Published in Nat Struct Mol Biol on June 19, 2005
Retromer. Curr Opin Cell Biol (2008) 3.89
Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7. J Cell Biol (2008) 2.56
Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. J Cell Sci (2009) 2.30
Functional architecture of the retromer cargo-recognition complex. Nature (2007) 2.26
The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol (2006) 2.09
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Mol Cell Biol (2006) 2.05
The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci (2010) 1.91
Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. J Cell Biol (2007) 1.65
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. Nat Commun (2014) 1.61
Plant retromer, localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors. Plant Cell (2006) 1.54
Retromer: a master conductor of endosome sorting. Cold Spring Harb Perspect Biol (2014) 1.46
Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. J Cell Sci (2011) 1.29
Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol (2014) 1.21
Pathogenic mutation in VPS35 impairs its protection against MPP(+) cytotoxicity. Int J Biol Sci (2013) 1.09
The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide. Biochem J (2006) 1.09
A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability. J Biol Chem (2009) 1.06
Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex. Biochem J (2007) 1.05
Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling. Mol Biol Cell (2011) 1.02
A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proc Natl Acad Sci U S A (2014) 1.00
VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins. PLoS One (2011) 0.99
A mechanism for retromer endosomal coat complex assembly with cargo. Proc Natl Acad Sci U S A (2013) 0.98
VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface. Dev Cell (2014) 0.98
RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. J Cell Sci (2014) 0.98
Structural features of vps35p involved in interaction with other subunits of the retromer complex. Traffic (2007) 0.95
Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly. Traffic (2007) 0.94
The phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). J Biol Chem (2009) 0.92
Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptor. Exp Cell Res (2006) 0.89
Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation. J Virol (2011) 0.88
Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87
Multiple Roles of the Small GTPase Rab7. Cells (2016) 0.87
Mechanisms governing the endosomal membrane recruitment of the core retromer in Arabidopsis. J Biol Chem (2013) 0.87
Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages. Mol Biol Cell (2015) 0.84
Biogenesis of endosome-derived transport carriers. Cell Mol Life Sci (2015) 0.82
In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila. Mol Brain (2014) 0.82
The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review. Mol Genet Genomics (2014) 0.81
Bioluminescence-activated deep-tissue photodynamic therapy of cancer. Theranostics (2015) 0.80
Genome wide in silico analysis of Plasmodium falciparum phosphatome. BMC Genomics (2014) 0.79
Evolutionary variations of VPS29, and their implications for the heteropentameric model of retromer. Commun Integr Biol (2011) 0.78
The non-catalytic "cap domain" of a mycobacterial metallophosphoesterase regulates its expression and localization in the cell. J Biol Chem (2014) 0.78
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5. Nat Commun (2016) 0.78
Structural Mechanism for Cargo Recognition by the Retromer Complex. Cell (2016) 0.77
Retromer-driven membrane tubulation separates endosomal recycling from Rab7/Ypt7-dependent fusion. Mol Biol Cell (2017) 0.75
Role of the Retromer Complex in Neurodegenerative Diseases. Front Aging Neurosci (2016) 0.75
Retromer association with membranes: plants have their own rules! Plant Signal Behav (2013) 0.75
The giardial VPS35 retromer subunit is necessary for multimeric complex assembly and interaction with the vacuolar protein sorting receptor. Biochim Biophys Acta (2013) 0.75
Clathrin-mediated endocytosis in AP-2-depleted cells. J Cell Biol (2003) 6.35
Molecular architecture and functional model of the endocytic AP2 complex. Cell (2002) 5.44
The fifth adaptor protein complex. PLoS Biol (2011) 2.94
Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2. Mol Cell (2005) 2.42
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. Cell (2010) 2.35
Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly. Dev Cell (2006) 1.95
The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci (2010) 1.91
Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII. J Biol Chem (2005) 1.82
Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb. Cell (2008) 1.75
Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. Biochem J (2012) 1.74
Functional analysis of AP-2 alpha and mu2 subunits. Mol Biol Cell (2006) 1.67
The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell (2011) 1.66
A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles. Nature (2007) 1.61
Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain beta-propeller. Nat Struct Mol Biol (2004) 1.59
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. Nat Struct Mol Biol (2011) 1.53
Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment. J Cell Sci (2007) 1.48
EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval. Traffic (2007) 1.38
Class I HDACs share a common mechanism of regulation by inositol phosphates. Mol Cell (2013) 1.37
Structure of Vps26B and mapping of its interaction with the retromer protein complex. Traffic (2007) 1.33
Structural basis for binding of accessory proteins by the appendage domain of GGAs. Nat Struct Biol (2003) 1.32
Endocytic sorting of transmembrane protein cargo. Curr Opin Cell Biol (2011) 1.31
Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging (2012) 1.30
Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors. J Cell Sci (2005) 1.30
Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin. Structure (2002) 1.27
Endocytosis and vesicle trafficking. Curr Opin Struct Biol (2002) 1.26
Gamma-COP appendage domain - structure and function. Traffic (2004) 1.24
Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein. J Biol Chem (2005) 1.24
Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. Mol Biol Cell (2003) 1.21
Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol. J Am Chem Soc (2009) 1.19
Multiple roles for cyclin G-associated kinase in clathrin-mediated sorting events. Traffic (2005) 1.16
A screen for endocytic motifs. Traffic (2010) 1.15
Molecular basis for recognition of dilysine trafficking motifs by COPI. Dev Cell (2012) 1.11
The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function. Biochim Biophys Acta (2012) 1.08
The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs. Dev Cell (2003) 1.06
Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex. Biochem J (2007) 1.05
Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One (2009) 1.05
The role of cargo proteins in GGA recruitment. Traffic (2007) 1.04
The effects of fundamental frequency contour manipulations on speech intelligibility in background noise. J Acoust Soc Am (2010) 1.04
Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. Proc Natl Acad Sci U S A (2013) 1.03
An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome. J Cell Biol (2013) 1.03
Syntaxin binding mechanism and disease-causing mutations in Munc18-2. Proc Natl Acad Sci U S A (2013) 1.01
The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation. Nat Struct Mol Biol (2012) 1.01
Assembly and solution structure of the core retromer protein complex. Traffic (2010) 1.01
VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins. PLoS One (2011) 0.99
RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. J Cell Sci (2014) 0.98
Rab7 mutants associated with Charcot-Marie-Tooth disease cause delayed growth factor receptor transport and altered endosomal and nuclear signaling. J Biol Chem (2012) 0.96
Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex. Dev Cell (2012) 0.96
Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Biochem J (2004) 0.93
A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems. Nanomedicine (2011) 0.92
An evolving understanding of nuclear receptor coregulator proteins. J Mol Endocrinol (2013) 0.89
Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent. Mol Pharm (2013) 0.84
Structures and mechanisms of vesicle coat components and multisubunit tethering complexes. Curr Opin Cell Biol (2012) 0.82
Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models. Mol Pharm (2012) 0.82
Refinement of speech breathing in healthy 4- to 6-year-old children. J Speech Lang Hear Res (2009) 0.81
Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: potential therapeutics for type II diabetes. J Org Chem (2003) 0.81
Transient expression in HEK 293 cells: an alternative to E. coli for the production of secreted and intracellular mammalian proteins. Methods Mol Biol (2015) 0.81
Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers. Mol Pharm (2011) 0.80
PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin. J Control Release (2013) 0.79
N-acetylation and phosphorylation of Sec complex subunits in the ER membrane. BMC Cell Biol (2012) 0.79
Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker. J Control Release (2011) 0.79
Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria. Carbohydr Res (2007) 0.79
Evolutionary variations of VPS29, and their implications for the heteropentameric model of retromer. Commun Integr Biol (2011) 0.78
Developing optimal search strategies for finding information on herbs and other medicinal plants in MEDLINE. J Altern Complement Med (2005) 0.77
Parkinson's disease and the effect of lexical factors on vowel articulation. J Acoust Soc Am (2008) 0.77
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats. Mol Pharm (2015) 0.77
Enhanced SnapShot: endosome-to-golgi retrieval. Cell (2009) 0.76
Erratum: Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2. Nat Struct Mol Biol (2017) 0.75
Structural and functional causes of hypernasality in velocardiofacial syndrome. A pilot study. Folia Phoniatr Logop (2009) 0.75
Endosome sorting: GSE complex minds the Gap. Nat Cell Biol (2006) 0.75
The effects of lung volume initiation on speech: a perceptual study. J Voice (2004) 0.75