Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation.

PubWeight™: 1.12‹?› | Rank: Top 10%

🔗 View Article (PMID 14715519)

Published in Am J Physiol Gastrointest Liver Physiol on February 01, 2004

Authors

C Barmeyer1, M Harren, H Schmitz, U Heinzel-Pleines, J Mankertz, U Seidler, I Horak, B Wiedenmann, M Fromm, J D Schulzke

Author Affiliations

1: Department of Gastroenterology, Charité-University Medicine Berlin, 12200 Berlin, Germany.

Articles citing this

Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS One (2007) 1.86

Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis. Am J Physiol Gastrointest Liver Physiol (2008) 1.32

Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea. Inflamm Bowel Dis (2009) 1.26

Evidence that tight junctions are disrupted due to intimate bacterial contact and not inflammation during attaching and effacing pathogen infection in vivo. Infect Immun (2006) 1.13

Decreased expression of colonic Slc26a3 and carbonic anhydrase iv as a cause of fatal infectious diarrhea in mice. Infect Immun (2009) 1.08

Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity. Am J Physiol Cell Physiol (2008) 1.00

Diarrhea as a cause of mortality in a mouse model of infectious colitis. Genome Biol (2008) 0.99

Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol (2013) 0.92

ENaCs and ASICs as therapeutic targets. Am J Physiol Cell Physiol (2012) 0.91

Transcriptional regulation of the intestinal luminal Na⁺ and Cl⁻ transporters. Biochem J (2011) 0.88

Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis. Pflugers Arch (2014) 0.88

Chronic colitis induces expression of β-defensins in murine intestinal epithelial cells. Clin Exp Immunol (2010) 0.88

The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs. PLoS One (2012) 0.87

Reduced susceptibility to dextran sulphate sodium-induced colitis in the interleukin-2 heterozygous (IL-2) mouse. Immunology (2005) 0.86

Mutation of EpCAM leads to intestinal barrier and ion transport dysfunction. J Mol Med (Berl) (2014) 0.83

Epithelial transport in inflammatory bowel diseases. Inflamm Bowel Dis (2014) 0.82

Upregulation of colonic ion channels in APC ( Min/+ ) mice. Pflugers Arch (2008) 0.82

NHE3 modulates the severity of colitis in IL-10-deficient mice. Am J Physiol Gastrointest Liver Physiol (2011) 0.82

Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease-Associated Diarrhea. Inflamm Bowel Dis (2015) 0.82

Involvement of the mannose receptor and p38 mitogen-activated protein kinase signaling pathway of the microdomain of the integral membrane protein after enteropathogenic Escherichia coli infection. Infect Immun (2012) 0.79

Pathophysiology of Intestinal Na(+)/H(+) exchange. Cell Mol Gastroenterol Hepatol (2017) 0.75

Protective function of interleukin 27 in colitis-associated cancer via suppression of inflammatory cytokines in intestinal epithelial cells. Oncoimmunology (2017) 0.75

Reduced Epithelial Na+/H+ Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis. PLoS One (2016) 0.75

Plasma membrane insertion of epithelial sodium channels occurs with dual kinetics. Pflugers Arch (2016) 0.75

Articles by these authors

Expression of genes transferred into monocot and dicot plant cells by electroporation. Proc Natl Acad Sci U S A (1985) 12.21

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell (1993) 11.95

Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands. Nat Biotechnol (2001) 11.41

Deletion mapping of DNA regions required for SV40 early region promoter function in vivo. J Mol Appl Genet (1982) 10.71

Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell (1985) 6.06

TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch (2006) 5.86

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature (1991) 5.51

Introns increase gene expression in cultured maize cells. Genes Dev (1987) 5.32

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell (1996) 4.74

Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell (2000) 4.69

Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome. Gastroenterology (2001) 4.30

Propagation of both parental mitochondrial DNAs in rat-human and mouse-human hybrid cells. J Mol Biol (1973) 3.93

TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch (2007) 3.89

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut (2006) 3.70

A prospective randomised study on narrow-band imaging versus conventional colonoscopy for adenoma detection: does narrow-band imaging induce a learning effect? Gut (2007) 3.60

Worldwide epidemiology of human adenovirus infections. Am J Epidemiol (1983) 3.45

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol (1995) 3.34

Immune responses in interleukin-2-deficient mice. Science (1993) 3.29

Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science (1996) 3.01

Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane. EMBO J (1995) 2.96

Detection of dengue virus RNA in patients after primary or secondary dengue infection by using the TaqMan automated amplification system. J Clin Microbiol (1999) 2.96

Clathrin-coated vesicles contain an ATP-dependent proton pump. Proc Natl Acad Sci U S A (1983) 2.84

Imported lassa fever in Germany: molecular characterization of a new lassa virus strain. Emerg Infect Dis (2000) 2.69

Crypts are the site of intestinal fluid and electrolyte secretion. Science (1982) 2.66

Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system. Ann Oncol (2004) 2.54

Simian virus 40 early- and late-region promoter functions are enhanced by the 72-base-pair repeat inserted at distant locations and inverted orientations. Mol Cell Biol (1983) 2.53

Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS). Neuroendocrinology (2005) 2.49

Transcription in vivo from SV40 early promoter deletion mutants without repression by large T antigen. J Mol Appl Genet (1983) 2.48

IgM antibodies to Epstein-Barr virus in infectious mononucleosis. Arch Gesamte Virusforsch (1972) 2.47

Prognostic significance of extent of disease in bone in patients with androgen-independent prostate cancer. J Clin Oncol (1999) 2.38

Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology (1999) 2.37

Somatostatin-receptor imaging of neuroendocrine gastroenteropancreatic tumors. Gastroenterology (1993) 2.29

Complex regulation of simian virus 40 early-region transcription from different overlapping promoters. Mol Cell Biol (1984) 2.28

Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J Cell Sci (1999) 2.19

Detection of IgM antibodies to cytomegalovirus (CMV) using an enzyme-labelled antigen (ELA). J Gen Virol (1980) 2.13

Determination of different cytomegalovirus immunoglobulins (IgG, IgA, IgM) by immunofluorescence. Arch Gesamte Virusforsch (1972) 2.04

Identification of a protein essential for replication of porcine circovirus. J Gen Virol (1998) 1.92

Insulin-like growth factor-I is an autocrine regulator of chromogranin A secretion and growth in human neuroendocrine tumor cells. Cancer Res (2000) 1.90

Magnetic resonance cholangiopancreatography-guided unilateral endoscopic stent placement for Klatskin tumors. Gastrointest Endosc (2001) 1.90

Epithelial transport and barrier function in occludin-deficient mice. Biochim Biophys Acta (2005) 1.88

Tomographic 3D reconstruction of quick-frozen, Ca2+-activated contracting insect flight muscle. Cell (1999) 1.85

Sustained virological response in hepatitis C virus type 1b infected patients is predicted by the number of mutations within the NS5A-ISDR: a meta-analysis focused on geographical differences. Gut (2004) 1.85

Photoregulation of a phytochrome gene promoter from oat transferred into rice by particle bombardment. Proc Natl Acad Sci U S A (1989) 1.84

IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. Am J Physiol (1999) 1.83

Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut (2004) 1.82

cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virus. J Virol (1993) 1.80

Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias. Blood (1998) 1.80

Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. FASEB J (2000) 1.79

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Blood (2001) 1.78

Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis. J Exp Med (1997) 1.77

Solid-phase enzyme immunoassay for immunoglobulin M antibodies to cytomegalovirus. J Clin Microbiol (1977) 1.75

Molecular characterization of synaptophysin, a major calcium-binding protein of the synaptic vesicle membrane. EMBO J (1986) 1.73

LI-cadherin: a marker of gastric metaplasia and neoplasia. Gut (2001) 1.72

Pancreatic carcinoma. Lancet (1997) 1.72

Mapping and characterization of the origin of DNA replication of porcine circovirus. J Virol (1997) 1.71

Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea. Am J Trop Med Hyg (1996) 1.70

Synaptophysin: a marker protein for neuroendocrine cells and neoplasms. Proc Natl Acad Sci U S A (1986) 1.70

Transfer of foreign genes into intact maize cells with high-velocity microprojectiles. Proc Natl Acad Sci U S A (1988) 1.69

TNM staging of neoplasms of the endocrine pancreas: results from a large international cohort study. J Natl Cancer Inst (2012) 1.65

CFTR and its key role in in vivo resting and luminal acid-induced duodenal HCO3- secretion. Acta Physiol (Oxf) (2008) 1.65

Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut (2008) 1.65

The emerging role of PDZ adapter proteins for regulation of intestinal ion transport. Am J Physiol Gastrointest Liver Physiol (2006) 1.64

Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity. Dig Dis (2001) 1.63

Detection of Lassa virus RNA in specimens from patients with Lassa fever by using the polymerase chain reaction. J Clin Microbiol (1990) 1.61

Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci (2000) 1.60

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Eur J Immunol (1994) 1.57

Health-related quality of life in patients with pancreatic cancer. Digestion (2006) 1.57

Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology (2001) 1.56

Family of middle repetitive DNA sequences in the mouse genome with structural features of solitary retroviral long terminal repeats. Proc Natl Acad Sci U S A (1983) 1.54

Guanylin strongly stimulates rat duodenal HCO3- secretion: proposed mechanism and comparison with other secretagogues. Gastroenterology (1996) 1.53

[S3-Guidelines "Exocrine pancreatic cancer" 2007]. Z Gastroenterol (2007) 1.52

Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry. Am J Pathol (1987) 1.51

Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice. Proc Natl Acad Sci U S A (1999) 1.50

The oral multitarget tumour growth inhibitor, ZK 304709, inhibits growth of pancreatic neuroendocrine tumours in an orthotopic mouse model. Gut (2008) 1.49

Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein. Blood (1999) 1.49

Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice. Acta Physiol (Oxf) (2014) 1.48

Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis. J Lipid Res (1989) 1.47

Progressive encephalopathy and myopathy in transgenic mice expressing human foamy virus genes. Science (1991) 1.46

Management and outcomes of haemorrhage after pancreatogastrostomy versus pancreatojejunostomy. Br J Surg (2011) 1.46

The prevalence of antibodies to HIV-1 and HIV-2 in onchocerciasis-endemic rural areas in southern Benin. AIDS (1993) 1.44

Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol Cell Biol (2000) 1.44

Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis. J Lipid Res (1985) 1.43

Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum. J Infect Dis (2001) 1.40

Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation. Am J Pathol (1993) 1.39

The synthesis of poxvirus-specific RNA in interferon-treated cells. Virology (1972) 1.38

Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways. Infect Immun (2006) 1.38

IgM antibodies to cytomegalovirus during pregnancy. Arch Virol (1977) 1.38