Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?

PubWeight™: 1.25‹?› | Rank: Top 10%

🔗 View Article (PMC 3921503)

Published in World J Gastroenterol on February 07, 2014

Authors

Georgina L Hold1, Megan Smith1, Charlie Grange1, Euan Robert Watt1, Emad M El-Omar1, Indrani Mukhopadhya1

Author Affiliations

1: Georgina L Hold, Megan Smith, Charlie Grange, Euan Robert Watt, Emad M El-Omar, Indrani Mukhopadhya, Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB252ZD, United Kingdom.

Articles citing this

The gut microbiota and host health: a new clinical frontier. Gut (2015) 1.91

Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis. Inflamm Bowel Dis (2015) 1.06

Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis. PLoS One (2016) 0.99

The dormant blood microbiome in chronic, inflammatory diseases. FEMS Microbiol Rev (2015) 0.99

The gastrointestinal microbiota and colorectal cancer. Am J Physiol Gastrointest Liver Physiol (2014) 0.94

Gut microbiome and colorectal adenomas. Cancer J (2014) 0.94

Review article: dietary fibre-microbiota interactions. Aliment Pharmacol Ther (2015) 0.92

SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis. EMBO J (2015) 0.90

Dissecting the Interplay Between Intestinal Microbiota and Host Immunity in Health and Disease: Lessons Learned from Germfree and Gnotobiotic Animal Models. Eur J Microbiol Immunol (Bp) (2016) 0.88

A transgenic probiotic secreting a parasite immunomodulator for site-directed treatment of gut inflammation. Mol Ther (2014) 0.87

The Gastrointestinal Microbiome: Alcohol Effects on the Composition of Intestinal Microbiota. Alcohol Res (2015) 0.87

Systematic analysis of the association between gut flora and obesity through high-throughput sequencing and bioinformatics approaches. Biomed Res Int (2014) 0.86

Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation. Bone Marrow Transplant (2016) 0.86

Characterization of Bacterial and Fungal Microbiome in Children with Hirschsprung Disease with and without a History of Enterocolitis: A Multicenter Study. PLoS One (2015) 0.85

The role of the microbiota in ageing: current state and perspectives. Wiley Interdiscip Rev Syst Biol Med (2015) 0.85

Intestinal Microbiota Is Influenced by Gender and Body Mass Index. PLoS One (2016) 0.84

Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis. Proc Natl Acad Sci U S A (2015) 0.83

Gut Mucosal Barrier Dysfunction, Microbial Dysbiosis, and Their Role in HIV-1 Disease Progression. J Infect Dis (2016) 0.82

Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice. Biol Sex Differ (2014) 0.82

Oral Campylobacter species: Initiators of a subgroup of inflammatory bowel disease? World J Gastroenterol (2015) 0.81

Factors Determining Colorectal Cancer: The Role of the Intestinal Microbiota. Front Oncol (2015) 0.80

Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response. PLoS One (2015) 0.80

Detection of a fluorescent-labeled avidin-nucleic acid nanoassembly by confocal laser endomicroscopy in the microvasculature of chronically inflamed intestinal mucosa. Int J Nanomedicine (2015) 0.80

Strain-resolved microbial community proteomics reveals simultaneous aerobic and anaerobic function during gastrointestinal tract colonization of a preterm infant. Front Microbiol (2015) 0.79

The microbiome at the pulmonary alveolar niche and its role in Mycobacterium tuberculosis infection. Tuberculosis (Edinb) (2015) 0.79

Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology. F1000Res (2015) 0.79

Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis. Periodontol 2000 (2015) 0.77

Intrinsic immunomodulatory effects of low-digestible carbohydrates selectively extend their anti-inflammatory prebiotic potentials. Biomed Res Int (2015) 0.77

Giardia alters commensal microbial diversity throughout the murine gut. Infect Immun (2017) 0.77

Decoding molecular interactions in microbial communities. FEMS Microbiol Rev (2016) 0.75

Registered report: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Elife (2016) 0.75

Correlation between early-life regulation of the immune system by microbiota and allergy development. J Allergy Clin Immunol (2017) 0.75

Medical Therapy of Active Ulcerative Colitis. Viszeralmedizin (2015) 0.75

Carrageenan Gum and Adherent Invasive Escherichia coli in a Piglet Model of Inflammatory Bowel Disease: Impact on Intestinal Mucosa-associated Microbiota. Front Microbiol (2016) 0.75

Prebiotic Potential of a Maize-Based Soluble Fibre and Impact of Dose on the Human Gut Microbiota. PLoS One (2016) 0.75

Rett Syndrome: A Focus on Gut Microbiota. Int J Mol Sci (2017) 0.75

Microbiota Modulates Behavior and Protein Kinase C mediated cAMP response element-binding protein Signaling. Sci Rep (2016) 0.75

Understanding the regulation of pattern recognition receptors in inflammatory diseases - a 'Nod' in the right direction. Immunology (2016) 0.75

The Probiotic VSL#3 Modulates Colonic Macrophages, Inflammation, and Microflora in Acute Trinitrobenzene Sulfonic Acid Colitis. J Histochem Cytochem (2017) 0.75

The Research Progress on Intestinal Stem Cells and Its Relationship with Intestinal Microbiota. Front Immunol (2017) 0.75

A randomized double-blind placebo-controlled trial of a multi-strain probiotic in treatment of symptomatic uncomplicated diverticular disease. Inflammopharmacology (2017) 0.75

Distribution and phylogenetic analysis of Blastocystis sp. subtypes isolated from IBD patients and healthy individuals in Iran. Eur J Clin Microbiol Infect Dis (2017) 0.75

Articles cited by this

(truncated to the top 100)

A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24

The NIH Human Microbiome Project. Genome Res (2009) 24.61

Enterotypes of the human gut microbiome. Nature (2011) 24.36

Inflammatory bowel disease. N Engl J Med (2002) 21.17

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A (2007) 20.60

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08

Linking long-term dietary patterns with gut microbial enterotypes. Science (2011) 17.30

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A (2010) 15.22

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A (2008) 14.18

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell (2004) 12.71

Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (2010) 12.54

Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology (2011) 12.09

A framework for human microbiome research. Nature (2012) 11.41

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science (2000) 10.98

Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut (2005) 10.95

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem (2003) 9.37

Mucosal flora in inflammatory bowel disease. Gastroenterology (2002) 8.42

Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease. Lancet (2004) 6.84

Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science (2010) 6.04

High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology (2004) 5.94

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83

Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun (2000) 5.65

Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. J Clin Microbiol (2005) 5.62

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med (2009) 5.43

Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease. Gastroenterology (2007) 5.40

Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut (2004) 5.32

A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology (2010) 5.29

Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon. Gut (2003) 5.19

Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A (2005) 5.05

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology (1998) 5.02

Enhanced Escherichia coli adherence and invasion in Crohn's disease and colon cancer. Gastroenterology (2004) 4.89

Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis (2009) 4.72

Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe (2010) 4.54

Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterology (2004) 4.42

Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology (2003) 4.40

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol (2005) 4.28

Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest (2005) 4.26

Activation of innate immune antiviral responses by Nod2. Nat Immunol (2009) 4.19

Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe (2008) 4.14

High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota. Gut (2008) 4.10

The gut microbiota in IBD. Nat Rev Gastroenterol Hepatol (2012) 3.88

Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol (2011) 3.81

Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut (2004) 3.80

European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut (2006) 3.59

Detection and Isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn's disease in Sardinia. Am J Gastroenterol (2005) 3.47

Is Crohn's disease caused by a mycobacterium? Comparisons with leprosy, tuberculosis, and Johne's disease. Lancet Infect Dis (2003) 3.42

Should we standardize the 1,700-year-old fecal microbiota transplantation? Am J Gastroenterol (2012) 3.38

Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe (2007) 3.28

Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut (2004) 3.17

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease. BMC Microbiol (2011) 3.11

Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease. Gut (2011) 3.11

Detection and verification of Mycobacterium avium subsp. paratuberculosis in fresh ileocolonic mucosal biopsy specimens from individuals with and without Crohn's disease. J Clin Microbiol (2003) 3.09

Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis. J Clin Microbiol (2006) 3.02

Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut (2004) 3.01

Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum. ISME J (2007) 3.00

Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest (2008) 3.00

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet (2005) 2.93

VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis. Am J Gastroenterol (2005) 2.90

Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut (2008) 2.90

Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest (2008) 2.88

Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease. Inflamm Bowel Dis (2009) 2.85

Prebiotics: the concept revisited. J Nutr (2007) 2.83

Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology (2002) 2.80

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis (2010) 2.62

Safety, tolerability, and clinical response after fecal transplantation in children and young adults with ulcerative colitis. J Pediatr Gastroenterol Nutr (2013) 2.57

Increased short- and long-term risk of inflammatory bowel disease after salmonella or campylobacter gastroenteritis. Gastroenterology (2009) 2.57

Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. J Immunol (2005) 2.52

Specificities of the fecal microbiota in inflammatory bowel disease. Inflamm Bowel Dis (2006) 2.45

CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest (2007) 2.44

High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease. Gut (2006) 2.43

Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol (2009) 2.34

Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol (2003) 2.30

Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease. Gut (2006) 2.24

Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci U S A (2007) 2.20

The clinical importance of emerging Campylobacter species. Nat Rev Gastroenterol Hepatol (2011) 2.12

Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae. J Clin Invest (2011) 2.10

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A (2005) 2.08

Detection and isolation of Campylobacter species other than C. jejuni from children with Crohn's disease. J Clin Microbiol (2008) 2.06

Recent trends in the prevalence of Crohn's disease and ulcerative colitis in a commercially insured US population. Dig Dis Sci (2012) 2.05

Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol (2011) 2.04

IBD-what role do Proteobacteria play? Nat Rev Gastroenterol Hepatol (2012) 2.03

A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nat Immunol (2009) 2.00

Genomic approaches to studying the human microbiota. Nature (2012) 2.00

Enteric Salmonella or Campylobacter infections and the risk of inflammatory bowel disease. Gut (2010) 1.94

Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease. Am J Gastroenterol (2002) 1.94

Molecular diversity of Escherichia coli in the human gut: new ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohn's disease. Inflamm Bowel Dis (2009) 1.88

Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease. PLoS One (2012) 1.84

Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria. J Immunol (2005) 1.82

Alteration of intestinal dysbiosis by fecal microbiota transplantation does not induce remission in patients with chronic active ulcerative colitis. Inflamm Bowel Dis (2013) 1.79

Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. Inflamm Bowel Dis (2006) 1.79

Faecalibacterium prausnitzii and human intestinal health. Curr Opin Microbiol (2013) 1.79

Evaluation of Helicobacter species in inflammatory bowel disease. Aliment Pharmacol Ther (2003) 1.73

Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease. Gastroenterology (2006) 1.71

Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohn's disease. Inflamm Bowel Dis (2010) 1.69