PubRank

J J O'Shea

Author PubWeight™ 143.15‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Jaks and STATs: biological implications. Annu Rev Immunol 1998 7.18
2 Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 1992 5.94
3 Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 1999 5.01
4 T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A 2001 4.76
5 Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 1995 3.43
6 Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 1994 3.31
7 Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995 3.15
8 Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils. J Immunol 1985 3.02
9 Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995 2.93
10 Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci U S A 1995 2.52
11 Expression of specific binding sites on Candida with functional and antigenic characteristics of human complement receptors. J Immunol 1986 2.28
12 The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators. Blood 2000 2.24
13 Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques. Mucosal Immunol 2008 2.23
14 IFN-gamma production by antigen-presenting cells: mechanisms emerge. Trends Immunol 2001 2.13
15 Loss of T-cell receptor zeta chain and p56lck in T-cells infiltrating human renal cell carcinoma. Cancer Res 1993 2.01
16 IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J Immunol 2000 2.01
17 Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge. Nat Immunol 2000 1.84
18 Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J Immunol 2001 1.81
19 Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J Exp Med 1995 1.78
20 Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J Immunol 1996 1.68
21 TNFRSF1A mutations and autoinflammatory syndromes. Curr Opin Immunol 2000 1.68
22 The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers. Am J Hum Genet 2001 1.68
23 Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fc-mediated phagocytosis by cultured human macrophages. J Exp Med 1985 1.62
24 Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell 2001 1.61
25 Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation. J Immunol 2000 1.59
26 The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. Proc Natl Acad Sci U S A 1997 1.53
27 Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes. J Immunol 2000 1.52
28 Signaling by type I and II cytokine receptors: ten years after. Curr Opin Immunol 2001 1.50
29 Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine. N Engl J Med 1988 1.49
30 Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII). J Immunol 1991 1.48
31 Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity. Proc Natl Acad Sci U S A 1997 1.47
32 Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains. Mol Cell Biol 2000 1.38
33 Structural and functional basis for JAK3-deficient severe combined immunodeficiency. Blood 1997 1.34
34 Alterations in T cell receptor and signal transduction molecules in melanoma patients. Clin Cancer Res 1995 1.33
35 Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction. J Immunol 1991 1.31
36 Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood 2000 1.28
37 Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells. J Clin Invest 1995 1.25
38 Calcium requirements for increased complement receptor expression during neutrophil activation. J Immunol 1985 1.21
39 Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency. J Leukoc Biol 1996 1.19
40 T cell receptor tyrosine phosphorylation. Variable coupling for different activating ligands. J Biol Chem 1987 1.17
41 Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain. EMBO J 1999 1.15
42 Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7. J Exp Med 1995 1.14
43 Receptor-induced death in human natural killer cells: involvement of CD16. J Exp Med 1995 1.14
44 Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways. Immunity 1996 1.13
45 Tumor-promoting phorbol esters induce rapid internalization of the C3b receptor via a cytoskeleton-dependent mechanism. J Immunol 1985 1.09
46 Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases. J Biol Chem 1995 1.09
47 Characterization of the C3 receptor induced by herpes simplex virus type 1 infection of human epidermal, endothelial, and A431 cells. J Immunol 1987 1.09
48 STAM2, a new member of the STAM family, binding to the Janus kinases. FEBS Lett 2000 1.08
49 T cell antigen receptor phosphorylation induced by an anti-receptor antibody. J Immunol 1987 1.08
50 Unexpected and variable phenotypes in a family with JAK3 deficiency. Genes Immun 2001 1.05
51 Similarities and differences in signal transduction by interleukin 4 and interleukin 13: analysis of Janus kinase activation. Proc Natl Acad Sci U S A 1995 1.05
52 Tyrosine kinase-regulated and inositol phosphate-independent Ca2+ elevation and mobilization in T cells. J Biol Chem 1992 1.03
53 The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common gamma chain-using cytokines. J Biol Chem 2000 1.02
54 Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2. Blood 1995 1.01
55 T cell antigen receptor: structure, assembly and function. Year Immunol 1989 1.01
56 Structural and functional studies on the human C3b/C4b receptor (CR1) purified by affinity chromatography using a monoclonal antibody. Complement 1986 1.01
57 IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. J Immunol 1999 0.99
58 Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation. Mol Cell Biol 2000 0.99
59 Molecular modeling of the Jak3 kinase domains and structural basis for severe combined immunodeficiency. Clin Immunol 2000 0.98
60 Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3. FEBS Lett 1995 0.97
61 Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain. Cytokine 1995 0.95
62 Expression of v-src in T cells correlates with nuclear expression of NF-kappa B. J Immunol 1994 0.95
63 Lymphoid development and function in X-linked severe combined immunodeficiency mice after stem cell gene therapy. Mol Ther 2000 0.94
64 Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID). J Immunol 1994 0.94
65 Regulation of JAK3 expression and activation in human B cells and B cell malignancies. J Immunol 1995 0.93
66 A fever gene comes in from the cold. Nat Genet 2001 0.92
67 Fibronectin-enhanced phagocytosis of an alternative pathway activator by human culture-derived macrophages is mediated by the C4b/C3b complement receptor (CR1). J Immunol 1985 0.91
68 Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha. J Biol Chem 1995 0.91
69 Molecular cloning of lsk, a carboxyl-terminal src kinase (csk) related gene, expressed in leukocytes. Oncogene 1994 0.90
70 Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role. J Immunol 1998 0.90
71 Severe combined immune deficiencies due to defects of the common gamma chain-JAK3 signaling pathway. Springer Semin Immunopathol 1998 0.89
72 Janus kinases and their role in growth and disease. Life Sci 1999 0.89
73 Activation of the C3b receptor: effect of diacylglycerols and calcium mobilization. J Immunol 1985 0.88
74 Stable isotope dilution analysis of n-hexanoylglycine, 3-phenylpropionylglycine and suberylglycine in human urine using chemical ionization gas chromatography/mass spectrometry selected ion monitoring. Biomed Environ Mass Spectrom 1989 0.87
75 Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association. J Biol Chem 1995 0.87
76 Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation. Arthritis Res 1999 0.87
77 The enzymatic basis for the dehydrogenation of 3-phenylpropionic acid: in vitro reaction of 3-phenylpropionyl-CoA with various acyl-CoA dehydrogenases. Pediatr Res 1990 0.86
78 IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes. J Exp Med 1994 0.85
79 Diagnosis of medium chain acyl-CoA dehydrogenase deficiency by stable isotope dilution analysis of urinary acylglycines: retrospective and prospective studies, and comparison of its accuracy to acylcarnitine identification by FAB/mass spectrometry. Prog Clin Biol Res 1990 0.85
80 Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex. J Biol Chem 2001 0.85
81 In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction. J Exp Med 1996 0.84
82 Peripheral T cell lymphoma presenting as hypereosinophilia with vasculitis. Clinical, pathologic, and immunologic features. Am J Med 1987 0.83
83 Signal transduction by interleukin-12 and interleukin-2. A comparison and contrast. Ann N Y Acad Sci 1996 0.83
84 Expression of the human epidermal growth factor receptor in a murine T-cell hybridoma. A transmembrane protein tyrosine kinase can synergize with the T-cell antigen receptor. J Biol Chem 1992 0.83
85 Inherited deficiencies of complement and complement-related proteins. Clin Immunol Immunopathol 1986 0.81
86 Ethylmalonic/adipic aciduria: effects of oral medium-chain triglycerides, carnitine, and glycine on urinary excretion of organic acids, acylcarnitines, and acylglycines. Pediatr Res 1991 0.81
87 Interleukin-4 signaling in B lymphocytes from patients with X-linked severe combined immunodeficiency. J Biol Chem 1997 0.80
88 Genomic sequence, organization, and chromosomal localization of human JAK3. Genomics 1996 0.80
89 Evidence for a conformational change in human fibronectin which occurs between 4 and 37 degrees C. Mol Immunol 1987 0.79
90 TGF-beta does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs. J Immunol 1999 0.79
91 Osmotic stress and the freeze-thaw cycle cause shedding of Fc and C3b receptors by human polymorphonuclear leukocytes. J Immunol 1985 0.78
92 IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2. J Immunol 1999 0.78
93 Retroviral-mediated gene correction for X-linked severe combined immunodeficiency. Blood 1996 0.78
94 The inhibitory effect of cyclic AMP on phosphatidylinositol kinase is not mediated by the cAMP dependent protein kinase. Biochem Biophys Res Commun 1987 0.78
95 Complete genomic organization of the human JAK3 gene and mutation analysis in severe combined immunodeficiency by single-strand conformation polymorphism. Hum Genet 2000 0.77
96 Identification and characterization of the phosphatidylinositol kinase in membranes of murine T lymphocytes. J Immunol 1986 0.77
97 Jak3 activation in human lymphocyte precursor cells. Clin Exp Immunol 1997 0.77
98 Not just another meeting: the coming of age of JAKs and STATs. Immunol Today 1998 0.77
99 Advances in cytokine signaling: the role of Jaks and STATs. Transplant Proc 1999 0.77
100 Molecular and biochemical characterization of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: implications for treatment. Br J Haematol 1998 0.76
101 Phosphorylation of the T cell antigen receptor: multiple signal transduction pathways. J Cell Physiol Suppl 1987 0.75
102 Substrate stereochemistry of 2-methyl-branched-chain acyl-CoA dehydrogenase: elimination of one hydrogen each from (pro-2S)-methyl and alpha-methine of isobutyryl-CoA. Biochim Biophys Acta 1986 0.75
103 Further comments on objective testing. Radiography 1973 0.75
104 Partially purified phosphatidylinositol kinase does not catalyze the formation of phosphatidylinositol-4,5-bisphosphate. Biochem Biophys Res Commun 1987 0.75
105 Comparison of urinary acylglycines and acylcarnitines as diagnostic markers of medium-chain acyl-CoA dehydrogenase deficiency. J Inherit Metab Dis 1989 0.75
106 Differential basal protein tyrosine phosphorylation in natural killer (NK) and T cells: a biochemical correlate of lymphoid functional activity. Cell Immunol 1996 0.75
107 Assembling an 8 mm cine-film into a loop cassette. Radiography 1971 0.75
108 Letters and card holders for staff dispositions. Radiography 1968 0.75
109 A six-year experience with nontraditional methods in a child clinic setting. Am J Orthopsychiatry 1967 0.75
110 Glucocorticoid-inducible genes that regulate T-cell function. Ernst Schering Res Found Workshop 2002 0.75