminished immunoreactivity of gamma-glutamylcysteine synthetase in the airways of smokers' lung. Am J Respir Crit Care Med (2002) 1.64

Peroxiredoxins in breast carcinoma. Clin Cancer Res (2003) 1.59

Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 1.56

Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase. J Biol Chem (2003) 1.55

Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney. EMBO J (2003) 1.53

Serum matrix metalloproteinase-9 in head and neck squamous cell carcinoma is a prognostic marker. Int J Cancer (2005) 1.52

Laminin-5 gamma2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2003) 1.49

Tissue inhibitor of matrix metalloproteinase-1 is prognostic in head and neck squamous cell carcinoma: comparison of the circulating and tissue immunoreactive protein. Clin Cancer Res (2005) 1.48

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish. Blood (2013) 1.48

Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Res (2006) 1.48

Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst (2012) 1.47

Inhibition of the human thioredoxin system. A molecular mechanism of mercury toxicity. J Biol Chem (2008) 1.45

Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A (2010) 1.44

Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies. APMIS (2007) 1.41

Thoracoscopic lung biopsy is a safe procedure in diagnosing usual interstitial pneumonia. Chest (2005) 1.39

Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis. Clin Cancer Res (2006) 1.36

Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid Redox Signal (2008) 1.33

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. J Clin Invest (2010) 1.33

Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase. J Biol Chem (2006) 1.33

Thioredoxin system in cell death progression. Antioxid Redox Signal (2012) 1.32

Regulation of the catalytic activity and structure of human thioredoxin 1 via oxidation and S-nitrosylation of cysteine residues. J Biol Chem (2008) 1.32

Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. Nat Struct Mol Biol (2011) 1.32

Insights into deglutathionylation reactions. Different intermediates in the glutaredoxin and protein disulfide isomerase catalyzed reactions are defined by the gamma-linkage present in glutathione. J Biol Chem (2006) 1.32

Chaperone properties of Escherichia coli thioredoxin and thioredoxin reductase. Biochem J (2003) 1.30

Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. Am J Respir Crit Care Med (2007) 1.29

Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. Am J Pathol (2006) 1.28

Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV. J Biol Chem (2008) 1.28

Abnormal glycosylation and altered Golgi structure in colorectal cancer: dependence on intra-Golgi pH. FEBS Lett (2002) 1.28

Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo. J Am Chem Soc (2006) 1.25

Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. PLoS One (2009) 1.25

The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. Mol Cell Biol (2006) 1.25

Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes. J Cell Sci (2006) 1.24

Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential. BMC Mol Biol (2007) 1.24

Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice. J Biol Chem (2006) 1.23

Structurally altered basement membranes and hydrocephalus in a type XVIII collagen deficient mouse line. Hum Mol Genet (2004) 1.23

Reversible silencing of CFTR chloride channels by glutathionylation. J Gen Physiol (2005) 1.22

Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease. Respir Res (2006) 1.22

Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release. Biochem Biophys Res Commun (2005) 1.21

Molecular and structural basis for redox regulation of beta-actin. J Mol Biol (2007) 1.20

Cellular and plasma levels of human glutaredoxin 1 and 2 detected by sensitive ELISA systems. Biochem Biophys Res Commun (2004) 1.20

Folate, vitamin B12, and homocysteine levels in South Asian women with growth-retarded fetuses. Acta Obstet Gynecol Scand (2005) 1.20

Prognostic evaluation of oral tongue cancer: means, markers and perspectives (I). Oral Oncol (2010) 1.19

Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. Hum Pathol (2004) 1.19

Expression of matrix metalloproteinase-9 in head and neck squamous cell carcinoma: a potential marker for prognosis. Clin Cancer Res (2004) 1.19

Peroxiredoxins, a novel protein family in lung cancer. Int J Cancer (2004) 1.19

A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductase. J Biol Chem (2005) 1.19

Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem (2010) 1.18

Protein folding drives disulfide formation. Cell (2012) 1.18

Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD. Respir Res (2006) 1.17

Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase. J Biol Chem (2009) 1.16

Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide. Proc Natl Acad Sci U S A (2004) 1.16

MiR-221/222 target the DNA methyltransferase MGMT in glioma cells. PLoS One (2013) 1.16

A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase. J Biol Chem (2002) 1.16

Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice. J Biol Chem (2006) 1.16

Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice. Proc Natl Acad Sci U S A (2004) 1.15