Published in Traffic on February 01, 2004
ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif. EMBO J (2005) 2.37
COPI-mediated transport. J Membr Biol (2006) 1.66
Consensus nomenclature for the human ArfGAP domain-containing proteins. J Cell Biol (2008) 1.42
COPI budding within the Golgi stack. Cold Spring Harb Perspect Biol (2011) 1.33
Coat-tether interaction in Golgi organization. Mol Biol Cell (2008) 1.24
Two human ARFGAPs associated with COP-I-coated vesicles. Traffic (2007) 1.23
Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. Mol Cell Biol (2006) 1.13
A COPI coat subunit interacts directly with an early-Golgi localized Arf exchange factor. EMBO Rep (2008) 1.10
Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. J Cell Biol (2008) 1.10
Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat. Proc Natl Acad Sci U S A (2010) 1.09
Oligomerization and dissociation of AP-1 adaptors are regulated by cargo signals and by ArfGAP1-induced GTP hydrolysis. Mol Biol Cell (2005) 0.99
Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat. Mol Biol Cell (2008) 0.97
Three homologous ArfGAPs participate in coat protein I-mediated transport. J Biol Chem (2009) 0.97
The exomer cargo adaptor structure reveals a novel GTPase-binding domain. EMBO J (2012) 0.92
Several ADP-ribosylation factor (Arf) isoforms support COPI vesicle formation. J Biol Chem (2011) 0.89
ARFGAP2 and ARFGAP3 are essential for COPI coat assembly on the Golgi membrane of living cells. J Biol Chem (2010) 0.83
ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment. Curr Biol (2013) 0.83
Structural basis for the binding of tryptophan-based motifs by δ-COP. Proc Natl Acad Sci U S A (2015) 0.81
Evolutionary history of the TBP-domain superfamily. Nucleic Acids Res (2013) 0.80
Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function. BMC Cell Biol (2008) 0.79
Full-length structural model of RET3 and SEC21 in COPI: identification of binding sites on the appendage for accessory protein recruitment motifs. J Mol Model (2012) 0.76
δ-COP contains a helix C-terminal to its longin domain key to COPI dynamics and function. Proc Natl Acad Sci U S A (2016) 0.76
Crystallization and preliminary X-ray analysis of the C-terminal domain of δ-COP, a medium-sized subunit of the COPI complex involved in membrane trafficking. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.75
9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments. Elife (2017) 0.75
Structure of Golgi transport proteins. Cold Spring Harb Perspect Biol (2011) 0.75
A proteomic insight into the midgut proteome of Ornithodoros moubata females reveals novel information on blood digestion in argasid ticks. Parasit Vectors (2017) 0.75
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet (2004) 14.31
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet (2002) 6.56
Molecular architecture and functional model of the endocytic AP2 complex. Cell (2002) 5.44
Adaptors for clathrin coats: structure and function. Annu Rev Cell Dev Biol (2004) 3.41
Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2. Mol Cell (2005) 2.42
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. Cell (2010) 2.35
Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly. Dev Cell (2006) 1.95
Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII. J Biol Chem (2005) 1.82
Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb. Cell (2008) 1.75
The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins. J Cell Biol (2002) 1.74
Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly. Nat Struct Mol Biol (2005) 1.71
Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease. Biochem J (2012) 1.68
Functional analysis of AP-2 alpha and mu2 subunits. Mol Biol Cell (2006) 1.67
The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell (2011) 1.66
A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles. Nature (2007) 1.61
Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller. Nat Struct Mol Biol (2004) 1.59
Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proc Natl Acad Sci U S A (2011) 1.57
Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton. Curr Biol (2004) 1.41
ArfGAP1 dynamics and its role in COPI coat assembly on Golgi membranes of living cells. J Cell Biol (2005) 1.40
Structure of Vps26B and mapping of its interaction with the retromer protein complex. Traffic (2007) 1.33
The alpha- and beta'-COP WD40 domains mediate cargo-selective interactions with distinct di-lysine motifs. Mol Biol Cell (2003) 1.32
Structural basis for binding of accessory proteins by the appendage domain of GGAs. Nat Struct Biol (2003) 1.32
Endocytic sorting of transmembrane protein cargo. Curr Opin Cell Biol (2011) 1.31
Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors. J Cell Sci (2005) 1.30
ARF-GAP-mediated interaction between the ER-Golgi v-SNAREs and the COPI coat. J Cell Biol (2002) 1.30
Structural and thermodynamic analysis of the GFP:GFP-nanobody complex. Protein Sci (2010) 1.28
Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin. Structure (2002) 1.27
Endocytosis and vesicle trafficking. Curr Opin Struct Biol (2002) 1.26
Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells. Mol Biol Cell (2009) 1.24
Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein. J Biol Chem (2005) 1.24
The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer. Traffic (2013) 1.23
Two human ARFGAPs associated with COP-I-coated vesicles. Traffic (2007) 1.23
Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci U S A (2010) 1.22
Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. Mol Biol Cell (2003) 1.21
Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet (2003) 1.19
Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol. J Am Chem Soc (2009) 1.19
Multiple roles for cyclin G-associated kinase in clathrin-mediated sorting events. Traffic (2005) 1.16
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A (2013) 1.13
Molecular basis for recognition of dilysine trafficking motifs by COPI. Dev Cell (2012) 1.11
Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide. Proc Natl Acad Sci U S A (2012) 1.08
The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs. Dev Cell (2003) 1.06
Applications of isothermal titration calorimetry in pure and applied research--survey of the literature from 2010. J Mol Recognit (2012) 1.06
Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One (2009) 1.05
Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytes. J Biol Chem (2007) 1.03
Fluorescence resonance energy transfer analysis of protein-protein interactions in single living cells by multifocal multiphoton microscopy. J Biotechnol (2002) 1.03
Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. Proc Natl Acad Sci U S A (2013) 1.03
Abrogating Munc18-1-SNARE complex interaction has limited impact on exocytosis in PC12 cells. J Biol Chem (2009) 1.03
COG complexes form spatial landmarks for distinct SNARE complexes. Nat Commun (2013) 1.03
Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF). J Biol Chem (2012) 1.03
Syntaxin binding mechanism and disease-causing mutations in Munc18-2. Proc Natl Acad Sci U S A (2013) 1.01
Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae. Elife (2013) 1.01
The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation. Nat Struct Mol Biol (2012) 1.01
Munc18-1 as a key regulator of neurosecretion. J Neurochem (2010) 1.01
Assembly and solution structure of the core retromer protein complex. Traffic (2010) 1.01
Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. Traffic (2011) 1.00
Vps26A and Vps26B subunits define distinct retromer complexes. Traffic (2011) 1.00
Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane. Mol Biol Cell (2011) 1.00
VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins. PLoS One (2011) 0.99
Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex. Dev Cell (2012) 0.96
A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems. Nanomedicine (2011) 0.92
Many faces of drebrin: from building dendritic spines and stabilizing gap junctions to shaping neurite-like cell processes. Histochem Cell Biol (2007) 0.91
Hepatocyte growth factor acutely perturbs actin filament anchorage at the epithelial zonula adherens. Curr Biol (2011) 0.91
Survey of the year 2008: applications of isothermal titration calorimetry. J Mol Recognit (2010) 0.91
The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane. J Cell Sci (2013) 0.86
Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. J Biol Chem (2012) 0.86
Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem J (2010) 0.86
Limiting transport steps and novel interactions of Connexin-43 along the secretory pathway. Histochem Cell Biol (2009) 0.85
Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent. Mol Pharm (2013) 0.84
Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi. J Biol Chem (2006) 0.83
PX-FERM proteins: A link between endosomal trafficking and signaling? Small GTPases (2011) 0.83
Regulated oligomerization induces uptake of a membrane protein into COPII vesicles independent of its cytosolic tail. Traffic (2014) 0.82
Structures and mechanisms of vesicle coat components and multisubunit tethering complexes. Curr Opin Cell Biol (2012) 0.82
Functional characterization of bovine viral diarrhea virus nonstructural protein 5A by reverse genetic analysis and live cell imaging. J Virol (2013) 0.82
Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. J Cell Sci (2015) 0.82
Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models. Mol Pharm (2012) 0.82
Survey of the year 2009: applications of isothermal titration calorimetry. J Mol Recognit (2011) 0.81
Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: potential therapeutics for type II diabetes. J Org Chem (2003) 0.81
Vesicle transport: a new player in APP trafficking. Curr Biol (2010) 0.80
Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers. Mol Pharm (2011) 0.80
Fast structural responses of gap junction membrane domains to AB5 toxins. Proc Natl Acad Sci U S A (2013) 0.80
PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin. J Control Release (2013) 0.79
Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor. PLoS One (2012) 0.79
Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker. J Control Release (2011) 0.79
Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria. Carbohydr Res (2007) 0.79
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats. Mol Pharm (2015) 0.77
Developing optimal search strategies for finding information on herbs and other medicinal plants in MEDLINE. J Altern Complement Med (2005) 0.77
The recognition of membrane-bound PtdIns3P by PX domains. Proteins (2014) 0.76
Erratum: Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2. Nat Struct Mol Biol (2017) 0.75
Live cell imaging: the 'green revolution' continues apace. Trends Cell Biol (2002) 0.75
Meeting report--Imaging membrane dynamics, 14-17 September, Royal Holloway--University of London, UK. Traffic (2007) 0.75