PubRank

Ashok B Kulkarni

Author PubWeight™ 100.08‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol 2008 4.28
2 Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science 2003 3.05
3 Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J Biol Chem 2003 3.03
4 Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. J Cell Biol 2004 3.00
5 The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol 2005 2.13
6 Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nat Immunol 2011 1.94
7 PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer. Clin Cancer Res 2013 1.81
8 Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. Neuron 2004 1.70
9 Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization. Matrix Biol 2009 1.64
10 Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. Cell Cycle 2012 1.62
11 Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development 2007 1.40
12 Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J Biol Chem 2003 1.38
13 Cyclin-dependent kinase 5 activity regulates pain signaling. Proc Natl Acad Sci U S A 2006 1.34
14 Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A 2006 1.31
15 Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J Biol Chem 2001 1.30
16 Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model. Clin Cancer Res 2012 1.30
17 Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. J Biol Chem 2008 1.30
18 Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res 2009 1.24
19 Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc Natl Acad Sci U S A 2005 1.21
20 Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability. J Neurochem 2005 1.20
21 MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma. Cancer Lett 2013 1.19
22 DSPP effects on in vivo bone mineralization. Bone 2008 1.19
23 Partial rescue of the amelogenin null dental enamel phenotype. J Biol Chem 2008 1.19
24 Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. Mol Cell Biol 2006 1.16
25 Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP gene. Connect Tissue Res 2002 1.15
26 Transgenic mouse expressing human mutant alpha-galactosidase A in an endogenous enzyme deficient background: a biochemical animal model for studying active-site specific chaperone therapy for Fabry disease. Biochim Biophys Acta 2004 1.14
27 Genetically altered mouse models: the good, the bad, and the ugly. Crit Rev Oral Biol Med 2003 1.14
28 Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J 2002 1.13
29 Cdk5: a new player in pain signaling. Cell Cycle 2006 1.10
30 Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol 2009 1.09
31 Comparison of body weight and gene expression in amelogenin null and wild-type mice. Eur J Oral Sci 2006 1.08
32 Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest 2010 1.08
33 Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. Am J Pathol 2004 1.08
34 Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. J Biol Chem 2003 1.07
35 A novel role of periostin in postnatal tooth formation and mineralization. J Biol Chem 2010 1.03
36 A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel. Eur J Oral Sci 2006 1.03
37 Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J Neurosci 2007 1.01
38 Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc Natl Acad Sci U S A 2004 1.00
39 Amelogenin: a potential regulator of cementum-associated genes. J Periodontol 2003 1.00
40 Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J Exp Med 2010 0.99
41 TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle 2007 0.99
42 Overview: engineering transgenic constructs and mice. Curr Protoc Cell Biol 2009 0.98
43 The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype. Cells Tissues Organs 2008 0.97
44 Rescue of the murine amelogenin null phenotype with two amelogenin transgenes. Eur J Oral Sci 2011 0.97
45 Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues. Arch Oral Biol 2012 0.96
46 The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice. J Biol Chem 2003 0.95
47 Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. Am J Pathol 2009 0.95
48 Genetic evidence for key roles of decorin and biglycan in dentin mineralization. Matrix Biol 2009 0.94
49 Overexpression of transforming growth factor-beta1 in teeth results in detachment of ameloblasts and enamel defects. Eur J Oral Sci 2006 0.93
50 Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. J Neurochem 2008 0.93
51 Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1. Biochem Biophys Res Commun 2010 0.92
52 Resveratrol inhibits Cdk5 activity through regulation of p35 expression. Mol Pain 2011 0.92
53 Transforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons. J Biol Chem 2012 0.91
54 Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma. Apoptosis 2014 0.91
55 Molecular Roles of Cdk5 in Pain Signaling. Drug Discov Today Ther Strateg 2009 0.90
56 Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands. Arthritis Rheum 2007 0.90
57 Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype. Cytokine 2002 0.89
58 Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes. J Neurosci Res 2011 0.88
59 Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain. J Neurosci 2002 0.88
60 Generation of gene knockout mice by ES cell microinjection. Curr Protoc Cell Biol 2009 0.88
61 Generation of transgenic mice. Curr Protoc Cell Biol 2009 0.88
62 Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation. Mol Biol Cell 2010 0.87
63 Manipulation of mouse embryonic stem cells for knockout mouse production. Curr Protoc Cell Biol 2009 0.86
64 Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease. J Biochem 2010 0.86
65 Overview: generation of gene knockout mice. Curr Protoc Cell Biol 2009 0.86
66 Neuron-specific TGF-beta signaling deficiency results in retinal detachment and cataracts in mice. Biochem Biophys Res Commun 2006 0.85
67 The use of animal models to explore amelogenin variants in amelogenesis imperfecta. Cells Tissues Organs 2005 0.85
68 A symptomatic Fabry disease mouse model generated by inducing globotriaosylceramide synthesis. Biochem J 2013 0.84
69 TGF-ß regulates enamel mineralization and maturation through KLK4 expression. PLoS One 2013 0.84
70 Targeting of interleukin-13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-β and PTEN signaling. J Transl Med 2013 0.84
71 TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Mol Pain 2013 0.83
72 Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions. Cell Cycle 2008 0.83
73 Inhibition of mTOR reduces anal carcinogenesis in transgenic mouse model. PLoS One 2013 0.82
74 Cdk5 regulates Rap1 activity. Neurochem Int 2013 0.81
75 Transforming growth factor-β3 (TGF-β3) knock-in ameliorates inflammation due to TGF-β1 deficiency while promoting glucose tolerance. J Biol Chem 2013 0.81
76 Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice. Neurochem Res 2011 0.81
77 A method for rapid demineralization of teeth and bones. Open Dent J 2010 0.81
78 An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1. J Oral Pathol Med 2010 0.81
79 Naked plasmid DNA-based alpha-galactosidase A gene transfer partially reduces systemic accumulation of globotriaosylceramide in Fabry mice. Mol Biotechnol 2007 0.80
80 Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1. Neurosignals 2006 0.80
81 Amelogenins: Multi-Functional Enamel Matrix Proteins and Their Binding Partners. J Oral Biosci 2011 0.80
82 Amelogenin- and enamelysin (Mmp-20)-deficient mice display altered birefringence in the secretory-stage enamel organic extracellular matrix. Connect Tissue Res 2007 0.79
83 Transforming growth factor-beta1 negatively regulates crystallin expression in teeth. J Bone Miner Res 2002 0.79
84 Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25. J Neurochem 2004 0.79
85 Mouse genetic background influences the dental phenotype. Cells Tissues Organs 2014 0.78
86 Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality. J Neuroinflammation 2014 0.78
87 The role of amelogenin during enamel-crystallite growth and organization in vivo. Eur J Oral Sci 2011 0.77
88 Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons. Pain 2016 0.75
89 Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. J Innate Immun 2016 0.75
90 Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372. Pain 2017 0.75