EBNA3C coactivation with EBNA2 requires a SUMO homology domain.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMC 303384)

Published in J Virol on January 01, 2004

Authors

Adam Rosendorff1, Diego Illanes, Gregory David, Jeffrey Lin, Elliott Kieff, Eric Johannsen

Author Affiliations

1: Virology Program and Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

Articles citing this

SUMO junction-what's your function? New insights through SUMO-interacting motifs. EMBO Rep (2007) 2.58

NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci U S A (2006) 1.59

Epstein-Barr virus nuclear protein EBNA3C is required for cell cycle progression and growth maintenance of lymphoblastoid cells. Proc Natl Acad Sci U S A (2006) 1.33

Human pathogens and the host cell SUMOylation system. J Virol (2011) 1.31

Genome-wide screen of three herpesviruses for protein subcellular localization and alteration of PML nuclear bodies. PLoS Pathog (2008) 1.20

Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2. J Virol (2009) 1.18

A cyclin-binding motif within the amino-terminal homology domain of EBNA3C binds cyclin A and modulates cyclin A-dependent kinase activity in Epstein-Barr virus-infected cells. J Virol (2004) 1.10

Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1. PLoS Pathog (2011) 1.07

Epstein-Barr virus nuclear protein EBNA3C residues critical for maintaining lymphoblastoid cell growth. Proc Natl Acad Sci U S A (2009) 1.07

Epstein-Barr virus nuclear protein 3C domains necessary for lymphoblastoid cell growth: interaction with RBP-Jkappa regulates TCL1. J Virol (2009) 0.98

SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function. J Virol (2012) 0.93

Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4. Proc Natl Acad Sci U S A (2006) 0.90

Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9. J Virol (2011) 0.90

E2F1 mediated apoptosis induced by the DNA damage response is blocked by EBV nuclear antigen 3C in lymphoblastoid cells. PLoS Pathog (2012) 0.89

Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers. Biol Cell (2011) 0.87

Sumoylation at the host-pathogen interface. Biomolecules (2012) 0.86

EBNA3C interacts with Gadd34 and counteracts the unfolded protein response. Virol J (2009) 0.86

Regulation of vaccinia virus E3 protein by small ubiquitin-like modifier proteins. J Virol (2011) 0.85

Dissecting the contribution of EBNA3C domains important for EBV-induced B-cell growth and proliferation. Oncotarget (2015) 0.77

LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1. J Virol (2015) 0.77

Role of EBNA-3 Family Proteins in EBV Associated B-cell Lymphomagenesis. Front Microbiol (2016) 0.76

EBV Nuclear Antigen 3C Mediates Regulation of E2F6 to Inhibit E2F1 Transcription and Promote Cell Proliferation. PLoS Pathog (2016) 0.75

Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy. Sci Rep (2016) 0.75

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nat Commun (2017) 0.75

Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C. Future Virol (2009) 0.75

Human Oncogenic Herpesvirus and Post-translational Modifications - Phosphorylation and SUMOylation. Front Microbiol (2016) 0.75

Articles cited by this

SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell (1998) 6.62

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast. Mol Cell (2000) 6.39

PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J Cell Biol (1999) 5.83

The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell (2002) 5.80

Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J Biol Chem (2000) 5.30

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus. EMBO J (1998) 5.15

Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J Biol Chem (2001) 5.04

SUMO, ubiquitin's mysterious cousin. Nat Rev Mol Cell Biol (2001) 4.65

Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood (1999) 4.58

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature (1995) 4.40

Role of SUMO-1-modified PML in nuclear body formation. Blood (2000) 4.05

Epstein-Barr virus nuclear proteins EBNA-3A and EBNA-3C are essential for B-lymphocyte growth transformation. J Virol (1993) 4.05

The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein. Proc Natl Acad Sci U S A (1994) 3.88

P300 transcriptional repression is mediated by SUMO modification. Mol Cell (2003) 3.67

Ubiquitin-like proteins: new wines in new bottles. Gene (2000) 3.46

SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell (2002) 2.93

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. Proc Natl Acad Sci U S A (2002) 2.85

Ubch9 conjugates SUMO but not ubiquitin. FEBS Lett (1997) 2.73

SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation. J Cell Sci (1999) 2.46

Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappa. J Virol (1995) 2.25

Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter. Proc Natl Acad Sci U S A (2000) 2.15

SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J Biol Chem (2002) 1.99

Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. J Biol Chem (1999) 1.97

The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa). J Virol (1996) 1.97

Subnuclear localization and phosphorylation of Epstein-Barr virus latent infection nuclear proteins. Virology (1990) 1.96

Epstein-Barr virus nuclear antigen 3C is a transcriptional regulator. J Virol (1995) 1.92

Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription. J Virol (1999) 1.92

Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation. J Virol (1997) 1.89

Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates. J Biol Chem (2001) 1.89

Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9. J Biol Chem (1997) 1.86

Epstein-Barr virus EBNA3A and EBNA3C proteins both repress RBP-J kappa-EBNA2-activated transcription by inhibiting the binding of RBP-J kappa to DNA. J Virol (1996) 1.71

A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa. J Virol (1996) 1.65

Second-site homologous recombination in Epstein-Barr virus: insertion of type 1 EBNA 3 genes in place of type 2 has no effect on in vitro infection. J Virol (1992) 1.64

Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1. J Virol (1996) 1.64

The Epstein-Barr virus-encoded nuclear antigen EBNA-5 accumulates in PML-containing bodies. J Virol (1996) 1.61

Epstein-Barr virus nuclear antigen EBNA3C/6 expression maintains the level of latent membrane protein 1 in G1-arrested cells. J Virol (1994) 1.60

Epstein-barr virus nuclear antigen 3C activates the latent membrane protein 1 promoter in the presence of Epstein-Barr virus nuclear antigen 2 through sequences encompassing an spi-1/Spi-B binding site. J Virol (2000) 1.60

Cloning of ubiquitin activating enzyme from wheat and expression of a functional protein in Escherichia coli. J Biol Chem (1990) 1.55

The binding interface between an E2 (UBC9) and a ubiquitin homologue (UBL1). J Biol Chem (1999) 1.52

Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21. J Virol (1997) 1.49

Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha. Mol Cell Biol (2000) 1.41

Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA. J Virol (1996) 1.41

Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C. J Biol Chem (1999) 1.37

Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. FEBS Lett (1999) 1.33

Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2. J Virol (2002) 1.33

Epstein-Barr virus (EBV) nuclear antigen 6 induces expression of the EBV latent membrane protein and an activated phenotype in Raji cells. J Gen Virol (1993) 1.33

Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation. J Virol (2002) 1.26

Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C. J Virol (2001) 1.25

Reversible nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 and hsp70 proteins after exposure to heat shock or cell density congestion. J Gen Virol (1995) 1.17

The ubiquitin-activating enzyme (E1) gene family in Arabidopsis thaliana. Plant J (1997) 1.16

Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP. J Biol Chem (2001) 1.14

Promoter-specific targeting of human SWI-SNF complex by Epstein-Barr virus nuclear protein 2. J Virol (2000) 1.11

Structural, functional, and genetic comparisons of Epstein-Barr virus nuclear antigen 3A, 3B, and 3C homologues encoded by the rhesus lymphocryptovirus. J Virol (2000) 1.10

The metastatic suppressor Nm23-H1 interacts with EBNA3C at sequences located between the glutamine- and proline-rich domains and can cooperate in activation of transcription. J Virol (2002) 1.04

The Mdm-2 amino terminus is required for Mdm2 binding and SUMO-1 conjugation by the E2 SUMO-1 conjugating enzyme Ubc9. J Biol Chem (2001) 0.97

Transcriptional regulatory properties of Epstein-Barr virus nuclear antigen 3C are conserved in simian lymphocryptoviruses. J Virol (2003) 0.95

Transcription. Switching partners in a regulatory tango. Science (2001) 0.80

Articles by these authors

Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet (2008) 5.08

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature (2012) 4.35

A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle. Mol Cell (2003) 3.88

Epstein-Barr virus and virus human protein interaction maps. Proc Natl Acad Sci U S A (2007) 3.50

Proteins of purified Epstein-Barr virus. Proc Natl Acad Sci U S A (2004) 3.11

mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev (2005) 2.37

Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J Virol (2004) 2.35

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.16

Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. Proc Natl Acad Sci U S A (2003) 1.96

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Res (2009) 1.87

Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. Clin Cancer Res (2002) 1.82

Virus and cell RNAs expressed during Epstein-Barr virus replication. J Virol (2006) 1.80

Epstein-barr virus-induced changes in B-lymphocyte gene expression. J Virol (2002) 1.72

Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J (2002) 1.65

Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6. Proc Natl Acad Sci U S A (2003) 1.60

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A (2011) 1.59

NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci U S A (2006) 1.59

Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. Mol Cell Biol (2002) 1.56

Viral perturbations of host networks reflect disease etiology. PLoS Comput Biol (2012) 1.54

Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication. J Virol (2007) 1.53

LMP1 TRAFficking activates growth and survival pathways. Adv Exp Med Biol (2007) 1.46

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation. EMBO J (2011) 1.34

Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2. J Virol (2002) 1.33

Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes. J Immunol (2005) 1.31

Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J (2005) 1.28

Use of CpG island microarrays to identify colorectal tumors with a high degree of concurrent methylation. Methods (2002) 1.21

Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4A and p14ARF expression. Proc Natl Acad Sci U S A (2011) 1.18

Epstein-Barr Virus nuclear protein EBNA3A is critical for maintaining lymphoblastoid cell line growth. J Virol (2003) 1.18

RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines. Proc Natl Acad Sci U S A (2006) 1.17

The mammalian Sin3 proteins are required for muscle development and sarcomere specification. Mol Cell Biol (2010) 1.17

The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun. Nat Cell Biol (2007) 1.16

Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. J Surg Res (2007) 1.15

Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling. Proc Natl Acad Sci U S A (2003) 1.14

Next-generation sequencing of human mitochondrial reference genomes uncovers high heteroplasmy frequency. PLoS Comput Biol (2012) 1.14

Genome-wide siRNA screen for mediators of NF-κB activation. Proc Natl Acad Sci U S A (2012) 1.12

Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. Cell Signal (2005) 1.09

Epstein-Barr virus nuclear protein 3A domains essential for growth of lymphoblasts: transcriptional regulation through RBP-Jkappa/CBF1 is critical. J Virol (2005) 1.08

EBNA3A association with RBP-Jkappa down-regulates c-myc and Epstein-Barr virus-transformed lymphoblast growth. J Virol (2003) 1.08

Inflammatory activation: cardiac, renal, and cardio-renal interactions in patients with the cardiorenal syndrome. Heart Fail Rev (2012) 1.07

Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress. Cancer Res (2009) 1.07

A Vibrio parahaemolyticus T3SS effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation. Cell Rep (2013) 1.04

Mineral dust photochemistry induces nucleation events in the presence of SO2. Proc Natl Acad Sci U S A (2012) 1.04

EBNA-3B- and EBNA-3C-regulated cellular genes in Epstein-Barr virus-immortalized lymphoblastoid cell lines. J Virol (2006) 1.04

A novel mammalian complex containing Sin3B mitigates histone acetylation and RNA polymerase II progression within transcribed loci. Mol Cell Biol (2010) 1.03

Epstein-Barr virus LF2: an antagonist to type I interferon. J Virol (2008) 1.03

Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways. Br J Haematol (2014) 1.02

Direct interactions between Epstein-Barr virus leader protein LP and the EBNA2 acidic domain underlie coordinate transcriptional regulation. Proc Natl Acad Sci U S A (2004) 1.02

How do hospitalized patients feel about resident work hours, fatigue, and discontinuity of care? J Gen Intern Med (2008) 1.01

Controlled delivery of platelet-rich plasma-derived growth factors for bone formation. J Biomed Mater Res A (2008) 1.01

p53-independent abrogation of a postmitotic checkpoint contributes to human papillomavirus E6-induced polyploidy. Cancer Res (2007) 1.01

Inhibition of androgen receptor and β-catenin activity in prostate cancer. Proc Natl Acad Sci U S A (2013) 1.01

Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas. J Natl Cancer Inst (2012) 1.01

Sin3B: an essential regulator of chromatin modifications at E2F target promoters during cell cycle withdrawal. Cell Cycle (2008) 0.99

The Epstein-Barr virus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines. J Virol (2002) 0.99

Ras-induced senescence and its physiological relevance in cancer. Curr Cancer Drug Targets (2010) 0.99

Epstein-Barr virus nuclear protein 3C domains necessary for lymphoblastoid cell growth: interaction with RBP-Jkappa regulates TCL1. J Virol (2009) 0.98

Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth. Virology (2011) 0.98

IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Proc Natl Acad Sci U S A (2006) 0.98

Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice. Proc Natl Acad Sci U S A (2005) 0.97

Epstein-Barr virus nuclear antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A. Proc Natl Acad Sci U S A (2013) 0.96

Chromatin modifications: the driving force of senescence and aging? Aging (Albany NY) (2009) 0.96

Epstein-Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines. Proc Natl Acad Sci U S A (2010) 0.96

Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins. Mol Cell Biol (2002) 0.96

Epstein-Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2. Proc Natl Acad Sci U S A (2013) 0.95

Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression. J Clin Invest (2014) 0.94

Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity. Virology (2005) 0.90

IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3. Proc Natl Acad Sci U S A (2008) 0.90

Four EBNA2 domains are important for EBNALP coactivation. J Virol (2004) 0.90

S100B attenuates microglia activation in gliomas: possible role of STAT3 pathway. Glia (2010) 0.90

Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance. J Virol (2011) 0.90

Canonical NF-kappaB activation is essential for Epstein-Barr virus latent membrane protein 1 TES2/CTAR2 gene regulation. J Virol (2011) 0.90

Silk-on-silk layer-by-layer microcapsules. Adv Mater (2011) 0.90

EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding. Proc Natl Acad Sci U S A (2011) 0.89

NF-kappaB inhibition in EBV-transformed lymphoblastoid cell lines. Recent Results Cancer Res (2002) 0.89

Sexual and physical victimization as predictors of HIV risk among felony drug offenders. AIDS Behav (2005) 0.88

Structural basis for molecular interactions involving MRG domains: implications in chromatin biology. Structure (2012) 0.88

Genome-wide analysis of Epstein-Barr virus Rta DNA binding. J Virol (2012) 0.87

LMP1 transmembrane domain 1 and 2 (TM1-2) FWLY mediates intermolecular interactions with TM3-6 to activate NF-kappaB. J Virol (2006) 0.87

Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice. J Virol (2008) 0.87

Negative autoregulation of Epstein-Barr virus (EBV) replicative gene expression by EBV SM protein. J Virol (2009) 0.86

Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2. Blood (2007) 0.86