Published in J Am Soc Nephrol on January 01, 2004
The myofibroblast: one function, multiple origins. Am J Pathol (2007) 8.64
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med (2010) 4.76
TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res (2005) 4.24
New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol (2009) 3.83
Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol (2011) 3.68
Wnt/beta-catenin signaling promotes renal interstitial fibrosis. J Am Soc Nephrol (2009) 3.42
Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol (2009) 2.99
Epithelial mesenchymal transition traits in human breast cancer cell lines. Clin Exp Metastasis (2008) 2.86
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J (2006) 2.80
Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol (2010) 2.55
Loss of MicroRNA-192 promotes fibrogenesis in diabetic nephropathy. J Am Soc Nephrol (2010) 2.45
Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest (2011) 2.43
Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria. Am J Pathol (2008) 2.35
Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway. Mol Biol Cell (2007) 2.29
Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol (2008) 2.18
Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int (2011) 2.15
Integrity of cell-cell contacts is a critical regulator of TGF-beta 1-induced epithelial-to-myofibroblast transition: role for beta-catenin. Am J Pathol (2004) 2.09
The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. J Am Soc Nephrol (2010) 2.04
Low-level laser therapy decreases renal interstitial fibrosis. Photomed Laser Surg (2012) 2.01
Obstructive nephropathy: insights from genetically engineered animals. Kidney Int (2005) 1.97
The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine. J Cell Mol Med (2007) 1.88
Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology (2007) 1.80
Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat. Histochem Cell Biol (2008) 1.77
Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation. Am J Pathol (2006) 1.76
Fibroblast activation and myofibroblast generation in obstructive nephropathy. Nat Rev Nephrol (2009) 1.76
Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells. Am J Pathol (2009) 1.75
The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells. Biochem J (2006) 1.72
Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochem Cell Biol (2005) 1.69
The renal cortical interstitium: morphological and functional aspects. Histochem Cell Biol (2008) 1.66
Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol (2008) 1.66
Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis. Transl Androl Urol (2014) 1.64
The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol (2011) 1.55
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol (2009) 1.53
Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol (2010) 1.53
Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system. J Am Soc Nephrol (2010) 1.50
Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle (2008) 1.49
Fibroblasts in fibrosis: novel roles and mediators. Front Pharmacol (2014) 1.47
Renal interstitial fibrosis: mechanisms and evaluation. Curr Opin Nephrol Hypertens (2012) 1.46
De novo expression of podocyte proteins in parietal epithelial cells during experimental glomerular disease. Am J Physiol Renal Physiol (2009) 1.45
Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol (2009) 1.45
Clinical significance of epithelial-mesenchymal transition. Clin Transl Med (2014) 1.44
Encapsulating peritoneal sclerosis: the state of affairs. Nat Rev Nephrol (2011) 1.44
Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism. J Am Soc Nephrol (2015) 1.44
Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol (2008) 1.42
MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382. Nucleic Acids Res (2010) 1.42
MicroRNA: a new frontier in kidney and blood pressure research. Am J Physiol Renal Physiol (2009) 1.41
Protein kinase B/Akt activity is involved in renal TGF-beta1-driven epithelial-mesenchymal transition in vitro and in vivo. Am J Physiol Renal Physiol (2008) 1.41
Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J (2010) 1.40
Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury. PLoS One (2016) 1.39
Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol (2007) 1.39
Tubulointerstitial injury and the progression of chronic kidney disease. Pediatr Nephrol (2011) 1.37
CLDN16 genotype predicts renal decline in familial hypomagnesemia with hypercalciuria and nephrocalcinosis. J Am Soc Nephrol (2007) 1.35
Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One (2012) 1.34
Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis. Front Endocrinol (Lausanne) (2013) 1.34
Epithelial-mesenchymal transition in renal fibrosis - evidence for and against. Int J Exp Pathol (2011) 1.34
Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. J Clin Invest (2007) 1.33
Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKD. J Am Soc Nephrol (2011) 1.32
hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists. J Am Soc Nephrol (2005) 1.31
Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7. Am J Respir Cell Mol Biol (2008) 1.30
EMT and tumor metastasis. Clin Transl Med (2015) 1.29
Early epithelial phenotypic changes predict graft fibrosis. J Am Soc Nephrol (2008) 1.29
Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia. Am J Pathol (2009) 1.27
Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy. Hum Genet (2007) 1.25
Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor. FEBS Lett (2007) 1.19
RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells. J Biol Chem (2009) 1.18
Childhood microscopic polyangiitis associated with MPO-ANCA. Pediatr Nephrol (2005) 1.18
Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications. J Transl Med (2011) 1.18
Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cells. Am J Pathol (2010) 1.17
Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int (2009) 1.16
The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury. Am J Physiol Renal Physiol (2011) 1.16
Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol (2010) 1.15
Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis. Transplant Rev (Orlando) (2008) 1.15
Hypoxia-inducible factor-1α contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney Int (2010) 1.12
Late kidney allograft loss: what we know about it, and what we can do about it. Clin J Am Soc Nephrol (2008) 1.11
HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis. Am J Physiol Renal Physiol (2008) 1.11
Serine proteases, inhibitors and receptors in renal fibrosis. Thromb Haemost (2009) 1.10
Mesenchymal-epithelial transition in epithelial response to injury: the role of Foxc2. Oncogene (2009) 1.10
The role of cell plasticity in progression and reversal of renal fibrosis. Int J Exp Pathol (2011) 1.08
Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells. Am J Physiol Renal Physiol (2008) 1.07
TGFbeta1 induces epithelial-mesenchymal transition, but not myofibroblast transdifferentiation of human kidney tubular epithelial cells in primary culture. Int J Exp Pathol (2006) 1.06
Genetic deficiency of Smad3 protects the kidneys from atrophy and interstitial fibrosis in 2K1C hypertension. Am J Physiol Renal Physiol (2012) 1.05
Autoantibodies and resident renal cells in the pathogenesis of lupus nephritis: getting to know the unknown. Clin Dev Immunol (2012) 1.05
Pathophysiological Consequences of HIF Activation: HIF as a modulator of fibrosis. Ann N Y Acad Sci (2009) 1.04
tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis. J Am Soc Nephrol (2008) 1.04
Cellular sources of extracellular matrix in hepatic fibrosis. Clin Liver Dis (2008) 1.03
Unified theory on the pathogenesis of Randall's plaques and plugs. Urolithiasis (2014) 1.02
Can renal fibrosis be reversed? Pediatr Nephrol (2005) 1.02
HIVAN phenotype: consequence of epithelial mesenchymal transdifferentiation. Am J Physiol Renal Physiol (2009) 1.01
Fibrosis and progression of autosomal dominant polycystic kidney disease (ADPKD). Biochim Biophys Acta (2011) 1.01
microRNAs and lung cancer: tumors and 22-mers. Cancer Metastasis Rev (2010) 1.01
Wnt/β-catenin signaling and kidney fibrosis. Kidney Int Suppl (2011) (2014) 1.01
Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis. J Steroid Biochem Mol Biol (2007) 1.00
Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-beta1 signal transduction pathway in vivo and in vitro. BMC Cell Biol (2010) 0.99
Alterations in renal cilium length during transient complete ureteral obstruction in the mouse. J Anat (2008) 0.99
Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype. J Biol Chem (2009) 0.99
Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat. Am J Pathol (2007) 0.98
Wnt signaling in kidney development and disease. Organogenesis (2008) 0.98
Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases. Arthritis Res Ther (2006) 0.97