Published in Mech Dev on February 20, 2009
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer (2009) 2.18
Development of the mammalian lymphatic vasculature. J Clin Invest (2014) 1.34
Transcriptional regulation of endothelial cell and vascular development. Circ Res (2013) 1.03
Tumor lymphangiogenesis as a potential therapeutic target. J Oncol (2012) 0.97
Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1. Oncotarget (2015) 0.96
Lymphatic development. Birth Defects Res C Embryo Today (2009) 0.93
Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. PLoS One (2013) 0.91
NFAT as cancer target: mission possible? Biochim Biophys Acta (2014) 0.91
Two heterozygous mutations in NFATC1 in a patient with Tricuspid Atresia. PLoS One (2012) 0.81
A Closer Look at Schlemm's Canal Cell Physiology: Implications for Biomimetics. J Funct Biomater (2015) 0.80
Tie1 is required for lymphatic valve and collecting vessel development. Dev Biol (2015) 0.78
Flow-regulated lymphatic vasculature development and signaling. Vasc Cell (2014) 0.76
Tissue-engineered lymphatic graft for the treatment of lymphedema. J Surg Res (2014) 0.75
VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol (2006) 12.09
Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature (1997) 9.99
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
Prox1 function is required for the development of the murine lymphatic system. Cell (1999) 7.57
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol (2003) 7.42
Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell (2002) 6.41
Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science (1998) 5.07
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J (2002) 5.07
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci U S A (1998) 4.48
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
The transcription factor NF-ATc is essential for cardiac valve formation. Nature (1998) 4.14
Proteolytic processing regulates receptor specificity and activity of VEGF-C. EMBO J (1997) 4.07
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J (2001) 3.88
T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J (2003) 3.82
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell (2004) 3.71
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature (2005) 3.67
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst (2002) 3.44
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev (1997) 3.29
Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn (2002) 3.10
Sox18 induces development of the lymphatic vasculature in mice. Nature (2008) 2.91
Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development (2002) 2.68
Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem (2004) 2.66
Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proc Natl Acad Sci U S A (2002) 2.56
Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator. J Biol Chem (2002) 2.49
NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity (2001) 2.38
Lymphatic vasculature development. Nat Rev Immunol (2004) 2.33
Adrenomedullin signaling is necessary for murine lymphatic vascular development. J Clin Invest (2008) 2.31
Prox 1, a prospero-related homeobox gene expressed during mouse development. Mech Dev (1993) 2.21
Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol (2004) 2.13
Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas. Am J Pathol (1999) 1.99
A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities. J Biol Chem (1998) 1.98
Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression. Mol Cell Biol (1999) 1.63
Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell (2005) 1.62
Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood (2004) 1.62
Markers for microscopic imaging of lymphangiogenesis and angiogenesis. Ann N Y Acad Sci (2008) 1.62
Defective T cell development and function in calcineurin A beta -deficient mice. Proc Natl Acad Sci U S A (2002) 1.53
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell (2006) 1.50
Lung morphometry: a new generation of tools and experiments for organ, tissue, cell, and molecular biology. Am J Physiol (1993) 1.49
NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells. J Biol Chem (2002) 1.46
Sustained NFAT signaling promotes a Th1-like pattern of gene expression in primary murine CD4+ T cells. J Immunol (2002) 1.35
Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol (2003) 1.33
Embryonic heart failure in NFATc1-/- mice: novel mechanistic insights from in utero ultrasound biomicroscopy. Circ Res (2004) 1.28
Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium. J Biol Chem (2006) 1.27
Mafs, Prox1, and Pax6 can regulate chicken betaB1-crystallin gene expression. J Biol Chem (2004) 1.18
Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial cells. J Biol Chem (2004) 1.12
DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Dev Biol (2004) 1.11
Reconstitution of T cell-specific transcription directed by composite NFAT/Oct elements. J Immunol (2000) 1.11
Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors. J Biol Chem (1998) 1.04
Current concepts in lymphatic malformation. Vasc Endovascular Surg (2005) 1.04
TGT3, thyroid transcription factor I, and Sp1 elements regulate transcriptional activity of the 1.3-kilobase pair promoter of T1alpha, a lung alveolar type I cell gene. J Biol Chem (1997) 1.02
Embryonic vasculogenesis by endothelial precursor cells derived from lung mesenchyme. Dev Dyn (2000) 0.97
Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish. Dev Dyn (2006) 0.97
Notch signaling in the developing cardiovascular system. Am J Physiol Cell Physiol (2007) 0.97
Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn (2002) 0.96
An allelic difference determines reciprocal patterns of expression of binding sites for Dolichos biflorus lectin in inbred strains of mice. J Embryol Exp Morphol (1985) 0.93
Signals and genes induced by angiogenic growth factors in comparison to inflammatory cytokines in endothelial cells. Clin Hemorheol Microcirc (2007) 0.93
Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res (2006) 0.86
Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease. Am J Pathol (2009) 1.37
Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol (2003) 1.33
Slit and robo expression in the developing mouse lung. Dev Dyn (2004) 1.01
Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Dev Dyn (2002) 0.96
Spatial analysis of preterm birth demonstrates opportunities for targeted intervention. Matern Child Health J (2012) 0.91
Increasing VLBW deliveries at subspecialty perinatal centers via perinatal outreach. Pediatrics (2011) 0.89
Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res (2006) 0.86
Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev (2010) 0.86
Overexpression of vascular endothelial growth factor in the germinal matrix induces neurovascular proteases and intraventricular hemorrhage. Sci Transl Med (2013) 0.85
Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in mice. Pediatr Res (2004) 0.84
Neonates with tongue-based airway obstruction: a systematic review. Otolaryngol Head Neck Surg (2011) 0.83
Intrapartum management of severe fetal airway obstruction. J Otolaryngol (2004) 0.77
Spatial analysis in support of community health intervention strategies. AMIA Annu Symp Proc (2012) 0.76
The challenge of car safety seats. J Pediatr (2007) 0.75