Published in Proc Natl Acad Sci U S A on December 18, 2001
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
CD4 T cells: fates, functions, and faults. Blood (2008) 7.03
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science (2010) 6.06
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med (2004) 5.13
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant. J Exp Med (2009) 4.27
Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity (2011) 3.24
Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A (2003) 3.23
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood (2005) 2.95
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol (2003) 2.93
MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells. Immunity (2011) 2.71
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity (2010) 2.70
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med (2006) 2.70
Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev (2010) 2.61
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol (2011) 2.59
Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses. Nat Immunol (2014) 2.52
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol (2011) 2.47
Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity (2012) 2.47
IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms. Proc Natl Acad Sci U S A (2003) 2.45
STATs shape the active enhancer landscape of T cell populations. Cell (2012) 2.45
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med (2006) 2.38
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity (2010) 2.38
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood (2006) 2.34
T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A (2003) 2.34
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity (2011) 2.34
A method for the generation of standardized qualitative dynamical systems of regulatory networks. Theor Biol Med Model (2006) 2.14
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Sci Transl Med (2011) 2.04
The transcription factor STAT3 is required for T helper 2 cell development. Immunity (2011) 2.03
Polarized immune responses differentially regulate cancer development. Immunol Rev (2008) 1.95
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87
The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses. Immunity (2012) 1.84
T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A (2005) 1.83
T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol (2013) 1.70
STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci U S A (2002) 1.69
Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet. Cell Metab (2013) 1.68
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J Exp Med (2005) 1.66
Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation. J Immunol (2011) 1.66
Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J Exp Med (2009) 1.61
An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature (2012) 1.60
Interleukin-35: odd one out or part of the family? Immunol Rev (2008) 1.60
Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur J Immunol (2010) 1.59
CD4⁺T cells: differentiation and functions. Clin Dev Immunol (2012) 1.56
Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction. J Exp Med (2014) 1.51
Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J Clin Invest (2006) 1.49
IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection. J Immunol (2012) 1.47
How diverse--CD4 effector T cells and their functions. J Mol Cell Biol (2009) 1.44
Interleukin 12 a key immunoregulatory cytokine in infection applications. Int J Mol Sci (2010) 1.41
T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease. Gut (2004) 1.39
Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol (2012) 1.36
Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation. EMBO J (2007) 1.36
miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis. J Immunol (2012) 1.35
The effects of TLR activation on T-cell development and differentiation. Clin Dev Immunol (2012) 1.33
STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunol (2010) 1.33
Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion. Proc Natl Acad Sci U S A (2006) 1.32
Low dose Leishmania major promotes a transient T helper cell type 2 response that is down-regulated by interferon gamma-producing CD8+ T cells. J Exp Med (2004) 1.31
Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB. EMBO J (2002) 1.31
The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells. Proc Natl Acad Sci U S A (2005) 1.30
Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. Blood (2007) 1.29
Cytokines in cancer immunotherapy. Cancers (Basel) (2011) 1.26
T-bet is essential for the progression of experimental autoimmune encephalomyelitis. Immunology (2006) 1.25
STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. Infect Immun (2004) 1.23
T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci U S A (2007) 1.23
Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. FASEB J (2008) 1.19
T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. Am J Respir Crit Care Med (2005) 1.18
IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis. J Immunol (2009) 1.18
JAK-STAT signaling in asthma. J Clin Invest (2002) 1.17
T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17. J Immunol (2008) 1.17
Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity (2009) 1.17
CD8(+) T cells in facioscapulohumeral muscular dystrophy patients with inflammatory features at muscle MRI. J Clin Immunol (2010) 1.16
Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells. Immunology (2009) 1.16
T helper subset development: roles of instruction, selection, and transcription. J Clin Invest (2002) 1.14
Predominance of type 1 CD4+ T cells in human abdominal aortic aneurysm. Clin Exp Immunol (2005) 1.13
Characterization of T-bet and eomes in peripheral human immune cells. Front Immunol (2014) 1.13
Pathogenesis of allergic airway inflammation. Curr Allergy Asthma Rep (2010) 1.11
Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes. Immunol Res (2009) 1.10
IFN-alpha is not sufficient to drive Th1 development due to lack of stable T-bet expression. J Immunol (2007) 1.10
Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions. J Neuroinflammation (2006) 1.10
Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biol (2013) 1.08
T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci U S A (2013) 1.08
Persistent antigenic stimulation alters the transcription program in T cells, resulting in antigen-specific tolerance. Eur J Immunol (2006) 1.07
JunD regulates lymphocyte proliferation and T helper cell cytokine expression. EMBO J (2004) 1.04
Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS One (2010) 1.04
Helper T cell differentiation enters a new era: le roi est mort; vive le roi! J Exp Med (2006) 1.03
Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr Opin Immunol (2012) 1.03
Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice. Blood (2005) 1.01
STAT6 activation by Toxoplasma gondii infection induces the expression of Th2 C-C chemokine ligands and B clade serine protease inhibitors in macrophage. Parasitol Res (2009) 1.01
Chitosan IFN-gamma-pDNA Nanoparticle (CIN) Therapy for Allergic Asthma. Genet Vaccines Ther (2003) 0.99
Genetic and epigenetic networks controlling T helper 1 cell differentiation. Immunology (2009) 0.98
Immunology and mathematics: crossing the divide. Immunology (2005) 0.98
Signal transduction and Th17 cell differentiation. Microbes Infect (2009) 0.98
Ectopic T-bet expression licenses dendritic cells for IL-12-independent priming of type 1 T cells in vitro. J Immunol (2009) 0.98
T cell directives for transcriptional regulation in asthma. Springer Semin Immunopathol (2003) 0.98
Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production. J Exp Med (2004) 0.96
IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine. Proc Natl Acad Sci U S A (2010) 0.96
Cellular and population plasticity of helper CD4(+) T cell responses. Front Physiol (2013) 0.96
Asthma: T-bet--a master controller? Curr Biol (2002) 0.96
Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa. Gut (2004) 0.96
Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation. Genome Res (2012) 0.95
Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model. Gut (2005) 0.95
A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria. Proc Natl Acad Sci U S A (2012) 0.94
Functional diversity of helper T lymphocytes. Nature (1996) 18.09
A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 12.68
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity (1996) 8.16
The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med (1992) 7.80
Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med (1997) 6.53
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature (1996) 6.23
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature (1996) 6.17
Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity (1998) 5.75
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (2001) 5.58
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature (1996) 5.45
Dendritic cell regulation of TH1-TH2 development. Nat Immunol (2000) 5.13
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity (2001) 3.84
Signaling and transcription in T helper development. Annu Rev Immunol (2000) 3.44
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc Natl Acad Sci U S A (1995) 2.52
IFN-gamma production by antigen-presenting cells: mechanisms emerge. Trends Immunol (2001) 2.13
Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells. J Exp Med (1997) 1.87
Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge. Nat Immunol (2000) 1.84
Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J Immunol (2001) 1.81
The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J Immunol (2001) 1.61
Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation. J Immunol (2000) 1.59
Regulation of interleukin-12 signalling during T helper phenotype development. Adv Exp Med Biol (1996) 1.13
Functional diversity of helper T lymphocytes. Nature (1996) 18.09
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol (2000) 14.74
Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science (1987) 13.03
Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature (1985) 11.55
Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med (1982) 9.49
Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol (1994) 8.43
Qualitative and Quantitative Analyses of Gibberellins in Vegetative Shoots of Normal, dwarf-1, dwarf-2, dwarf-3, and dwarf-5 Seedlings of Zea mays L. Plant Physiol (1988) 8.05
Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol (1990) 7.93
The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med (1992) 7.80
Jaks and STATs: biological implications. Annu Rev Immunol (1998) 7.18
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med (1990) 7.09
Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med (1988) 7.02
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci U S A (1993) 6.87
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med (1997) 6.53
The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol (1999) 6.19
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature (1996) 6.17
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol (1986) 6.16
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci U S A (1993) 6.12
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science (1992) 5.94
CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med (1994) 5.90
Carrier function in anti-hapten immune responses. I. Enhancement of primary and secondary anti-hapten antibody responses by carrier preimmunization. J Exp Med (1970) 5.71
Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature (1989) 5.10
Regulation of B-cell growth and differentiation by soluble factors. Annu Rev Immunol (1983) 5.09
Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J Exp Med (1991) 5.04
Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell (1999) 5.01
Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol (1994) 4.86
NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol (2000) 4.75
Gibberellin A(3) Is Biosynthesized from Gibberellin A(20) via Gibberellin A(5) in Shoots of Zea mays L. Plant Physiol (1990) 4.71
Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 4.69
Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol (1991) 4.69
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs. J Exp Med (1966) 4.58
Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J Exp Med (1985) 4.47
Functional specificity of thymus- dependent lymphocytes. Science (1977) 4.31
Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions. J Exp Med (1971) 4.29
The dominant non-gibberellin-responding dwarf mutant (D8) of maize accumulates native gibberellins. Proc Natl Acad Sci U S A (1988) 4.28
Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J Immunol (1989) 4.20
Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science (1993) 4.08
B-cell stimulatory factor-1/interleukin 4. Annu Rev Immunol (1987) 4.04
IL-4 is required to generate and sustain in vivo IgE responses. J Immunol (1988) 4.04
Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol (1992) 4.02
IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages. J Immunol (1992) 3.98
Functional heterogeneity of murine lymphoid cells. I. Responsiveness to and surface binding of concanavalin A and phytohemagglutinin. J Immunol (1972) 3.96
Histocompatibility-linked immune response gene function in guinea pigs. Specific inhibition of antigen-induced lymphocyte proliferation by alloantisera. J Exp Med (1972) 3.81
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun (1998) 3.80
X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells. J Exp Med (1975) 3.70
Interaction between antigen-presenting cells and primed T lymphocytes: an assessment of Ir gene expression in the antigen-presenting cell. Immunol Rev (1978) 3.67
Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J Immunol (1991) 3.65
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med (2001) 3.64
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med (1997) 3.62
T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 3.56
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science (1995) 3.43
Activation events during thymic selection. J Exp Med (1992) 3.43
Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43
Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science (1995) 3.37
Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J Immunol (1993) 3.34
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature (1994) 3.31
Frequency of B lymphocytes responsive to anti-immunoglobulin. J Exp Med (1982) 3.30
CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity (2000) 3.27
Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease. Immunol Rev (1989) 3.21
B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J Immunol (1987) 3.18
B-cell stimulatory factor 1 activates resting B cells. Proc Natl Acad Sci U S A (1985) 3.16
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol (1996) 3.15
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science (1995) 3.15
Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J Exp Med (1987) 3.12
Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest (1994) 3.12
Functional heterogeneity of murine lymphoid cells. 3. Differential responsiveness of T cells to phytohemagglutinin and concanavalin A as a probe for T cell subsets. J Immunol (1973) 3.04
Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine. Eur J Immunol (1972) 3.04
X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect. J Exp Med (1975) 3.03
Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils. J Immunol (1985) 3.02
Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cells. J Exp Med (1982) 3.01
Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci U S A (1991) 3.01
Secondary antibody responses in haptenic systems: cell population selection by antigen. J Immunol (1967) 3.01
Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J Exp Med (1994) 2.99
Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes. Science (1972) 2.98
The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta. Eur J Immunol (1992) 2.98
Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature (1987) 2.94
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature (1995) 2.93
Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature (1975) 2.92
Receptors on immunocompetent cells. II. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding lymphocytes of normal guinea pigs. J Exp Med (1971) 2.92
Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation. Proc Natl Acad Sci U S A (1992) 2.92
Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes. J Immunol (1985) 2.87
Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response. J Exp Med (1978) 2.86
Differential regulation of IgG1 and IgE synthesis by interleukin 4. J Exp Med (1988) 2.84
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. Proc Natl Acad Sci U S A (2000) 2.80
IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J Immunol (1992) 2.78
Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation. J Exp Med (1984) 2.71
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A (1997) 2.67
Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proc Natl Acad Sci U S A (1993) 2.65
T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera. J Immunol (1976) 2.64