Published in Cancer Biol Ther on January 10, 2004
Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol (2007) 2.59
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2007) 2.20
Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radic Biol Med (2011) 1.93
Vitamin C: update on physiology and pharmacology. Br J Pharmacol (2009) 1.53
The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid Redox Signal (2011) 1.24
Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci (2009) 1.14
Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish. BMC Pharmacol Toxicol (2014) 1.13
Copper regulation of hypoxia-inducible factor-1 activity. Mol Pharmacol (2008) 1.12
Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci (2011) 1.10
Ascorbate depletion: a critical step in nickel carcinogenesis? Environ Health Perspect (2005) 1.04
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol (2011) 1.00
The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II). Free Radic Biol Med (2007) 0.97
Global gene expression profiling in human lung cells exposed to cobalt. BMC Genomics (2007) 0.95
Identification of small molecule compounds that inhibit the HIF-1 signaling pathway. Mol Cancer (2009) 0.91
Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line. PLoS One (2011) 0.91
Characterisation of the active/de-active transition of mitochondrial complex I. Biochim Biophys Acta (2014) 0.90
Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells. Part Fibre Toxicol (2014) 0.90
Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets. Pharmacol Ther (2012) 0.88
Clinical iron deficiency disturbs normal human responses to hypoxia. J Clin Invest (2016) 0.87
Engineering vascularized tissues using natural and synthetic small molecules. Organogenesis (2008) 0.86
Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease. Mol Neurodegener (2010) 0.84
Apurinic/apyrimidinic endonuclease/redox effector factor-1(APE/Ref-1): a unique target for the prevention and treatment of human melanoma. Antioxid Redox Signal (2009) 0.83
Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J Cell Mol Med (2008) 0.82
PLAGL2 translocation and SP-C promoter activity--a cellular response of lung cells to hypoxia. Biochem Biophys Res Commun (2007) 0.81
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels. Cell Signal (2014) 0.81
Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein. Toxicol Sci (2008) 0.79
Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China. PLoS One (2015) 0.79
Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicol Sci (2013) 0.79
Transcriptional regulation and its misregulation in Alzheimer's disease. Mol Brain (2013) 0.79
The effect of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) on cell viability under hypoxia. Mol Vis (2013) 0.79
The role of oxidative stress in carcinogenesis induced by metals and xenobiotics. Cancers (Basel) (2010) 0.78
Trace Element Status (Iron, Zinc, Copper, Chromium, Cobalt, and Nickel) in Iron-Deficiency Anaemia of Children under 3 Years. Anemia (2014) 0.78
Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils. Biosci Rep (2016) 0.77
Up-regulation of Gadd45α after exposure to metal nanoparticles: the role of hypoxia inducible factor 1α. Environ Toxicol (2013) 0.76
Iron, oxygen, and the pulmonary circulation. J Appl Physiol (1985) (2015) 0.76
Subchronic inhalation of soluble manganese induces expression of hypoxia-associated angiogenic genes in adult mouse lungs. Toxicol Appl Pharmacol (2007) 0.75
Nickel-free stainless steel avoids neointima formation following coronary stent implantation. Sci Technol Adv Mater (2012) 0.75
Metal Ion Binding at the Catalytic Site Induces Widely Distributed Changes in a Sequence Specific Protein-DNA Complex. Biochemistry (2016) 0.75
A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. J Tissue Eng (2017) 0.75
Nickel carcinogenesis. Mutat Res (2003) 2.16
Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain. Lab Invest (2005) 1.22
Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors. Biochem Biophys Res Commun (2008) 1.10
Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. J Cell Biochem (2006) 1.10
Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with caucasian prostate cancer patients. Clin Cancer Res (2004) 0.97
The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II). Free Radic Biol Med (2007) 0.97
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. Cancer Res (2009) 0.96
Extracellular matrix and HIF-1 signaling: the role of prolidase. Int J Cancer (2008) 0.91
Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Mol Pharmacol (2003) 0.91
Molecular mechanisms in nickel carcinogenesis: modeling Ni(II) binding site in histone H4. Environ Health Perspect (2002) 0.91
Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells. Environ Health Perspect (2002) 0.88
Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicol Appl Pharmacol (2003) 0.86
Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling. J Environ Monit (2003) 0.84
Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol Appl Pharmacol (2004) 0.84
Effects of select PM-associated metals on alveolar macrophage phosphorylated ERK1 and -2 and iNOS expression during ongoing alteration in iron homeostasis. J Toxicol Environ Health A (2006) 0.84
Microarray analysis of altered gene expression in murine fibroblasts transformed by nickel(II) to nickel(II)-resistant malignant phenotype. Toxicol Appl Pharmacol (2005) 0.83
The role of oxidative stress in nickel and chromate genotoxicity. Mol Cell Biochem (2002) 0.83
Quantum chemical modeling of reaction mechanism for 2-oxoglutarate dependent enzymes: effect of substitution of iron by nickel and cobalt. J Phys Chem A (2006) 0.82
Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas. Mol Cell Biochem (2004) 0.82
Comparison of the cytotoxicity, cellular uptake, and DNA-protein crosslinks induced by potassium chromate in lymphoblast cell lines derived from three different individuals. Biol Trace Elem Res (2002) 0.79
Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein. Toxicol Sci (2008) 0.79
Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice. Toxicol Appl Pharmacol (2011) 0.75
A new intrinsic hypoxia marker in esophageal cancer. Adv Exp Med Biol (2003) 0.75