The emerging role of PDZ adapter proteins for regulation of intestinal ion transport.

PubWeight™: 1.64‹?› | Rank: Top 3%

🔗 View Article (PMID 16798722)

Published in Am J Physiol Gastrointest Liver Physiol on June 22, 2006

Authors

G Lamprecht1, U Seidler

Author Affiliations

1: First Medical Department, University of Tuebingen, Germany.

Articles citing this

Organizing the cell cortex: the role of ERM proteins. Nat Rev Mol Cell Biol (2010) 5.05

Genetic analysis of variation in human meiotic recombination. PLoS Genet (2009) 2.11

Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia. Cell (2007) 1.89

Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A. J Biol Chem (2010) 1.58

Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex. Trends Cell Biol (2009) 1.54

Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine. Am J Physiol Gastrointest Liver Physiol (2010) 1.38

Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology (2009) 1.33

CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners. Integr Biol (Camb) (2010) 1.32

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest (2009) 1.30

Defective jejunal and colonic salt absorption and alteredNa(+)/H (+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice. Pflugers Arch (2008) 1.26

Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factors. Pharmacol Rev (2011) 1.22

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol Rev (2014) 1.21

Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. BMC Dev Biol (2007) 1.21

A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization. Mol Biol Cell (2010) 1.15

Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell (2010) 1.14

The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity. Cell Microbiol (2008) 1.14

Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice. Pflugers Arch (2007) 1.06

Isoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epithelia. PLoS One (2010) 1.04

Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3. J Biomed Biotechnol (2010) 1.02

Ezrin-mediated apical integrity is required for intestinal homeostasis. Proc Natl Acad Sci U S A (2011) 0.99

Diarrhea as a cause of mortality in a mouse model of infectious colitis. Genome Biol (2008) 0.99

Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies. Clin Exp Nephrol (2011) 0.98

NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem (2010) 0.98

A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation. J Biol Chem (2009) 0.96

Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH. Cell Microbiol (2010) 0.94

Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium. J Biol Chem (2009) 0.93

Ion transport in the intestine. Curr Opin Gastroenterol (2009) 0.93

NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli. J Biol Chem (2012) 0.92

Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)/H(+) exchanger 3. Am J Physiol Gastrointest Liver Physiol (2012) 0.90

Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis. Pflugers Arch (2014) 0.88

Ezrin mediates tethering of the gamma-aminobutyric acid transporter GAT1 to actin filaments via a C-terminal PDZ-interacting domain. Biophys J (2009) 0.86

Activity and PI3-kinase dependent trafficking of the intestinal anion exchanger downregulated in adenoma depend on its PDZ interaction and on lipid rafts. Am J Physiol Gastrointest Liver Physiol (2010) 0.86

Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics (2010) 0.85

Response of porcine intestinal in vitro organ culture tissues following exposure to Lactobacillus plantarum JC1 and Salmonella enterica serovar Typhimurium SL1344. Appl Environ Microbiol (2010) 0.85

Adaptable hydrogel networks with reversible linkages for tissue engineering. Adv Mater (2015) 0.85

Downregulation of the NHE3-binding PDZ-adaptor protein PDZK1 expression during cytokine-induced inflammation in interleukin-10-deficient mice. PLoS One (2012) 0.84

Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod (2012) 0.84

Colonic mucosal gene expression and genotype in irritable bowel syndrome patients with normal or elevated fecal bile acid excretion. Am J Physiol Gastrointest Liver Physiol (2015) 0.81

MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transport. J Biol Chem (2013) 0.81

Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis. Mol Biol Cell (2011) 0.78

Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics (2011) 0.78

Shank2 mutant mice display a hypersecretory response to cholera toxin. J Physiol (2014) 0.78

Intestinal secretory mechanisms in irritable bowel syndrome-diarrhea. Clin Gastroenterol Hepatol (2014) 0.78

Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3. Cell Physiol Biochem (2013) 0.77

Systematic family-wide analysis of sodium bicarbonate cotransporter NBCn1/SLC4A7 interactions with PDZ scaffold proteins. Physiol Rep (2014) 0.77

Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24. Am J Physiol Gastrointest Liver Physiol (2016) 0.76

Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1. PLoS One (2013) 0.76

Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea. Gastroenterology (2016) 0.75

MAP17 Is a Necessary Activator of Renal Na+/Glucose Cotransporter SGLT2. J Am Soc Nephrol (2016) 0.75

The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9. Am J Physiol Lung Cell Mol Physiol (2017) 0.75

Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer. J Innate Immun (2017) 0.75

Articles by these authors

Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science (1996) 3.01

Epithelial transport and barrier function in occludin-deficient mice. Biochim Biophys Acta (2005) 1.88

CFTR and its key role in in vivo resting and luminal acid-induced duodenal HCO3- secretion. Acta Physiol (Oxf) (2008) 1.65

Guanylin strongly stimulates rat duodenal HCO3- secretion: proposed mechanism and comparison with other secretagogues. Gastroenterology (1996) 1.53

Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer and barrier impairment in mice. Acta Physiol (Oxf) (2014) 1.48

Defective jejunal and colonic salt absorption and alteredNa(+)/H (+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice. Pflugers Arch (2008) 1.26

cAMP-mediated regulation of murine intestinal/pancreatic Na+/HCO3- cotransporter subtype pNBC1. Am J Physiol Gastrointest Liver Physiol (2002) 1.13

The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation. Am J Physiol Gastrointest Liver Physiol (2004) 1.12

Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation. Am J Physiol Gastrointest Liver Physiol (2004) 1.12

Effect of inhibitors of Na+/H+-exchange and gastric H+/K+ ATPase on cell volume, intracellular pH and migration of human polymorphonuclear leucocytes. Br J Pharmacol (1998) 1.09

Role of Na(+)HCO(3)(-) cotransporter NBC1, Na(+)/H(+) exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion. Gastroenterology (2000) 1.07

Functional role of Na+-HCO3- cotransport in migration of transformed renal epithelial cells. J Physiol (2005) 1.02

Expression and regulation of the Na+-K+-2Cl- cotransporter NKCC1 in the normal and CFTR-deficient murine colon. J Physiol (2003) 0.95

Carbachol increases Na+-HCO3- cotransport activity in murine colonic crypts in a M3-, Ca2+/calmodulin-, and PKC-dependent manner. Am J Physiol Gastrointest Liver Physiol (2006) 0.94

Expression of AE2 anion exchanger in mouse intestine. Am J Physiol (1999) 0.94

Na+/HCO3- cotransport and expression of NBC1 and NBC2 in rabbit gastric parietal and mucous cells. Gastroenterology (1999) 0.92

Three 5'-variant mRNAs of anion exchanger AE2 in stomach and intestine of mouse, rabbit, and rat. Ann N Y Acad Sci (2000) 0.90

Characterization of gamma- and delta-subunits of Ca2+/calmodulin-dependent protein kinase II in rat gastric mucosal cell populations. Biochem J (1994) 0.87

Independence of apical Cl-/HCO3- exchange and anion conductance in duodenal HCO3- secretion. Am J Physiol Gastrointest Liver Physiol (2003) 0.86

Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics (2010) 0.85

Do we need gastric acid? Digestion (2008) 0.84

Differential expression and regulation of Na(+)/H(+) exchanger isoforms in rabbit parietal and mucous cells. Am J Physiol Gastrointest Liver Physiol (2001) 0.84

Pseudotype formation of Moloney murine leukemia virus with Sendai virus glycoprotein F. J Virol (1998) 0.83

The PDZ-interaction of the intestinal anion exchanger downregulated in adenoma (DRA; SLC26A3) facilitates its movement into Rab11a-positive recycling endosomes. Am J Physiol Gastrointest Liver Physiol (2013) 0.83

Different acid secretagogues activate different Na+/H+ exchanger isoforms in rabbit parietal cells. Am J Physiol (1998) 0.83

Basolateral ion transporters involved in colonic epithelial electrolyte absorption, anion secretion and cellular homeostasis. Acta Physiol (Oxf) (2011) 0.82

Different regulation by pHi and osmolarity of the rabbit ileum brush-border and parietal cell basolateral anion exchanger. J Physiol (1994) 0.81

Agonist-induced cytoplasmic volume changes in cultured rabbit parietal cells. Am J Physiol Gastrointest Liver Physiol (2000) 0.81

Differential expression and regulation of AE2 anion exchanger subtypes in rabbit parietal and mucous cells. J Physiol (2001) 0.81

Ca2+/calmodulin-dependent protein kinase II isoenzymes gamma and delta are both present in H+/K+-ATPase-containing rabbit gastric tubulovesicles. Eur J Biochem (1999) 0.81

[Cystic fibrosis in adults]. Internist (Berl) (2010) 0.79

Intracellular pH-regulating ion transport mechanisms in parietal cell basolateral membrane vesicles. Am J Physiol (1993) 0.79

Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics (2011) 0.78

The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br J Pharmacol (2000) 0.78

Motility-induced but not vasoactive intestinal peptide-induced increase in luminal alkalinization in rat duodenum is dependent on luminal Cl(-). Acta Physiol (Oxf) (2010) 0.77

Effect of PCO2 on intracellular pH in in vitro frog gastric mucosa. Am J Physiol (1989) 0.75

Up-regulation of prostaglandin E2 binding and of prostanoid release in rabbits producing antibodies against prostaglandin E2. Prostaglandins (1989) 0.75