Published in Cell Motil Cytoskeleton on February 01, 2004
WASP: a key immunological multitasker. Nat Rev Immunol (2010) 2.38
Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity (2006) 1.79
WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells. Curr Biol (2006) 1.43
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation. Immunobiology (2009) 1.32
Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations. Nat Commun (2013) 1.08
Viral interleukin-10 expressed by human cytomegalovirus during the latent phase of infection modulates latently infected myeloid cell differentiation. J Virol (2011) 1.06
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent. J Cell Biol (2008) 1.02
Dual-color superresolution microscopy reveals nanoscale organization of mechanosensory podosomes. Mol Biol Cell (2013) 1.01
The role of cathepsin X in cell signaling. Cell Adh Migr (2009) 0.97
N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer. Clin Exp Metastasis (2007) 0.96
Fascin1 promotes cell migration of mature dendritic cells. J Immunol (2011) 0.95
TGF-β suppresses β-catenin-dependent tolerogenic activation program in dendritic cells. PLoS One (2011) 0.94
Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. J Immunol (2011) 0.91
Mechanisms of dendritic cell trafficking across the blood-brain barrier. J Neuroimmune Pharmacol (2011) 0.91
Actin cytoskeletal defects in immunodeficiency. Immunol Rev (2013) 0.90
Signaling networks regulating leukocyte podosome dynamics and function. Cell Signal (2011) 0.88
Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X. J Leukoc Biol (2008) 0.87
Geometry sensing by dendritic cells dictates spatial organization and PGE(2)-induced dissolution of podosomes. Cell Mol Life Sci (2011) 0.87
Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines. Immunology (2014) 0.86
Polyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorption. BMC Cell Biol (2004) 0.86
LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro. BMC Cancer (2012) 0.86
Gliadin fragments promote migration of dendritic cells. J Cell Mol Med (2011) 0.85
The role of integrins in the recognition and response of dendritic cells to biomaterials. Biomaterials (2010) 0.84
Measles virus-induced immunosuppression: from effectors to mechanisms. Med Microbiol Immunol (2010) 0.83
Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. J Cell Biol (2016) 0.80
A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells. J Cell Sci (2014) 0.78
Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. J Cell Sci (2014) 0.78
Modulation of dendritic cell immunobiology via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. PLoS One (2014) 0.78
The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells. J Immunol (2011) 0.78
Spatiotemporal organization and mechanosensory function of podosomes. Cell Adh Migr (2014) 0.77
Presentation Modality of Glycoconjugates Modulates Dendritic Cell Phenotype. Biomater Sci (2014) 0.76
Wiskott-Aldrich syndrome: another piece in the puzzle. Clin Exp Immunol (2005) 0.76
Lymphatic metastasis and nm23H1 genetic instability in Chinese colon cancer patients. World J Gastroenterol (2004) 0.76
Human Immunodeficiencies Related to Defective APC/T Cell Interaction. Front Immunol (2015) 0.75
A Key Role for Inhibins in Dendritic Cell Maturation and Function. PLoS One (2016) 0.75
Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med (2008) 15.30
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med (2006) 9.68
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest (2008) 7.05
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med (2002) 6.25
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet (2004) 5.43
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med (2010) 4.76
Bayesian localization microscopy reveals nanoscale podosome dynamics. Nat Methods (2011) 4.16
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. J Clin Invest (2007) 3.28
A robust model for read count data in exome sequencing experiments and implications for copy number variant calling. Bioinformatics (2012) 3.10
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. J Clin Invest (2007) 2.80
Essential role of the NADPH oxidase subunit p47(phox) in endothelial cell superoxide production in response to phorbol ester and tumor necrosis factor-alpha. Circ Res (2002) 2.79
Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood (2007) 2.79
Effective gene therapy with nonintegrating lentiviral vectors. Nat Med (2006) 2.70
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors. Mol Ther (2009) 2.56
The Wiskott-Aldrich syndrome. J Allergy Clin Immunol (2006) 2.29
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore) (2010) 2.26
Comprehensive genomic access to vector integration in clinical gene therapy. Nat Med (2009) 2.19
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol (2007) 2.18
Successful reconstitution of immunity in ADA-SCID by stem cell gene therapy following cessation of PEG-ADA and use of mild preconditioning. Mol Ther (2006) 2.08
Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med (2012) 2.02
P-Rex1 regulates neutrophil function. Curr Biol (2005) 1.97
Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency. Sci Transl Med (2011) 1.81
Stable gene transfer to muscle using non-integrating lentiviral vectors. Mol Ther (2007) 1.81
Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction. Sci Transl Med (2011) 1.81
Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood (2006) 1.80
The cytoplasm of living cells behaves as a poroelastic material. Nat Mater (2013) 1.80
The leukocyte podosome. Eur J Cell Biol (2005) 1.72
Codon optimization of human factor VIII cDNAs leads to high-level expression. Blood (2010) 1.68
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming. Blood (2011) 1.67
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood (2013) 1.65
Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response. Blood (2004) 1.56
Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment. Blood (2006) 1.56
PTEN couples Sema3A signalling to growth cone collapse. J Cell Sci (2006) 1.54
A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors. Mol Ther (2010) 1.54
Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD). J Leukoc Biol (2003) 1.53
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta. Cancer Res (2003) 1.51
X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options. Blood (2010) 1.51
Autoimmune lymphoproliferative syndrome: molecular basis of disease and clinical phenotype. Br J Haematol (2006) 1.49
Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia. J Exp Med (2007) 1.49
Inhibition of calpain stabilises podosomes and impairs dendritic cell motility. J Cell Sci (2006) 1.47
SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease. Blood (2012) 1.44
Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency. Mol Ther (2008) 1.44
WIP regulates the stability and localization of WASP to podosomes in migrating dendritic cells. Curr Biol (2006) 1.43
Update on the hyper immunoglobulin M syndromes. Br J Haematol (2010) 1.43
A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes. Blood (2010) 1.43
The emerging importance of group II PAKs. Biochem J (2010) 1.42
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med (2014) 1.42
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. Mol Ther (2005) 1.38
A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF. Cell Signal (2008) 1.38
Signalling to cancer cell invasion through PAK family kinases. Front Biosci (Landmark Ed) (2011) 1.36
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis. Blood (2008) 1.35
Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein. Blood (2004) 1.35
Gene therapy of chronic granulomatous disease: the engraftment dilemma. Mol Ther (2010) 1.34
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation. Immunobiology (2009) 1.32
Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cells. J Pathol (2004) 1.31
Cognitive and behavioral abnormalities in children after hematopoietic stem cell transplantation for severe congenital immunodeficiencies. Blood (2008) 1.29
WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption. Blood (2004) 1.28
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood (2012) 1.27
Mechanisms of WASp-mediated hematologic and immunologic disease. Blood (2004) 1.26
AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa. Mol Ther (2003) 1.26
Nonintegrating lentivector vaccines stimulate prolonged T-cell and antibody responses and are effective in tumor therapy. J Virol (2009) 1.24
Cell migration in development and disease. Dev Cell (2002) 1.23
Gene therapy for PIDs: progress, pitfalls and prospects. Gene (2013) 1.22
Low-dose thalidomide in combination with oral weekly cyclophosphamide and pulsed dexamethasone is a well tolerated and effective regimen in patients with relapsed and refractory multiple myeloma. Br J Haematol (2005) 1.21
SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease. Blood (2004) 1.21
Role of WASP in cell polarity and podosome dynamics of myeloid cells. Eur J Cell Biol (2010) 1.20
Podoplanin associates with CD44 to promote directional cell migration. Mol Biol Cell (2010) 1.20
Gene therapy: is IL2RG oncogenic in T-cell development? Nature (2006) 1.18
Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis. J Immunol (2009) 1.18
Sleeping beauty transposition from nonintegrating lentivirus. Mol Ther (2009) 1.18
Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc Natl Acad Sci U S A (2009) 1.18
PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion. J Cell Sci (2010) 1.17
WASP-interacting protein (WIP): working in polymerisation and much more. Trends Cell Biol (2007) 1.17
Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood (2007) 1.15
Repeated courses of rituximab for autoimmune cytopenias may precipitate profound hypogammaglobulinaemia requiring replacement intravenous immunoglobulin. Br J Haematol (2009) 1.15
N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator. J Cell Sci (2002) 1.14
Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors. Mol Ther (2010) 1.13
Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy. J Gene Med (2003) 1.12
Brief report: self-organizing neuroepithelium from human pluripotent stem cells facilitates derivation of photoreceptors. Stem Cells (2013) 1.11
Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells. Mol Ther (2010) 1.11
GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. J Cell Biol (2003) 1.10
Myogenic cell proliferation and generation of a reversible tumorigenic phenotype are triggered by preirradiation of the recipient site. J Cell Biol (2002) 1.10