Published in Proc Natl Acad Sci U S A on January 31, 2008
Environmental neurotoxin-induced progressive model of parkinsonism in rats. Ann Neurol (2010) 2.17
Cholestenoic acids regulate motor neuron survival via liver X receptors. J Clin Invest (2014) 1.55
Expression of liver X receptor beta is essential for formation of superficial cortical layers and migration of later-born neurons. Proc Natl Acad Sci U S A (2008) 1.15
Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease. Proc Natl Acad Sci U S A (2012) 1.05
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Lipid pathway alterations in Parkinson's disease primary visual cortex. PLoS One (2011) 0.96
Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Mol Biosyst (2009) 0.96
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. J Neurochem (2008) 0.93
Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor β. Proc Natl Acad Sci U S A (2012) 0.90
Anxiety in liver X receptor β knockout female mice with loss of glutamic acid decarboxylase in ventromedial prefrontal cortex. Proc Natl Acad Sci U S A (2012) 0.89
Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice. Proc Natl Acad Sci U S A (2009) 0.89
Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor β ligand. Proc Natl Acad Sci U S A (2012) 0.87
The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease. PLoS One (2015) 0.86
Modulation of monoamine neurotransmitters in fighting fish Betta splendens exposed to waterborne phytoestrogens. Fish Physiol Biochem (2009) 0.85
Nuclear receptors in neurodegenerative diseases. Neurobiol Dis (2014) 0.85
Liver X receptor beta and thyroid hormone receptor alpha in brain cortical layering. Proc Natl Acad Sci U S A (2010) 0.84
Free and glycosylated sterol bioaccumulation in developing Cycas micronesica seeds. Food Chem (2009) 0.84
LXR Regulation of Brain Cholesterol: From Development to Disease. Trends Endocrinol Metab (2016) 0.81
Estrogen receptor β and Liver X receptor β: biology and therapeutic potential in CNS diseases. Mol Psychiatry (2014) 0.81
Defective cholesterol metabolism in amyotrophic lateral sclerosis. J Lipid Res (2016) 0.81
Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain. J Neurotrauma (2008) 0.80
Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage. J Neuroinflammation (2016) 0.79
Phenotypic Characteristics as Predictors of Phytosterols in Mature Cycas micronesica Seeds. HortScience (2009) 0.79
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Protein mediators of sterol transport across intestinal brush border membrane. Subcell Biochem (2010) 0.76
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Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann Neurol (2004) 2.46
Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam. Proc Natl Acad Sci U S A (2003) 2.20
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Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta Neuropathol (2007) 1.91
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The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis. Endocrinology (2005) 1.69
Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration. Proc Natl Acad Sci U S A (2002) 1.65
Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Ann Neurol (2002) 1.61
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The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function. J Neurosci (2006) 1.42
Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice. Proc Natl Acad Sci U S A (2005) 1.40
Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Gastroenterology (2004) 1.36
Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling. J Physiol (2006) 1.35
Oxysterols, cholesterol homeostasis, and Alzheimer disease. J Neurochem (2007) 1.26
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Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Gene (2000) 1.14
Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex. J Neurochem (2002) 1.13
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Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. J Lipid Res (2002) 1.13
Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol. J Biol Chem (2003) 1.10
Protecting motor neurons from toxic insult by antagonism of adenosine A2a and Trk receptors. J Neurosci (2006) 1.08
Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis. Neurol Res (2007) 1.07
Dietary plant sterols accumulate in the brain. Biochim Biophys Acta (2006) 1.04
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Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals. J Mol Endocrinol (2004) 1.01
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Two pools of Triton X-100-insoluble GABA(A) receptors are present in the brain, one associated to lipid rafts and another one to the post-synaptic GABAergic complex. J Neurochem (2007) 0.97
Image in cardiovascular medicine. Aortic xanthomatosis with coronary ostial occlusion in a child homozygous for a nonsense mutation in ABCG8. Circulation (2003) 0.96
What transgenic mice tell us about neurodegenerative disease. Bioessays (2000) 0.86
Sitosterolemia: a gateway to new knowledge about cholesterol metabolism. Ann Med (2003) 0.83
Cholesterol deficiency perturbs actin signaling and glutamate homeostasis in hippocampal astrocytes. Brain Res (2006) 0.82
Late appearance of glutamate transporter defects in a murine model of ALS-parkinsonism dementia complex. Neurochem Int (2006) 0.82
Mutations in the human ATP-binding cassette transporters ABCG5 and ABCG8 in sitosterolemia. Hum Mutat (2002) 0.82
Novel donor splice site mutation of ABCG5 gene in sitosterolemia. Mol Genet Metab (2002) 0.78
Influence of cholesterol depletion in plasma membrane of rat brain synaptosomes on calcium-dependent and calcium-independent exocytosis. Neurosci Lett (2006) 0.77
Estrogen receptors: how do they signal and what are their targets. Physiol Rev (2007) 5.27
Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov (2004) 4.19
Epidemiology of anesthesia-related mortality in the United States, 1999-2005. Anesthesiology (2009) 3.00
Estrogen signaling: a subtle balance between ER alpha and ER beta. Mol Interv (2003) 2.88
Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells. Genome Biol (2004) 2.77
Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci U S A (2004) 2.64
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science (2002) 2.45
Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a "ying yang" relationship between ERalpha and ERbeta in mice. Mol Endocrinol (2003) 2.38
Deaths: injuries, 2002. Natl Vital Stat Rep (2006) 2.30
International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol Rev (2006) 2.15
Characterization of an RNA granule from developing brain. Mol Cell Proteomics (2005) 2.07
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ Res (2004) 2.04
Estrogen receptor beta: an overview and update. Nucl Recept Signal (2008) 1.97
An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice. Proc Natl Acad Sci U S A (2003) 1.93
T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice. Circ Res (2009) 1.93
Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell (2009) 1.84
An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A (2002) 1.82
Drug-poisoning deaths involving heroin: United States, 2000-2013. NCHS Data Brief (2015) 1.76
Reflections on the discovery and significance of estrogen receptor beta. Endocr Rev (2005) 1.75
Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol (2004) 1.74
Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity. Endocrinology (2003) 1.73
Transcriptional corepression by SHP: molecular mechanisms and physiological consequences. Trends Endocrinol Metab (2005) 1.71
ERBB2 amplification is superior to protein expression status in predicting patient outcome in serous ovarian carcinoma. Gynecol Oncol (2004) 1.70
The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis. Endocrinology (2005) 1.69
Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation. Hepatology (2014) 1.68
Deaths: injuries, 2001. Natl Vital Stat Rep (2004) 1.68
Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis. Circ Res (2005) 1.67
Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland. Proc Natl Acad Sci U S A (2004) 1.66
Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration. Proc Natl Acad Sci U S A (2002) 1.65
Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene (2005) 1.65
Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Proc Natl Acad Sci U S A (2002) 1.63
The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism. J Biol Chem (2003) 1.61
Increased estrogen receptor betacx expression during mammary carcinogenesis. Clin Cancer Res (2005) 1.56
Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine. Cell Microbiol (2007) 1.55
Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med (2009) 1.54
Injuries at work in the US adult population: contributions to the total injury burden. Am J Public Health (2005) 1.54
Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha. Proc Natl Acad Sci U S A (2006) 1.53
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A (2005) 1.52
Isoflavone treatment for acute menopausal symptoms. Menopause (2007) 1.52
GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. Genes Dev (2010) 1.52
Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011. NCHS Data Brief (2014) 1.52
False positives in MALDI-TOF detection of ERbeta in mitochondria. Biochem Biophys Res Commun (2006) 1.51
Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate. Proc Natl Acad Sci U S A (2004) 1.51
Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver. Mol Endocrinol (2007) 1.50
Role of estrogen receptor beta in colonic epithelium. Proc Natl Acad Sci U S A (2006) 1.49
Dragon ERE Finder version 2: A tool for accurate detection and analysis of estrogen response elements in vertebrate genomes. Nucleic Acids Res (2003) 1.49
Disruption of estrogen receptor beta gene impairs spatial learning in female mice. Proc Natl Acad Sci U S A (2002) 1.47
Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice. Physiol Behav (2004) 1.45
Putative metabolic effects of the liver X receptor (LXR). Diabetes (2004) 1.44
Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Proc Natl Acad Sci U S A (2003) 1.44
Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity (2012) 1.44
ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. J Biol Chem (2002) 1.44
Regulation of postnatal lung development and homeostasis by estrogen receptor beta. Mol Cell Biol (2003) 1.44
LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J Biol Chem (2005) 1.44
Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. J Biol Chem (2002) 1.43
Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). PLoS One (2010) 1.43
Estrogen receptor (ER) beta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters. Mol Endocrinol (2005) 1.42
Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors. J Clin Endocrinol Metab (2004) 1.41
Effects of short-term estradiol and norethindrone acetate treatment on the breasts of normal postmenopausal women. Menopause (2013) 1.41
Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters. Mol Cell Biol (2005) 1.40
Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. Am J Physiol Endocrinol Metab (2008) 1.40
Uric acid stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice. Proc Natl Acad Sci U S A (2012) 1.40
Clinical presentation, temporal relationship, and outcome in thirty-three patients with type 2 heparin-induced thrombocytopenia after cardiotomy. Ann Thorac Surg (2006) 1.40
Changes in bile acid synthesis in gallstone disease: cause, consequence, or neither? Hepatology (2007) 1.40
Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. Cancer Res (2009) 1.40
Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice. Proc Natl Acad Sci U S A (2005) 1.40
Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation. Oncogene (2003) 1.39
Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J Biol Chem (2002) 1.39
Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells. Proc Natl Acad Sci U S A (2008) 1.38
Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice. Proc Natl Acad Sci U S A (2006) 1.37
Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol (2006) 1.36
Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis (2004) 1.36
Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β. PLoS One (2012) 1.36
Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts. Cancer Res (2006) 1.35
Estrogen receptor beta2 negatively regulates the transactivation of estrogen receptor alpha in human breast cancer cells. Cancer Res (2007) 1.35
Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma. PLoS Genet (2008) 1.35
Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha. J Biol Chem (2002) 1.35
Estrogen receptor and aryl hydrocarbon receptor signaling pathways. Nucl Recept Signal (2006) 1.35
Accumulation of foam cells in liver X receptor-deficient mice. Circulation (2002) 1.34
A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia. Proc Natl Acad Sci U S A (2009) 1.33
Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J Biol Chem (2003) 1.33
Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload. Am J Physiol Regul Integr Comp Physiol (2010) 1.32
A previously uncharacterized role for estrogen receptor beta: defeminization of male brain and behavior. Proc Natl Acad Sci U S A (2005) 1.32