Published in Diabetes Metab on November 01, 2003
Effects of ACC Inhibitor on Lipid and Lipoprotein Metabolism | NCT04395950
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest (2005) 9.09
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A (2009) 5.64
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology (2010) 5.35
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab (2011) 2.75
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature (2014) 2.30
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology (2007) 2.29
Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol (2010) 2.28
Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab (2009) 2.23
Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. Trends Endocrinol Metab (2011) 1.53
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J Lipid Res (2012) 1.53
Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease. J Clin Invest (2005) 1.33
Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction. Am J Clin Nutr (2011) 1.29
Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes (2008) 1.24
Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis (2009) 1.21
Expression of fatty acid synthase in nonalcoholic fatty liver disease. Int J Clin Exp Pathol (2010) 1.18
Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis. Am J Clin Nutr (2014) 1.08
Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine. Am J Physiol Gastrointest Liver Physiol (2010) 1.08
Mechanisms and clinical implications of hepatocyte lipoapoptosis. Clin Lipidol (2010) 1.07
Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease. Biofactors (2010) 1.04
Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease. Antioxid Redox Signal (2011) 1.02
Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. PLoS One (2010) 1.01
Assessing individual metabolic responsiveness to a lipid challenge using a targeted metabolomic approach. Metabolomics (2009) 1.00
E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemia. PLoS One (2012) 0.99
Apo-10'-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice. J Nutr (2012) 0.97
Olive oil consumption and non-alcoholic fatty liver disease. World J Gastroenterol (2009) 0.96
Mitochondria and redox signaling in steatohepatitis. Antioxid Redox Signal (2011) 0.96
GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice. PLoS One (2012) 0.95
Etiopathogenesis of nonalcoholic steatohepatitis: role of obesity, insulin resistance and mechanisms of hepatotoxicity. Int J Hepatol (2012) 0.95
Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats. World J Gastroenterol (2007) 0.94
The blind men 'see' the elephant-the many faces of fatty liver disease. World J Gastroenterol (2008) 0.94
The role of dietary sugars and de novo lipogenesis in non-alcoholic fatty liver disease. Nutrients (2014) 0.93
Prandial hypertriglyceridemia in metabolic syndrome is due to an overproduction of both chylomicron and VLDL triacylglycerol. Diabetes (2013) 0.92
Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity. Am J Physiol Regul Integr Comp Physiol (2014) 0.92
Hepatic Steatosis as a Marker of Metabolic Dysfunction. Nutrients (2015) 0.92
De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose. Biol Rev Camb Philos Soc (2015) 0.91
Stable isotope-labeled tracers for the investigation of fatty acid and triglyceride metabolism in humans in vivo. Clin Lipidol (2009) 0.89
CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice. J Lipid Res (2013) 0.89
Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling. J Biol Chem (2014) 0.88
Altered hepatic lipid metabolism contributes to nonalcoholic fatty liver disease in leptin-deficient Ob/Ob mice. J Obes (2013) 0.87
Fatty acid-mediated endoplasmic reticulum stress in vivo: differential response to the infusion of Soybean and Lard Oil in rats. Metabolism (2013) 0.87
Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver. Cell Biosci (2014) 0.85
The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients with Nonalcoholic Fatty Liver Disease. Int J Prev Med (2016) 0.85
Dietary conjugated linoleic Acid and hepatic steatosis: species-specific effects on liver and adipose lipid metabolism and gene expression. J Nutr Metab (2011) 0.85
Abdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis. Diabetes Obes Metab (2014) 0.84
Pathogenesis of selective insulin resistance in isolated hepatocytes. J Biol Chem (2015) 0.83
Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease. Dig Dis Sci (2016) 0.83
A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism. Diabetes (2015) 0.83
Hepatic fatty acid trafficking: multiple forks in the road. Adv Nutr (2013) 0.82
Hepatic Steatosis, Carbohydrate Intake, and Food Quotient in Patients with NAFLD. Int J Endocrinol (2013) 0.82
Role of transcription factor modifications in the pathogenesis of insulin resistance. Exp Diabetes Res (2011) 0.82
Focus on therapeutic strategies of nonalcoholic Fatty liver disease. Int J Hepatol (2012) 0.82
Dietary Broccoli Lessens Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and Fed a Western or Control Diet. J Nutr (2016) 0.81
De novo lipogenesis and cholesterol synthesis in humans with long-standing type 1 diabetes are comparable to non-diabetic individuals. PLoS One (2013) 0.81
Study of Valproic Acid-Enhanced Hepatocyte Steatosis. Biomed Res Int (2016) 0.80
Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance. Cardiovasc Diabetol (2009) 0.80
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells. Dig Dis Sci (2013) 0.80
Sex-Specific Differences in Hepatic Fat Oxidation and Synthesis May Explain the Higher Propensity for NAFLD in Men. J Clin Endocrinol Metab (2015) 0.80
Effect of L-carnitine on the hepatic transcript profile in piglets as animal model. Nutr Metab (Lond) (2011) 0.79
Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice. Diabetes (2015) 0.79
Dietary approach in the treatment of nonalcoholic fatty liver disease. World J Hepatol (2015) 0.78
Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. PLoS One (2013) 0.78
Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation. J Lipid Res (2013) 0.78
An Oral Load of [13C3]Glycerol and Blood NMR Analysis Detect Fatty Acid Esterification, Pentose Phosphate Pathway, and Glycerol Metabolism through the Tricarboxylic Acid Cycle in Human Liver. J Biol Chem (2016) 0.77
Comparative study of the modulation of fructose/sucrose-induced hepatic steatosis by mixed lipid formulations varying in unsaturated fatty acid content. Nutr Metab (Lond) (2015) 0.77
Desaturation index versus isotopically measured de novo lipogenesis as an indicator of acute systemic lipogenesis. BMC Res Notes (2015) 0.77
Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression. Am J Physiol Gastrointest Liver Physiol (2015) 0.76
Hepatic differentiated embryo-chondrocyte-expressed gene 1 (Dec1) inhibits sterol regulatory element-binding protein-1c (Srebp-1c) expression and alleviates fatty liver phenotype. J Biol Chem (2014) 0.76
Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease. Lipids Health Dis (2016) 0.76
Associations of Erythrocyte Fatty Acids in the De Novo Lipogenesis Pathway with Proxies of Liver Fat Accumulation in the EPIC-Potsdam Study. PLoS One (2015) 0.76
Pathogenesis and Prevention of Hepatic Steatosis. Gastroenterol Hepatol (N Y) (2015) 0.76
Increased Hepatic Fatty Acids Uptake and Oxidation by LRPPRC-Driven Oxidative Phosphorylation Reduces Blood Lipid Levels. Front Physiol (2016) 0.75
Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10. J Nutr Metab (2013) 0.75
XBP1s Is an Anti-lipogenic Protein. J Biol Chem (2016) 0.75
A Computational Model of Hepatic Energy Metabolism: Understanding Zonated Damage and Steatosis in NAFLD. PLoS Comput Biol (2016) 0.75
The Role of Lipid and Lipoprotein Metabolism in Non-Alcoholic Fatty Liver Disease. Children (Basel) (2017) 0.75
Metabolism of lipids in human white adipocyte. Diabetes Metab (2004) 1.56
Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic/mass spectrometric techniques. J Mass Spectrom (1997) 1.39
In vivo measurement of plasma cholesterol and fatty acid synthesis with deuterated water: determination of the average number of deuterium atoms incorporated. Metabolism (1996) 1.30
Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin. Diabetes (1999) 1.24
Assay of low deuterium enrichment of water by isotopic exchange with [U-13C3]acetone and gas chromatography-mass spectrometry. Anal Biochem (1998) 1.24
Assay of the deuterium enrichment of water via acetylene. J Mass Spectrom (1996) 1.13
Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification. Am J Physiol (1998) 1.08
Measuring gluconeogenesis with [2-13C]glycerol and mass isotopomer distribution analysis of glucose. Am J Physiol (1995) 1.02
Reappraisal of the effect of Ca2+ on the activity of liver microsomal glucose-6-phosphatase. J Biol Chem (1990) 0.98
The contribution of naturally labelled 13C fructose to glucose appearance in humans. Diabetologia (1993) 0.97
Identification of myocardial ischemia in the diabetic patient. Joint ALFEDIAM and SFC recommendations. Diabetes Metab (2004) 0.97
Insulin sensitivity of glucose and fat metabolism in severe sepsis. Clin Sci (Lond) (2000) 0.97
Use of a new gas chromatograph isotope ratio mass spectrometer to trace exogenous 13C labelled glucose at a very low level of enrichment in man. Diabetologia (1990) 0.95
Glucose metabolism in experimental hyperthyroidism: intact in vivo sensitivity to insulin with abnormal binding and increased glucose turnover. J Clin Endocrinol Metab (1984) 0.95
Antiketogenic effect of glucose per se in vivo in man and in vitro in isolated rat liver cells. Metabolism (1986) 0.90
Measuring glycerol turnover, gluconeogenesis from glycerol, and total gluconeogenesis with [2-13C] glycerol: role of the infusion-sampling mode. Metabolism (1996) 0.90
Nonhomogeneous labeling of liver extra-mitochondrial acetyl-CoA. Implications for the probing of lipogenic acetyl-CoA via drug acetylation and for the production of acetate by the liver. J Biol Chem (1994) 0.89
Non-invasive tracing of liver intermediary metabolism in normal subjects and in moderately hyperglycaemic NIDDM subjects. Evidence against increased gluconeogenesis and hepatic fatty acid oxidation in NIDDM. Diabetologia (1998) 0.89
Influence of human obesity on the metabolic fate of dietary long- and medium-chain triacylglycerols. Am J Clin Nutr (1998) 0.87
Determination of steady state and nonsteady-state glycerol kinetics in humans using deuterium-labeled tracer. J Lipid Res (1987) 0.86
Dawn phenomenon in type 1 (insulin-dependent) diabetic adolescents: influence of nocturnal growth hormone secretion. Diabetologia (1988) 0.86
Hepatic lipogenesis and cholesterol synthesis in hyperthyroid patients. J Clin Endocrinol Metab (2001) 0.86
Positional isotopic analysis of 13C-labelled glucose by mass spectrometry: applications to the study of gluconeogenesis in liver cells. Biomed Environ Mass Spectrom (1989) 0.86
Hormonal and metabolic effects of near physiological increase of plasma immunoreactive somatostatin 14. J Clin Endocrinol Metab (1983) 0.85
Assay of the human liver citric acid cycle probe phenylacetylglutamine and of phenylacetate in plasma by gas chromatography-mass spectrometry. Anal Biochem (1993) 0.84
Determination of human ketone body kinetics using stable-isotope labelled tracers. Diabetologia (1986) 0.84
Regulation of insulin receptor mRNA splicing in rat tissues. Effect of fasting, aging, and diabetes. Diabetes (1995) 0.84
Noninvasive tracing of human liver metabolism: comparison of phenylacetate and apoB-100 to sample glutamine. Am J Physiol (1999) 0.84
Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism. Am J Clin Nutr (2001) 0.83
Inhibition of glucose oxidation by vasoactive intestinal peptide in isolated rat enterocytes. J Biol Chem (1988) 0.83
Anti-tubulin antibodies in recent onset type 1 (insulin-dependent) diabetes mellitus: comparison with islet cell antibodies. Diabetologia (1984) 0.82
Effects of VIP on glucose and lactate metabolism in isolated rat liver cells. FEBS Lett (1982) 0.81
Lipase maturation factor 1: its expression in Zucker diabetic rats, and effects of metformin and fenofibrate. Diabetes Metab (2009) 0.81
Assay of the concentration and 13C enrichment of acetate and acetyl-CoA by gas chromatography-mass spectrometry. Anal Biochem (1994) 0.81
Effects of D-beta-hydroxybutyrate and long- and medium-chain triglycerides on leucine metabolism in humans. Am J Physiol (1992) 0.80
Regulation of somatostatin secretion in man: study of the role of free fatty acids and ketone bodies. Metabolism (1984) 0.80
Lactate and pyruvate isotopic enrichments in plasma and tissues of postabsorptive and starved rats. Am J Physiol (1995) 0.80
Respective role of plasma nonesterified fatty acid oxidation and total lipid oxidation in lipid-induced insulin resistance. Metabolism (1995) 0.80
Assay of the 13C and 2H mass isotopomer distribution of phosphoenolpyruvate by gas chromatography/mass spectrometry. J Mass Spectrom (1996) 0.79
In vivo expression of carbohydrate responsive element binding protein in lean and obese rats. Diabetes Metab (2005) 0.79
Morphological findings on peripheral nerve biopsies in 15 patients with human immunodeficiency virus infection. Acta Neuropathol (1992) 0.79
Use of labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis. Am J Physiol (1997) 0.78
Decrease of platelet activity after intake of small amounts of eicosapentaenoic acid in diabetics. Thromb Haemost (1982) 0.78
Vasoactive intestinal peptide stimulates long-chain fatty acid oxidation and inhibits acetyl-coenzyme A carboxylase activity in isolated rat enterocytes. J Biol Chem (1989) 0.78
Three cases of primary cerebral lymphoma in AIDS patients: detection of Epstein-Barr virus by in situ hybridization and Southern blot technique. Acta Neuropathol (1992) 0.78
Increased ketonaemia in hyperthyroidism. Evidence for a beta-adrenergic mechanism. Diabetologia (1980) 0.78
Lipogenesis in arterial wall and vascular smooth muscle cells of Psammomys obesus: its regulation and abnormalities in diabetes. Diabetes Metab (2010) 0.78
Mechanisms of the glucose lowering effect of a carnitine palmitoyl transferase inhibitor in normal and diabetic rats. Metabolism (1991) 0.77
Hormonal and metabolic effects of chronic interleukin-2 infusion in cancer patients. J Biol Response Mod (1990) 0.77
Role of catecholamines in the ketonemic response to somatostatin in normal man. J Clin Endocrinol Metab (1983) 0.77
Lack of beta-adrenergic role for catecholamines in the development of hyperglycemia and ketonaemia following acute insulin withdrawal in type I diabetic patients. Diabete Metab (1985) 0.77
Decreased glucose-induced thermogenesis at the onset of obesity. Am J Clin Nutr (1993) 0.77
Use of [6,6-2H2]glucose and of low-enrichment [U-13C6]-glucose for sequential or simultaneous measurements of glucose turnover by gas chromatography-mass spectrometry. Anal Biochem (1994) 0.77
Effects of ketone bodies on basal and insulin-stimulated glucose utilization in man. J Clin Endocrinol Metab (1986) 0.77
Effects of different lipid substrates on glucose metabolism in normal postabsorptive humans. Metabolism (1992) 0.77
Noninvasive probing of citric acid cycle intermediates in primate liver with phenylacetylglutamine. Am J Physiol (1996) 0.77
[Increase of energy expenditure in Parkinson's disease]. Rev Neurol (Paris) (1991) 0.76
Hormonal control of glucose production and pyruvate kinase activity in isolated rat liver cells: influence of hypothyroidism. Mol Cell Endocrinol (1987) 0.76
Interactions of glucagon and free fatty acids with insulin in control of glucose metabolism. Metabolism (1990) 0.76
Hypersensitivity to insulin during remissions in cyclosporin-treated IDDM patients. Diabetes Care (1993) 0.76
Use of gas chromatography/isotope ratio-mass spectrometry to study triglyceride metabolism in humans. Lipids (1995) 0.76
Study of the regulation by nutrients of the expression of genes involved in lipogenesis and obesity in humans and animals. Nutr Metab Cardiovasc Dis (2001) 0.76
Metabolic fate of an oral long-chain triglyceride load in humans. Am J Physiol (1996) 0.76
[Effects of propranolol and indomethacin upon urinary hydroxyproline in hyperthyroid patients (author's transl)]. Nouv Presse Med (1982) 0.76
[Measurement of insulin sensitivity using the somatostatin-insulin-glucose test. Importance of the determination of plasma free fatty acids and insulin clearance]. Presse Med (1983) 0.75
[relations between free fatty acids and protein metabolism in vivo]. Diabete Metab (1992) 0.75
[Effect of thyroid function on ketogenesis (author's transl)]. Ann Endocrinol (Paris) (1981) 0.75
Mechanisms of glucose intolerance during triglyceride infusion. Am J Physiol (1998) 0.75
[Normalization of the secretion of growth hormone after excision of a somatotropic adenoma]. Nouv Presse Med (1981) 0.75
Thermogenic effect of slight hyperglycemia during a lipid infusion. Metabolism (1999) 0.75
Glucose production and gluconeogenesis in postabsorptive and starved normal and streptozotocin-diabetic rats. Metabolism (1997) 0.75
[Budd-Chiari syndrome caused by thrombosis of the inferior vena cava due to catheter migration and membranous stenosis]. Ann Med Interne (Paris) (1978) 0.75
[Post-micturition bladder residue in diabetics. Comparison of abdominal findings without preparation and bladder echography]. Presse Med (1983) 0.75
[In vivo study of lipolysis and ketogenesis in man]. Journ Annu Diabetol Hotel Dieu (1986) 0.75
Reduction by propranolol of urinary hydroxyproline excretion in human hyperthyroidism: a beta-receptor blockade effect or a membrane stabilizing mechanism? Metabolism (1984) 0.75
In vivo measurement of gluconeogenesis in animals and humans with deuterated water: a simplified method. Diabetes Metab (2000) 0.75
[Comparison between the value of urinary free cortisol and 17-hydroxycorticosteroids for the diagnosis of Cushing's syndrome]. Presse Med (1986) 0.75
[Hyperthyroidism and glucose metabolism]. Journ Annu Diabetol Hotel Dieu (1991) 0.75
Assay of the acetyl-CoA probe acetyl-sulfamethoxazole and of sulfamethoxazole by gas chromatography-mass spectrometry. Anal Biochem (1993) 0.75
Effects of colonic fermentation on respiratory gas exchanges following a glucose load in man. Metabolism (1993) 0.75
Regulation of peripheral plasma somatostatin like immunoreactivity in type I diabetes: role of the degree of metabolic control. Diabete Metab (1986) 0.75
Measurement of post-absorptive glucose kinetics in non-insulin-dependent diabetic patients: methodological aspects. Eur J Clin Invest (1996) 0.75
Regulation of ketonaemia in hyperthyroidism: study of the role of free fatty acids. Diabete Metab (1983) 0.75
[Serum lipids in diabetes mellitus. Relation to equilibration and microangiopathy]. Diabete Metab (1983) 0.75
[Diabetic orthostatic hypotension. Trial of indomethacin therapy]. Nouv Presse Med (1982) 0.75
Abnormalities of heart rate and arterial blood pressure regulation in diabetes mellitus. Relation with age, duration of diabetes and presence of peripheral neuropathy. Diabete Metab (1983) 0.75
Ultrasonographic determination of residual urine in diabetic subjects: relationship to neuropathy and urinary tract infection. Diabetes Care (1984) 0.75
Reduction of increased levels of blood glycerol and ketone bodies by propranolol in human hyperthyroidism: role of the fall of the triiodothyronine level. Metabolism (1984) 0.75
[New techniques for investigation of human nutrition]. Bull Acad Natl Med (1991) 0.75
Dephosphorylation of L-pyruvate kinase during rat liver hepatocyte isolation. Arch Biochem Biophys (1985) 0.75
[Absence of effect of propranolol on urinary excretion of 3-methylhistidine in hyperthyroidism]. Presse Med (1984) 0.75
[New research techniques in human nutrition]. Ann Gastroenterol Hepatol (Paris) (1992) 0.75