Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry.

PubWeight™: 0.96‹?› | Rank: Top 15%

🔗 View Article (PMID 26086041)

Published in JAMA Oncol on May 01, 2015

Authors

Matthew B Yurgelun, Serena Masciari, Victoria A Joshi, Rowena C Mercado, Noralane M Lindor, Steven Gallinger, John L Hopper, Mark A Jenkins, Daniel D Buchanan, Polly A Newcomb, John D Potter, Robert W Haile, Raju Kucherlapati, Sapna Syngal, Colon Cancer Family Registry

Articles cited by this

A method and server for predicting damaging missense mutations. Nat Methods (2010) 78.53

Predicting deleterious amino acid substitutions. Genome Res (2001) 28.95

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat (2007) 12.98

Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med (1969) 6.54

A cancer family syndrome in twenty-four kindreds. Cancer Res (1988) 6.39

Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer. Cancer Epidemiol Biomarkers Prev (2007) 6.00

Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol (2009) 4.84

Identification of Lynch syndrome among patients with colorectal cancer. JAMA (2012) 2.77

Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer. Clin Gastroenterol Hepatol (2010) 2.50

Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype. Cancer Res (2003) 2.08

Multiplex genetic testing for cancer susceptibility: out on the high wire without a net? J Clin Oncol (2013) 2.03

2009 version of the Chompret criteria for Li Fraumeni syndrome. J Clin Oncol (2009) 1.97

Follow-up study of twenty-four families with Li-Fraumeni syndrome. Cancer Res (1991) 1.89

Li-fraumeni syndrome. Genes Cancer (2011) 1.77

Sensitivity and predictive value of criteria for p53 germline mutation screening. J Med Genet (2001) 1.77

Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study. Gastroenterology (2008) 1.69

The increasing incidence of young-onset colorectal cancer: a call to action. Mayo Clin Proc (2014) 1.61

Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors. Am J Hum Genet (1999) 1.57

Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families. J Med Genet (2008) 1.53

A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples. Leuk Res (2011) 1.52

Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features. Mod Pathol (2012) 1.52

Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16. Am J Hum Genet (1996) 1.43

Germline p53 mutations are frequently detected in young children with rhabdomyosarcoma. J Clin Invest (1995) 1.43

Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients. J Med Genet (2004) 1.38

Younger age of cancer initiation is associated with shorter telomere length in Li-Fraumeni syndrome. Cancer Res (2007) 1.38

High frequency of germline p53 mutations in childhood adrenocortical cancer. J Natl Cancer Inst (1994) 1.33

Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas. JAMA (2012) 1.31

Population-based estimate of the contribution of TP53 mutations to subgroups of early-onset breast cancer: Australian Breast Cancer Family Study. Cancer Res (2010) 1.26

F18-fluorodeoxyglucose-positron emission tomography/computed tomography screening in Li-Fraumeni syndrome. JAMA (2008) 1.26

Cancer genomics and inherited risk. J Clin Oncol (2014) 1.24

BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives. Eur J Cancer (2006) 1.24

High frequency of de novo mutations in Li-Fraumeni syndrome. J Med Genet (2009) 1.19

Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome. Gastroenterology (2006) 1.08

Gastric cancer in individuals with Li-Fraumeni syndrome. Genet Med (2011) 1.05

Familial colorectal cancer, beyond Lynch syndrome. Clin Gastroenterol Hepatol (2013) 1.03

High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. Brain Pathol (1999) 1.02

Early onset HER2-positive breast cancer is associated with germline TP53 mutations. Cancer (2011) 1.01

MSH6 and MUTYH deficiency is a frequent event in early-onset colorectal cancer. Clin Cancer Res (2010) 1.01

p53 compound heterozygosity in a severely affected child with Li-Fraumeni syndrome. Oncogene (1999) 0.96

Germline mutations of TP53 and BRCA2 genes in breast cancer/sarcoma families. Eur J Cancer (2007) 0.92

Two TP53 germline mutations in a classical Li-Fraumeni syndrome family. Fam Cancer (2007) 0.87

Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposis. Fam Cancer (2010) 0.86

Germline TP53 mutations in BRCA1 and BRCA2 mutation-negative French Canadian breast cancer families. Breast Cancer Res Treat (2007) 0.86

TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset. Fam Cancer (2009) 0.86

High frequency of germline TP53 mutations in a prospective adult-onset sarcoma cohort. PLoS One (2013) 0.85

Germ-line TP53 mutations in Finnish cancer families exhibiting features of the Li-Fraumeni syndrome and negative for BRCA1 and BRCA2. Cancer Genet Cytogenet (1999) 0.83

Three germline mutations in the TP53 gene. Hum Mutat (1997) 0.79

Successful treatment of an unresectable choroid plexus carcinoma in a patient with Li-Fraumeni syndrome. J Pediatr Hematol Oncol (2005) 0.77

Articles by these authors

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol (2007) 25.52

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52

Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet (2008) 15.43

Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst (2004) 14.97

Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med (2003) 12.17

The somatic genomic landscape of glioblastoma. Cell (2013) 11.73

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88

First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol (2008) 9.43

A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med (2003) 9.18

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31

Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24

Study design and cohort characteristics of the Childhood Cancer Survivor Study: a multi-institutional collaborative project. Med Pediatr Oncol (2002) 8.03

Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA (2007) 7.93

A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet (2008) 6.97

Association between body-mass index and risk of death in more than 1 million Asians. N Engl J Med (2011) 6.89

Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. J Clin Oncol (2010) 6.87

Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: standards for study design. J Natl Cancer Inst (2008) 6.79

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet (2008) 6.75

Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA (2010) 6.65

Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data. Bioinformatics (2005) 6.44

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet (2008) 6.26

Genetic variation and cancer: improving the environment for publication of association studies. Cancer Epidemiol Biomarkers Prev (2004) 6.24

Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22

Heritability of mammographic density, a risk factor for breast cancer. N Engl J Med (2002) 6.19

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet (2009) 6.04

Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer. Cancer Epidemiol Biomarkers Prev (2007) 6.00

Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst (2008) 5.82

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58

Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med (2008) 5.43

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14

Colorectal cancer in mice genetically deficient in the mucin Muc2. Science (2002) 5.08

Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev (2002) 5.04

Breast-cancer risk in families with mutations in PALB2. N Engl J Med (2014) 4.97

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet (2010) 4.96

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science (2012) 4.92

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics (2013) 4.61

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst (2010) 4.54

The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer. Breast Cancer Res (2004) 4.54

Landscape of somatic retrotransposition in human cancers. Science (2012) 4.37

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35

Prediction of germline mutations and cancer risk in the Lynch syndrome. JAMA (2006) 4.34

Colorectal cancer in patients under close colonoscopic surveillance. Gastroenterology (2005) 4.31

Antibiotic use in relation to the risk of breast cancer. JAMA (2004) 4.28

Antihypertensive treatments obscure familial contributions to blood pressure variation. Hypertension (2003) 4.19

Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res (2006) 4.11

Is it time to abandon the food frequency questionnaire? Cancer Epidemiol Biomarkers Prev (2005) 4.11

DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy. J Natl Cancer Inst (2011) 4.08

Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol (2005) 3.99

VITamins And Lifestyle cohort study: study design and characteristics of supplement users. Am J Epidemiol (2004) 3.97

Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat Genet (2009) 3.94

Genome-wide association study identifies three loci associated with melanoma risk. Nat Genet (2009) 3.89

Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell (2011) 3.88

Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Nat Genet (2006) 3.81

Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81

Common sequence variants on 20q11.22 confer melanoma susceptibility. Nat Genet (2008) 3.79

Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet (2005) 3.76

Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol (2006) 3.75

Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69

Improving gene set analysis of microarray data by SAM-GS. BMC Bioinformatics (2007) 3.68

Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA (2007) 3.62

Dominant negative ATM mutations in breast cancer families. J Natl Cancer Inst (2002) 3.46

Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial. J Natl Cancer Inst (2003) 3.44

The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations. Gastroenterology (2008) 3.35

Variation of breast cancer risk among BRCA1/2 carriers. JAMA (2008) 3.30

Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network. Genet Med (2012) 3.29

ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov (2011) 3.27

Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial. JAMA (2003) 3.22

Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20

Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer. J Clin Oncol (2005) 3.19

Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat Rev Cancer (2006) 3.19

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nat Genet (2012) 3.19

Physical activity and survival after diagnosis of invasive breast cancer. Cancer Epidemiol Biomarkers Prev (2008) 3.11

American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers. J Clin Oncol (2014) 3.07

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet (2011) 3.07

Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome. J Natl Cancer Inst (2013) 3.06