Published in J Immunol on November 15, 2003
Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med (2006) 4.38
Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. J Clin Invest (2010) 2.87
The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity (2008) 2.13
Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells. Br J Pharmacol (2008) 1.52
New drugs targeting Th2 lymphocytes in asthma. J Occup Med Toxicol (2008) 1.03
Airways inflammation and treatment during acute exacerbations of COPD. Int J Chron Obstruct Pulmon Dis (2008) 1.00
Arsenic trioxide, a potent inhibitor of NF-kappaB, abrogates allergen-induced airway hyperresponsiveness and inflammation. Respir Res (2006) 0.98
Preclinical evaluation of synthetic -2 RANTES as a candidate vaginal microbicide to target CCR5. Antimicrob Agents Chemother (2006) 0.89
Chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy. Pathophysiology (2012) 0.83
Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection. J Neuroinflammation (2014) 0.77
The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science (2005) 17.00
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol (2007) 8.33
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol (2004) 7.22
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature (2002) 6.58
A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med (2007) 6.02
HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol (2010) 5.65
Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature (2006) 5.49
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol (2003) 5.07
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol (2003) 4.66
Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proc Natl Acad Sci U S A (2003) 3.77
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med (2006) 3.76
IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med (2009) 2.78
Role of YKL-40 in bronchial smooth muscle remodeling in asthma. Am J Respir Crit Care Med (2012) 2.53
Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling. Am J Respir Crit Care Med (2003) 2.44
The open access malaria box: a drug discovery catalyst for neglected diseases. PLoS One (2013) 2.43
IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med (2010) 2.36
Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat Rev Immunol (2006) 2.28
Designing the next generation of medicines for malaria control and eradication. Malar J (2013) 2.25
Mature T cells depend on signaling through the IKK complex. Immunity (2003) 2.21
Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum (2009) 2.14
International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev (2013) 2.11
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A (2004) 2.09
Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism. J Immunol (2004) 2.06
Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice. Circ Res (2003) 1.99
NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury. J Biol Chem (2009) 1.91
Overcoming hurdles in developing successful drugs targeting chemokine receptors. Nat Rev Immunol (2011) 1.91
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol (2010) 1.86
A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res (2003) 1.78
YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages. J Immunol (2008) 1.78
Programmed death-1 targeting can promote allograft survival. J Immunol (2002) 1.68
MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol (2007) 1.67
The state of the art in anti-malarial drug discovery and development. Curr Top Med Chem (2011) 1.66
ICOS controls the pool size of effector-memory and regulatory T cells. J Immunol (2008) 1.62
Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. Blood (2004) 1.61
IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization. J Allergy Clin Immunol (2012) 1.59
Amelioration of rat adjuvant-induced arthritis by Met-RANTES. Arthritis Rheum (2005) 1.58
Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest (2012) 1.58
The global pipeline of new medicines for the control and elimination of malaria. Malar J (2012) 1.57
Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.49
TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock. J Immunol (2007) 1.48
Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES. Antimicrob Agents Chemother (2003) 1.46
Neutralization of IFNgamma defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice. EMBO Mol Med (2009) 1.44
Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med (2008) 1.44
Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation. Eur J Immunol (2006) 1.42
The X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors. Structure (2004) 1.42
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol (2010) 1.41
Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis. J Exp Med (2002) 1.41
Interference with heparin binding and oligomerization creates a novel anti-inflammatory strategy targeting the chemokine system. J Immunol (2004) 1.39
A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.39
IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice. PLoS One (2011) 1.37
Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema. J Clin Invest (2005) 1.37
Germinal center B cells govern their own fate via antibody feedback. J Exp Med (2013) 1.36
Ticks produce highly selective chemokine binding proteins with antiinflammatory activity. J Exp Med (2008) 1.34
B7-H3 promotes acute and chronic allograft rejection. Eur J Immunol (2005) 1.31
Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice. Circulation (2006) 1.31
IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells. Blood (2010) 1.31
Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis. J Immunol (2008) 1.30
Nod1 participates in the innate immune response to Pseudomonas aeruginosa. J Biol Chem (2005) 1.29
Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflamm Bowel Dis (2010) 1.28
CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J Immunol (2006) 1.25
Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs. J Immunol (2010) 1.23
Expression of programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulator ligand on human respiratory tract epithelial cells and regulation by respiratory syncytial virus and type 1 and 2 cytokines. J Infect Dis (2005) 1.23
Development of Potential Pharmacodynamic and Diagnostic Markers for Anti-IFN-α Monoclonal Antibody Trials in Systemic Lupus Erythematosus. Hum Genomics Proteomics (2009) 1.22
Evidence for altered interleukin 18 (IL)-18 pathway in human heart failure. FASEB J (2004) 1.22
Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J Immunol (2005) 1.21
Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. Antimicrob Agents Chemother (2008) 1.21
Chemokine blockers--therapeutics in the making? Trends Pharmacol Sci (2005) 1.21
Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease. J Immunol (2003) 1.19
RANTES (CCL5) uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement. Blood (2003) 1.18
Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue. Am J Respir Cell Mol Biol (2003) 1.17
A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines. Int J Parasitol (2012) 1.17
CCL3/MIP-1alpha is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liver. Eur J Immunol (2004) 1.16
Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation. Immunol Cell Biol (2005) 1.16
RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. J Exp Med (2013) 1.15
CCR5 deficiency drives enhanced natural killer cell trafficking to and activation within the liver in murine T cell-mediated hepatitis. Am J Pathol (2007) 1.15
Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice. PLoS Pathog (2010) 1.14
Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus. J Biol Chem (2007) 1.14
Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis. J Infect Dis (2008) 1.13
Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction. J Biol Chem (2002) 1.12
Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection. J Virol (2005) 1.12
Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses. J Immunol (2007) 1.12
Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma. J Allergy Clin Immunol (2004) 1.12
Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease. Am J Respir Crit Care Med (2010) 1.11
The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. J Virol (2005) 1.11
Deep sequencing of phage display libraries to support antibody discovery. Methods (2013) 1.11
Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium. Blood (2003) 1.11
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production. Blood (2002) 1.10
Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival. J Exp Med (2002) 1.10
Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis. J Immunol (2007) 1.10
New therapeutics that modulate chemokine networks. Nat Rev Drug Discov (2002) 1.10
B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody. J Pharmacol Exp Ther (2010) 1.09
Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein. J Immunol (2009) 1.09