Published in Am J Physiol Renal Physiol on July 29, 2009
Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol (2010) 2.55
Histone deacetylase: a potential therapeutic target for fibrotic disorders. J Pharmacol Exp Ther (2010) 1.51
Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling. PLoS One (2013) 1.26
Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis. J Am Soc Nephrol (2012) 1.19
Histone deacetylase inhibitor enhances recovery after AKI. J Am Soc Nephrol (2013) 1.19
Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism. Am J Pathol (2011) 1.17
Histone deacetylases as targets for treatment of multiple diseases. Clin Sci (Lond) (2013) 1.16
Valproic acid attenuates proteinuria and kidney injury. J Am Soc Nephrol (2011) 1.08
Suramin inhibits renal fibrosis in chronic kidney disease. J Am Soc Nephrol (2011) 1.07
Zebrafish kidney development: basic science to translational research. Birth Defects Res C Embryo Today (2011) 1.02
Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury. Am J Pathol (2013) 1.01
Regulation of STAT signaling by acetylation. Cell Signal (2013) 0.99
HDAC inhibitors in experimental liver and kidney fibrosis. Fibrogenesis Tissue Repair (2013) 0.96
A DDX5 S480A polymorphism is associated with increased transcription of fibrogenic genes in hepatic stellate cells. J Biol Chem (2009) 0.93
Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer. PLoS One (2013) 0.92
Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy. J Pharmacol Exp Ther (2014) 0.90
Epigenomics: the science of no-longer-junk DNA. Why study it in chronic kidney disease? Semin Nephrol (2013) 0.90
Class I HDAC activity is required for renal protection and regeneration after acute kidney injury. Am J Physiol Renal Physiol (2014) 0.88
STAT1 signaling is not regulated by a phosphorylation-acetylation switch. Mol Cell Biol (2011) 0.88
Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase. J Am Soc Nephrol (2013) 0.87
HDAC inhibitors in kidney development and disease. Pediatr Nephrol (2012) 0.86
Suramin alleviates glomerular injury and inflammation in the remnant kidney. PLoS One (2012) 0.85
Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. J Pharmacol Exp Ther (2011) 0.84
Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats. J Sex Med (2014) 0.84
Enhancer of Zeste Homolog 2 Inhibition Attenuates Renal Fibrosis by Maintaining Smad7 and Phosphatase and Tensin Homolog Expression. J Am Soc Nephrol (2015) 0.84
P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells. Acta Pharmacol Sin (2014) 0.83
Epigenetics within the matrix: a neo-regulator of fibrotic disease. Epigenetics (2012) 0.83
Treatment of chronic kidney diseases with histone deacetylase inhibitors. Front Physiol (2015) 0.83
Anti-Fibrotic Effects of Class I HDAC Inhibitor, Mocetinostat Is Associated with IL-6/Stat3 Signaling in Ischemic Heart Failure. Int J Mol Sci (2015) 0.82
All-trans retinoic acid and sodium butyrate enhance natriuretic peptide receptor a gene transcription: role of histone modification. Mol Pharmacol (2014) 0.80
Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. Am J Physiol Renal Physiol (2013) 0.80
Class I histone deacetylase activity is required for proliferation of renal epithelial cells. Am J Physiol Renal Physiol (2013) 0.80
Inhibition of histone deacetylase 2 mitigates profibrotic TGF-β1 responses in fibroblasts derived from Peyronie's plaque. Asian J Androl (2013) 0.80
Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis. J Pharmacol Exp Ther (2015) 0.79
Therapeutic efficacy of valproic acid in a combined monocrotaline and chronic hypoxia rat model of severe pulmonary hypertension. PLoS One (2015) 0.79
ITF2357 transactivates Id3 and regulate TGFβ/BMP7 signaling pathways to attenuate corneal fibrosis. Sci Rep (2016) 0.79
Inhibition of STAT3 acetylation is associated with angiotesin renal fibrosis in the obstructed kidney. Acta Pharmacol Sin (2014) 0.79
Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice. Sci Rep (2017) 0.78
Gene regulation in the vascular endothelium: why epigenetics is important for the kidney. Semin Nephrol (2012) 0.77
Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. PLoS One (2016) 0.76
Chromatin-modifying agents reactivate embryonic renal stem/progenitor genes in human adult kidney epithelial cells but abrogate dedifferentiation and stemness. Cell Reprogram (2013) 0.76
Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells. J Cell Mol Med (2016) 0.76
Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis. Oncotarget (2016) 0.75
Evaluation of Caspase 3 Enzyme and TNF-alpha as Biomarkers in Ureteropelvic Junction Obstruction in Children- a preliminary report. Pak J Med Sci (2017) 0.75
Inhibition of HDAC6 protects against rhabdomyolysis-induced acute kidney injury. Am J Physiol Renal Physiol (2017) 0.75
Epigenetics and Liver Fibrosis. Cell Mol Gastroenterol Hepatol (2017) 0.75
Mefunidone attenuates tubulointerstitial fibrosis in a rat model of unilateral ureteral obstruction. PLoS One (2015) 0.75
Vorinostat protects against calcium oxalate-induced kidney injury in mice. Mol Med Rep (2015) 0.75
Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ. J Am Soc Nephrol (2016) 0.75
Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts. J Am Soc Nephrol (2016) 0.75
Effect of erythropoietin on the expression of dynamin-related protein-1 in rat renal interstitial fibrosis. Exp Ther Med (2015) 0.75
Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro. Acta Pharmacol Sin (2016) 0.75
Cellular and molecular mechanisms of fibrosis. J Pathol (2008) 14.01
Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest (2002) 12.22
Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J (2003) 11.27
Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell (2008) 6.93
Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol (2004) 5.43
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J (2002) 5.33
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science (2002) 4.61
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature (1996) 4.04
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 3.94
Tubulin modifications and their cellular functions. Curr Opin Cell Biol (2008) 3.52
Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. J Biol Chem (2006) 3.15
Fibroblast-specific protein 1 is a specific prognostic marker for renal survival in patients with IgAN. Kidney Int (2005) 2.58
Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation (2005) 2.44
Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol (2002) 2.31
Mechanisms of disease: Fibroblasts--a new look at an old problem. Nat Clin Pract Nephrol (2006) 2.14
Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol (2007) 2.07
A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev (2009) 1.98
Obstructive nephropathy: insights from genetically engineered animals. Kidney Int (2005) 1.97
Histone deacetylase inhibitors. Eur J Med Chem (2005) 1.94
Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. J Mol Cell Cardiol (2008) 1.90
Isoform-selective histone deacetylase inhibitors. Chem Soc Rev (2008) 1.72
STAT3: a critical transcription activator in angiogenesis. Med Res Rev (2008) 1.69
Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines. Blood (2008) 1.69
Acetylation-dependent signal transduction for type I interferon receptor. Cell (2007) 1.68
Histone deacetylases--an important class of cellular regulators with a variety of functions. Appl Microbiol Biotechnol (2007) 1.65
Touched and moved by STAT3. Sci STKE (2006) 1.52
Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. J Am Soc Nephrol (2006) 1.51
Requirement of histone deacetylase activity for signaling by STAT1. J Biol Chem (2004) 1.48
Histone deacetylase inhibitors in cancer therapy. Curr Opin Oncol (2008) 1.44
Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. Exp Cell Res (2002) 1.36
Histone deacetylases: target enzymes for cancer therapy. Clin Exp Metastasis (2007) 1.35
Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1. Exp Hematol (2006) 1.30
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure. Cardiovasc Res (2008) 1.26
Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat. Nephrol Dial Transplant (2007) 1.20
Cell signaling. Stat acetylation--a key facet of cytokine signaling? Science (2005) 1.14
Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol (2006) 1.12
STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells. Kidney Int (2006) 1.08
Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction. Nephrology (Carlton) (2007) 1.08
Renal cell apoptosis in chronic obstructive uropathy: the roles of caspases. Kidney Int (2001) 1.05
Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy. J Am Soc Nephrol (2003) 1.01
Inhibition of histone deacetylase activates side population cells in kidney and partially reverses chronic renal injury. Stem Cells (2007) 0.99
Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells. Am J Physiol Renal Physiol (2007) 0.98
Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents. J Pharmacol Exp Ther (2008) 0.96
Morphometry of interstitial fibrosis. Nephrol Dial Transplant (2000) 0.95
Progression of chronic kidney disease: insights from animal models. Curr Opin Nephrol Hypertens (2006) 0.94
Inhibition of Jak/STAT signaling ameliorates mice experimental nephrotic syndrome. Am J Nephrol (2007) 0.93
Histone deacetylase inhibitors in cancer therapy: new compounds and clinical update of benzamide-type agents. Curr Top Med Chem (2008) 0.93
Selective transcription and cellular proliferation induced by PDGF require histone deacetylase activity. Biochem Biophys Res Commun (2006) 0.85
Histological, immunohistochemical and biological data in assessing interstitial fibrosis in patients with chronic glomerulonephritis. Acta Histochem (2007) 0.81
Extracellular matrix in fetal kidney after experimental obstruction. J Urol (2001) 0.81
Glomerulosclerosis: the role of interstitial myofibroblasts in its progression. Curr Top Pathol (1999) 0.78
Dissecting histone deacetylase function. Chem Biol (2002) 0.77
Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science (2005) 5.31
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med (2013) 2.85
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int (2010) 2.32
GSK3beta promotes apoptosis after renal ischemic injury. J Am Soc Nephrol (2010) 1.85
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol (2009) 1.80
Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. J Exp Med (2008) 1.76
Acetylation-dependent signal transduction for type I interferon receptor. Cell (2007) 1.68
Au-Fe3O4 dumbbell nanoparticles as dual-functional probes. Angew Chem Int Ed Engl (2008) 1.64
P2X7 receptors mediate deleterious renal epithelial-fibroblast cross talk. Am J Physiol Renal Physiol (2010) 1.57
Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China. Nephrol Dial Transplant (2008) 1.55
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev (2003) 1.51
Histone deacetylase: a potential therapeutic target for fibrotic disorders. J Pharmacol Exp Ther (2010) 1.51
Clinicopathologic features and treatment response in nephrotic IgA nephropathy with minimal change disease. Clin Nephrol (2013) 1.48
Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3. J Immunol (2009) 1.45
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J Biol Chem (2002) 1.44
Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax. J Am Soc Nephrol (2009) 1.31
Delayed administration of a single dose of lithium promotes recovery from AKI. J Am Soc Nephrol (2014) 1.28
Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation. J Biol Chem (2002) 1.28
Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling. PLoS One (2013) 1.26
FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways. Obesity (Silver Spring) (2010) 1.24
Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation. J Biol Chem (2006) 1.21
Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol (2004) 1.19
Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis. J Am Soc Nephrol (2012) 1.19
Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. J Biol Chem (2010) 1.16
Histone deacetylases as targets for treatment of multiple diseases. Clin Sci (Lond) (2013) 1.16
Role of epidermal growth factor receptor in acute and chronic kidney injury. Kidney Int (2013) 1.14
Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. J Pharmacol Exp Ther (2012) 1.12
SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol Cell (2012) 1.11
HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol (2008) 1.10
Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial. Kidney Blood Press Res (2011) 1.10
Transforming growth factor {beta}1 induces epithelial-mesenchymal transition by activating the JNK-Smad3 pathway in rat peritoneal mesothelial cells. Perit Dial Int (2008) 1.09
Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted hearts. J Biol Chem (2012) 1.08
Suramin inhibits renal fibrosis in chronic kidney disease. J Am Soc Nephrol (2011) 1.07
Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II. Mol Cell Biol (2005) 1.06
Stat3 cleavage by caspases: impact on full-length Stat3 expression, fragment formation, and transcriptional activity. J Biol Chem (2006) 1.05
HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol (2003) 1.02
HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathway. J Cell Biochem (2011) 1.02
The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metab (2013) 1.01
Acetylation modulates prolactin receptor dimerization. Proc Natl Acad Sci U S A (2010) 1.01
Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury. Am J Pathol (2013) 1.01
HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition. J Am Soc Nephrol (2010) 0.99
Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. J Cell Biochem (2011) 0.98
Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury. Kidney Int (2012) 0.98
Histone deacetylase 6 (HDAC6) deacetylates survivin for its nuclear export in breast cancer. J Biol Chem (2012) 0.96
Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells. Biochim Biophys Acta (2007) 0.96
Alkaline phosphatase and mortality in patients on peritoneal dialysis. Clin J Am Soc Nephrol (2014) 0.95
Clinical outcome and risk factors for mortality in Chinese patients with diabetes on peritoneal dialysis: a 5-year clinical cohort study. Diabetes Res Clin Pract (2013) 0.95
A crosstalk between the Smad and JNK signaling in the TGF-β-induced epithelial-mesenchymal transition in rat peritoneal mesothelial cells. PLoS One (2012) 0.94
Monodisperse magnetite nanoparticles coupled with nuclear localization signal peptide for cell-nucleus targeting. Chem Asian J (2008) 0.93
Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats. Am J Pathol (2011) 0.92
Impaired TGF-beta signalling enhances peritoneal inflammation induced by E. coli in rats. Nephrol Dial Transplant (2009) 0.91
MicroRNA-21 is overexpressed in renal cell carcinoma. Int J Biol Markers (2013) 0.90
DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest (2014) 0.89
Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and -independent mechanisms. Kidney Int (2013) 0.88
ERK pathway mediates P2X7 expression and cell death in renal interstitial fibroblasts exposed to necrotic renal epithelial cells. Am J Physiol Renal Physiol (2011) 0.88
Hepatocyte growth factor ameliorates progression of interstitial fibrosis in rats with established renal injury. Kidney Int (2004) 0.88
Regulation of dedifferentiation and redifferentiation in renal proximal tubular cells by the epidermal growth factor receptor. J Pharmacol Exp Ther (2008) 0.88
Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. Am J Physiol Renal Physiol (2009) 0.87
STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. Am J Physiol Gastrointest Liver Physiol (2007) 0.87
Conditional ablation of glycogen synthase kinase 3β in postnatal mouse kidney. Lab Invest (2010) 0.87
HDAC inhibition elicits myocardial protective effect through modulation of MKK3/Akt-1. PLoS One (2013) 0.87
Is cystatin C a better marker than creatinine for evaluating residual renal function in patients on continuous ambulatory peritoneal dialysis? Nephrol Dial Transplant (2011) 0.86
Src regulates cell cycle protein expression and renal epithelial cell proliferation via PI3K/Akt signaling-dependent and -independent mechanisms. Am J Physiol Renal Physiol (2008) 0.86
Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3. J Biol Chem (2008) 0.85
EGFR activity is required for renal tubular cell dedifferentiation and proliferation in a murine model of folic acid-induced acute kidney injury. Am J Physiol Renal Physiol (2012) 0.85
Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug. Curr Clin Pharmacol (2011) 0.85
Identification of the linker-SH2 domain of STAT as the origin of the SH2 domain using two-dimensional structural alignment. Mol Cell Proteomics (2004) 0.85
Inflammation and oxidative stress in obesity-related glomerulopathy. Int J Nephrol (2012) 0.85
Suramin alleviates glomerular injury and inflammation in the remnant kidney. PLoS One (2012) 0.85
Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activity. Am J Physiol Renal Physiol (2010) 0.85
Prevalence and risk factors of sleep disturbance in continuous ambulatory peritoneal dialysis patients in Guangzhou, southern China. Int Urol Nephrol (2011) 0.85
Antibodies immobilized as arrays to profile protein post-translational modifications in mammalian cells. Mol Cell Proteomics (2004) 0.84
Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy. J Pharmacol Exp Ther (2011) 0.84
HDAC4 degradation mediates HDAC inhibition-induced protective effects against hypoxia/reoxygenation injury. J Cell Physiol (2015) 0.84
V-ATPase promotes transforming growth factor-β-induced epithelial-mesenchymal transition of rat proximal tubular epithelial cells. Am J Physiol Renal Physiol (2011) 0.84
Pharmacological targeting of GSK3β confers protection against podocytopathy and proteinuria by desensitizing mitochondrial permeability transition. Br J Pharmacol (2014) 0.83