Published in Pharmacol Rev on December 01, 2003
The NIFSTD and BIRNLex vocabularies: building comprehensive ontologies for neuroscience. Neuroinformatics (2008) 5.38
Insect sodium channels and insecticide resistance. Invert Neurosci (2007) 2.06
Interactions of local anesthetics with voltage-gated Na+ channels. J Membr Biol (2004) 1.62
Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding. Mol Pharmacol (2004) 1.57
RNA editing generates tissue-specific sodium channels with distinct gating properties. J Biol Chem (2004) 1.50
Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons. J Physiol (2008) 1.46
Channelopathies in Cav1.1, Cav1.3, and Cav1.4 voltage-gated L-type Ca2+ channels. Pflugers Arch (2010) 1.45
Ion channels: molecular targets of neuroactive insecticides. Invert Neurosci (2005) 1.28
The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation. Mol Pharmacol (2010) 1.18
Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects. Eur Biophys J (2004) 1.09
mRNA expression of ion channels in GnRH neurons: subtype-specific regulation by 17β-estradiol. Mol Cell Endocrinol (2013) 1.00
Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. Toxicon (2008) 0.97
Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons. Mol Pain (2012) 0.96
A fast Na+/Ca2+-based action potential in a marine diatom. PLoS One (2009) 0.96
Regulatory Role of Voltage-Gated Na Channel β Subunits in Sensory Neurons. Front Pharmacol (2011) 0.95
Expression of skeletal muscle Na(V)1.4 Na channel isoform in canine cardiac Purkinje myocytes. Biochem Biophys Res Commun (2007) 0.91
De novo assembly of a transcriptome for Calanus finmarchicus (Crustacea, Copepoda)--the dominant zooplankter of the North Atlantic Ocean. PLoS One (2014) 0.91
17Beta-estradiol regulation of the mRNA expression of T-type calcium channel subunits: role of estrogen receptor alpha and estrogen receptor beta. J Comp Neurol (2009) 0.91
Sodium channel blockers for the treatment of neuropathic pain. Neurotherapeutics (2009) 0.91
Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation. J Biol Chem (2013) 0.89
Molecular and functional characterization of voltage-gated sodium channels in human sperm. Reprod Biol Endocrinol (2009) 0.88
DDESC: Dragon database for exploration of sodium channels in human. BMC Genomics (2008) 0.87
Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells. PLoS One (2013) 0.85
No evidence for induction or selection of mutant sodium channel expression in the copepod Acartia husdsonica challenged with the toxic dinoflagellate Alexandrium fundyense. Ecol Evol (2014) 0.83
Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]. Proc Natl Acad Sci U S A (2012) 0.83
New insights in the contribution of voltage-gated Na(v) channels to rat aorta contraction. PLoS One (2009) 0.82
Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models. Front Physiol (2012) 0.79
Voltage-gated sodium channels and cancer: is excitability their primary role? Front Pharmacol (2015) 0.78
Effective contractile response to voltage-gated Na+ channels revealed by a channel activator. Am J Physiol Cell Physiol (2013) 0.78
Inhibition of the cardiac Na(+) channel α-subunit Nav1.5 by propofol and dexmedetomidine. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.77
Late sodium current (INaL) in pancreatic β-cells. Pflugers Arch (2014) 0.77
Drosophila sodium channel mutations: Contributions to seizure-susceptibility. Exp Neurol (2015) 0.76
Action potentials in primary osteoblasts and in the MG-63 osteoblast-like cell line. J Bioenerg Biomembr (2011) 0.76
THE ROLE OF INTRACELLULAR SODIUM (Na) IN THE REGULATION OF CALCIUM (Ca)-MEDIATED SIGNALING AND TOXICITY. Health (Irvine Calif) (2010) 0.75
Src family tyrosine kinase inhibitors suppress Nav1.1 expression in cultured rat spiral ganglion neurons. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2016) 0.75
Tetrodotoxin-sensitive α-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev (2005) 5.40
De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP. Am J Hum Genet (2012) 3.58
Gain of function Naν1.7 mutations in idiopathic small fiber neuropathy. Ann Neurol (2011) 3.53
Sodium channels in normal and pathological pain. Annu Rev Neurosci (2010) 3.47
The Na(V)1.7 sodium channel: from molecule to man. Nat Rev Neurosci (2012) 2.71
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. J Physiol (2006) 2.62
A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proc Natl Acad Sci U S A (2006) 2.61
Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J Neurosci (2006) 2.60
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders. J Clin Invest (2007) 2.58
Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. Pain (2012) 2.34
From genes to pain: Na v 1.7 and human pain disorders. Trends Neurosci (2007) 2.29
Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons. J Physiol (2003) 2.21
Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain. Pain (2004) 2.10
The roles of sodium channels in nociception: Implications for mechanisms of pain. Pain (2007) 2.06
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression. J Neurosci (2006) 2.05
Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger. Proc Natl Acad Sci U S A (2004) 1.99
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones. J Physiol (2005) 1.95
Inherited erythermalgia: limb pain from an S4 charge-neutral Na channelopathy. Neurology (2006) 1.95
Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy. J Neurosci (2004) 1.93
NaN/Nav1.9: a sodium channel with unique properties. Trends Neurosci (2002) 1.93
Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. J Neurosci (2004) 1.91
Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons. FEBS Lett (2005) 1.85
The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons. J Neurosci (2002) 1.85
Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation. Brain (2009) 1.82
Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. J Neurosci (2002) 1.80
A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons. Exp Neurol (2010) 1.78
Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neurosci (2003) 1.76
Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke. Brain (2011) 1.73
Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem (2010) 1.70
Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B. J Biol Chem (2002) 1.64
GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. J Physiol (2003) 1.62
International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev (2003) 1.61
A case of inherited erythromelalgia. Nat Clin Pract Neurol (2007) 1.60
Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia (2010) 1.59
A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis. Ann Neurol (2012) 1.59
Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine. Ann Neurol (2007) 1.56
Early treatment suppresses the development of spike-wave epilepsy in a rat model. Epilepsia (2007) 1.53
FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels. Mol Cell Neurosci (2009) 1.51
Gain-of-function Nav1.8 mutations in painful neuropathy. Proc Natl Acad Sci U S A (2012) 1.50
Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. J Neurosci (2007) 1.49
Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7. Ann Neurol (2006) 1.48
Nav1.5 sodium channels in macrophages in multiple sclerosis lesions. Mult Scler (2012) 1.45
Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury. J Comp Neurol (2003) 1.43
International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels. Pharmacol Rev (2003) 1.43
Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE. Brain (2003) 1.42
Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons. J Neurosci (2006) 1.42
Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conduction. Brain Res Mol Brain Res (2002) 1.40
Familial pain syndromes from mutations of the NaV1.7 sodium channel. Ann N Y Acad Sci (2010) 1.40
Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily. Eur J Neurosci (2006) 1.39
PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins. Brain Res (2004) 1.39
ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties. J Neurosci (2010) 1.38
Calmodulin binds to the C terminus of sodium channels Nav1.4 and Nav1.6 and differentially modulates their functional properties. J Neurosci (2003) 1.38
Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas. Ann Neurol (2008) 1.37
Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21. J Neurosci (2007) 1.36
Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis. Epilepsia (2008) 1.36
Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons. J Neurosci (2008) 1.35
A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. J Physiol (2007) 1.35
Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals. Mol Pain (2010) 1.33
Selective expression of a persistent tetrodotoxin-resistant Na+ current and NaV1.9 subunit in myenteric sensory neurons. J Neurosci (2003) 1.33
Voltage-gated sodium channels: therapeutic targets for pain. Pain Med (2009) 1.33
Transfection of rat or mouse neurons by biolistics or electroporation. Nat Protoc (2009) 1.32
A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis (2009) 1.32
Deletion mutation of sodium channel Na(V)1.7 in inherited erythromelalgia: enhanced slow inactivation modulates dorsal root ganglion neuron hyperexcitability. Brain (2011) 1.32
Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain. Pain (2008) 1.32
Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable. Mol Pain (2008) 1.26
Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination. Brain (2003) 1.25
A sodium channel gene SCN9A polymorphism that increases nociceptor excitability. Ann Neurol (2009) 1.25
Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J Neurosci (2004) 1.24
trkA is expressed in nociceptive neurons and influences electrophysiological properties via Nav1.8 expression in rapidly conducting nociceptors. J Neurosci (2005) 1.24
A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. Neuron (2004) 1.24
Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase. J Neurosci (2005) 1.23
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS. Glia (2005) 1.22
Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade. Mol Pain (2008) 1.21
Changes of sodium channel expression in experimental painful diabetic neuropathy. Ann Neurol (2002) 1.20
Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Res (2004) 1.20
Differential slow inactivation and use-dependent inhibition of Nav1.8 channels contribute to distinct firing properties in IB4+ and IB4- DRG neurons. J Neurophysiol (2006) 1.20
Small-fibre neuropathies--advances in diagnosis, pathophysiology and management. Nat Rev Neurol (2012) 1.19
The brain in diabetes: molecular changes in neurons and their implications for end-organ damage. Lancet Neurol (2003) 1.18
A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia. Ann Neurol (2009) 1.18
An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability. J Neurosci (2006) 1.17
Voltage-clamp and current-clamp recordings from mammalian DRG neurons. Nat Protoc (2009) 1.16
The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking. J Neurosci (2009) 1.16
Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue. Pflugers Arch (2005) 1.16
Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification. J Immunol (2007) 1.16
Neuropathic pain memory is maintained by Rac1-regulated dendritic spine remodeling after spinal cord injury. J Neurosci (2008) 1.15
Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury. Brain (2005) 1.15
Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE. Brain (2006) 1.15
Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating. J Biol Chem (2006) 1.15
An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier. J Neurosci (2012) 1.13
Novel SCN1A mutation in a proband with malignant migrating partial seizures of infancy. Arch Neurol (2011) 1.12
Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A. J Biol Chem (2009) 1.12
Neurobiology: a channel sets the gain on pain. Nature (2006) 1.10
Neurological channelopathies: new insights into disease mechanisms and ion channel function. J Physiol (2010) 1.09
Increased neuronal firing in computer simulations of sodium channel mutations that cause generalized epilepsy with febrile seizures plus. J Neurophysiol (2003) 1.09
Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of NaV1.7. Mol Pain (2011) 1.09
Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury. Exp Brain Res (2006) 1.09
Mesenchymal stem cells: therapeutic outlook for stroke. Trends Mol Med (2012) 1.08