Published in Gastroenterology on January 01, 2004
Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest (2007) 3.01
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
Intestinal lipid absorption. Am J Physiol Endocrinol Metab (2009) 2.41
Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol. J Biol Chem (2009) 1.71
ATP-binding cassette, subfamily G (ABCG family). Pflugers Arch (2006) 1.37
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med (2004) 1.28
Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. Proc Natl Acad Sci U S A (2008) 1.26
Emerging roles of the intestine in control of cholesterol metabolism. World J Gastroenterol (2006) 1.23
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Reverse cholesterol transport: from classical view to new insights. World J Gastroenterol (2010) 1.03
Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice. Hepatology (2007) 0.98
Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk. J Lipid Res (2011) 0.96
Relative roles of ABCG5/ABCG8 in liver and intestine. J Lipid Res (2014) 0.96
Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine. BMC Gastroenterol (2004) 0.95
Liver transplantation in a patient with sitosterolemia and cirrhosis. Gastroenterology (2006) 0.95
A reappraisal of the mechanism by which plant sterols promote neutral sterol loss in mice. PLoS One (2011) 0.90
Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8. Biochemistry (2008) 0.89
Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols. Pflugers Arch (2006) 0.89
The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. J Lipid Res (2006) 0.87
Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia. Blood (2013) 0.86
Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice. J Lipid Res (2012) 0.84
Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice. Am J Pathol (2013) 0.82
Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8). Immunol Endocr Metab Agents Med Chem (2009) 0.81
Plasma plant sterols serve as poor markers of cholesterol absorption in man. J Lipid Res (2012) 0.80
Liver X receptor agonist modulation of cholesterol efflux in mice with intestine-specific deletion of microsomal triglyceride transfer protein. Arterioscler Thromb Vasc Biol (2012) 0.80
Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex. Hepatology (2012) 0.79
Plant sterols and stanols: their role in health and disease. J Clin Lipidol (2008) 0.79
Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains. Genet Sel Evol (2012) 0.79
Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. Plant Foods Hum Nutr (2011) 0.78
ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph. Lipids (2015) 0.77
Discovery Genetics - The History and Future of Spontaneous Mutation Research. Curr Protoc Mouse Biol (2012) 0.76
Protein mediators of sterol transport across intestinal brush border membrane. Subcell Biochem (2010) 0.76
Hepatic or intestinal ABCG5 and ABCG8 are sufficient to block the development of sitosterolemia. J Lipid Res (2014) 0.75
Leucine supplementation via drinking water reduces atherosclerotic lesions in apoE null mice. Acta Pharmacol Sin (2015) 0.75
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology (2012) 6.04
Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev (2009) 5.11
The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem (2005) 3.51
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A (2009) 3.39
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci U S A (2002) 2.79
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell (2002) 2.68
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res (2013) 2.67
Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. J Biol Chem (2002) 2.61
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest (2006) 2.55
Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study. Lancet (2002) 2.39
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem (2006) 2.38
Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology (2014) 2.19
Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism. Hepatology (2010) 2.16
Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha. Gastroenterology (2008) 2.06
Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia. Arterioscler Thromb Vasc Biol (2010) 2.03
Improved staging of patients with carcinoid and islet cell tumors with 18F-dihydroxy-phenyl-alanine and 11C-5-hydroxy-tryptophan positron emission tomography. J Clin Oncol (2008) 2.03
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes (2007) 2.01
The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol. Structure (2007) 1.99
The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. J Biol Chem (2005) 1.85
The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol (2005) 1.84
ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis. J Biol Chem (2004) 1.81
Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol (2006) 1.80
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. J Clin Invest (2002) 1.80
Staging of carcinoid tumours with 18F-DOPA PET: a prospective, diagnostic accuracy study. Lancet Oncol (2006) 1.79
Ritonavir impairs lipoprotein lipase-mediated lipolysis and decreases uptake of fatty acids in adipose tissue. Arterioscler Thromb Vasc Biol (2005) 1.75
Plasma free metanephrine measurement using automated online solid-phase extraction HPLC tandem mass spectrometry. Clin Chem (2007) 1.74
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes (2011) 1.73
Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol. J Biol Chem (2009) 1.71
HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes. Exp Hematol (2005) 1.70
Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. Gastroenterology (2007) 1.69
Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse. Gastroenterology (2003) 1.64
Glucose regulates the expression of the farnesoid X receptor in liver. Diabetes (2004) 1.63
Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. Dev Biol (2009) 1.62
Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. J Hepatol (2003) 1.61
Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem (2003) 1.61
New insights in the pathogenesis of non-alcoholic fatty liver disease. Curr Opin Lipidol (2006) 1.58
LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest (2012) 1.58
Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l. Br J Nutr (2012) 1.57
Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Arterioscler Thromb Vasc Biol (2007) 1.56
Platelet serotonin levels in pervasive developmental disorders and mental retardation: diagnostic group differences, within-group distribution, and behavioral correlates. J Am Acad Child Adolesc Psychiatry (2004) 1.53
Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice. Endocrinology (2006) 1.51
High fat feeding induces hepatic fatty acid elongation in mice. PLoS One (2009) 1.51
Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem (2002) 1.50
Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. Gastroenterology (2005) 1.50
Carcinoid crisis after injection of 6-18F-fluorodihydroxyphenylalanine in a patient with metastatic carcinoid. J Nucl Med (2005) 1.45
Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver. J Biol Chem (2003) 1.45
Accuracy of 6 routine 25-hydroxyvitamin D assays: influence of vitamin D binding protein concentration. Clin Chem (2012) 1.44
Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. Curr Biol (2005) 1.40
Transintestinal cholesterol efflux. Curr Opin Lipidol (2010) 1.39
Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice. J Biol Chem (2009) 1.38
CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance. J Lipid Res (2005) 1.35
Bile acid sequestrants and the treatment of type 2 diabetes mellitus. Drugs (2007) 1.34
Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice. Biochem Biophys Res Commun (2002) 1.32
A role of the bile salt receptor FXR in atherosclerosis. Arterioscler Thromb Vasc Biol (2010) 1.30
Discovery and fine mapping of serum protein loci through transethnic meta-analysis. Am J Hum Genet (2012) 1.29
Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study. J Lipid Res (2006) 1.28
Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a. Pediatr Res (2008) 1.28
A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med (2004) 1.28
Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases. Gastroenterology (2006) 1.28
Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin. Diabetes (2003) 1.28
24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux. J Biol Chem (2006) 1.28
Vitamin D status indicators in indigenous populations in East Africa. Eur J Nutr (2012) 1.27
Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. J Lipid Res (2004) 1.26
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell (2013) 1.25
Emerging roles of the intestine in control of cholesterol metabolism. World J Gastroenterol (2006) 1.23
Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res (2006) 1.22
ABC transporter expression in hematopoietic stem cells and the role in AML drug resistance. Crit Rev Oncol Hematol (2007) 1.21
Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett (2005) 1.21
111In-octreotide is superior to 123I-metaiodobenzylguanidine for scintigraphic detection of head and neck paragangliomas. J Nucl Med (2008) 1.21
Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice. Hepatology (2009) 1.20
Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice. Lab Invest (2010) 1.20
Accelerated lipid absorption in mice overexpressing intestinal SR-BI. J Biol Chem (2006) 1.19
The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction. Am J Physiol Regul Integr Comp Physiol (2009) 1.18