Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3β activation in human liver cells.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 24132507)

Published in Dig Dis Sci on October 17, 2013

Authors

Jie Cao1, Xiao-Xia Feng, Long Yao, Bo Ning, Zhao-Xia Yang, Dian-Liang Fang, Wei Shen

Author Affiliations

1: Department of Gastroenterology and Hepatology, The 2nd Affiliated Hospital of Chongqing Medical University, No. 74 Linjiang Road, Chongqing, 400010, China, 840331cj@163.com.

Articles cited by this

Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 33.06

Nonalcoholic fatty liver disease. N Engl J Med (2002) 22.41

A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27

The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology (2005) 15.74

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest (2005) 9.09

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem (1998) 5.09

JNK signaling in apoptosis. Oncogene (2008) 4.72

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem (2006) 3.57

Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res (2006) 3.12

Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology (2007) 3.06

Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci (2004) 3.05

Cellular and molecular mechanisms of liver injury. Gastroenterology (2008) 3.02

The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Biochim Biophys Acta (2007) 2.83

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology (2009) 2.78

JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem (2006) 2.71

JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology (2006) 2.70

Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology (2005) 2.47

Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia (2008) 2.32

Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology (2007) 2.25

Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab (2003) 2.21

Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J Neurosci (2004) 2.20

Lipoapoptosis: its mechanism and its diseases. Biochim Biophys Acta (2002) 2.10

Glycogen synthase kinase 3: an emerging therapeutic target. Trends Mol Med (2002) 1.85

JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem (2009) 1.82

Diabetes and apoptosis: lipotoxicity. Apoptosis (2009) 1.75

Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation. J Biol Chem (2002) 1.68

Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig Dis Sci (2001) 1.65

ER stress: can the liver cope? J Hepatol (2006) 1.58

Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. J Cell Sci (2004) 1.58

Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells. Mol Cell Biochem (2007) 1.47

Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. Am J Physiol Endocrinol Metab (2010) 1.44

Endoplasmic reticulum stress and liver injury. Semin Liver Dis (2007) 1.42

Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3. J Biol Chem (2007) 1.37

Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1). J Biol Chem (2003) 1.22

Akt up- and down-regulation in response to endoplasmic reticulum stress. Brain Res (2007) 1.21

Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem (2010) 1.20

Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. Endocrinology (2001) 1.18

Insulin and exercise decrease glycogen synthase kinase-3 activity by different mechanisms in rat skeletal muscle. J Biol Chem (1999) 1.13

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Mol Cell Biochem (2012) 1.13

Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2. Pharmacogenomics J (2005) 1.08

Saturated free fatty acid, palmitic acid, induces apoptosis in fetal hepatocytes in culture. Exp Toxicol Pathol (2005) 1.03

Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells. Exp Cell Res (2011) 1.02

Saturated free fatty acids, palmitic acid and stearic acid, induce apoptosis by stimulation of ceramide generation in rat testicular Leydig cell. Biochem Biophys Res Commun (2003) 0.99

Regulation of glycogen synthase kinase-3 in human skeletal muscle: effects of food intake and bicycle exercise. Diabetes (2001) 0.97

Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia. J Pharmacol Exp Ther (2009) 0.93

Caspase-dependent apoptosis induced by thapsigargin was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical neurons. Neurochem Res (2007) 0.92

Glycogen synthase kinase-3beta regulates etoposide-induced apoptosis via Bcl-2 mediated caspase-3 activation in C3H10T1/2 cells. Apoptosis (2009) 0.82

Involvement of liver X receptor alpha in histone modifications across the target fatty acid synthase gene. Lipids (2011) 0.78

Cholesterol overloading leads to hepatic L02 cell damage through activation of the unfolded protein response. Int J Mol Med (2009) 0.75

Articles by these authors

Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov (2012) 4.72

International Cancer Genome Consortium Data Portal--a one-stop shop for cancer genomics data. Database (Oxford) (2011) 4.53

Gender differences in insulin resistance, body composition, and energy balance. Gend Med (2009) 3.19

BioMart: a data federation framework for large collaborative projects. Database (Oxford) (2011) 2.90

Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem (2008) 2.75

Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity (2011) 2.64

Primary anatomic double-bundle anterior cruciate ligament reconstruction: a preliminary 2-year prospective study. Am J Sports Med (2008) 2.57

The association between polymorphisms in the leptin receptor gene and risk of breast cancer: a systematic review and pooled analysis. Breast Cancer Res Treat (2012) 2.15

Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5mg and 10mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial. Eur Urol (2006) 2.01

Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis. J Biol Chem (2007) 1.96

Osseous landmarks of the femoral attachment of the anterior cruciate ligament: an anatomic study. Arthroscopy (2007) 1.89

Down-regulated miR-9 and miR-433 in human gastric carcinoma. J Exp Clin Cancer Res (2009) 1.84

A perspective on paper-based microfluidics: Current status and future trends. Biomicrofluidics (2012) 1.82

A systematic review of the femoral origin and tibial insertion morphology of the ACL. Knee Surg Sports Traumatol Arthrosc (2009) 1.77

Percentage body fat ranges associated with metabolic syndrome risk: results based on the third National Health and Nutrition Examination Survey (1988-1994). Am J Clin Nutr (2003) 1.75

Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. J Urol (2002) 1.65

Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjects. Am J Clin Nutr (2008) 1.63

iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration. Hum Mol Genet (2012) 1.59

Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects. Breast Cancer Res Treat (2010) 1.57

Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults. J Appl Physiol (1985) (2004) 1.57

Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones. J Urol (2003) 1.55

Approximation of total visceral adipose tissue with a single magnetic resonance image. Am J Clin Nutr (2007) 1.55

Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses. Invest Ophthalmol Vis Sci (2012) 1.50

Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents. Am J Clin Nutr (2006) 1.48

Association between two polymorphisms of ABCB1 and breast cancer risk in the current studies: a meta-analysis. Breast Cancer Res Treat (2010) 1.46

The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on the human QT interval. J Am Coll Cardiol (2005) 1.46

Plant-expressed recombinant mountain cedar allergen Jun a 1 is allergenic and has limited pectate lyase activity. Int Arch Allergy Immunol (2010) 1.45

Ethnicity-related skeletal muscle differences across the lifespan. Am J Hum Biol (2009) 1.42

Enhanced cortical expression of myeloid differentiation primary response protein 88 (Myd88) in patients with traumatic brain injury. J Surg Res (2012) 1.41

Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J Virol (2007) 1.41

Association between polymorphisms of the ataxia telangiectasia mutated gene and breast cancer risk: evidence from the current studies. Breast Cancer Res Treat (2010) 1.40

Combination of BMI and Waist Circumference for Identifying Cardiovascular Risk Factors in Whites. Obes Res (2004) 1.40

Carbon quantum dots and their applications. Chem Soc Rev (2014) 1.40

[Idiopathic CD4+ T-lymphocytopenia in a child with disseminated cryptococcosis]. Zhonghua Er Ke Za Zhi (2005) 1.39

Field testing the ENSEMBLE Minimum Dataset: performance of an instrument to address heterogeneity of treatment effects. J Comp Eff Res (2014) 1.38

Fabrication of paper-based microfluidic sensors by printing. Colloids Surf B Biointerfaces (2010) 1.38

Electrogenerated chemiluminescence detection in paper-based microfluidic sensors. Anal Chem (2011) 1.38

Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system. J Biol Chem (2009) 1.36

A cellular-level approach to predicting resting energy expenditure across the adult years. Am J Clin Nutr (2005) 1.33

A membrane associated mCherry fluorescent reporter line for studying vascular remodeling and cardiac function during murine embryonic development. Anat Rec (Hoboken) (2009) 1.33

Impact of incident vertebral fractures on health related quality of life (HRQOL) in postmenopausal women with prevalent vertebral fractures. Osteoporos Int (2004) 1.31

Quantitative biomarker assay with microfluidic paper-based analytical devices. Anal Bioanal Chem (2009) 1.28

Analysis of KIT mutations in sporadic and familial gastrointestinal stromal tumors: therapeutic implications through protein modeling. Clin Cancer Res (2005) 1.26

Microbial conversion of glycerol to 1,3-propanediol by an engineered strain of Escherichia coli. Appl Environ Microbiol (2009) 1.24

Paper-based microfluidic devices by plasma treatment. Anal Chem (2008) 1.23

Body-composition differences between African American and white women: relation to resting energy requirements. Am J Clin Nutr (2004) 1.23

Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction. J Mol Biol (2006) 1.22

Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus. Antimicrob Agents Chemother (2004) 1.21

Paper diagnostic for instantaneous blood typing. Anal Chem (2010) 1.21

Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. J Biol Chem (2011) 1.19

Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood (2011) 1.18

Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects. Am J Clin Nutr (2008) 1.18

Anatomic double-bundle anterior cruciate ligament reconstruction: where are we today? Arthroscopy (2008) 1.17

Exome sequencing and cis-regulatory mapping identify mutations in MAK, a gene encoding a regulator of ciliary length, as a cause of retinitis pigmentosa. Am J Hum Genet (2011) 1.16

2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis. Biochem J (2007) 1.15

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Mol Cell Biochem (2012) 1.13

MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer. Cell Signal (2013) 1.12

Multi-scale Convolutional Neural Networks for Lung Nodule Classification. Inf Process Med Imaging (2015) 1.12

Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells. Cell Signal (2013) 1.11

Does night work increase the risk of breast cancer? A systematic review and meta-analysis of epidemiological studies. Cancer Epidemiol (2013) 1.10

Prevalence of depressive symptoms in postmenopausal women with low bone mineral density and/or prevalent vertebral fracture: results from the Multiple Outcomes of Raloxifene Evaluation (MORE) study. J Rheumatol (2007) 1.09

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res (2010) 1.09

Rhein inhibits liver fibrosis induced by carbon tetrachloride in rats. Acta Pharmacol Sin (2002) 1.09

Thread as a versatile material for low-cost microfluidic diagnostics. ACS Appl Mater Interfaces (2010) 1.08

Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway. Histochem Cell Biol (2011) 1.07

Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegaly. J Clin Endocrinol Metab (2008) 1.07

Functional analysis of serially expanded human iPS cell-derived RPE cultures. Invest Ophthalmol Vis Sci (2013) 1.07

Proliferating cell nuclear antigen (PCNA) regulates primordial follicle assembly by promoting apoptosis of oocytes in fetal and neonatal mouse ovaries. PLoS One (2011) 1.07

Pathogenic role of diabetes-induced PPAR-α down-regulation in microvascular dysfunction. Proc Natl Acad Sci U S A (2013) 1.07

Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia. Cancer Res (2005) 1.07

Simultaneous photoacoustic microscopy of microvascular anatomy, oxygen saturation, and blood flow. Opt Lett (2015) 1.06

Fibroblast responses to cyclic mechanical stretching depend on cell orientation to the stretching direction. J Biomech (2004) 1.06

Down-regulation of Dicer in hepatocellular carcinoma. Med Oncol (2010) 1.06

Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease. Hepatol Int (2010) 1.06

MRI assessment of lean and adipose tissue distribution in female patients with Cushing's disease. Clin Endocrinol (Oxf) (2010) 1.05

Biosurface engineering through ink jet printing. Colloids Surf B Biointerfaces (2009) 1.05

Screening of a new cadmium hyperaccumulator, Galinsoga parviflora, from winter farmland weeds using the artificially high soil cadmium concentration method. Environ Toxicol Chem (2014) 1.04

Validation of paper-based assay for rapid blood typing. Anal Chem (2012) 1.04

Tadalafil improved erectile function at twenty-four and thirty-six hours after dosing in men with erectile dysfunction: US trial. J Androl (2005) 1.04

Guidelines for the diagnosis and management of alcoholic liver disease: update 2010: (published in Chinese on Chinese Journal of Hepatology 2010; 18: 167-170). J Dig Dis (2011) 1.04

Prognostic evaluation of Nanog, Oct4, Sox2, PCNA, Ki67 and E-cadherin expression in gastric cancer. Med Oncol (2014) 1.03

Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease. PLoS One (2013) 1.03

Assessing model fit in joint models of longitudinal and survival data with applications to cancer clinical trials. Stat Med (2014) 1.01

Increased fat mass and high incidence of overweight despite low body mass index in patients with spinal muscular atrophy. Neuromuscul Disord (2009) 1.01

High-throughput functional microRNAs profiling by recombinant AAV-based microRNA sensor arrays. PLoS One (2012) 1.01

Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocytes. Mol Biol Rep (2011) 1.00

Morphology of the tibial insertion of the posterior cruciate ligament. J Bone Joint Surg Am (2009) 1.00

Natural killer T-cell lymphoma originating from the orbit. Chin Med J (Engl) (2012) 0.99

BMI and risk of serious upper body injury following motor vehicle crashes: concordance of real-world and computer-simulated observations. PLoS Med (2010) 0.99

Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis. J Clin Invest (2013) 0.99

Total body protein: a new cellular level mass and distribution prediction model. Am J Clin Nutr (2003) 0.98

The effect of ultrasound on lipase-catalyzed hydrolysis of soy oil in solvent-free system. Ultrason Sonochem (2007) 0.97

The impact of incident vertebral and non-vertebral fragility fractures on health-related quality of life in established postmenopausal osteoporosis: results from the teriparatide randomized, placebo-controlled trial in postmenopausal women. J Rheumatol (2003) 0.97

P53 status as a predictive biomarker for patients receiving neoadjuvant radiation-based treatment: a meta-analysis in rectal cancer. PLoS One (2012) 0.96

Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells. Mol Cell Biochem (2013) 0.96

Analysis of oocyte-like cells differentiated from porcine fetal skin-derived stem cells. Stem Cells Dev (2011) 0.96