Published in Mutat Res on October 29, 2003
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev (2014) 2.66
Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. Int J Cancer (2011) 1.70
DNA repair deficiency in neurodegeneration. Prog Neurobiol (2011) 1.55
Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family. Chem Res Toxicol (2008) 1.12
Site-specific protein adducts of 4-hydroxy-2(E)-nonenal in human THP-1 monocytic cells: protein carbonylation is diminished by ascorbic acid. Chem Res Toxicol (2010) 1.07
Formation and repair of tobacco carcinogen-derived bulky DNA adducts. J Nucleic Acids (2010) 0.98
Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts. Biochemistry (2004) 0.96
Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid. Chem Res Toxicol (2009) 0.93
Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates. J Biol Chem (2013) 0.93
Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. J Nutrigenet Nutrigenomics (2010) 0.91
DNA cross-link induced by trans-4-hydroxynonenal. Environ Mol Mutagen (2010) 0.90
Analysis of endogenous glutathione-adducts and their metabolites. Biomed Chromatogr (2010) 0.87
Rearrangement of the (6S,8R,11S) and (6R,8S,11R) exocyclic 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal to N2-deoxyguanosine cyclic hemiacetal adducts when placed complementary to cytosine in duplex DNA. J Am Chem Soc (2008) 0.85
The stereochemistry of trans-4-hydroxynonenal-derived exocyclic 1,N2-2'-deoxyguanosine adducts modulates formation of interstrand cross-links in the 5'-CpG-3' sequence. Biochemistry (2008) 0.84
Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells. Oncotarget (2014) 0.84
4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway. J Biol Chem (2013) 0.83
Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal. Mutat Res (2009) 0.82
Conformational interconversion of the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N(2)-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA. Chem Res Toxicol (2009) 0.80
Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. Chem Res Toxicol (2012) 0.80
Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli. Int J Biol Sci (2009) 0.78
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. DNA Repair (Amst) (2015) 0.77
Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct. J Am Chem Soc (2011) 0.76
AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249. Oncotarget (2017) 0.75
Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites. J Biomed Sci (2017) 0.75
Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload. J Hepatol (2017) 0.75
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell (2004) 8.18
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res (2007) 3.55
MDM2 is a central node in the p53 pathway: 12 years and counting. Curr Cancer Drug Targets (2005) 3.04
Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair. Proc Natl Acad Sci U S A (2006) 2.74
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci U S A (2007) 2.36
A plausible model for the digital response of p53 to DNA damage. Proc Natl Acad Sci U S A (2005) 2.32
Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J Natl Cancer Inst (2002) 1.95
A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect. Cancer Res (2005) 1.90
The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A (2011) 1.87
Oxidative DNA damage repair in mammalian cells: a new perspective. DNA Repair (Amst) (2006) 1.85
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A (2009) 1.79
The tumor suppressor p53: cancer and aging. Cell Cycle (2008) 1.66
Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage. Toxicology (2003) 1.52
The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis (2002) 1.43
Tumor suppressor p53 meets microRNAs. J Mol Cell Biol (2011) 1.39
Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. Am J Hum Genet (2009) 1.29
Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A (2004) 1.26
Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase. J Biol Chem (2006) 1.18
Detection of functional single-nucleotide polymorphisms that affect apoptosis. Proc Natl Acad Sci U S A (2005) 1.18
Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation. Cancer Res (2012) 1.17
Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells. Biochemistry (2003) 1.16
Transcriptional regulation of the base excision repair pathway by BRCA1. J Biol Chem (2010) 1.16
Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts. Cancer Res (2002) 1.15
4-aminobiphenyl is a major etiological agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene. Carcinogenesis (2002) 1.12
Truncation of amino-terminal tail stimulates activity of human endonuclease III (hNTH1). J Mol Biol (2002) 1.12
Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts. Proc Natl Acad Sci U S A (2010) 1.11
LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway. Oncotarget (2014) 1.08
Regulation of female reproduction by p53 and its family members. FASEB J (2011) 1.08
Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.08
Targeting base excision repair for chemosensitization. Anticancer Agents Med Chem (2008) 1.07
Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. J Biol Chem (2012) 1.07
Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells. PLoS One (2011) 1.04
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. Carcinogenesis (2009) 1.03
N-hydroxy-4-aminobiphenyl-DNA binding in human p53 gene: sequence preference and the effect of C5 cytosine methylation. Biochemistry (2002) 1.00
Multicenter phase II study of apatinib in non-triple-negative metastatic breast cancer. BMC Cancer (2014) 0.99
Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis. FASEB J (2009) 0.99
The regulation of MDM2 oncogene and its impact on human cancers. Acta Biochim Biophys Sin (Shanghai) (2014) 0.97
N-terminal extension of N-methylpurine DNA glycosylase is required for turnover in hypoxanthine excision reaction. J Biol Chem (2007) 0.97
Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mol Nutr Food Res (2011) 0.97
A critical role of PI-3K/Akt/JNKs pathway in benzo[a]pyrene diol-epoxide (B[a]PDE)-induced AP-1 transactivation in mouse epidermal Cl41 cells. Oncogene (2004) 0.97
Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model. Nucleic Acids Res (2010) 0.96
Detection of the acrolein-derived cyclic DNA adduct by a quantitative 32P-postlabeling/solid-phase extraction/HPLC method: blocking its artifact formation with glutathione. Anal Biochem (2007) 0.96
Repair kinetics of trans-4-hydroxynonenal-induced cyclic 1,N2-propanodeoxyguanine DNA adducts by human cell nuclear extracts. Biochemistry (2004) 0.96
Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair. Mutat Res (2006) 0.93
In vitro and in vivo dimerization of human endonuclease III stimulates its activity. J Biol Chem (2003) 0.93
Development of a novel assay for human tyrosyl DNA phosphodiesterase 2. Anal Biochem (2011) 0.93
Reconstructing signal transduction pathways: challenges and opportunities. Ann N Y Acad Sci (2007) 0.92
Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. Oncotarget (2014) 0.91
The regulation of human reproduction by p53 and its pathway. Cell Cycle (2009) 0.90
Transcription-coupled DNA repair is genomic context-dependent. J Biol Chem (2002) 0.90
Excised damaged base determines the turnover of human N-methylpurine-DNA glycosylase. DNA Repair (Amst) (2009) 0.90
DNA wrapping is required for DNA damage recognition in the Escherichia coli DNA nucleotide excision repair pathway. Proc Natl Acad Sci U S A (2009) 0.89
Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin. Mol Nutr Food Res (2011) 0.88
Cigarette smoke component acrolein modulates chromatin assembly by inhibiting histone acetylation. J Biol Chem (2013) 0.88
Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors. Cell Cycle (2011) 0.88
A unified method for purification of basic proteins. Anal Biochem (2010) 0.87
Induction and prevention of carcinogenesis in rat skin exposed to space radiation. Radiat Environ Biophys (2007) 0.87
Transcription-coupled and transcription-independent repair of cyclobutane pyrimidine dimers in the dihydrofolate reductase gene. J Biol Chem (2002) 0.87
Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis. Carcinogenesis (2012) 0.87
Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. Carcinogenesis (2003) 0.87
Binding of specific DNA base-pair mismatches by N-methylpurine-DNA glycosylase and its implication in initial damage recognition. J Mol Biol (2002) 0.86
Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats. Cancer Res (2003) 0.86
Discrimination of lesion removal of N-methylpurine-DNA glycosylase revealed by a potent neutralizing monoclonal antibody. DNA Repair (Amst) (2007) 0.86
Expression of the DNA repair enzyme, N-methylpurine-DNA glycosylase (MPG) in astrocytic tumors. Anticancer Res (2003) 0.85
Prognostic Role of Tumor-Infiltrating Lymphocytes in Lung Cancer: a Meta-Analysis. Cell Physiol Biochem (2015) 0.85
Expression, purification and characterization of codon-optimized human N-methylpurine-DNA glycosylase from Escherichia coli. Protein Expr Purif (2007) 0.85
Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies. Carcinogenesis (2012) 0.84
Acrolein- and 4-Aminobiphenyl-DNA adducts in human bladder mucosa and tumor tissue and their mutagenicity in human urothelial cells. Oncotarget (2014) 0.84
Evidence of complete cellular repair of 1,N6-ethenoadenine, a mutagenic and potential damage for human cancer, revealed by a novel method. Mol Cell Biochem (2008) 0.83
An ammonium bicarbonate-enhanced stable isotope dilution UHPLC-MS/MS method for sensitive and accurate quantification of acrolein-DNA adducts in human leukocytes. Anal Chem (2013) 0.83
A comparative study of recombinant mouse and human apurinic/apyrimidinic endonuclease. Mol Cell Biochem (2011) 0.83
Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates. J Mol Recognit (2009) 0.83
Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE). J Environ Pathol Toxicol Oncol (2007) 0.82
Dipole-dipole interaction stabilizes the transition state of apurinic/apyrimidinic endonuclease--abasic site interaction. J Biol Chem (2007) 0.82
TAp63γ enhances nucleotide excision repair through transcriptional regulation of DNA repair genes. DNA Repair (Amst) (2011) 0.81
Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver. Chem Res Toxicol (2005) 0.81
Chromium (VI) induces both bulky DNA adducts and oxidative DNA damage at adenines and guanines in the p53 gene of human lung cells. Carcinogenesis (2012) 0.79
Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in human gonads. Anticancer Res (2002) 0.79
[Reconstituting turkey herpesvirus with bacterial artificial chromosome clones]. Wei Sheng Wu Xue Bao (2008) 0.78
Effects of genomic context and chromatin structure on transcription-coupled and global genomic repair in mammalian cells. Nucleic Acids Res (2003) 0.78
Repair kinetics of acrolein- and (E)-4-hydroxy-2-nonenal-derived DNA adducts in human colon cell extracts. Mutat Res (2013) 0.76
High-throughput, quantitative analysis of acrolein-derived DNA adducts in human oral cells by immunohistochemistry. J Histochem Cytochem (2012) 0.76