Published in Crit Care Med on January 01, 2004
Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med (2010) 2.28
Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med (2010) 2.12
Combined neuronal and inducible nitric oxide synthase inhibition in ovine acute lung injury. Crit Care Med (2009) 1.68
Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med (2008) 1.61
Beneficial effects of concomitant neuronal and inducible nitric oxide synthase inhibition in ovine burn and inhalation injury. Shock (2011) 1.42
Animal models of sepsis. Virulence (2013) 1.22
Clinical review: The liver in sepsis. Crit Care (2012) 1.21
The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis. Nat Rev Drug Discov (2011) 1.21
Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literature. Crit Care (2007) 1.18
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J Clin Invest (2011) 1.01
Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration. Crit Care (2008) 0.98
The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. Intensive Care Med (2010) 0.95
The role of the liver in sepsis. Int Rev Immunol (2014) 0.95
Early diagnosis of sepsis-related hepatic dysfunction and its prognostic impact on survival: a prospective study with the LiMAx test. Crit Care (2013) 0.94
Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis Model Mech (2013) 0.93
Arginine-based inhibitors of nitric oxide synthase: therapeutic potential and challenges. Mediators Inflamm (2012) 0.86
The role of endothelium and endogenous vasoactive substances in sepsis. Hippokratia (2010) 0.85
Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85
Critical care trial design and interpretation: a primer. Crit Care Med (2010) 0.83
Mediator modulation therapy of severe sepsis and septic shock: does it work? Crit Care Med (2004) 0.83
Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2. J Immunol (2006) 0.82
Impaired cell functions of hepatocytes incubated with plasma of septic patients. Inflamm Res (2012) 0.81
Inotropes and vasopressors: more than haemodynamics! Br J Pharmacol (2012) 0.81
Systems engineering medicine: engineering the inflammation response to infectious and traumatic challenges. J R Soc Interface (2010) 0.80
Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expression. J Pharmacol Pharmacother (2015) 0.79
Ido brings down the pressure in systemic inflammation. Nat Med (2010) 0.78
Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase. Bioorg Med Chem (2012) 0.78
Bioartificial Therapy of Sepsis: Changes of Norepinephrine-Dosage in Patients and Influence on Dynamic and Cell Based Liver Tests during Extracorporeal Treatments. Biomed Res Int (2016) 0.77
Procalcitonin Impairs Liver Cell Viability and Function In Vitro: A Potential New Mechanism of Liver Dysfunction and Failure during Sepsis? Biomed Res Int (2017) 0.75
Statin research in critical illness: hampered by poor trial design? Crit Care (2009) 0.75
A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis. Clin Infect Dis (2006) 4.29
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med (2004) 4.24
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA (2012) 4.13
Linking "big" personality traits to anxiety, depressive, and substance use disorders: a meta-analysis. Psychol Bull (2010) 3.88
Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock. Crit Care Med (2005) 3.58
Delineating the structure of normal and abnormal personality: an integrative hierarchical approach. J Pers Soc Psychol (2005) 3.51
Identification and characterisation of the high-risk surgical population in the United Kingdom. Crit Care (2006) 3.30
HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. Blood (2006) 2.95
Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med (2014) 2.90
Confirmatory factor analyses of posttraumatic stress symptoms in deployed and nondeployed veterans of the Gulf War. J Abnorm Psychol (2002) 2.77
The accuracy of pain and fatigue items across different reporting periods. Pain (2008) 2.57
Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients. Intensive Care Med (2008) 2.57
Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. Clin Infect Dis (2003) 2.54
The structure of common DSM-IV and ICD-10 mental disorders in the Australian general population. Psychol Med (2006) 2.52
Parsing the general and specific components of depression and anxiety with bifactor modeling. Depress Anxiety (2008) 2.51
Affective instability: measuring a core feature of borderline personality disorder with ecological momentary assessment. J Abnorm Psychol (2008) 2.38
Environmental whole-genome amplification to access microbial populations in contaminated sediments. Appl Environ Microbiol (2006) 2.24
Effect of sedation level on the prevalence of delirium when assessed with CAM-ICU and ICDSC. Intensive Care Med (2013) 2.08
Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients. Proc Natl Acad Sci U S A (2006) 2.08
Variability in outcome and resource use in intensive care units. Intensive Care Med (2007) 2.04
The pulmonary artery catheter: in medio virtus. Crit Care Med (2008) 2.01
Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells. J Virol (2005) 1.97
Membrane microdialysis: Evaluation of a new method to assess splanchnic tissue metabolism. Crit Care Med (2006) 1.95
Global trend according to estimated number of occupational accidents and fatal work-related diseases at region and country level. J Safety Res (2009) 1.90
Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial. Crit Care (2009) 1.87
Exogenous natural surfactant for treatment of acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med (2009) 1.83
Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. J Infect Dis (2005) 1.80
Dissociating hippocampal versus basal ganglia contributions to learning and transfer. J Cogn Neurosci (2003) 1.77
Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci U S A (2006) 1.75
Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood (2012) 1.69
Efficacy and safety of darbepoetin alfa in anaemic patients with lymphoproliferative malignancies: a randomized, double-blind, placebo-controlled study. Br J Haematol (2003) 1.67
Accumulation of DC-SIGN+CD40+ dendritic cells with reduced CD80 and CD86 expression in lymphoid tissue during acute HIV-1 infection. AIDS (2002) 1.67
Global estimates of fatal work-related diseases. Am J Ind Med (2007) 1.64
Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive Care Med (2008) 1.63
Highly active antiretroviral therapy improves neurocognitive functioning. J Acquir Immune Defic Syndr (2004) 1.61
Identification and characterization of the unique N-linked glycan common to the flagellins and S-layer glycoprotein of Methanococcus voltae. J Biol Chem (2005) 1.60
Change in stroke volume in response to fluid challenge: assessment using esophageal Doppler. Intensive Care Med (2003) 1.55
New dimensions in the quantitative classification of mental illness. Arch Gen Psychiatry (2011) 1.54
Quantification of NTproBNP in rat serum using immunoprecipitation and LC/MS/MS: a biomarker of drug-induced cardiac hypertrophy. Anal Chem (2008) 1.51
Re-thinking resuscitation: leaving blood pressure cosmetics behind and moving forward to permissive hypotension and a tissue perfusion-based approach. Crit Care (2013) 1.50
Comparison of continuous and intermittent renal replacement therapy for acute renal failure. Nephrol Dial Transplant (2005) 1.50
Angiotensin II in septic shock: effects on tissue perfusion, organ function, and mitochondrial respiration in a porcine model of fecal peritonitis. Crit Care Med (2014) 1.49
Treatment of acne using a 3-milligram drospirenone/20-microgram ethinyl estradiol oral contraceptive administered in a 24/4 regimen: a randomized controlled trial. Obstet Gynecol (2008) 1.49
Arterial blood pressure during early sepsis and outcome. Intensive Care Med (2009) 1.49
Orthogonal polarization spectroscopy to detect mesenteric hypoperfusion. Intensive Care Med (2008) 1.48
Safe long-distance interhospital ground transfer of critically ill patients with acute severe unstable respiratory and circulatory failure. Intensive Care Med (2002) 1.48
Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment. Blood (2005) 1.48
Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection. J Immunol (2004) 1.46
Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function. Crit Care (2013) 1.44
Argon plasma coagulation ablation versus endoscopic surveillance of Barrett's esophagus: late outcomes from two randomized trials. Endoscopy (2013) 1.43
HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation. Blood (2004) 1.42
Immunoglobulin G treatment of postcardiac surgery patients with score-identified severe systemic inflammatory response syndrome--the ESSICS study. Crit Care Med (2008) 1.42
Intra-individual variation of the cuff-leak test as a predictor of post-extubation stridor. Respir Care (2012) 1.42
Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial. Crit Care (2010) 1.41
Early prognostic value of the medical emergency team calling criteria in patients admitted to intensive care from the emergency department. Crit Care Med (2008) 1.40
A clinical prediction model to identify patients at high risk of death in the emergency department. Intensive Care Med (2015) 1.40
The development of autoimmune features in aging mice is closely associated with alterations of the peripheral CD4⁺ T-cell compartment. Eur J Immunol (2014) 1.40
Causes of death and determinants of outcome in critically ill patients. Crit Care (2006) 1.40
Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock. Crit Care Med (2007) 1.39
Jejunal luminal microdialysate lactate in cardiac tamponade--effect of low systemic blood flow on gut mucosa. Intensive Care Med (2002) 1.39
Changes in regional blood flow and pCO(2) gradients during isolated abdominal aortic blood flow reduction. Intensive Care Med (2003) 1.39
Increased splanchnic oxygen extraction because of routine nursing procedures. Crit Care Med (2009) 1.38
Pilot-scale in situ bioremedation of uranium in a highly contaminated aquifer. 2. Reduction of u(VI) and geochemical control of u(VI) bioavailability. Environ Sci Technol (2006) 1.38
Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open (2012) 1.34
Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study. Crit Care (2010) 1.33
Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection. J Virol (2007) 1.32
rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector. PLoS One (2008) 1.31
Introduction to the special section: toward a dimensionally based taxonomy of psychopathology. J Abnorm Psychol (2005) 1.29
The role of person versus situation in life satisfaction: a critical examination. Psychol Bull (2004) 1.29
Hoarding and its relation to obsessive-compulsive disorder. Behav Res Ther (2005) 1.28
Early immune activation in gut-associated and peripheral lymphoid tissue during acute HIV infection. AIDS (2007) 1.28
In situ bioreduction of uranium (VI) to submicromolar levels and reoxidation by dissolved oxygen. Environ Sci Technol (2007) 1.27
Local immune responses in human tuberculosis: learning from the site of infection. J Infect Dis (2012) 1.27
Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications. Intensive Care Med (2008) 1.26
Differential relations of depression and social anxiety symptoms to the facets of extraversion/positive emotionality. J Abnorm Psychol (2009) 1.26
Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med (2004) 1.24
Microbial communities in contaminated sediments, associated with bioremediation of uranium to submicromolar levels. Appl Environ Microbiol (2008) 1.24
Impact of a collaborative shared antenatal care program for urban Indigenous women: a prospective cohort study. Med J Aust (2005) 1.21
Impaired probabilistic category learning in hypoxic subjects with hippocampal damage. Neuropsychologia (2004) 1.20
Mobius sequence--a Swedish multidiscipline study. Eur J Paediatr Neurol (2002) 1.20
CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. Eur J Immunol (2007) 1.20
Responses of microbial community functional structures to pilot-scale uranium in situ bioremediation. ISME J (2010) 1.19
On the temporal stability of personality: evidence for differential stability and the role of life experiences. J Pers Soc Psychol (2002) 1.18
Differential stability and individual growth trajectories of big five and affective traits during young adulthood. J Pers (2008) 1.17
Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions. Am J Pathol (2009) 1.17
Effect of fluid resuscitation on mortality and organ function in experimental sepsis models. Crit Care (2009) 1.16
Neuropsychological characteristics and personality traits in pathological gambling. CNS Spectr (2008) 1.16
The role of dopamine in cognitive sequence learning: evidence from Parkinson's disease. Behav Brain Res (2005) 1.15
The two-factor structure of sleep complaints and its relation to depression and anxiety. J Abnorm Psychol (2009) 1.15
Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study. Crit Care (2010) 1.14
Parallel decline of CD8+/CD38++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection. AIDS (2002) 1.14