Published in Obes Res on December 01, 2003
Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions. Peptides (2007) 1.29
Neuropeptide Y in normal eating and in genetic and dietary-induced obesity. Philos Trans R Soc Lond B Biol Sci (2006) 1.20
Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice. Peptides (2007) 1.20
Body mass influences cortical bone mass independent of leptin signaling. Bone (2008) 1.03
The role of leptin in the control of insulin-glucose axis. Front Neurosci (2013) 1.00
Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation. Peptides (2009) 0.96
Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice. Peptides (2008) 0.95
The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity. Mamm Genome (2012) 0.93
Chronic administration of brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reverses obesity induced by high-fat diet. Am J Physiol Regul Integr Comp Physiol (2010) 0.92
Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay. Peptides (2009) 0.91
The role of leptin in glucose homeostasis. J Diabetes Investig (2012) 0.90
Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis. Am J Physiol Heart Circ Physiol (2008) 0.86
Reduction of high-fat diet-induced obesity after chronic administration of brain-derived neurotrophic factor in the hypothalamic ventromedial nucleus. Neuroscience (2011) 0.85
Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches. Nutrition (2008) 0.85
Interactions of gastrointestinal peptides: ghrelin and its anorexigenic antagonists. Int J Pept (2010) 0.80
To subjugate NPY is to improve the quality of life and live longer. Peptides (2007) 0.78
Ghrelin and the central regulation of feeding and energy balance. Indian J Endocrinol Metab (2012) 0.77
Neuronal Control of Adaptive Thermogenesis. Front Endocrinol (Lausanne) (2015) 0.76
Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling. Mol Metab (2016) 0.75
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway. Redox Biol (2017) 0.75
The glucoregulatory actions of leptin. Mol Metab (2017) 0.75
Peripheral leptin regulates bone formation. J Bone Miner Res (2013) 2.00
Ghrelin and leptin pulse discharge in fed and fasted rats. Endocrinology (2002) 1.24
Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice. Peptides (2007) 1.20
Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice. Peptides (2009) 1.15
Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels. Diabetes (2002) 1.11
Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul Pept (2003) 1.10
Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice. Peptides (2006) 1.03
AAV-mediated leptin receptor installation improves energy balance and the reproductive status of obese female Koletsky rats. Peptides (2005) 1.01
Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy. Endocrinology (2004) 0.99
Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes. Pediatr Res (2002) 0.99
Neuropeptide Y: a physiological orexigen modulated by the feedback action of ghrelin and leptin. Endocrine (2003) 0.99
Hypothalamic clamp on insulin release by leptin-transgene expression. Peptides (2006) 0.99
Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin. Neurobiol Aging (2006) 0.99
Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods. Peptides (2002) 0.98
Suppression of fat deposition for the life time with gene therapy. Peptides (2005) 0.97
Overlapping and interactive pathways regulating appetite and craving. J Addict Dis (2004) 0.97
Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice. Peptides (2008) 0.95
Stimulation of appetite by ghrelin is regulated by leptin restraint: peripheral and central sites of action. J Nutr (2005) 0.93
Central leptin gene therapy blocks ovariectomy-induced adiposity. Obesity (Silver Spring) (2006) 0.93
Gene-transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life expectancy. Trends Pharmacol Sci (2005) 0.92
Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay. Peptides (2009) 0.91
Neuroendocrine control of energy homeostasis: update on new insights. Prog Brain Res (2010) 0.90
Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats. J Bone Miner Res (2011) 0.88
Increased leptin expression in the dorsal vagal complex suppresses adiposity without affecting energy intake and metabolic hormones. Obesity (Silver Spring) (2006) 0.87
Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation. Peptides (2005) 0.87
High-fat diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats. Obes Res (2005) 0.87
Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis. Am J Physiol Heart Circ Physiol (2008) 0.86
Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight. Peptides (2005) 0.85
NPY--an endearing journey in search of a neurochemical on/off switch for appetite, sex and reproduction. Peptides (2004) 0.84
Obesity and metabolic syndrome: long-term benefits of central leptin gene therapy. Drugs Today (Barc) (2002) 0.83
Low abundance of NPY in the hypothalamus can produce hyperphagia and obesity. Peptides (2007) 0.83
Neuropeptide Y delays hippocampal kindling in the rat. Hippocampus (2003) 0.83
The hypothalamic paraventricular nucleus is not essential for orexigenic NPY or anorexigenic melanocortin action. Peptides (2006) 0.82
Plasma leptin levels are pulsatile in adult rats: effects of gonadectomy. Neuroendocrinology (2002) 0.80
To subjugate NPY is to improve the quality of life and live longer. Peptides (2007) 0.78
Neuropeptidergic characterization of the leptin receptor mutated obese Koletsky rat. Regul Pept (2004) 0.78
Leptin-receptor gene transfer into the arcuate nucleus of female Fatty zucker rats using recombinant adeno-associated viral vectors stimulates the hypothalamo-pituitary-gonadal axis. Biol Reprod (2004) 0.77
Anorexigenic melanocortin signaling in the hypothalamus is augmented in association with failure-to-thrive in a transgenic mouse model for Prader-Willi syndrome. Brain Res (2002) 0.77
Decreased hypothalamic concentration of neuropeptide Y correlates with onset of hyperphagia in fa/fa rats on postnatal day 12. Physiol Behav (2003) 0.75
Office visceral slide test compared with two perioperative tests for predicting periumbilical adhesions. Obstet Gynecol (2014) 0.75