Published in Pharmacol Rev on December 01, 2003
The NIFSTD and BIRNLex vocabularies: building comprehensive ontologies for neuroscience. Neuroinformatics (2008) 5.38
Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev (2009) 2.53
Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintainance of epilepsy. Pharmacol Ther (2004) 1.94
Synaptic transmission at retinal ribbon synapses. Prog Retin Eye Res (2005) 1.85
Taste receptor signaling in the mammalian gut. Curr Opin Pharmacol (2007) 1.81
Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication. Nucleic Acids Res (2006) 1.62
Olfactory stimulation selectively modulates the OFF pathway in the retina of zebrafish. Neuron (2013) 1.48
The CaV2.3 R-type voltage-gated Ca2+ channel in mouse sleep architecture. Sleep (2014) 1.27
The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword. Prog Neurobiol (2010) 1.23
Ca2+-dependent modulation of voltage-gated Ca2+ channels. Biochim Biophys Acta (2011) 1.16
Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels. J Membr Biol (2004) 1.13
Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570. Proc Natl Acad Sci U S A (2010) 1.11
Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder. J Biol Chem (2005) 1.10
Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat (2007) 1.01
Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth. Cell Mol Neurobiol (2010) 0.95
Two PEST-like motifs regulate Ca2+/calpain-mediated cleavage of the CaVbeta3 subunit and provide important determinants for neuronal Ca2+ channel activity. Eur J Neurosci (2006) 0.94
Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn. J Physiol (2007) 0.92
Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2. J Biol Chem (2009) 0.90
Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels. J Biol Chem (2009) 0.90
Anatomical and neurochemical characterization of dopaminergic interplexiform processes in mouse and rat retinas. J Comp Neurol (2008) 0.90
Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders. Prog Neurobiol (2015) 0.89
Regulation of neuronal ion channels via P2Y receptors. Purinergic Signal (2004) 0.89
Transcriptional response of rat frontal cortex following acute in vivo exposure to the pyrethroid insecticides permethrin and deltamethrin. BMC Genomics (2008) 0.88
Functions of neuronal P2Y receptors. Pflugers Arch (2006) 0.88
Identification of calcium channel alpha1 subunit mRNA expressed in retinal bipolar neurons. Mol Vis (2006) 0.87
Voltage-gated divalent currents in descending vasa recta pericytes. Am J Physiol Renal Physiol (2010) 0.86
Functional role of voltage gated Ca(2+) channels in heart automaticity. Front Physiol (2015) 0.86
Repeated cocaine treatment enhances HIV-1 Tat-induced cortical excitability via over-activation of L-type calcium channels. J Neuroimmune Pharmacol (2014) 0.85
Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model. Pflugers Arch (2012) 0.85
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers. J Med Chem (2013) 0.84
Pulmonary expression of voltage-gated calcium channels: special reference to sensory airway receptors. Histochem Cell Biol (2007) 0.83
The involvement of voltage-operated calcium channels in somato-dendritic oxytocin release. PLoS One (2011) 0.83
Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients. PLoS One (2015) 0.82
Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology. J Physiol (2016) 0.82
Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels. Front Physiol (2014) 0.81
Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2. Am J Physiol Cell Physiol (2010) 0.80
Agonist-like autoantibodies against calcium channel in patients with dilated cardiomyopathy. Heart Vessels (2011) 0.80
Peptide neurotoxins that affect voltage-gated calcium channels: a close-up on ω-agatoxins. Toxins (Basel) (2011) 0.79
Dissociation between rat hippocampal CA1 and dentate gyrus cells in their response to corticosterone: effects on calcium channel protein and current. Endocrinology (2009) 0.79
Pentobarbital inhibition of human recombinant alpha1A P/Q-type voltage-gated calcium channels involves slow, open channel block. Br J Pharmacol (2010) 0.78
Selective release of ATP from sympathetic nerves of rat vas deferens by the toxin TsTX-I from Brazilian scorpion Tityus serrulatus. Br J Pharmacol (2005) 0.77
A folding pathway-dependent score to recognize membrane proteins. PLoS One (2011) 0.76
Omega-conotoxins as experimental tools and therapeutics in pain management. Mar Drugs (2013) 0.76
Variation in CACNA1C is Associated with Amygdala Structure and Function in Adolescents. J Child Adolesc Psychopharmacol (2015) 0.75
Nifedipine Inhibition of High-Voltage Activated Calcium Channel Currents in Cerebral Artery Myocytes Is Influenced by Extracellular Divalent Cations. Front Physiol (2017) 0.75
Voltage-gated calcium channels - from basic mechanisms to disease. J Physiol (2016) 0.75
Correlative study on the JAK-STAT/PSMβ3 signal transduction pathway in asthenozoospermia. Exp Ther Med (2016) 0.75
No apparent role for T-type Ca(2+) channels in renal autoregulation. Pflugers Arch (2015) 0.75
Cardiac Ion Channel Regulation in Obesity and the Metabolic Syndrome: Relevance to Long QT Syndrome and Atrial Fibrillation. Front Physiol (2017) 0.75
International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev (2005) 5.25
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet (2013) 2.63
Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. EMBO J (2004) 2.15
CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cells. J Neurosci (2003) 2.12
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Curr Biol (2007) 1.70
Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons. Proc Natl Acad Sci U S A (2002) 1.64
Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels. Mol Pharmacol (2008) 1.63
Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons. Proc Natl Acad Sci U S A (2006) 1.62
International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev (2003) 1.61
The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution. J Neurosci (2004) 1.57
The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. J Neurosci (2005) 1.52
Ca(V)3 T-type calcium channel isoforms differentially distribute to somatic and dendritic compartments in rat central neurons. Eur J Neurosci (2006) 1.48
Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability. J Physiol (2002) 1.48
International Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels. Pharmacol Rev (2003) 1.40
T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci Transl Med (2012) 1.39
Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. J Neurosci (2007) 1.38
Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells. J Neurosci (2010) 1.37
UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants. Curr Biol (2007) 1.36
Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci (2009) 1.36
Role of voltage-gated calcium channels in ascending pain pathways. Brain Res Rev (2008) 1.35
Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel. J Neurosci (2005) 1.33
A molecular determinant of nickel inhibition in Cav3.2 T-type calcium channels. J Biol Chem (2005) 1.22
Contributions of T-type calcium channel isoforms to neuronal firing. Channels (Austin) (2010) 1.20
A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy. J Neurosci (2009) 1.20
The I-II loop controls plasma membrane expression and gating of Ca(v)3.2 T-type Ca2+ channels: a paradigm for childhood absence epilepsy mutations. J Neurosci (2007) 1.19
CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus. J Physiol (2006) 1.18
Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. J Neurosci (2011) 1.17
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci (2007) 1.14
Transfer of beta subunit regulation from high to low voltage-gated Ca2+ channels. FEBS Lett (2005) 1.13
Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels. Br J Pharmacol (2005) 1.12
Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci (2002) 1.11
The C. elegans T-type calcium channel CCA-1 boosts neuromuscular transmission. J Exp Biol (2005) 1.11
Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties. J Neurosci (2003) 1.11
I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels. PLoS One (2008) 1.09
Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation. Biophys J (2002) 1.09
Role of voltage-gated calcium channels in epilepsy. Pflugers Arch (2009) 1.08
Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade. J Neurophysiol (2002) 1.06
T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. Proc Natl Acad Sci U S A (2011) 1.06
Ca(V)2.1 P/Q-type calcium channel alternative splicing affects the functional impact of familial hemiplegic migraine mutations: implications for calcium channelopathies. Channels (Austin) (2009) 1.05
Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy. J Biol Chem (2004) 1.03
Pseudomigraine with lymphocytic pleocytosis: a calcium channelopathy? Clinical description of 10 cases and genetic analysis of the familial hemiplegic migraine gene CACNA1A. Headache (2003) 1.03
Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity. PLoS One (2008) 1.02
Stimulation of recombinant Ca(v)3.2, T-type, Ca(2+) channel currents by CaMKIIgamma(C). J Physiol (2002) 1.01
Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels. J Biol Chem (2002) 1.00
Characterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels. J Biol Chem (2008) 0.99
International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor. Pharmacol Rev (2008) 0.98
Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy. Ann Neurol (2005) 0.97
T-type calcium channels in burst-firing, network synchrony, and epilepsy. Biochim Biophys Acta (2012) 0.96
Splice-variant changes of the Ca(V)3.2 T-type calcium channel mediate voltage-dependent facilitation and associate with cardiac hypertrophy and development. Channels (Austin) (2010) 0.95
Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci (2009) 0.95
International Union of Pharmacology. XLII. Compendium of voltage-gated ion channels: cyclic nucleotide-modulated channels. Pharmacol Rev (2003) 0.95
Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology (2006) 0.95
Orientation of palmitoylated CaVbeta2a relative to CaV2.2 is critical for slow pathway modulation of N-type Ca2+ current by tachykinin receptor activation. J Gen Physiol (2009) 0.94
Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker. J Pharmacol Exp Ther (2010) 0.94
Validation of high throughput screening assays against three subtypes of Ca(v)3 T-type channels using molecular and pharmacologic approaches. Assay Drug Dev Technol (2007) 0.94
Alternative splicing of the rat Ca(v)3.3 T-type calcium channel gene produces variants with distinct functional properties(1). FEBS Lett (2002) 0.93
Functional impact of alternative splicing of human T-type Cav3.3 calcium channels. J Neurophysiol (2004) 0.93
Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel. Proc Natl Acad Sci U S A (2010) 0.93
Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity. J Neurosci (2010) 0.93
A blocker of N- and T-type voltage-gated calcium channels attenuates ethanol-induced intoxication, place preference, self-administration, and reinstatement. J Neurosci (2008) 0.93
Ca(V)1.3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells. J Neurosci (2012) 0.91
Voltage-gated calcium channels and disease. Biofactors (2011) 0.91
Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility. J Physiol (2013) 0.91
Structural determinants of the high affinity extracellular zinc binding site on Cav3.2 T-type calcium channels. J Biol Chem (2009) 0.89
Low threshold T-type calcium channels as targets for novel epilepsy treatments. Br J Clin Pharmacol (2014) 0.89
A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain. Pain (2011) 0.88
Contributions of T-type voltage-gated calcium channels to postsynaptic calcium signaling within Purkinje neurons. Cerebellum (2012) 0.88
Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors. J Biol Chem (2007) 0.87
Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node. J Physiol (2012) 0.87
Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels. FEBS Lett (2008) 0.87
Functional implications of a novel EA2 mutation in the P/Q-type calcium channel. Ann Neurol (2004) 0.87
Modulation of Ca(v)3.2 T-type Ca2+ channels by protein kinase C. FEBS Lett (2003) 0.87
Mammalian voltage-gated calcium channels are potently blocked by the pyrethroid insecticide allethrin. J Pharmacol Exp Ther (2003) 0.86
Cloning of a novel one-repeat calcium channel-like gene. Biochem Biophys Res Commun (2003) 0.86
The voltage dependence of gating currents of the neuronal CA(v)3.3 channel is determined by the gating brake in the I-II loop. Pflugers Arch (2011) 0.86
Single-channel pharmacology of mibefradil in human native T-type and recombinant Ca(v)3.2 calcium channels. Mol Pharmacol (2002) 0.86
Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett (2009) 0.86
Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation. Circ Arrhythm Electrophysiol (2011) 0.86
Functional analysis of Ca3.2 T-type calcium channel mutations linked to childhood absence epilepsy. Epilepsia (2006) 0.86
The role of voltage gated T-type Ca2+ channel isoforms in mediating "capacitative" Ca2+ entry in cancer cells. Cell Calcium (2004) 0.85
T-type Ca(2+) channel modulation by otilonium bromide. Am J Physiol Gastrointest Liver Physiol (2010) 0.84
Modulation of low-voltage-activated T-type Ca²⁺ channels. Biochim Biophys Acta (2012) 0.83
Contrasting the effects of nifedipine on subtypes of endogenous and recombinant T-type Ca2+ channels. Biochem Pharmacol (2005) 0.83
Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A(1)-receptor activation. Epilepsia (2011) 0.82
Inhibition of high voltage-activated calcium channels by spider toxin PnTx3-6. J Pharmacol Exp Ther (2005) 0.81
Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors. Bioorg Med Chem Lett (2012) 0.81
Block of voltage-gated calcium channels stimulates dopamine efflux in rat mesocorticolimbic system. Neuropharmacology (2009) 0.81
Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels. Mol Pharmacol (2011) 0.81
A fluorescence-based high-throughput screening assay for the identification of T-type calcium channel blockers. Assay Drug Dev Technol (2009) 0.81
Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels. J Gen Physiol (2012) 0.81
Thalamocortical neurons display suppressed burst-firing due to an enhanced Ih current in a genetic model of absence epilepsy. Pflugers Arch (2014) 0.80
Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons. Mol Pain (2011) 0.80
Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors. Bioorg Med Chem Lett (2010) 0.80
Cav 1.3 L-type Ca ( 2+) channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure. Channels (Austin) (2012) 0.79
Repression of a potassium channel by nuclear hormone receptor and TGF-β signaling modulates insulin signaling in Caenorhabditis elegans. PLoS Genet (2012) 0.79
Modular, efficient synthesis of asymmetrically substituted piperazine scaffolds as potent calcium channel blockers. Bioorg Med Chem Lett (2013) 0.79