Published in Proc Natl Acad Sci U S A on April 16, 2012
Behavioral stress accelerates prostate cancer development in mice. J Clin Invest (2013) 1.52
Human social genomics. PLoS Genet (2014) 1.24
The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer (2012) 1.06
The regulation of MDM2 oncogene and its impact on human cancers. Acta Biochim Biophys Sin (Shanghai) (2014) 0.97
Chronic psychological stress induces the accumulation of myeloid-derived suppressor cells in mice. PLoS One (2013) 0.95
Biobehavioral approaches to cancer progression and survival: Mechanisms and interventions. Am Psychol (2015) 0.94
The aging clock and circadian control of metabolism and genome stability. Front Genet (2015) 0.94
Hyperglycemia, a neglected factor during cancer progression. Biomed Res Int (2014) 0.91
Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle (2012) 0.89
Chronic restraint stress after injury and shock is associated with persistent anemia despite prolonged elevation in erythropoietin levels. J Trauma Acute Care Surg (2015) 0.89
Nervous system regulation of the cancer genome. Brain Behav Immun (2012) 0.86
The gateway theory: bridging neural and immune interactions in the CNS. Front Neurosci (2013) 0.86
Press-pulse: a novel therapeutic strategy for the metabolic management of cancer. Nutr Metab (Lond) (2017) 0.85
Depression in cancer patients: Pathogenesis, implications and treatment (Review). Oncol Lett (2015) 0.83
Breast cancer and social environment: getting by with a little help from our friends. Breast Cancer Res (2016) 0.82
Urea transporter UT-B deletion induces DNA damage and apoptosis in mouse bladder urothelium. PLoS One (2013) 0.81
SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget (2016) 0.80
In vivo radioadaptive response: a review of studies relevant to radiation-induced cancer risk. Hum Exp Toxicol (2014) 0.79
Effects on DNA Damage and/or Repair Processes as Biological Mechanisms Linking Psychological Stress to Cancer Risk. J Appl Biobehav Res (2014) 0.78
Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis. J Cell Mol Med (2013) 0.77
Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice. J Radiat Res (2015) 0.76
Corticosterone mediates the inhibitory effect of restraint stress on the migration of mesenchymal stem cell to carbon tetrachloride-induced fibrotic liver by downregulating CXCR4/7 expression. Stem Cells Dev (2014) 0.76
Revisiting the health effects of psychological stress-its influence on susceptibility to ionizing radiation: a mini-review. J Radiat Res (2016) 0.75
The ethanol extract of Aquilariae Lignum ameliorates hippocampal oxidative stress in a repeated restraint stress mouse model. BMC Complement Altern Med (2017) 0.75
The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia. Mol Neurobiol (2016) 0.75
Development of a new analog of SGK1 inhibitor and its evaluation as a therapeutic molecule of colorectal cancer. J Cancer (2017) 0.75
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54
Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med (2006) 6.18
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol (2001) 5.82
Stress-induced immune dysfunction: implications for health. Nat Rev Immunol (2005) 5.75
The P53 pathway: what questions remain to be explored? Cell Death Differ (2006) 4.91
Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol (2008) 3.90
Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol (1993) 3.48
p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat Genet (1994) 2.61
TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer. IARC Sci Publ (2004) 2.23
Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res (2008) 1.85
Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol (2003) 1.85
Social support, psychological distress, and natural killer cell activity in ovarian cancer. J Clin Oncol (2005) 1.61
Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids. J Biol Chem (2010) 1.59
Mechanisms generating diversity in glucocorticoid receptor signaling. Ann N Y Acad Sci (2009) 1.56
Depression and functional status as predictors of death among cancer patients. Cancer (2002) 1.38
Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and aging. J Gerontol A Biol Sci Med Sci (2001) 1.27
A mouse model of depression induced by repeated corticosterone injections. Eur J Pharmacol (2007) 1.13
Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation. J Mol Med (Berl) (2009) 1.08
Psychosocial stress augments tumor development through beta-adrenergic activation in mice. Jpn J Cancer Res (2002) 1.03
Depressive reactions to lung cancer are common and often followed by a poor outcome. Eur Respir J (1998) 0.99
Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer. BMC Cancer (2006) 0.91
Effects of social isolation on ehrlich tumor growth and tumor leukocyte infiltration in mice: evidence of participation of the submaxillary salivary gland. Neuroimmunomodulation (2001) 0.84
Effect of immobilization stress on tumor growth in mice. Neoplasma (1994) 0.81
Stochastic gene expression in a single cell. Science (2002) 34.54
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59
The p53 pathway: positive and negative feedback loops. Oncogene (2005) 9.75
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell (2004) 8.18
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer (2006) 7.53
The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A (2005) 7.38
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A (2010) 4.99
p53 regulates maternal reproduction through LIF. Nature (2007) 4.12
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov (2008) 4.03
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res (2007) 3.55
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Res (2006) 3.26
The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res (2006) 3.22
MDM2 is a central node in the p53 pathway: 12 years and counting. Curr Cancer Drug Targets (2005) 3.04
Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency. Proc Natl Acad Sci U S A (2008) 2.90
Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair. Proc Natl Acad Sci U S A (2006) 2.74
Allele-specific p53 mutant reactivation. Cancer Cell (2012) 2.51
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma. BMC Syst Biol (2010) 2.49
High expression of lymphocyte-associated genes in node-negative HER2+ breast cancers correlates with lower recurrence rates. Cancer Res (2007) 2.48
Molecular classification of prostate cancer using curated expression signatures. Proc Natl Acad Sci U S A (2011) 2.46
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci U S A (2007) 2.36
The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol (2010) 2.33
Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. PLoS Pathog (2010) 2.32
A plausible model for the digital response of p53 to DNA damage. Proc Natl Acad Sci U S A (2005) 2.32
Comparison of avian and human influenza A viruses reveals a mutational bias on the viral genomes. J Virol (2006) 2.06
Highly conserved regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging. J Virol (2007) 2.05
Sustained relief of generalized dystonia despite prolonged interruption of deep brain stimulation. Mov Disord (2013) 2.01
Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science (2005) 2.01
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
Patterns of evolution and host gene mimicry in influenza and other RNA viruses. PLoS Pathog (2008) 1.96
Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J Natl Cancer Inst (2002) 1.95
Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell (2010) 1.92
Tissue-specific codon usage and the expression of human genes. Proc Natl Acad Sci U S A (2004) 1.91
Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome. Am J Hum Genet (2012) 1.91
A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect. Cancer Res (2005) 1.90
The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A (2011) 1.87
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. Proc Natl Acad Sci U S A (2009) 1.79
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc Natl Acad Sci U S A (2010) 1.78
p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism. FASEB J (2010) 1.77
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proc Natl Acad Sci U S A (2003) 1.69
Laparoscopic versus open nephroureterectomy for the treatment of upper urinary tract urothelial carcinoma: a systematic review and cumulative analysis of comparative studies. Eur Urol (2012) 1.67
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res (2007) 1.67
The tumor suppressor p53: cancer and aging. Cell Cycle (2008) 1.66
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell (2004) 1.65
Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart. Genome Biol (2005) 1.64
Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention. Am J Physiol Cell Physiol (2013) 1.62
p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes Dev (2002) 1.57
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. Proc Natl Acad Sci U S A (2009) 1.54
MDM2 antagonist can inhibit tumor growth in hepatocellular carcinoma with different types of p53 in vitro. J Gastroenterol Hepatol (2011) 1.53
A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell (2010) 1.49
Role of microRNA in anticancer drug resistance. Int J Cancer (2010) 1.48
A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells. J Biol Chem (2005) 1.47
Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma. Hepatology (2013) 1.41
Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival. Proc Natl Acad Sci U S A (2011) 1.40
Tumor suppressor p53 meets microRNAs. J Mol Cell Biol (2011) 1.39
The regulation of the endosomal compartment by p53 the tumor suppressor gene. FEBS J (2009) 1.39
Sequences from ancestral single-stranded DNA viruses in vertebrate genomes: the parvoviridae and circoviridae are more than 40 to 50 million years old. J Virol (2010) 1.38
Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway. Genes Cancer (2010) 1.38
LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells (2012) 1.36
MDM2 SNP309 accelerates colorectal tumour formation in women. J Med Genet (2006) 1.35
Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. J Biol Chem (2003) 1.29
Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. Am J Hum Genet (2009) 1.29
Haplotype structure and selection of the MDM2 oncogene in humans. Proc Natl Acad Sci U S A (2007) 1.28
Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A (2004) 1.26
Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets. Nucleic Acids Res (2007) 1.22
Non-random reassortment in human influenza A viruses. Influenza Other Respir Viruses (2008) 1.20
p53: a new player in reproduction. Cell Cycle (2008) 1.20
Anomalies in the influenza virus genome database: new biology or laboratory errors? J Virol (2008) 1.19
Detection of functional single-nucleotide polymorphisms that affect apoptosis. Proc Natl Acad Sci U S A (2005) 1.18
Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation. Cancer Res (2012) 1.17
Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells. Biochemistry (2003) 1.16
Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts. Cancer Res (2002) 1.15
Unravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering. BMC Genomics (2007) 1.15
A relative-entropy algorithm for genomic fingerprinting captures host-phage similarities. J Bacteriol (2005) 1.14
Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival. Cancer Res (2009) 1.13
Association of nuclear localization of a long interspersed nuclear element-1 protein in breast tumors with poor prognostic outcomes. Genes Cancer (2010) 1.12
p63 regulates glutaminase 2 expression. Cell Cycle (2013) 1.12