|
1
|
A randomized trial of aspirin to prevent colorectal adenomas.
|
N Engl J Med
|
2003
|
9.18
|
|
2
|
Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.
|
JAMA
|
2007
|
7.93
|
|
3
|
Colorectal cancer in patients under close colonoscopic surveillance.
|
Gastroenterology
|
2005
|
4.31
|
|
4
|
Recent developments in genomewide association scans: a workshop summary and review.
|
Am J Hum Genet
|
2005
|
3.76
|
|
5
|
Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial.
|
J Natl Cancer Inst
|
2003
|
3.44
|
|
6
|
Variation of breast cancer risk among BRCA1/2 carriers.
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JAMA
|
2008
|
3.30
|
|
7
|
Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome.
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J Natl Cancer Inst
|
2013
|
3.06
|
|
8
|
Folic acid and risk of prostate cancer: results from a randomized clinical trial.
|
J Natl Cancer Inst
|
2009
|
2.64
|
|
9
|
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
Gastroenterology
|
2012
|
2.57
|
|
10
|
Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer.
|
Clin Gastroenterol Hepatol
|
2010
|
2.50
|
|
11
|
Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome.
|
J Natl Cancer Inst
|
2012
|
2.44
|
|
12
|
Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study.
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Gastroenterology
|
2007
|
2.39
|
|
13
|
Cigarette smoking and colorectal cancer risk by molecularly defined subtypes.
|
J Natl Cancer Inst
|
2010
|
2.38
|
|
14
|
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
Hum Genet
|
2011
|
2.35
|
|
15
|
Metachronous colorectal cancer risk for mismatch repair gene mutation carriers: the advantage of more extensive colon surgery.
|
Gut
|
2010
|
2.30
|
|
16
|
Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study.
|
J Clin Oncol
|
2012
|
2.22
|
|
17
|
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.
|
Cancer Epidemiol Biomarkers Prev
|
2008
|
2.12
|
|
18
|
Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.
|
Breast Cancer Res
|
2004
|
2.03
|
|
19
|
Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry.
|
Cancer Res
|
2007
|
2.02
|
|
20
|
Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status.
|
J Natl Cancer Inst
|
2010
|
1.99
|
|
21
|
Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study.
|
J Natl Cancer Inst
|
2010
|
1.91
|
|
22
|
Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.
|
Cancer Epidemiol Biomarkers Prev
|
2009
|
1.88
|
|
23
|
Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2.
|
J Clin Oncol
|
2010
|
1.85
|
|
24
|
Prolonged effect of calcium supplementation on risk of colorectal adenomas in a randomized trial.
|
J Natl Cancer Inst
|
2007
|
1.73
|
|
25
|
Associations between smoking, alcohol consumption, and colorectal cancer, overall and by tumor microsatellite instability status.
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Cancer Epidemiol Biomarkers Prev
|
2009
|
1.72
|
|
26
|
Effect of calcium supplementation on the risk of large bowel polyps.
|
J Natl Cancer Inst
|
2004
|
1.67
|
|
27
|
Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study.
|
Int J Radiat Oncol Biol Phys
|
2008
|
1.58
|
|
28
|
Cancer risks for MLH1 and MSH2 mutation carriers.
|
Hum Mutat
|
2013
|
1.55
|
|
29
|
Risk factors for advanced colorectal adenomas: a pooled analysis.
|
Cancer Epidemiol Biomarkers Prev
|
2002
|
1.48
|
|
30
|
Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger.
|
Breast Cancer Res Treat
|
2011
|
1.47
|
|
31
|
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships.
|
Hum Genet
|
2012
|
1.47
|
|
32
|
Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.
|
Hum Mutat
|
2010
|
1.40
|
|
33
|
The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum.
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Cancer Epidemiol Biomarkers Prev
|
2009
|
1.35
|
|
34
|
Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer.
|
Hum Mutat
|
2003
|
1.33
|
|
35
|
Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry.
|
Clin Cancer Res
|
2010
|
1.32
|
|
36
|
Quality assessment and correlation of microsatellite instability and immunohistochemical markers among population- and clinic-based colorectal tumors results from the Colon Cancer Family Registry.
|
J Mol Diagn
|
2011
|
1.27
|
|
37
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Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology Study.
|
J Natl Cancer Inst
|
2007
|
1.18
|
|
38
|
Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control study.
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Carcinogenesis
|
2004
|
1.16
|
|
39
|
Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa.
|
Cancer Prev Res (Phila)
|
2010
|
1.15
|
|
40
|
A multifactorial likelihood model for MMR gene variant classification incorporating probabilities based on sequence bioinformatics and tumor characteristics: a report from the Colon Cancer Family Registry.
|
Hum Mutat
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2012
|
1.14
|
|
41
|
cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue.
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PLoS One
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2012
|
1.14
|
|
42
|
Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: a report from the Women's Environmental Cancer and Radiation Epidemiology Study.
|
J Clin Oncol
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2012
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1.13
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43
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Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer.
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Breast Cancer Res Treat
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2010
|
1.11
|
|
44
|
Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.
|
J Natl Cancer Inst
|
2006
|
1.11
|
|
45
|
Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.
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Cancer Epidemiol Biomarkers Prev
|
2002
|
1.10
|
|
46
|
Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer.
|
Int J Cancer
|
2011
|
1.10
|
|
47
|
Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk.
|
Carcinogenesis
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2008
|
1.10
|
|
48
|
Role of lipid peroxidation in the epidemiology and prevention of breast cancer.
|
Cancer Epidemiol Biomarkers Prev
|
2005
|
1.08
|
|
49
|
Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry.
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Cancer Epidemiol Biomarkers Prev
|
2010
|
1.07
|
|
50
|
Methodological Issues in Multistage Genome-wide Association Studies.
|
Stat Sci
|
2009
|
1.06
|
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51
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Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat.
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Cancer Epidemiol Biomarkers Prev
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2010
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1.06
|
|
52
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Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal adenoma risk: observational follow-up of a randomized study.
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J Natl Cancer Inst
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2009
|
1.05
|
|
53
|
Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation.
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Cancer Epidemiol Biomarkers Prev
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2008
|
1.05
|
|
54
|
Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center.
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Clin Cancer Res
|
2010
|
1.05
|
|
55
|
Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modeling.
|
Genet Epidemiol
|
2011
|
1.04
|
|
56
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Frequency of deletions of EPCAM (TACSTD1) in MSH2-associated Lynch syndrome cases.
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J Mol Diagn
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2010
|
1.04
|
|
57
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Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study.
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Nutr Cancer
|
2012
|
1.03
|
|
58
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Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry.
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Cancer Epidemiol Biomarkers Prev
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2010
|
1.03
|
|
59
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Risk of metachronous colon cancer following surgery for rectal cancer in mismatch repair gene mutation carriers.
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Ann Surg Oncol
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2013
|
1.03
|
|
60
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Accuracy of colorectal polyp self-reports: findings from the colon cancer family registry.
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Cancer Epidemiol Biomarkers Prev
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2007
|
1.03
|
|
61
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XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk.
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Cancer Epidemiol Biomarkers Prev
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2006
|
1.02
|
|
62
|
Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.
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Cancer Res
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2008
|
1.00
|
|
63
|
Alcohol intake and cigarette smoking and risk of a contralateral breast cancer: The Women's Environmental Cancer and Radiation Epidemiology Study.
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Am J Epidemiol
|
2009
|
1.00
|
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64
|
A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.
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Cancer Epidemiol Biomarkers Prev
|
2010
|
0.99
|
|
65
|
Reproductive history and risk of second primary breast cancer: the WECARE study.
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Cancer Epidemiol Biomarkers Prev
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2007
|
0.99
|
|
66
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Cigarette smoking and colorectal cancer risk by KRAS mutation status among older women.
|
Am J Gastroenterol
|
2012
|
0.99
|
|
67
|
A randomized trial to increase colonoscopy screening in members of high-risk families in the colorectal cancer family registry and cancer genetics network.
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Cancer Epidemiol Biomarkers Prev
|
2014
|
0.99
|
|
68
|
Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older women.
|
Gastroenterology
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2013
|
0.98
|
|
69
|
Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study.
|
Hum Mutat
|
2011
|
0.98
|
|
70
|
Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk.
|
Int J Cancer
|
2011
|
0.97
|
|
71
|
Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry.
|
Carcinogenesis
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2010
|
0.96
|
|
72
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Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry.
|
JAMA Oncol
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2015
|
0.96
|
|
73
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Aspirin may be more effective in preventing colorectal adenomas in patients with higher BMI (United States).
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Cancer Causes Control
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2006
|
0.95
|
|
74
|
Body mass index in early adulthood and endometrial cancer risk for mismatch repair gene mutation carriers.
|
Obstet Gynecol
|
2011
|
0.95
|
|
75
|
Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.
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Genes Chromosomes Cancer
|
2013
|
0.94
|
|
76
|
Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women.
|
Gut
|
2011
|
0.94
|
|
77
|
Colorectal adenomas in a randomized folate trial: the role of baseline dietary and circulating folate levels.
|
Cancer Epidemiol Biomarkers Prev
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2008
|
0.94
|
|
78
|
No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years.
|
Cancer Epidemiol Biomarkers Prev
|
2006
|
0.93
|
|
79
|
Reliability in the classification of advanced colorectal adenomas.
|
Cancer Epidemiol Biomarkers Prev
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2002
|
0.93
|
|
80
|
Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22.
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PLoS One
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2012
|
0.93
|
|
81
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Body mass index and risk of second primary breast cancer: the WECARE Study.
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Breast Cancer Res Treat
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2011
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0.93
|
|
82
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Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study.
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Breast Cancer Res
|
2011
|
0.92
|
|
83
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Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia.
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Gut
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2013
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0.92
|
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84
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Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
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Eur J Cancer
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2013
|
0.92
|
|
85
|
Postmenopausal hormone therapy and colorectal cancer risk in relation to somatic KRAS mutation status among older women.
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Cancer Epidemiol Biomarkers Prev
|
2012
|
0.92
|
|
86
|
Breast cancer risks for BRCA1/2 carriers.
|
Science
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2004
|
0.92
|
|
87
|
Genes involved with folate uptake and distribution and their association with colorectal cancer risk.
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Cancer Causes Control
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2009
|
0.92
|
|
88
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Using the results of a baseline and a surveillance colonoscopy to predict recurrent adenomas with high-risk characteristics.
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Ann Intern Med
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2009
|
0.92
|
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89
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Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report.
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Eur J Cancer
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2013
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0.90
|
|
90
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Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women.
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Cancer Prev Res (Phila)
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2011
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0.88
|
|
91
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Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry.
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Cancer Prev Res (Phila)
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2011
|
0.88
|
|
92
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Identification of novel variants in colorectal cancer families by high-throughput exome sequencing.
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Cancer Epidemiol Biomarkers Prev
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2013
|
0.88
|
|
93
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K-ras mutations in incident sporadic colorectal adenomas.
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Cancer
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2006
|
0.87
|
|
94
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XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk.
|
Cancer Epidemiol Biomarkers Prev
|
2005
|
0.87
|
|
95
|
Comparison of techniques for the successful detection of BRCA1 mutations in fixed paraffin-embedded tissue.
|
Cancer Epidemiol Biomarkers Prev
|
2002
|
0.86
|
|
96
|
Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study.
|
Cancer Causes Control
|
2011
|
0.85
|
|
97
|
Interaction of calcium supplementation and nonsteroidal anti-inflammatory drugs and the risk of colorectal adenomas.
|
Cancer Epidemiol Biomarkers Prev
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2005
|
0.83
|
|
98
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Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status.
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Breast Cancer Res Treat
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2010
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0.83
|
|
99
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Folate-genetics and colorectal neoplasia: what we know and need to know next.
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Mol Nutr Food Res
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2013
|
0.83
|
|
100
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Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study.
|
Cancer Causes Control
|
2010
|
0.82
|
|
101
|
Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women.
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Cancer Epidemiol Biomarkers Prev
|
2013
|
0.82
|
|
102
|
Use of folic acid-containing supplements after a diagnosis of colorectal cancer in the Colon Cancer Family Registry.
|
Cancer Epidemiol Biomarkers Prev
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2010
|
0.82
|
|
103
|
Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry.
|
PLoS One
|
2013
|
0.81
|
|
104
|
Reproductive status at first diagnosis influences risk of radiation-induced second primary contralateral breast cancer in the WECARE study.
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Int J Radiat Oncol Biol Phys
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2012
|
0.81
|
|
105
|
Oral contraceptives, postmenopausal hormones, and risk of asynchronous bilateral breast cancer: the WECARE Study Group.
|
J Clin Oncol
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2008
|
0.80
|
|
106
|
Glutathione transferase GSTT1, broccoli, and prevalence of colorectal adenomas.
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Pharmacogenetics
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2002
|
0.80
|
|
107
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Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk.
|
PLoS One
|
2013
|
0.80
|
|
108
|
MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial.
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Cancer Epidemiol Biomarkers Prev
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2008
|
0.80
|
|
109
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Variants in tamoxifen metabolizing genes: a case-control study of contralateral breast cancer risk in the WECARE study.
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Int J Mol Epidemiol Genet
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2013
|
0.80
|
|
110
|
The MnSOD A16V mitochondrial targeting sequence polymorphism is not associated with increased risk of distal colorectal adenomas: data from a sigmoidoscopy-based case control study.
|
Cancer Epidemiol Biomarkers Prev
|
2002
|
0.79
|
|
111
|
Variation in genes related to obesity, weight, and weight change and risk of contralateral breast cancer in the WECARE Study population.
|
Cancer Epidemiol Biomarkers Prev
|
2012
|
0.79
|
|
112
|
Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study.
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Breast Cancer Res Treat
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2009
|
0.77
|
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113
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Genetic variation in insulin pathway genes and distal colorectal adenoma risk.
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Int J Colorectal Dis
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2012
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0.76
|
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114
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Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.
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Prostaglandins Other Lipid Mediat
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2011
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0.75
|
|
115
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Common variants in genes coding for chemotherapy metabolizing enzymes, transporters, and targets: a case-control study of contralateral breast cancer risk in the WECARE Study.
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Cancer Causes Control
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2013
|
0.75
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