Published in J Am Chem Soc on December 17, 2003
Chemical exchange saturation transfer (CEST): what is in a name and what isn't? Magn Reson Med (2011) 4.08
Chemical exchange saturation transfer contrast agents for magnetic resonance imaging. Annu Rev Biomed Eng (2008) 3.53
Paramagnetic lanthanide complexes as PARACEST agents for medical imaging. Chem Soc Rev (2006) 3.02
Alternatives to gadolinium-based metal chelates for magnetic resonance imaging. Chem Rev (2010) 2.25
A concentration-independent method to measure exchange rates in PARACEST agents. Magn Reson Med (2010) 2.17
Multimodal MRI contrast agents. J Biol Inorg Chem (2007) 1.86
PARACEST MRI with improved temporal resolution. Magn Reson Med (2009) 1.69
CEST: from basic principles to applications, challenges and opportunities. J Magn Reson (2012) 1.59
High-throughput screening of chemical exchange saturation transfer MR contrast agents. Contrast Media Mol Imaging (2010) 1.59
Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects. J Am Chem Soc (2007) 1.51
Modulation of water exchange in Eu(III) DOTA-tetraamide complexes: considerations for in vivo imaging of PARACEST agents. Contrast Media Mol Imaging (2009) 1.43
Imaging the tissue distribution of glucose in livers using a PARACEST sensor. Magn Reson Med (2008) 1.35
Simultaneous determination of labile proton concentration and exchange rate utilizing optimal RF power: Radio frequency power (RFP) dependence of chemical exchange saturation transfer (CEST) MRI. J Magn Reson (2009) 1.34
Lanthanide probes for bioresponsive imaging. Chem Rev (2013) 1.34
In vivo off-resonance saturation magnetic resonance imaging of alphavbeta3-targeted superparamagnetic nanoparticles. Cancer Res (2009) 1.32
A multislice gradient echo pulse sequence for CEST imaging. Magn Reson Med (2010) 1.29
A responsive europium(III) chelate that provides a direct readout of pH by MRI. J Am Chem Soc (2010) 1.28
Toward the Design of MR Agents for Imaging β-Cell Function. Curr Med Chem Immunol Endocr Metab Agents (2004) 1.28
Simplified and scalable numerical solution for describing multi-pool chemical exchange saturation transfer (CEST) MRI contrast. J Magn Reson (2010) 1.26
Multi-frequency PARACEST agents based on europium(III)-DOTA-tetraamide ligands. Angew Chem Int Ed Engl (2009) 1.20
Albumin-binding PARACEST agents. J Biol Inorg Chem (2007) 1.17
Optimizing pulsed-chemical exchange saturation transfer imaging sequences. Magn Reson Med (2011) 1.16
Molecular imaging probe development: a chemistry perspective. Am J Nucl Med Mol Imaging (2012) 1.10
T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation. Magn Reson Med (2011) 1.09
A PARACEST agent responsive to inner- and outer-sphere phosphate ester interactions for MRI applications. J Am Chem Soc (2009) 1.09
Simulation and optimization of pulsed radio frequency irradiation scheme for chemical exchange saturation transfer (CEST) MRI-demonstration of pH-weighted pulsed-amide proton CEST MRI in an animal model of acute cerebral ischemia. Magn Reson Med (2011) 1.08
CEST phase mapping using a length and offset varied saturation (LOVARS) scheme. Magn Reson Med (2012) 1.07
Ultrafast scanning of exchangeable sites by NMR spectroscopy. Angew Chem Int Ed Engl (2013) 1.02
SWIFT-CEST: a new MRI method to overcome T₂ shortening caused by PARACEST contrast agents. Magn Reson Med (2011) 0.98
Advances in molecular imaging of pancreatic beta cells. Front Biosci (2008) 0.98
A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA-tetraglycinate. NMR Biomed (2011) 0.97
Effect of the regiochemistry of butyl amide substituents on the solution-state structures of lanthanide(III) DOTA-tetraamide complexes. Inorg Chem (2009) 0.97
Using frequency-labeled exchange transfer to separate out conventional magnetization transfer effects from exchange transfer effects when detecting ParaCEST agents. Magn Reson Med (2012) 0.97
The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent. Inorg Chem (2010) 0.93
Advances in beta-cell imaging. Eur J Radiol (2009) 0.93
In vivo detection of PARACEST agents with relaxation correction. Magn Reson Med (2010) 0.93
Multifunctional Polymeric Scaffolds for Enhancement of PARACEST Contrast Sensitivity and Performance: The Effects of Random Copolymer Variations. Macromolecules (2010) 0.91
Evaluation of the dependence of CEST-EPI measurement on repetition time, RF irradiation duty cycle and imaging flip angle for enhanced pH sensitivity. Phys Med Biol (2013) 0.91
PARACEST properties of a dinuclear neodymium(III) complex bound to DNA or carbonate. Bioconjug Chem (2009) 0.89
The use of silica coated MnO nanoparticles to control MRI relaxivity in response to specific physiological changes. Biomaterials (2012) 0.87
Sensitivity-enhanced chemical exchange saturation transfer (CEST) MRI with least squares optimization of Carr Purcell Meiboom Gill multi-echo echo planar imaging. Contrast Media Mol Imaging (2014) 0.86
Advantages of paramagnetic chemical exchange saturation transfer (CEST) complexes having slow to intermediate water exchange properties as responsive MRI agents. NMR Biomed (2012) 0.85
Comparison of divalent transition metal ion paraCEST MRI contrast agents. J Biol Inorg Chem (2013) 0.85
pCEST: Positive contrast using Chemical Exchange Saturation Transfer. J Magn Reson (2011) 0.83
Dendrimer-Based Responsive MRI Contrast Agents (G1-G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS). Bioconjug Chem (2015) 0.81
A review of optimization and quantification techniques for chemical exchange saturation transfer MRI toward sensitive in vivo imaging. Contrast Media Mol Imaging (2015) 0.81
The stereochemistry of amide side chains containing carboxyl groups influences water exchange rates in EuDOTA-tetraamide complexes. J Biol Inorg Chem (2013) 0.80
Spectroscopic Characterization of the 3+ and 2+ Oxidation States of Europium in a Macrocyclic Tetraglycinate Complex. Inorg Chem (2016) 0.79
Nanoparticle-based PARACEST agents: the quenching effect of silica nanoparticles on the CEST signal from surface-conjugated chelates. Contrast Media Mol Imaging (2012) 0.78
Magnetization transfer prepared gradient echo MRI for CEST imaging. PLoS One (2014) 0.77
In vivo imaging of paraCEST agents using frequency labeled exchange transfer MRI. Magn Reson Med (2013) 0.77
Imaging metabolic syndrome. EMBO Mol Med (2010) 0.77
Functional nanoparticles for magnetic resonance imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2016) 0.77
Molecular Imaging Using Endogenous Cellular Proteins. Bo Pu Xue Za Zhi (2013) 0.75
Synthesis of a cell penetrating peptide modified superparamagnetic iron oxide and MRI detection of bladder cancer. Oncotarget (2016) 0.75
Imaging extracellular lactate in vitro and in vivo using CEST MRI and a paramagnetic shift reagent. Chemistry (2016) 0.75
Chemical Exchange Saturation Transfer is Unaffected by Modest Changes in Pressure. Eur J Inorg Chem (2012) 0.75
Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI. Magn Reson Med (2005) 4.75
PARACEST agents: modulating MRI contrast via water proton exchange. Acc Chem Res (2003) 4.44
MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci U S A (2007) 3.97
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett (2006) 3.94
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci U S A (2007) 3.15
Paramagnetic lanthanide complexes as PARACEST agents for medical imaging. Chem Soc Rev (2006) 3.02
MRI thermometry based on PARACEST agents. J Am Chem Soc (2005) 2.47
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab (2007) 2.47
Alternatives to gadolinium-based metal chelates for magnetic resonance imaging. Chem Rev (2010) 2.25
A concentration-independent method to measure exchange rates in PARACEST agents. Magn Reson Med (2010) 2.17
Renal and systemic pH imaging by contrast-enhanced MRI. Magn Reson Med (2003) 2.05
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc Natl Acad Sci U S A (2002) 2.04
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J Biol Chem (2006) 2.03
Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. J Lipid Res (2008) 2.01
Metabolic cycling in control of glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab (2008) 1.99
High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity. Magn Reson Med (2006) 1.97
Selective sensing of zinc ions with a PARACEST contrast agent. Angew Chem Int Ed Engl (2005) 1.88
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem (2004) 1.86
Responsive MRI agents for sensing metabolism in vivo. Acc Chem Res (2009) 1.84
Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart. Proc Natl Acad Sci U S A (2005) 1.82
Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. J Biol Chem (2006) 1.80
Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem (2006) 1.74
Towards the rational design of magnetic resonance imaging contrast agents: isolation of the two coordination isomers of lanthanide DOTA-type complexes. Angew Chem Int Ed Engl (2003) 1.62
CEST: from basic principles to applications, challenges and opportunities. J Magn Reson (2012) 1.59
MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo. Magn Reson Med (2007) 1.57
DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal. J Am Chem Soc (2011) 1.55
Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-. Magn Reson Med (2008) 1.52
Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects. J Am Chem Soc (2007) 1.51
Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative. Anal Biochem (2004) 1.49
Cyclen-based phenylboronate ligands and their Eu3+ complexes for sensing glucose by MRI. Bioconjug Chem (2004) 1.46
Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pH. Inorg Chem (2007) 1.44
Solution dynamics and stability of lanthanide(III) (S)-2-(p-nitrobenzyl)DOTA complexes. Inorg Chem (2004) 1.44
CEST and PARACEST MR contrast agents. Acta Radiol (2010) 1.44
In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma. Proc Natl Acad Sci U S A (2014) 1.44
Modulation of water exchange in Eu(III) DOTA-tetraamide complexes: considerations for in vivo imaging of PARACEST agents. Contrast Media Mol Imaging (2009) 1.43
Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue. J Biol Chem (2004) 1.43
The amide protons of an ytterbium(III) dota tetraamide complex act as efficient antennae for transfer of magnetization to bulk water. Angew Chem Int Ed Engl (2002) 1.42
pH-sensitive modulation of the second hydration sphere in lanthanide(III) tetraamide-DOTA complexes: a novel approach to smart MR contrast media. Chemistry (2003) 1.40
Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents. NMR Biomed (2011) 1.40
Polymeric PARACEST agents for enhancing MRI contrast sensitivity. J Am Chem Soc (2008) 1.40
Europium(III) macrocyclic complexes with alcohol pendant groups as chemical exchange saturation transfer agents. J Am Chem Soc (2006) 1.39
BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy. Chemistry (2011) 1.39
Unusually sharp dependence of water exchange rate versus lanthanide ionic radii for a series of tetraamide complexes. J Am Chem Soc (2002) 1.37
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes (2003) 1.36
Imaging the tissue distribution of glucose in livers using a PARACEST sensor. Magn Reson Med (2008) 1.35
Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting. Am J Physiol Endocrinol Metab (2005) 1.34
The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain. Magn Reson Imaging (2008) 1.33
In vivo off-resonance saturation magnetic resonance imaging of alphavbeta3-targeted superparamagnetic nanoparticles. Cancer Res (2009) 1.32
Bimodal MR-PET agent for quantitative pH imaging. Angew Chem Int Ed Engl (2010) 1.32
A multislice gradient echo pulse sequence for CEST imaging. Magn Reson Med (2010) 1.29
Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance. Proc Natl Acad Sci U S A (2011) 1.29
A responsive europium(III) chelate that provides a direct readout of pH by MRI. J Am Chem Soc (2010) 1.28
Toward the Design of MR Agents for Imaging β-Cell Function. Curr Med Chem Immunol Endocr Metab Agents (2004) 1.28
Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agent. Chemistry (2008) 1.28
Structural and chiroptical properties of the two coordination isomers of YbDOTA-type complexes. Inorg Chem (2005) 1.27
Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange. Dalton Trans (2005) 1.27
On-resonance low B1 pulses for imaging of the effects of PARACEST agents. J Magn Reson (2005) 1.26
Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets. J Biol Chem (2008) 1.25
A new gadolinium-based MRI zinc sensor. J Am Chem Soc (2009) 1.24
A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes. Inorg Chem (2007) 1.24
Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion. J Biol Chem (2007) 1.23
Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry. Anal Biochem (2003) 1.23
Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate. Am J Physiol Heart Circ Physiol (2010) 1.22
Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR. Biochem J (2006) 1.21
Multi-frequency PARACEST agents based on europium(III)-DOTA-tetraamide ligands. Angew Chem Int Ed Engl (2009) 1.20
Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance. J Am Chem Soc (2007) 1.19
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. J Clin Invest (2015) 1.19
Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent. Proc Natl Acad Sci U S A (2011) 1.17
Albumin-binding PARACEST agents. J Biol Inorg Chem (2007) 1.17
Sensitivity enhancement of multidimensional NMR experiments by paramagnetic relaxation effects. J Am Chem Soc (2006) 1.16
Synthesis, relaxometric and photophysical properties of a new pH-responsive MRI contrast agent: the effect of other ligating groups on dissociation of a p-nitrophenolic pendant arm. J Am Chem Soc (2004) 1.15
Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors. J Am Chem Soc (2012) 1.15
Could 13C MRI assist clinical decision-making for patients with heart disease? NMR Biomed (2011) 1.14
Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose. Am J Physiol Endocrinol Metab (2004) 1.11
T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation. Magn Reson Med (2011) 1.09
Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach. Diabetes (2002) 1.09
Magnetic resonance imaging detects a specific peptide-protein binding event. J Am Chem Soc (2002) 1.08
Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO. J Phys Chem A (2012) 1.07
In vivo magnetic resonance imaging of tissue pH using a novel pH-sensitive contrast agent, GdDOTA-4AmP. Acad Radiol (2002) 1.06
Synthesis and Characterization of DOTA-(amide)(4) Derivatives: Equilibrium and Kinetic Behavior of Their Lanthanide(III) Complexes. Eur J Inorg Chem (2007) 1.05
The effect of the amide substituent on the biodistribution and tolerance of lanthanide(III) DOTA-tetraamide derivatives. Invest Radiol (2008) 1.04
Size-induced enhancement of chemical exchange saturation transfer (CEST) contrast in liposomes. J Am Chem Soc (2008) 1.03
Nephrogenic systemic fibrosis: a chemical perspective. Radiology (2008) 1.03
1H MRS of intramyocellular lipids in soleus muscle at 7 T: spectral simplification by using long echo times without water suppression. Magn Reson Med (2010) 1.02
Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism. J Biol Chem (2008) 1.01
Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells. J Biol Chem (2014) 1.01
Hyperpolarized 89Y complexes as pH sensitive NMR probes. J Am Chem Soc (2010) 1.00
Labeling of adenovirus particles with PARACEST agents. Bioconjug Chem (2008) 0.99
SWIFT-CEST: a new MRI method to overcome T₂ shortening caused by PARACEST contrast agents. Magn Reson Med (2011) 0.98
Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formate. J Magn Reson (2007) 0.98
Advances in molecular imaging of pancreatic beta cells. Front Biosci (2008) 0.98
Synthesis and luminescence studies of aryl substituted tetraamide complexes of europium(III): a new approach to pH responsive luminescent europium probes. Inorg Chem (2003) 0.98
A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA-tetraglycinate. NMR Biomed (2011) 0.97
Effect of the regiochemistry of butyl amide substituents on the solution-state structures of lanthanide(III) DOTA-tetraamide complexes. Inorg Chem (2009) 0.97
Orientation of lipid strands in the extracellular compartment of muscle: effect on quantitation of intramyocellular lipids. Magn Reson Med (2009) 0.97
Using frequency-labeled exchange transfer to separate out conventional magnetization transfer effects from exchange transfer effects when detecting ParaCEST agents. Magn Reson Med (2012) 0.97
Towards the rational design of MRI contrast agents: electron spin relaxation is largely unaffected by the coordination geometry of gadolinium(III)-DOTA-type complexes. Chemistry (2008) 0.96
13C isotopomer analysis of glutamate by tandem mass spectrometry. Anal Biochem (2002) 0.96
In vivo behavior of copper-64-labeled methanephosphonate tetraaza macrocyclic ligands. J Biol Inorg Chem (2002) 0.96