Published in RNA on January 01, 2004
Deleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics. Proc Natl Acad Sci U S A (2005) 1.21
Missense suppressor mutations in 16S rRNA reveal the importance of helices h8 and h14 in aminoacyl-tRNA selection. RNA (2010) 1.16
Mutations conferring aminoglycoside and spectinomycin resistance in Borrelia burgdorferi. Antimicrob Agents Chemother (2006) 1.06
The highly efficient translation initiation region from the Escherichia coli rpsA gene lacks a shine-dalgarno element. J Bacteriol (2006) 1.00
Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA. Antimicrob Agents Chemother (2004) 0.97
Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal DeltaA1916 mutation in the 23S rRNA of Escherichia coli. Mol Genet Genomics (2007) 0.84
A functional relationship between helix 1 and the 900 tetraloop of 16S ribosomal RNA within the bacterial ribosome. RNA (2005) 0.83
Solution probing of metal ion binding by helix 27 from Escherichia coli 16S rRNA. RNA (2005) 0.80
The role of the mitochondrial ribosome in human disease: searching for mutations in 12S mitochondrial rRNA with high disruptive potential. Hum Mol Genet (2013) 0.79
Solution structure of an alternate conformation of helix27 from Escherichia coli16S rRNA. Biopolymers (2011) 0.75
Structure of the 30S ribosomal subunit. Nature (2000) 23.11
Crystal structure of the ribosome at 5.5 A resolution. Science (2001) 18.21
Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution. Cell (2000) 12.43
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature (2000) 11.30
Construction and fine mapping of recombinant plasmids containing the rrnB ribosomal RNA operon of E. coli. Plasmid (1981) 9.00
Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science (2001) 8.68
Locking and unlocking of ribosomal motions. Cell (2003) 6.59
A ratchet-like inter-subunit reorganization of the ribosome during translocation. Nature (2000) 6.29
Selection of tRNA by the ribosome requires a transition from an open to a closed form. Cell (2002) 5.62
An experimentally-derived model for the secondary structure of the 16S ribosomal RNA from Escherichia coli. Nucleic Acids Res (1980) 5.13
Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli. Nucleic Acids Res (1984) 3.94
Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA. J Mol Biol (2002) 3.76
Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy. Proc Natl Acad Sci U S A (2003) 3.64
Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. Methods Enzymol (1988) 3.60
Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process. EMBO J (2002) 3.57
A common motif organizes the structure of multi-helix loops in 16 S and 23 S ribosomal RNAs. J Mol Biol (1998) 3.02
An Escherichia coli strain with all chromosomal rRNA operons inactivated: complete exchange of rRNA genes between bacteria. Proc Natl Acad Sci U S A (1999) 2.85
Insights into the decoding mechanism from recent ribosome structures. Trends Biochem Sci (2003) 2.71
EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome. Nat Struct Biol (1999) 2.56
A conformational switch in Escherichia coli 16S ribosomal RNA during decoding of messenger RNA. Science (1997) 2.43
Translation rates and misreading characteristics of rpsD mutants in Escherichia coli. Mol Gen Genet (1982) 1.95
Dominant lethal mutations in a conserved loop in 16S rRNA. Proc Natl Acad Sci U S A (1990) 1.91
Isolation of temperature-sensitive mutants of 16 S rRNA in Escherichia coli. J Mol Biol (1989) 1.82
X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli. Proc Natl Acad Sci U S A (2003) 1.58
Domain motions of EF-G bound to the 70S ribosome: insights from a hand-shaking between multi-resolution structures. Biophys J (2000) 1.52
Movement of the decoding region of the 16 S ribosomal RNA accompanies tRNA translocation. J Mol Biol (2000) 1.42
Major rearrangements in the 70S ribosomal 3D structure caused by a conformational switch in 16S ribosomal RNA. EMBO J (1999) 1.32
Isolation of kasugamycin resistant mutants in the 16 S ribosomal RNA of Escherichia coli. J Mol Biol (1999) 1.29
Aminoglycoside resistance with homogeneous and heterogeneous populations of antibiotic-resistant ribosomes. Antimicrob Agents Chemother (2001) 1.14
Ribosome as a molecular machine. FEBS Lett (2002) 1.13
Pseudoknot in domain II of 23 S rRNA is essential for ribosome function. J Mol Biol (1995) 1.00
Mutations in helix 27 of the yeast Saccharomyces cerevisiae 18S rRNA affect the function of the decoding center of the ribosome. RNA (2000) 1.00
Ratchet-like movements between the two ribosomal subunits: their implications in elongation factor recognition and tRNA translocation. Cold Spring Harb Symp Quant Biol (2001) 0.95
Functional studies of the 900 tetraloop capping helix 27 of 16S ribosomal RNA. J Mol Biol (2002) 0.93
Genetic and comparative analyses reveal an alternative secondary structure in the region of nt 912 of Escherichia coli 16S rRNA. Proc Natl Acad Sci U S A (1995) 0.86
Context dependent RNA-RNA recognition in a three-dimensional model of the 16S rRNA core. Bioorg Med Chem (1997) 0.80
Alterations in the peptidyltransferase and decoding domains of ribosomal RNA suppress mutations in the elongation factor G gene. RNA (2000) 0.77
Structural analysis of kasugamycin inhibition of translation. Nat Struct Mol Biol (2006) 1.51
Initiation factor IF2, thiostrepton and micrococcin prevent the binding of elongation factor G to the Escherichia coli ribosome. J Mol Biol (2002) 1.46
The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo. J Mol Biol (2002) 1.32
Thiostrepton-resistant mutants of Thermus thermophilus. Nucleic Acids Res (2004) 1.24
Extending ribosomal protein identifications to unsequenced bacterial strains using matrix-assisted laser desorption/ionization mass spectrometry. Proteomics (2005) 1.23
Modification of 16S ribosomal RNA by the KsgA methyltransferase restructures the 30S subunit to optimize ribosome function. RNA (2010) 1.17
Mutational analysis of 16S and 23S rRNA genes of Thermus thermophilus. J Bacteriol (2005) 1.17
Thermus thermophilus L11 methyltransferase, PrmA, is dispensable for growth and preferentially modifies free ribosomal protein L11 prior to ribosome assembly. J Bacteriol (2004) 1.09
Serial femtosecond X-ray diffraction of 30S ribosomal subunit microcrystals in liquid suspension at ambient temperature using an X-ray free-electron laser. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 1.04
Multiple defects in translation associated with altered ribosomal protein L4. Nucleic Acids Res (2004) 1.03
A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA. RNA (2008) 1.02
Severity of the streptomycin resistance and streptomycin dependence phenotypes of ribosomal protein S12 of Thermus thermophilus depends on the identity of highly conserved amino acid residues. J Bacteriol (2005) 0.98
Crystal structure of the Thermus thermophilus 16 S rRNA methyltransferase RsmC in complex with cofactor and substrate guanosine. J Biol Chem (2008) 0.97
Effects of streptomycin resistance mutations on posttranslational modification of ribosomal protein S12. J Bacteriol (2006) 0.96
Multiple-site trimethylation of ribosomal protein L11 by the PrmA methyltransferase. Structure (2008) 0.94
A structural basis for streptomycin-induced misreading of the genetic code. Nat Commun (2013) 0.93
Mutations in conserved helix 69 of 23S rRNA of Thermus thermophilus that affect capreomycin resistance but not posttranscriptional modifications. J Bacteriol (2008) 0.93
Recognition of ribosomal protein L11 by the protein trimethyltransferase PrmA. EMBO J (2007) 0.92
Transposition of an insertion sequence, ISTth7, in the genome of the extreme thermophile Thermus thermophilus HB8. FEMS Microbiol Lett (2008) 0.90
Effects of a number of classes of 50S inhibitors on stop codon readthrough during protein synthesis. Antimicrob Agents Chemother (2004) 0.90
Capreomycin susceptibility is increased by TlyA-directed 2'-O-methylation on both ribosomal subunits. Mol Microbiol (2012) 0.88
Translation initiation factor IF1 of Bacillus stearothermophilus and Thermus thermophilus substitute for Escherichia coli IF1 in vivo and in vitro without a direct IF1-IF2 interaction. Mol Microbiol (2008) 0.87
Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. J Mol Biol (2009) 0.87
Testing the conservation of the translational machinery over evolution in diverse environments: assaying Thermus thermophilus ribosomes and initiation factors in a coupled transcription-translation system from Escherichia coli. Nucleic Acids Res (2004) 0.87
Isolation of spectinomycin resistance mutations in the 16S rRNA of Salmonella enterica serovar Typhimurium and expression in Escherichia coli and Salmonella. Curr Microbiol (2002) 0.86
Genetic and structural analysis of base substitutions in the central pseudoknot of Thermus thermophilus 16S ribosomal RNA. RNA (2009) 0.86
The central role of protein S12 in organizing the structure of the decoding site of the ribosome. RNA (2013) 0.86
Peptide bond formation is all about proximity. Nat Struct Mol Biol (2004) 0.84
A mutation in the decoding center of Thermus thermophilus 16S rRNA suggests a novel mechanism of streptomycin resistance. J Bacteriol (2005) 0.84
The A2453-C2499 wobble base pair in Escherichia coli 23S ribosomal RNA is responsible for pH sensitivity of the peptidyltransferase active site conformation. Nucleic Acids Res (2004) 0.82
Initiation of protein synthesis: a target for antimicrobials. Expert Opin Ther Targets (2008) 0.81
Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG. RNA (2009) 0.79
Transposon mutagenesis of the extremely thermophilic bacterium Thermus thermophilus HB27. Extremophiles (2014) 0.77
Kinetic and thermodynamic studies of peptidyltransferase in ribosomes from the extreme thermophile Thermus thermophilus. RNA (2008) 0.76
Decreased requirement for 4.5S RNA in 16S and 23S rRNA mutants of Escherichia coli. FEBS Lett (2002) 0.76
Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of the EGF receptor ErbB1. Cell Signal (2011) 0.75
Enhancement of radiosensitivity of the MCF-7 breast cancer cell line with human chorionic gonadotropin. Breast Cancer Res Treat (2002) 0.75