Published in Blood on January 15, 2004
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays (2007) 3.26
Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma. Blood (2012) 2.29
The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly. PLoS One (2007) 2.06
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. J Clin Invest (2010) 1.71
Cortactin has an essential and specific role in osteoclast actin assembly. Mol Biol Cell (2006) 1.52
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation. Immunobiology (2009) 1.32
N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts. Mol Biol Cell (2006) 1.31
The role of palladin in actin organization and cell motility. Eur J Cell Biol (2008) 1.22
Role of WASP in cell polarity and podosome dynamics of myeloid cells. Eur J Cell Biol (2010) 1.20
Signaling role of Cdc42 in regulating mammalian physiology. J Biol Chem (2010) 1.18
Osteoclast motility: putting the brakes on bone resorption. Ageing Res Rev (2009) 1.12
The regulation of osteoclast function and bone resorption by small GTPases. Small GTPases (2011) 1.11
Invadopodia and matrix degradation, a new property of prostate cancer cells during migration and invasion. J Biol Chem (2008) 1.10
Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth. Mol Cell Biol (2006) 1.09
Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption. Mol Cell Biol (2005) 1.08
Membrane lipids in invadopodia and podosomes: key structures for cancer invasion and metastasis. Oncotarget (2010) 1.00
Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. J Immunol (2011) 0.91
Signaling networks regulating leukocyte podosome dynamics and function. Cell Signal (2011) 0.88
Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts. J Biol Chem (2010) 0.88
N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis. Exp Cell Res (2010) 0.88
Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton. Eur J Cell Biol (2010) 0.87
Polyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorption. BMC Cell Biol (2004) 0.86
Effects of surface microtopography on the assembly of the osteoclast resorption apparatus. J R Soc Interface (2011) 0.86
The non-redundant role of N-WASP in podosome-mediated matrix degradation in macrophages. Eur J Cell Biol (2010) 0.84
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. J Clin Invest (2015) 0.84
Regulation of osteoclasts by membrane-derived lipid mediators. Cell Mol Life Sci (2013) 0.83
Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures. Mol Pharm (2011) 0.82
Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid. J Mol Signal (2008) 0.81
Invadosomes in their natural habitat. Eur J Cell Biol (2014) 0.81
Modulation of osteoclast differentiation and bone resorption by Rho GTPases. Small GTPases (2014) 0.80
RNA therapeutics targeting osteoclast-mediated excessive bone resorption. Adv Drug Deliv Rev (2011) 0.80
Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. J Cell Sci (2014) 0.78
Role and mechanism of action of leucine-rich repeat kinase 1 in bone. Bone Res (2017) 0.75
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α. Sci Rep (2015) 0.75
Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med (2008) 15.30
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med (2006) 9.68
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest (2008) 7.05
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med (2002) 6.25
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet (2004) 5.43
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med (2010) 4.76
Bayesian localization microscopy reveals nanoscale podosome dynamics. Nat Methods (2011) 4.16
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J Clin Invest (2007) 3.28
A robust model for read count data in exome sequencing experiments and implications for copy number variant calling. Bioinformatics (2012) 3.10
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. J Clin Invest (2007) 2.80
Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha. Circ Res (2002) 2.79
Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood (2007) 2.79
Effective gene therapy with nonintegrating lentiviral vectors. Nat Med (2006) 2.70
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors. Mol Ther (2009) 2.56
A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest (2003) 2.37
The Wiskott-Aldrich syndrome. J Allergy Clin Immunol (2006) 2.29
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore) (2010) 2.26
Comprehensive genomic access to vector integration in clinical gene therapy. Nat Med (2009) 2.19
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol (2007) 2.18
Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning. Mol Ther (2006) 2.08
Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med (2012) 2.02
The conventional autopsy in modern medicine. J R Soc Med (2008) 2.00
P-Rex1 regulates neutrophil function. Curr Biol (2005) 1.97
Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency. Sci Transl Med (2011) 1.81
Stable gene transfer to muscle using non-integrating lentiviral vectors. Mol Ther (2007) 1.81
Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction. Sci Transl Med (2011) 1.81
Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood (2006) 1.80
The cytoplasm of living cells behaves as a poroelastic material. Nat Mater (2013) 1.80
Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A (2005) 1.75
The leukocyte podosome. Eur J Cell Biol (2005) 1.72
Codon optimization of human factor VIII cDNAs leads to high-level expression. Blood (2010) 1.68
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming. Blood (2011) 1.67
Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology (2004) 1.66
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood (2013) 1.65
Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response. Blood (2004) 1.56
Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment. Blood (2006) 1.56
PTEN couples Sema3A signalling to growth cone collapse. J Cell Sci (2006) 1.54
A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors. Mol Ther (2010) 1.54
Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD). J Leukoc Biol (2003) 1.53
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta. Cancer Res (2003) 1.51
X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options. Blood (2010) 1.51
Autoimmune lymphoproliferative syndrome: molecular basis of disease and clinical phenotype. Br J Haematol (2006) 1.49
Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. J Exp Med (2007) 1.49
Inhibition of calpain stabilises podosomes and impairs dendritic cell motility. J Cell Sci (2006) 1.47
Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency. Mol Ther (2008) 1.44
SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease. Blood (2012) 1.44
WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells. Curr Biol (2006) 1.43
Update on the hyper immunoglobulin M syndromes. Br J Haematol (2010) 1.43
A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes. Blood (2010) 1.43
The emerging importance of group II PAKs. Biochem J (2010) 1.42
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med (2014) 1.42
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. Mol Ther (2005) 1.38
A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF. Cell Signal (2008) 1.38
Signalling to cancer cell invasion through PAK family kinases. Front Biosci (Landmark Ed) (2011) 1.36
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis. Blood (2008) 1.35
Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein. Blood (2004) 1.35
Gene therapy of chronic granulomatous disease: the engraftment dilemma. Mol Ther (2010) 1.34
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation. Immunobiology (2009) 1.32
Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells. J Pathol (2004) 1.31
Maturation of DC is associated with changes in motile characteristics and adherence. Cell Motil Cytoskeleton (2004) 1.31
Cognitive and behavioral abnormalities in children after hematopoietic stem cell transplantation for severe congenital immunodeficiencies. Blood (2008) 1.29
CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. J Cell Biochem (2002) 1.27
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood (2012) 1.27
Mechanisms of WASp-mediated hematologic and immunologic disease. Blood (2004) 1.26
AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa. Mol Ther (2003) 1.26
Nonintegrating lentivector vaccines stimulate prolonged T-cell and antibody responses and are effective in tumor therapy. J Virol (2009) 1.24
Cell migration in development and disease. Dev Cell (2002) 1.23
Gene therapy for PIDs: progress, pitfalls and prospects. Gene (2013) 1.22
SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease. Blood (2004) 1.21
Role of WASP in cell polarity and podosome dynamics of myeloid cells. Eur J Cell Biol (2010) 1.20
Podoplanin associates with CD44 to promote directional cell migration. Mol Biol Cell (2010) 1.20
Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis. J Immunol (2009) 1.18
Gene therapy: is IL2RG oncogenic in T-cell development? Nature (2006) 1.18
Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc Natl Acad Sci U S A (2009) 1.18
Sleeping beauty transposition from nonintegrating lentivirus. Mol Ther (2009) 1.18
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion. J Cell Sci (2010) 1.17
WASP-interacting protein (WIP): working in polymerisation and much more. Trends Cell Biol (2007) 1.17
Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood (2007) 1.15
Repeated courses of rituximab for autoimmune cytopenias may precipitate profound hypogammaglobulinaemia requiring replacement intravenous immunoglobulin. Br J Haematol (2009) 1.15
N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator. J Cell Sci (2002) 1.14
Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors. Mol Ther (2010) 1.13
Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy. J Gene Med (2003) 1.12