Published in Nat Rev Drug Discov on December 01, 2003
Programming cells by multiplex genome engineering and accelerated evolution. Nature (2009) 6.64
Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol (2009) 4.11
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Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. PLoS One (2011) 1.18
The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. Nat Prod Rep (2015) 1.11
A synthetic library of RNA control modules for predictable tuning of gene expression in yeast. Mol Syst Biol (2011) 1.10
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Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture. Proc Natl Acad Sci U S A (2009) 0.97
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Spirotetronate polyketides as leads in drug discovery. J Nat Prod (2014) 0.85
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DNA signatures for detecting genetic engineering in bacteria. Genome Biol (2008) 0.80
Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. J Ind Microbiol Biotechnol (2011) 0.79
Evolution, ecology and the engineered organism: lessons for synthetic biology. Genome Biol (2009) 0.77
In silico discovery of terpenoid metabolism in Cannabis sativa. F1000Res (2017) 0.75
Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature (2006) 13.86
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol (2003) 6.74
Microbial production of fatty-acid-derived fuels and chemicals from plant biomass. Nature (2010) 5.84
Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol (2009) 4.11
Microbial engineering for the production of advanced biofuels. Nature (2012) 3.60
Designed divergent evolution of enzyme function. Nature (2006) 3.09
Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes. Nat Biotechnol (2006) 3.02
Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels. Curr Opin Biotechnol (2008) 2.80
Precise and reliable gene expression via standard transcription and translation initiation elements. Nat Methods (2013) 2.61
Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids. Nat Biotechnol (2012) 2.55
Production of isoprenoid pharmaceuticals by engineered microbes. Nat Chem Biol (2006) 2.35
Model-driven engineering of RNA devices to quantitatively program gene expression. Science (2011) 2.33
BglBricks: A flexible standard for biological part assembly. J Biol Eng (2010) 2.32
Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab Eng (2006) 2.31
Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol. Microb Cell Fact (2008) 2.26
Biofuel alternatives to ethanol: pumping the microbial well. Trends Biotechnol (2008) 2.18
Microbially derived artemisinin: a biotechnology solution to the global problem of access to affordable antimalarial drugs. Am J Trop Med Hyg (2007) 2.15
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc Natl Acad Sci U S A (2012) 2.06
Quantitative estimation of activity and quality for collections of functional genetic elements. Nat Methods (2013) 2.03
Biosynthesis of plant isoprenoids: perspectives for microbial engineering. Annu Rev Plant Biol (2009) 1.98
Engineering microbial biofuel tolerance and export using efflux pumps. Mol Syst Biol (2011) 1.96
Advanced biofuel production in microbes. Biotechnol J (2010) 1.94
Retrograde signaling by the plastidial metabolite MEcPP regulates expression of nuclear stress-response genes. Cell (2012) 1.87
Genes involved in long-chain alkene biosynthesis in Micrococcus luteus. Appl Environ Microbiol (2009) 1.87
High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. PLoS One (2009) 1.83
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. Metab Eng (2008) 1.81
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat Chem Biol (2007) 1.79
j5 DNA assembly design automation software. ACS Synth Biol (2011) 1.78
Synthesis of three advanced biofuels from ionic liquid-pretreated switchgrass using engineered Escherichia coli. Proc Natl Acad Sci U S A (2011) 1.75
Functional genomic study of exogenous n-butanol stress in Escherichia coli. Appl Environ Microbiol (2010) 1.69
Salt stress in Desulfovibrio vulgaris Hildenborough: an integrated genomics approach. J Bacteriol (2006) 1.68
Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid. BMC Biotechnol (2008) 1.68
Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production. Structure (2011) 1.67
Identification and microbial production of a terpene-based advanced biofuel. Nat Commun (2011) 1.65
Metabolic engineering of microbial pathways for advanced biofuels production. Curr Opin Biotechnol (2011) 1.64
Metabolic engineering delivers next-generation biofuels. Nat Biotechnol (2008) 1.60
High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically engineered Escherichia coli. Biotechnol Bioeng (2006) 1.53
Engineering static and dynamic control of synthetic pathways. Cell (2010) 1.52
Design and construction of a double inversion recombination switch for heritable sequential genetic memory. PLoS One (2008) 1.49
Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. Appl Environ Microbiol (2007) 1.40
Pathway confirmation and flux analysis of central metabolic pathways in Desulfovibrio vulgaris hildenborough using gas chromatography-mass spectrometry and Fourier transform-ion cyclotron resonance mass spectrometry. J Bacteriol (2006) 1.40
Design, implementation and practice of JBEI-ICE: an open source biological part registry platform and tools. Nucleic Acids Res (2012) 1.39
Application of functional genomics to pathway optimization for increased isoprenoid production. Appl Environ Microbiol (2008) 1.38
Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids. Metab Eng (2006) 1.36
A tightly regulated inducible expression system utilizing the fim inversion recombination switch. Biotechnol Bioeng (2006) 1.35
Mono and diterpene production in Escherichia coli. Biotechnol Bioeng (2004) 1.35
Chemical synthesis using synthetic biology. Curr Opin Biotechnol (2009) 1.34
Membrane proteomics of phagosomes suggests a connection to autophagy. Proc Natl Acad Sci U S A (2008) 1.34
Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. Metab Eng (2013) 1.31
Metabolic flux elucidation for large-scale models using 13C labeled isotopes. Metab Eng (2007) 1.31
Modular engineering of L-tyrosine production in Escherichia coli. Appl Environ Microbiol (2011) 1.31
Advances in analysis of microbial metabolic fluxes via (13)C isotopic labeling. Mass Spectrom Rev (2009) 1.31
A propionate-inducible expression system for enteric bacteria. Appl Environ Microbiol (2005) 1.30
Enhancing fatty acid production by the expression of the regulatory transcription factor FadR. Metab Eng (2012) 1.30
Targeted proteomics for metabolic pathway optimization: application to terpene production. Metab Eng (2011) 1.29
Engineering dynamic pathway regulation using stress-response promoters. Nat Biotechnol (2013) 1.27
Directed evolution of AraC for improved compatibility of arabinose- and lactose-inducible promoters. Appl Environ Microbiol (2007) 1.26
Developing Aspergillus as a host for heterologous expression. Biotechnol Adv (2008) 1.26
Identification of genes affecting lycopene accumulation in Escherichia coli using a shot-gun method. Biotechnol Bioeng (2005) 1.23
Investigation of carbon metabolism in "Dehalococcoides ethenogenes" strain 195 by use of isotopomer and transcriptomic analyses. J Bacteriol (2009) 1.22
High-throughput metabolic engineering: advances in small-molecule screening and selection. Annu Rev Biochem (2010) 1.22
Shewanella oneidensis MR-1 fluxome under various oxygen conditions. Appl Environ Microbiol (2006) 1.22
Lutein accumulation in the absence of zeaxanthin restores nonphotochemical quenching in the Arabidopsis thaliana npq1 mutant. Plant Cell (2009) 1.20
Synthesis: A constructive debate. Nature (2012) 1.19
Catabolite repression of the propionate catabolic genes in Escherichia coli and Salmonella enterica: evidence for involvement of the cyclic AMP receptor protein. J Bacteriol (2005) 1.19
Process design for microbial plastic factories: metabolic engineering of polyhydroxyalkanoates. Curr Opin Biotechnol (2003) 1.18
Anaerobic central metabolic pathways in Shewanella oneidensis MR-1 reinterpreted in the light of isotopic metabolite labeling. J Bacteriol (2006) 1.17
Engineering of bacterial methyl ketone synthesis for biofuels. Appl Environ Microbiol (2011) 1.16
Importance of systems biology in engineering microbes for biofuel production. Curr Opin Biotechnol (2008) 1.16
Biosynthesis and engineering of isoprenoid small molecules. Appl Microbiol Biotechnol (2006) 1.15
Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. Biotechnol Bioeng (2008) 1.15
Transcription factor-based screens and synthetic selections for microbial small-molecule biosynthesis. ACS Synth Biol (2012) 1.15
Combinatorial expression of bacterial whole mevalonate pathway for the production of beta-carotene in E. coli. J Biotechnol (2009) 1.15
Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. Biotechnol Bioeng (2006) 1.14
Cell-wide responses to low-oxygen exposure in Desulfovibrio vulgaris Hildenborough. J Bacteriol (2007) 1.14
Polyphosphate kinase from activated sludge performing enhanced biological phosphorus removal. Appl Environ Microbiol (2002) 1.13
Engineering cotton (+)-delta-cadinene synthase to an altered function: germacrene D-4-ol synthase. Chem Biol (2006) 1.12
Three members of the Arabidopsis glycosyltransferase family 8 are xylan glucuronosyltransferases. Plant Physiol (2012) 1.10
Global transcriptional, physiological, and metabolite analyses of the responses of Desulfovibrio vulgaris hildenborough to salt adaptation. Appl Environ Microbiol (2009) 1.10
A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3). ACS Chem Biol (2009) 1.10
XAX1 from glycosyltransferase family 61 mediates xylosyltransfer to rice xylan. Proc Natl Acad Sci U S A (2012) 1.09
Study of nitrate stress in Desulfovibrio vulgaris Hildenborough using iTRAQ proteomics. Brief Funct Genomic Proteomic (2006) 1.09
Flux analysis of central metabolic pathways in Geobacter metallireducens during reduction of soluble Fe(III)-nitrilotriacetic acid. Appl Environ Microbiol (2007) 1.09
A thermophilic ionic liquid-tolerant cellulase cocktail for the production of cellulosic biofuels. PLoS One (2012) 1.09
Engineering triterpene production in Saccharomyces cerevisiae-beta-amyrin synthase from Artemisia annua. FEBS J (2008) 1.07
Metabolic engineering of microorganisms for isoprenoid production. Nat Prod Rep (2008) 1.07
Synergies between synthetic biology and metabolic engineering. Nat Biotechnol (2011) 1.06
Overexpression of a BAHD acyltransferase, OsAt10, alters rice cell wall hydroxycinnamic acid content and saccharification. Plant Physiol (2013) 1.06
Optimization of DsRed production in Escherichia coli: effect of ribosome binding site sequestration on translation efficiency. Biotechnol Bioeng (2005) 1.05
Polyphosphate kinase genes from full-scale activated sludge plants. Appl Microbiol Biotechnol (2007) 1.04
Effect of lacY expression on homogeneity of induction from the P(tac) and P(trc) promoters by natural and synthetic inducers. Biotechnol Prog (2002) 1.04
A model for improving microbial biofuel production using a synthetic feedback loop. Syst Synth Biol (2010) 1.04
Global analysis of host response to induction of a latent bacteriophage. BMC Microbiol (2007) 1.03
Analysis of amino acid isotopomers using FT-ICR MS. Anal Chem (2007) 1.03
HipA-triggered growth arrest and β-lactam tolerance in Escherichia coli are mediated by RelA-dependent ppGpp synthesis. J Bacteriol (2013) 1.03
Microbial sensors for small molecules: development of a mevalonate biosensor. Metab Eng (2006) 1.02
Analysis of metabolic pathways and fluxes in a newly discovered thermophilic and ethanol-tolerant Geobacillus strain. Biotechnol Bioeng (2009) 1.00
Biosynthesis and incorporation of side-chain-truncated lignin monomers to reduce lignin polymerization and enhance saccharification. Plant Biotechnol J (2012) 1.00
Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts. Metab Eng (2011) 1.00
Charge-associated effects of fullerene derivatives on microbial structural integrity and central metabolism. Nano Lett (2007) 1.00