Published in J Periodontol on October 01, 2003
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab (2007) 9.62
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell (2010) 6.76
An Arabidopsis thaliana T-DNA mutagenized population (GABI-Kat) for flanking sequence tag-based reverse genetics. Plant Mol Biol (2003) 6.57
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol (2008) 4.28
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell (2006) 3.82
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res (2010) 3.57
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell (2011) 3.53
Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions. Hum Gene Ther (2005) 3.49
A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med (2002) 3.22
Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science (2003) 3.05
Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J Biol Chem (2003) 3.03
Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. J Cell Biol (2004) 3.00
Therapeutic targeting of SPINK1-positive prostate cancer. Sci Transl Med (2011) 2.83
Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev (2005) 2.56
MicroRNAs in NF-kappaB signaling. J Mol Cell Biol (2011) 2.50
miR-301a as an NF-κB activator in pancreatic cancer cells. EMBO J (2010) 2.47
Orbital cerebrospinal fluid space in glaucoma: the Beijing intracranial and intraocular pressure (iCOP) study. Ophthalmology (2012) 2.44
Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids Res (2009) 2.43
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Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun (2013) 2.27
Low-temperature oxidation of CO catalysed by Co(3)O(4) nanorods. Nature (2009) 2.24
Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J (2007) 2.20
The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol (2005) 2.13
Roles played by chemolipiodolization and embolization in chemoembolization for hepatocellular carcinoma: single-blind, randomized trial. J Natl Cancer Inst (2012) 2.10
Characterization of KRAS rearrangements in metastatic prostate cancer. Cancer Discov (2011) 2.02
Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol (2010) 1.98
Relationships between transforming growth factor-beta1, myostatin, and decorin: implications for skeletal muscle fibrosis. J Biol Chem (2007) 1.96
Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nat Immunol (2011) 1.94
Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing. Mol Cell Biol (2008) 1.88
Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell (2011) 1.86
Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials (2006) 1.86
TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem (2006) 1.85
Angiotensin II receptor blockade administered after injury improves muscle regeneration and decreases fibrosis in normal skeletal muscle. Am J Sports Med (2008) 1.83
A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. EMBO J (2012) 1.82
A new species of yunnanozoan with implications for deuterostome evolution. Science (2003) 1.82
PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer. Clin Cancer Res (2013) 1.81
Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. Curr Biol (2004) 1.80
Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum Reprod (2008) 1.79
Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem (2008) 1.78
Apoptosis and the target genes of microRNA-21. Chin J Cancer (2011) 1.74
Extracellular signal-regulated kinase signaling pathway regulates breast cancer cell migration by maintaining slug expression. Cancer Res (2009) 1.74
Intralesional targeted alpha therapy for metastatic melanoma. Cancer Biol Ther (2005) 1.71
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell (2010) 1.71
Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. Neuron (2004) 1.70
T-DNA-mediated transfer of Agrobacterium tumefaciens chromosomal DNA into plants. Nat Biotechnol (2008) 1.68
Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.64
Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells. Blood (2014) 1.64
Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization. Matrix Biol (2009) 1.64
Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation. Am J Physiol Gastrointest Liver Physiol (2009) 1.63
Human neuropathy target esterase catalyzes hydrolysis of membrane lipids. J Biol Chem (2002) 1.62
Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growth. J Invest Dermatol (2010) 1.62
Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. Cell Cycle (2012) 1.62
Transcriptional profiling implicates novel interactions between abiotic stress and hormonal responses in Thellungiella, a close relative of Arabidopsis. Plant Physiol (2006) 1.62
Improvement of muscle healing through enhancement of muscle regeneration and prevention of fibrosis. Muscle Nerve (2003) 1.61
The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Mol Cell (2004) 1.61
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat Commun (2013) 1.61
Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells. Clin Cancer Res (2009) 1.59
Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis. Cancer Res (2012) 1.58
Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions. J Biol Chem (2010) 1.57
[Changes of China agricultural climate resources under the background of climate change. VIII. Change characteristics of heat resources during the growth period of double cropping rice in Jiangxi Province]. Ying Yong Sheng Tai Xue Bao (2011) 1.56
The COOH terminus of the amelogenin, LRAP, is oriented next to the hydroxyapatite surface. J Biol Chem (2004) 1.55
Virion-wide protein interactions of Kaposi's sarcoma-associated herpesvirus. J Virol (2008) 1.54
Tyrosine-protein phosphatase nonreceptor type 12 is a novel prognostic biomarker for esophageal squamous cell carcinoma. Ann Thorac Surg (2012) 1.54
Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell (2005) 1.53
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin. J Biol Chem (2004) 1.53
Generation of NY-ESO-1-specific CD4+ and CD8+ T cells by a single peptide with dual MHC class I and class II specificities: a new strategy for vaccine design. Cancer Res (2002) 1.52
90Y-edotreotide for metastatic carcinoid refractory to octreotide. J Clin Oncol (2010) 1.49
Inverse relationship between long-chain n-3 fatty acids and risk of sudden cardiac death in patients starting hemodialysis. Kidney Int (2013) 1.48
JunB as a downstream mediator of PTHrP actions in cementoblasts. J Bone Miner Res (2005) 1.47
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Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem J (2012) 1.44
Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4. Cells Tissues Organs (2008) 1.43
Bioactive nanofibers instruct cells to proliferate and differentiate during enamel regeneration. J Bone Miner Res (2008) 1.42
Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J Biol Chem (2005) 1.42
A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin overexpression. J Biol Chem (2003) 1.42
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development (2007) 1.40
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J Biol Chem (2003) 1.38
A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing. J Cell Biol (2006) 1.38
Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evol Dev (2005) 1.38
The inositol oxygenase gene family of Arabidopsis is involved in the biosynthesis of nucleotide sugar precursors for cell-wall matrix polysaccharides. Planta (2005) 1.37
Cyclin-dependent kinase 5 activity regulates pain signaling. Proc Natl Acad Sci U S A (2006) 1.34
Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J Bone Miner Res (2002) 1.33
The use of suramin, an antifibrotic agent, to improve muscle recovery after strain injury. Am J Sports Med (2005) 1.33
Advances in defining regulators of cementum development and periodontal regeneration. Curr Top Dev Biol (2007) 1.32
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A (2006) 1.31
RNase P cleaves transient structures in some riboswitches. Proc Natl Acad Sci U S A (2005) 1.31
Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J Biol Chem (2001) 1.30
Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model. Clin Cancer Res (2012) 1.30
Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. J Biol Chem (2008) 1.30
The Arabidopsis COW1 gene encodes a phosphatidylinositol transfer protein essential for root hair tip growth. Plant J (2004) 1.29
Antifibrotic effects of suramin in injured skeletal muscle after laceration. J Appl Physiol (1985) (2003) 1.28
Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice. Mol Cell Biol (2004) 1.27