Crohn's disease: the cold chain hypothesis.

Decanalization and the origin of complex disease. Nat Rev Genet (2009) 3.12

Incidence and paris classification of pediatric inflammatory bowel disease. Gastroenterol Res Pract (2014) 1.45

Etiology of inflammatory bowel disease: a unified hypothesis. World J Gastroenterol (2012) 1.36

Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll" ? World J Gastroenterol (2006) 1.35

Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? World J Gastroenterol (2014) 1.25

Hygiene hypothesis in inflammatory bowel disease: a critical review of the literature. World J Gastroenterol (2008) 1.21

Crohn's disease: an immune deficiency state. Clin Rev Allergy Immunol (2010) 1.10

Raw cow milk bacterial population shifts attributable to refrigeration. Appl Environ Microbiol (2004) 1.08

Innate immunity in inflammatory bowel disease: a disease hypothesis. J Pathol (2008) 1.08

Lessons from model organisms: phenotypic robustness and missing heritability in complex disease. PLoS Genet (2012) 1.06

Causes of early-onset type 1 diabetes: toward data-driven environmental approaches. J Exp Med (2008) 1.05

Effective heat inactivation of Mycobacterium avium subsp. paratuberculosis in raw milk contaminated with naturally infected feces. Appl Environ Microbiol (2007) 0.97

Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease. World J Gastroenterol (2008) 0.95

Identification and characterisation of Pseudomonas 16S ribosomal DNA from ileal biopsies of children with Crohn's disease. PLoS One (2008) 0.95

Molecular-phylogenetic characterization of the microbiota in ulcerated and non-ulcerated regions in the patients with Crohn's disease. PLoS One (2012) 0.94

Crohn's disease and early exposure to domestic refrigeration. PLoS One (2009) 0.90

Combinatorial effects of diet and genetics on inflammatory bowel disease pathogenesis. Inflamm Bowel Dis (2015) 0.82

Pseudomonas fluorescens alters epithelial permeability and translocates across Caco-2/TC7 intestinal cells. Gut Pathog (2010) 0.82

Influence of environmental factors in the development of inflammatory bowel diseases. World J Gastrointest Pharmacol Ther (2016) 0.80

Crohn's disease: the cold chain hypothesis. Int J Colorectal Dis (2005) 0.78

Microbiome-Epigenome Interactions and the Environmental Origins of Inflammatory Bowel Diseases. J Pediatr Gastroenterol Nutr (2016) 0.78

Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum. World J Gastroenterol (2006) 0.77

Another explanation for the low allergy rate in the rural Alpine foothills. Clin Mol Allergy (2005) 0.77

Incidence of Crohn's disease and CARD15 mutation in a small township in Sicily. Eur J Epidemiol (2006) 0.77

Finding inflammatory bowel disease genes will not lead to a cure. Can J Gastroenterol (2006) 0.75

The study of gastric mucosa for possible bacterial causative agent of Crohn's disease. Iran J Med Sci (2012) 0.75

Network Modeling of Crohn's Disease Incidence. PLoS One (2016) 0.75

Which Environmental Factors Cause IBD Relapses? Dig Dis Sci (2015) 0.75

Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths. PLoS Genet (2009) 8.51

CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet (2002) 5.31

Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proc Natl Acad Sci U S A (2012) 3.42

Octogenarians reaching end-stage renal disease: cohort study of decision-making and clinical outcomes. J Am Soc Nephrol (2003) 3.25

Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome. J Am Soc Nephrol (2007) 3.04

The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults. Am J Respir Crit Care Med (2002) 2.79

Outbreak of Shiga toxin-producing Escherichia coli O104:H4 associated with organic fenugreek sprouts, France, June 2011. Clin Infect Dis (2012) 2.71

Using and reporting the Delphi method for selecting healthcare quality indicators: a systematic review. PLoS One (2011) 2.51

Henoch-Schönlein Purpura in adults: outcome and prognostic factors. J Am Soc Nephrol (2002) 2.44

Drug administration errors and their determinants in pediatric in-patients. Int J Qual Health Care (2005) 2.31

Association between childhood migraine and history of infantile colic. JAMA (2013) 2.26

Sensitivity of the bacterial meningitis score in 889 children with bacterial meningitis. J Pediatr (2007) 2.24

Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital. Antimicrob Agents Chemother (2004) 2.23

Recruitment in pediatric clinical research was influenced by study characteristics and pediatricians' perceptions: a multicenter survey. J Clin Epidemiol (2013) 2.19

Calibration and discrimination by daily Logistic Organ Dysfunction scoring comparatively with daily Sequential Organ Failure Assessment scoring for predicting hospital mortality in critically ill patients. Crit Care Med (2002) 2.07

A variant pattern of calretinin immunohistochemistry on rectal suction-biopsies is fully specific of short-segment Hirschsprung's disease. Pediatr Surg Int (2014) 2.00

Phylogenetic analysis and prevalence of urosepsis strains of Escherichia coli bearing pathogenicity island-like domains. Infect Immun (2002) 1.90

Kidney transplant in black recipients: are African Europeans different from African Americans? Am J Transplant (2005) 1.88

Modulation of erythroid adhesion receptor expression by hydroxyurea in children with sickle cell disease. Haematologica (2008) 1.87

Tracheostomy does not improve the outcome of patients requiring prolonged mechanical ventilation: a propensity analysis. Crit Care Med (2007) 1.87

High frequency of mutator strains among human uropathogenic Escherichia coli isolates. J Bacteriol (2002) 1.85

Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches. Gut (2009) 1.83

Age-related prevalence and distribution of nontuberculous mycobacterial species among patients with cystic fibrosis. J Clin Microbiol (2005) 1.83

Impact of 13-valent pneumococcal conjugate vaccine on pneumococcal nasopharyngeal carriage in children with acute otitis media. Pediatr Infect Dis J (2012) 1.83

Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. Lab Invest (2004) 1.82

Invasive aspergillosis in allogeneic stem cell transplant recipients: increasing antigenemia is associated with progressive disease. Clin Infect Dis (2002) 1.79

Experimental designs for small randomised clinical trials: an algorithm for choice. Orphanet J Rare Dis (2013) 1.77

Addition of cyclophosphamide to steroids provides no benefit compared with steroids alone in treating adult patients with severe Henoch Schönlein Purpura. Kidney Int (2010) 1.71

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell (2008) 1.70

Clinical features and outcome of pediatric Neisseria meningitidis serogroup W135 infection: a report of 5 cases. Clin Infect Dis (2004) 1.69

Performance of a predictive rule to distinguish bacterial and viral meningitis. J Infect (2006) 1.61

Pseudomonas aeruginosa may accumulate drug resistance mechanisms without losing its ability to cause bloodstream infections. Antimicrob Agents Chemother (2007) 1.58

A prospective study of the efficacy and tolerance of a chimeric antibody to tumor necrosis factors (remicade) in severe pediatric crohn disease. J Pediatr Gastroenterol Nutr (2003) 1.57

Molecular analysis and experimental virulence of French and North American Escherichia coli neonatal meningitis isolates: identification of a new virulent clone. J Infect Dis (2003) 1.54

Neonatal Bacterial Meningitis: 444 Cases in 7 Years. Pediatr Infect Dis J (2011) 1.53

The plasmid of Escherichia coli strain S88 (O45:K1:H7) that causes neonatal meningitis is closely related to avian pathogenic E. coli plasmids and is associated with high-level bacteremia in a neonatal rat meningitis model. Infect Immun (2009) 1.53

New real-time PCR-based method for Kingella kingae DNA detection: application to samples collected from 89 children with acute arthritis. J Clin Microbiol (2009) 1.46

Pre/postbronchodilator interrupter resistance values in healthy young children. Am J Respir Crit Care Med (2002) 1.45

First detection of the Ambler class C 1 AmpC beta-lactamase in Citrobacter freundii by a new, simple double-disk synergy test. J Clin Microbiol (2006) 1.44

The effect of atropine on rhythm and conduction disturbances during 322 critical care intubations. Pediatr Crit Care Med (2013) 1.44

Effects of recombinant human growth hormone for 1 year on body composition and muscle strength in children on long-term steroid therapy: randomized controlled, delayed-start study. J Clin Endocrinol Metab (2013) 1.43

CARD15/NOD2 is required for Peyer's patches homeostasis in mice. PLoS One (2007) 1.41

Combined multilocus sequence typing and O serogrouping distinguishes Escherichia coli subtypes associated with infant urosepsis and/or meningitis. J Infect Dis (2007) 1.38

Ileosigmoid knotting in a child. The first case report in a French girl. Gastroenterol Clin Biol (2006) 1.37

Population snapshot of Streptococcus pneumoniae serotype 19A isolates before and after introduction of seven-valent pneumococcal Vaccination for French children. J Clin Microbiol (2008) 1.36

Macrolide-resistant Shigella sonnei. Emerg Infect Dis (2008) 1.34

Epidemiology and economic evaluation of severe sepsis in France: age, severity, infection site, and place of acquisition (community, hospital, or intensive care unit) as determinants of workload and cost. J Crit Care (2005) 1.31

Detection and identification by PCR of a highly virulent phylogenetic subgroup among extraintestinal pathogenic Escherichia coli B2 strains. Appl Environ Microbiol (2007) 1.29

Meningitis caused by Escherichia coli producing TEM-52 extended-spectrum beta-lactamase within an extensive outbreak in a neonatal ward: epidemiological investigation and characterization of the strain. J Clin Microbiol (2010) 1.27

Efficacy of adequate early antibiotic therapy in ventilator-associated pneumonia: influence of disease severity. Intensive Care Med (2004) 1.27

Phenotypic screening of carbapenemases and associated β-lactamases in carbapenem-resistant Enterobacteriaceae. J Clin Microbiol (2012) 1.25

Determinants of postintensive care unit mortality: a prospective multicenter study. Crit Care Med (2003) 1.24

Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment. J Clin Endocrinol Metab (2008) 1.23

A uropathogenicity island contributes to the pathogenicity of Escherichia coli strains that cause neonatal meningitis. Infect Immun (2002) 1.22

In vivo transfer of plasmid-encoded ACC-1 AmpC from Klebsiella pneumoniae to Escherichia coli in an infant and selection of impermeability to imipenem in K. pneumoniae. Antimicrob Agents Chemother (2005) 1.19

Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen. MBio (2013) 1.19

Cyclophosphamide in steroid-dependent nephrotic syndrome. Pediatr Nephrol (2011) 1.18

Invasive group B streptococcal infections in infants, France. Emerg Infect Dis (2008) 1.18

Analysis of penicillin-binding protein genes of clinical isolates of Streptococcus pneumoniae with reduced susceptibility to amoxicillin. Antimicrob Agents Chemother (2002) 1.16

CTX-M-15-producing Escherichia coli in fatal neonatal meningitis: failure of empirical chemotherapy. J Antimicrob Chemother (2008) 1.15

Molecular epidemiology of Escherichia coli causing neonatal meningitis. Int J Med Microbiol (2005) 1.15

Impact of unplanned extubation and reintubation after weaning on nosocomial pneumonia risk in the intensive care unit: a prospective multicenter study. Anesthesiology (2002) 1.15

Presence of enterohemorrhagic Escherichia coli ST678/O104:H4 in France prior to 2011. Appl Environ Microbiol (2011) 1.14

Ileal involvement is age dependent in pediatric Crohn's disease. Inflamm Bowel Dis (2005) 1.14

The siderophore receptor IroN, but not the high-pathogenicity island or the hemin receptor ChuA, contributes to the bacteremic step of Escherichia coli neonatal meningitis. Infect Immun (2004) 1.12

Insulin resistance and the metabolic syndrome in obese French children. Clin Endocrinol (Oxf) (2006) 1.11

The spectrum of cardiac anomalies in Noonan syndrome as a result of mutations in the PTPN11 gene. Pediatrics (2007) 1.11

Novel mutations in TTC37 associated with tricho-hepato-enteric syndrome. Hum Mutat (2011) 1.10

A new O-antigen gene cluster has a key role in the virulence of the Escherichia coli meningitis clone O45:K1:H7. J Bacteriol (2007) 1.10

Peer review of grant applications: criteria used and qualitative study of reviewer practices. PLoS One (2012) 1.09

Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. Cell Host Microbe (2012) 1.09

Clinical and biological consequences of immunization to infliximab in pediatric Crohn's disease. Clin Immunol (2005) 1.08

The relationship between the GH/IGF-I axis and serum markers of bone turnover metabolism in healthy children. Eur J Endocrinol (2007) 1.07

Pulmonary function tests in preschool children with cystic fibrosis. Am J Respir Crit Care Med (2002) 1.05

PneumococcaL meningitis in french children before and after the introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J (2011) 1.05

Consequences of being born small for gestational age on body composition: an 8-year follow-up study. J Clin Endocrinol Metab (2008) 1.05

Syndromic (phenotypic) diarrhea in early infancy. Orphanet J Rare Dis (2008) 1.05

Molecular characterization of serotype III group B-streptococcus isolates causing neonatal meningitis. J Infect Dis (2003) 1.04

Implication of TNF-related apoptosis-inducing ligand in inflammatory intestinal epithelial lesions. Gastroenterology (2006) 1.04

Molecular epidemiology of the sil streptococcal invasive locus in group A streptococci causing invasive infections in French children. J Clin Microbiol (2007) 1.04

Escherichia coli O104:H4 south-west France, June 2011. Lancet Infect Dis (2011) 1.04

Microstructural development of human brain assessed in utero by diffusion tensor imaging. Pediatr Radiol (2006) 1.04

Temporal dynamics of interferon gamma responses in children evaluated for tuberculosis. PLoS One (2009) 1.03

Pneumothorax in the intensive care unit: incidence, risk factors, and outcome. Anesthesiology (2006) 1.02

Genotype-phenotype correlations in fetuses and neonates with autosomal recessive polycystic kidney disease. Kidney Int (2009) 1.02

TTC7A mutations disrupt intestinal epithelial apicobasal polarity. J Clin Invest (2014) 1.02

Improvement in bone mineral density and body composition in survivors of childhood acute lymphoblastic leukemia: a 1-year prospective study. Pediatrics (2005) 1.02

Phenotypic and genetic diversity of invasive pneumococcal isolates recovered from French children. J Clin Microbiol (2002) 1.02

Severe early-onset colitis revealing mevalonate kinase deficiency. Pediatrics (2013) 1.02

Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. Dig Liver Dis (2011) 1.02

Phylogenetic background and carriage of pathogenicity island-like domains in relation to antibiotic resistance profiles among Escherichia coli urosepsis isolates. J Antimicrob Chemother (2006) 1.01

Expression of TLR-2, TLR-4, NOD2 and pNF-kappaB in a neonatal rat model of necrotizing enterocolitis. PLoS One (2007) 1.01

Escherichia coli isolates causing bacteremia via gut translocation and urinary tract infection in young infants exhibit different virulence genotypes. J Infect Dis (2011) 1.01

Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease. Gastroenterology (2012) 1.01

Species distribution and ribotype diversity of Burkholderia cepacia complex isolates from French patients with cystic fibrosis. J Clin Microbiol (2004) 1.01

Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus. J Immunol (2003) 1.00

Noninvitation of eligible individuals to participate in pediatric studies: a qualitative study. Arch Pediatr Adolesc Med (2007) 1.00

Multilocus sequence typing and rtxA toxin gene sequencing analysis of Kingella kingae isolates demonstrates genetic diversity and international clones. PLoS One (2012) 1.00