Published in J Am Chem Soc on May 13, 2011
Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chem Soc Rev (2013) 1.41
BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy. Chemistry (2011) 1.39
Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO. J Phys Chem A (2012) 1.07
Production and NMR characterization of hyperpolarized (107,109)Ag complexes. Angew Chem Int Ed Engl (2011) 1.02
Hyperpolarized 15N-pyridine derivatives as pH-sensitive MRI agents. Sci Rep (2015) 1.01
Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP. Phys Chem Chem Phys (2013) 0.95
The efficiency of DPPH as a polarising agent for DNP-NMR spectroscopy. RSC Adv (2012) 0.93
Solvent-free dynamic nuclear polarization of amorphous and crystalline ortho-terphenyl. J Phys Chem B (2013) 0.92
Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent. J Magn Reson (2012) 0.91
Hyperpolarized NMR probes for biological assays. Sensors (Basel) (2014) 0.89
Influence of deuteration in the glassing matrix on 13C dynamic nuclear polarization. Phys Chem Chem Phys (2013) 0.84
Mathematical Modeling and Data Analysis of NMR Experiments using Hyperpolarized (13)C Metabolites. Magn Reson Insights (2013) 0.82
Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism. Magn Reson Med (2014) 0.81
Impact of Ho(3+)-doping on (13)C dynamic nuclear polarization using trityl OX063 free radical. Phys Chem Chem Phys (2016) 0.77
Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs. Methods Enzymol (2015) 0.77
Development and performance of a 129-GHz dynamic nuclear polarizer in an ultra-wide bore superconducting magnet. MAGMA (2014) 0.76
The Relationship between NMR Chemical Shifts of Thermally Polarized and Hyperpolarized (89) Y Complexes and Their Solution Structures. Chemistry (2016) 0.75
Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State. Sci Rep (2017) 0.75
Influence of Dy(3+) and Tb(3+) doping on (13)C dynamic nuclear polarization. J Chem Phys (2017) 0.75
Biochemical phosphates observed using hyperpolarized (31)P in physiological aqueous solutions. Nat Commun (2017) 0.75
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR. Proc Natl Acad Sci U S A (2003) 15.81
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat Med (2007) 6.84
Real-time metabolic imaging. Proc Natl Acad Sci U S A (2006) 5.89
Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res (2006) 5.79
Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Magn Reson Med (2007) 4.13
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci U S A (2007) 3.15
Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors. Proc Natl Acad Sci U S A (2009) 2.04
Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson (2010) 1.84
Therapeutic target metabolism observed using hyperpolarized 15N choline. J Am Chem Soc (2008) 1.60
Dynamic Nuclear Polarization of [1-13C]pyruvic acid at 4.6 tesla. J Magn Reson (2008) 1.58
Longitudinal relaxation and diffusion measurements using magnetic resonance signals from laser-hyperpolarized 129Xe nuclei. J Magn Reson (1997) 1.49
A 140 GHz prepolarizer for dissolution dynamic nuclear polarization. J Chem Phys (2008) 1.36
In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-(13)C]pyruvate and [2-(13)C]pyruvate. J Magn Reson (2010) 1.33
Feasibility of in vivo 15N MRS detection of hyperpolarized 15N labeled choline in rats. Phys Chem Chem Phys (2010) 1.28
Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance. J Am Chem Soc (2007) 1.19
Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate. Int J Cancer (2010) 1.16
Hyperpolarized 89Y complexes as pH sensitive NMR probes. J Am Chem Soc (2010) 1.00
Kinetics of yttrium-ligand complexation monitored using hyperpolarized (89)Y as a model for gadolinium in contrast agents. J Am Chem Soc (2010) 0.87
Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia (2011) 5.53
Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI. Magn Reson Med (2005) 4.75
PARACEST agents: modulating MRI contrast via water proton exchange. Acc Chem Res (2003) 4.44
MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci U S A (2007) 3.97
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. Nano Lett (2006) 3.94
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med (2012) 3.30
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci U S A (2007) 3.15
Paramagnetic lanthanide complexes as PARACEST agents for medical imaging. Chem Soc Rev (2006) 3.02
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab (2012) 2.86
A paramagnetic CEST agent for imaging glucose by MRI. J Am Chem Soc (2003) 2.50
MRI thermometry based on PARACEST agents. J Am Chem Soc (2005) 2.47
Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab (2007) 2.47
Alternatives to gadolinium-based metal chelates for magnetic resonance imaging. Chem Rev (2010) 2.25
A concentration-independent method to measure exchange rates in PARACEST agents. Magn Reson Med (2010) 2.17
Metabolism of [U-13 C]glucose in human brain tumors in vivo. NMR Biomed (2012) 2.06
Renal and systemic pH imaging by contrast-enhanced MRI. Magn Reson Med (2003) 2.05
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc Natl Acad Sci U S A (2002) 2.04
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J Biol Chem (2006) 2.03
Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. J Lipid Res (2008) 2.01
Metabolic cycling in control of glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab (2008) 1.99
High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity. Magn Reson Med (2006) 1.97
Selective sensing of zinc ions with a PARACEST contrast agent. Angew Chem Int Ed Engl (2005) 1.88
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem (2004) 1.86
Responsive MRI agents for sensing metabolism in vivo. Acc Chem Res (2009) 1.84
Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart. Proc Natl Acad Sci U S A (2005) 1.82
Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. J Biol Chem (2006) 1.80
Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem (2006) 1.74
The synthesis and chelation chemistry of DOTA-peptide conjugates. Bioconjug Chem (2007) 1.66
Towards the rational design of magnetic resonance imaging contrast agents: isolation of the two coordination isomers of lanthanide DOTA-type complexes. Angew Chem Int Ed Engl (2003) 1.62
CEST: from basic principles to applications, challenges and opportunities. J Magn Reson (2012) 1.59
MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo. Magn Reson Med (2007) 1.57
Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-. Magn Reson Med (2008) 1.52
Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects. J Am Chem Soc (2007) 1.51
Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative. Anal Biochem (2004) 1.49
Cyclen-based phenylboronate ligands and their Eu3+ complexes for sensing glucose by MRI. Bioconjug Chem (2004) 1.46
Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pH. Inorg Chem (2007) 1.44
Solution dynamics and stability of lanthanide(III) (S)-2-(p-nitrobenzyl)DOTA complexes. Inorg Chem (2004) 1.44
CEST and PARACEST MR contrast agents. Acta Radiol (2010) 1.44
In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma. Proc Natl Acad Sci U S A (2014) 1.44
Modulation of water exchange in Eu(III) DOTA-tetraamide complexes: considerations for in vivo imaging of PARACEST agents. Contrast Media Mol Imaging (2009) 1.43
Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue. J Biol Chem (2004) 1.43
The amide protons of an ytterbium(III) dota tetraamide complex act as efficient antennae for transfer of magnetization to bulk water. Angew Chem Int Ed Engl (2002) 1.42
pH-sensitive modulation of the second hydration sphere in lanthanide(III) tetraamide-DOTA complexes: a novel approach to smart MR contrast media. Chemistry (2003) 1.40
Imaging the extracellular pH of tumors by MRI after injection of a single cocktail of T1 and T2 contrast agents. NMR Biomed (2011) 1.40
Polymeric PARACEST agents for enhancing MRI contrast sensitivity. J Am Chem Soc (2008) 1.40
Europium(III) macrocyclic complexes with alcohol pendant groups as chemical exchange saturation transfer agents. J Am Chem Soc (2006) 1.39
BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy. Chemistry (2011) 1.39
Unusually sharp dependence of water exchange rate versus lanthanide ionic radii for a series of tetraamide complexes. J Am Chem Soc (2002) 1.37
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes (2003) 1.36
Imaging the tissue distribution of glucose in livers using a PARACEST sensor. Magn Reson Med (2008) 1.35
Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting. Am J Physiol Endocrinol Metab (2005) 1.34
The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain. Magn Reson Imaging (2008) 1.33
In vivo off-resonance saturation magnetic resonance imaging of alphavbeta3-targeted superparamagnetic nanoparticles. Cancer Res (2009) 1.32
Bimodal MR-PET agent for quantitative pH imaging. Angew Chem Int Ed Engl (2010) 1.32
A multislice gradient echo pulse sequence for CEST imaging. Magn Reson Med (2010) 1.29
Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance. Proc Natl Acad Sci U S A (2011) 1.29
A responsive europium(III) chelate that provides a direct readout of pH by MRI. J Am Chem Soc (2010) 1.28
Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agent. Chemistry (2008) 1.28
Toward the Design of MR Agents for Imaging β-Cell Function. Curr Med Chem Immunol Endocr Metab Agents (2004) 1.28
Structural and chiroptical properties of the two coordination isomers of YbDOTA-type complexes. Inorg Chem (2005) 1.27
Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange. Dalton Trans (2005) 1.27
On-resonance low B1 pulses for imaging of the effects of PARACEST agents. J Magn Reson (2005) 1.26
Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets. J Biol Chem (2008) 1.25
A new gadolinium-based MRI zinc sensor. J Am Chem Soc (2009) 1.24
A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes. Inorg Chem (2007) 1.24
Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion. J Biol Chem (2007) 1.23
Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proc Natl Acad Sci U S A (2006) 1.23
Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry. Anal Biochem (2003) 1.23
Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR. NMR Biomed (2012) 1.23
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. NMR Biomed (2012) 1.23
Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors. Magn Reson Med (2011) 1.22
Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate. Am J Physiol Heart Circ Physiol (2010) 1.22
Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism. Diabetes (2008) 1.21