Published in Dev Biol on December 15, 2003
Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol (2010) 2.52
Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J (2009) 1.68
FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network. Development (2007) 1.67
Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood (2008) 1.47
Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol (2009) 1.38
Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease. Am J Pathol (2009) 1.37
Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling. Mol Biol Cell (2004) 1.29
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc Natl Acad Sci U S A (2005) 1.27
A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways. Development (2011) 1.18
The a"MAZE"ing world of lung-specific transgenic mice. Am J Respir Cell Mol Biol (2011) 1.07
Induction of podocyte VEGF164 overexpression at different stages of development causes congenital nephrosis or steroid-resistant nephrotic syndrome. Am J Pathol (2010) 1.07
Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning. Cytokine Growth Factor Rev (2013) 1.05
Vascular instruction of pancreas development. Development (2012) 1.01
Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation. Dev Biol (2011) 1.01
Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. Am J Physiol Lung Cell Mol Physiol (2010) 0.95
Cutaneous manipulation of vascular growth factors leads to alterations in immunocytes, blood vessels and nerves: Evidence for a cutaneous neurovascular unit. J Dermatol Sci (2010) 0.93
MiR-221 and miR-130a regulate lung airway and vascular development. PLoS One (2013) 0.92
Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced angiopoietin-2 and VEGF. Am J Physiol Lung Cell Mol Physiol (2010) 0.91
Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. Funct Integr Genomics (2011) 0.89
NFATc1 regulates lymphatic endothelial development. Mech Dev (2009) 0.89
Hyperoxia enhances VEGF release from A549 cells via post-transcriptional processes. Free Radic Biol Med (2007) 0.86
Endothelial cell activation in a VEGF-A gradient: relevance to cell fate decisions. Microvasc Res (2010) 0.84
Antiangiogenic therapy in lung cancer: focus on vascular endothelial growth factor pathway. Exp Biol Med (Maywood) (2010) 0.84
Partial pulmonary embolization disrupts alveolarization in fetal sheep. Respir Res (2010) 0.82
Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis. Biol Open (2012) 0.81
Engineering de novo assembly of fetal pulmonary organoids. Tissue Eng Part A (2014) 0.80
Comparative molecular developmental aspects of the mammalian- and the avian lungs, and the insectan tracheal system by branching morphogenesis: recent advances and future directions. Front Zool (2012) 0.79
Pulmonary hypoplasia associated with congenital heart diseases: a fetal study. PLoS One (2014) 0.79
Prenatal administration of vitamin A alters pulmonary and plasma levels of vascular endothelial growth factor in the developing mouse. Int J Exp Pathol (2007) 0.78
Immune modulatory effects of IL-22 on allergen-induced pulmonary inflammation. PLoS One (2014) 0.77
Kelch-like ECT2-interacting protein KLEIP regulates late-stage pulmonary maturation via Hif-2α in mice. Dis Model Mech (2014) 0.76
Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A (2002) 5.54
Pulmonary alveolar proteinosis. N Engl J Med (2003) 4.93
ABCA3 gene mutations in newborns with fatal surfactant deficiency. N Engl J Med (2004) 4.64
Conditional gene expression in the respiratory epithelium of the mouse. Transgenic Res (2002) 4.01
Transcriptional control of lung morphogenesis. Physiol Rev (2007) 3.58
beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem (2003) 3.37
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet (2008) 3.37
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nat Immunol (2004) 2.86
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
ABCA3 mutations associated with pediatric interstitial lung disease. Am J Respir Crit Care Med (2005) 2.52
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development (2007) 2.40
Foxa2 regulates alveolarization and goblet cell hyperplasia. Development (2004) 2.35
Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene. J Mol Med (Berl) (2002) 2.34
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest (2009) 2.28
Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol (2005) 2.28
Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense. Annu Rev Physiol (2002) 2.23
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem (2005) 2.15
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. J Clin Invest (2006) 2.15
Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell (2009) 2.14
The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J Clin Invest (2002) 2.13
Transdifferentiation of ciliated cells during repair of the respiratory epithelium. Am J Respir Cell Mol Biol (2005) 2.12
SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol (2003) 2.00
TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem (2004) 1.98
SPDEF regulates goblet cell hyperplasia in the airway epithelium. J Clin Invest (2007) 1.96
Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis. PLoS One (2009) 1.93
Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol (2005) 1.93
Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis. Thorax (2011) 1.93
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. J Exp Med (2008) 1.88
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest (2007) 1.86
Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. Am J Respir Crit Care Med (2011) 1.84
GM-CSF in the lung protects against lethal influenza infection. Am J Respir Crit Care Med (2011) 1.83
Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol (2005) 1.83
GATA6 regulates differentiation of distal lung epithelium. Development (2002) 1.82
Genetic disorders of surfactant dysfunction. Pediatr Dev Pathol (2009) 1.77
Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am J Pathol (2005) 1.76
Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn (2004) 1.75
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues. Gene Expr Patterns (2004) 1.75
TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem (2003) 1.75
Mutations in the surfactant protein C gene associated with interstitial lung disease. Chest (2002) 1.74
Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells. PLoS One (2009) 1.69
R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development (2008) 1.66
C/EBPalpha is required for lung maturation at birth. Development (2006) 1.65
Pneumonitis and emphysema in sp-C gene targeted mice. J Biol Chem (2003) 1.62
Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis. N Engl J Med (2009) 1.58
Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci U S A (2004) 1.57
EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.51
Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest (2004) 1.51
Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol (2007) 1.51
Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol (2008) 1.49
Surfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus. Am J Respir Cell Mol Biol (2004) 1.47
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas. PLoS One (2008) 1.46
In defense of the lung: surfactant protein A and surfactant protein D. Curr Opin Pharmacol (2006) 1.44
Transcriptional programs controlling perinatal lung maturation. PLoS One (2012) 1.41
Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis (2005) 1.39
Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol (2009) 1.38
IL-1beta disrupts postnatal lung morphogenesis in the mouse. Am J Respir Cell Mol Biol (2006) 1.38
Surfactant composition and function in patients with ABCA3 mutations. Pediatr Res (2006) 1.37
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol (2009) 1.36
Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. J Clin Invest (2012) 1.36
Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development (2008) 1.35
GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol (2008) 1.34
Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol (2006) 1.33
Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest (2006) 1.33
Forkhead Box m1 transcription factor is required for perinatal lung function. Proc Natl Acad Sci U S A (2008) 1.32
Conditional control of gene expression in the respiratory epithelium: A cautionary note. Am J Respir Cell Mol Biol (2006) 1.32
A common mutation in the surfactant protein C gene associated with lung disease. J Pediatr (2005) 1.31
GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS. Am J Respir Cell Mol Biol (2006) 1.31
Midkine is regulated by hypoxia and causes pulmonary vascular remodeling. J Biol Chem (2004) 1.30
Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2007) 1.29
Sox2 activates cell proliferation and differentiation in the respiratory epithelium. Am J Respir Cell Mol Biol (2010) 1.29
GATA-6 is required for maturation of the lung in late gestation. Am J Physiol Lung Cell Mol Physiol (2002) 1.26
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol (2009) 1.24
Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J (2013) 1.23
Bronchoalveolar lavage fluid surfactant protein-A and surfactant protein-D are inversely related to inflammation in early cystic fibrosis. Am J Respir Crit Care Med (2003) 1.22
Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol (2003) 1.22
Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med (2010) 1.21
Expression of ABCA3 in developing lung and other tissues. J Histochem Cytochem (2006) 1.21
Immunolocalization of surfactant protein-D (SP-D) in human fetal, newborn, and adult tissues. J Histochem Cytochem (2002) 1.20
GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J Biol Chem (2001) 1.19
Increased expression of thyroid transcription factor-1 (TTF-1) in respiratory epithelial cells inhibits alveolarization and causes pulmonary inflammation. Dev Biol (2002) 1.19
Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. Carcinogenesis (2005) 1.19
Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. J Immunol (2006) 1.17
Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysema. J Biol Chem (2002) 1.14
Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol (2010) 1.13
Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol (2008) 1.13
Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein. J Biol Chem (2002) 1.12
Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells. J Biol Chem (2004) 1.12
Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol (2010) 1.12
Reversibility of lung inflammation caused by SP-B deficiency. Am J Physiol Lung Cell Mol Physiol (2005) 1.11
Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol (2007) 1.11
Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med (2010) 1.10
Resident cellular components of the lung: developmental aspects. Proc Am Thorac Soc (2008) 1.10
Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells. BMC Genomics (2007) 1.10
The pulmonary collectins and respiratory syncytial virus: is there a clinical link? J Pediatr (2010) 1.10
Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium. PLoS One (2009) 1.10
Signaling pathways in the epithelial origins of pulmonary fibrosis. Cell Cycle (2010) 1.10
Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1. J Immunol (2002) 1.09
Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. J Biol Chem (2008) 1.09
Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Pathol (2009) 1.07