Published in Toxicol Appl Pharmacol on February 26, 2011
Improving the human hazard characterization of chemicals: a Tox21 update. Environ Health Perspect (2013) 2.95
The Essential Medicinal Chemistry of Curcumin. J Med Chem (2017) 1.68
Paradigm shift in toxicity testing and modeling. AAPS J (2012) 1.07
Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach. Environ Health Perspect (2012) 0.86
Are hERG channel blockers also phospholipidosis inducers? Bioorg Med Chem Lett (2013) 0.81
Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform. Curr Chem Genom Transl Med (2014) 0.80
Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride. Toxicol Appl Pharmacol (2013) 0.79
Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates. Toxicol Sci (2014) 0.77
Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide. Eur J Pharmacol (2014) 0.75
Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data. Environ Health Perspect (2016) 0.75
Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev (1999) 10.44
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A (2006) 9.92
Toxicology. Transforming environmental health protection. Science (2008) 7.50
A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A (1994) 5.77
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res (2003) 5.39
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev (2005) 3.50
Compound cytotoxicity profiling using quantitative high-throughput screening. Environ Health Perspect (2008) 3.11
Tetraethylammonium ions and the potassium permeability of excitable cells. Rev Physiol Biochem Pharmacol (1983) 2.54
High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem (1992) 2.13
The multitude and diversity of environmental carcinogens. Environ Res (2007) 1.73
Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal (2008) 1.64
HERG K+ channels: friend and foe. Trends Pharmacol Sci (2001) 1.63
Agonist-induced Ca2+ influx in human neutrophils is secondary to the emptying of intracellular calcium stores. Biochem J (1991) 1.62
Q-T prolongation and polymorphous ("torsade de pointes") ventricular arrhythmias associated with organophosphorus insecticide poisoning. Am J Cardiol (1982) 1.59
Toxicological effects of malachite green. Aquat Toxicol (2004) 1.42
I(Kr): the hERG channel. J Mol Cell Cardiol (2001) 1.39
The toxicity of commercial jet oils. Environ Res (2002) 1.31
Can pharmacogenetics help rescue drugs withdrawn from the market? Pharmacogenomics (2006) 1.27
HIF-1: an oxygen and metal responsive transcription factor. Cancer Biol Ther (2004) 1.25
Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci (2009) 1.14
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics. Eur Biophys J (2003) 1.11
A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Anal Biochem (2009) 1.11
Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels. Mol Pharmacol (2008) 1.07
Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol (2004) 1.06
High-dose oral tamoxifen, a potential multidrug-resistance-reversal agent: phase I trial in combination with vinblastine. J Natl Cancer Inst (1992) 1.04
HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers. Mol Pharmacol (1998) 1.04
Contribution of voltage-gated potassium channels to the regulation of apoptosis. FEBS Lett (2010) 1.03
Quinidine. N Engl J Med (1998) 1.03
Identification and characterization of quaternary ammonium compound resistant staphylococci from the food industry. Int J Food Microbiol (1999) 1.03
High throughput ion-channel pharmacology: planar-array-based voltage clamp. Assay Drug Dev Technol (2003) 0.98
Structural basis of voltage-gated K+ channel pharmacology. Trends Pharmacol Sci (1992) 0.96
Vascular effects of calcium channel antagonists: new evidence. Drugs (2005) 0.96
Interactions of tetramethrin, fenvalerate and DDT at the sodium channel in rat dorsal root ganglion neurons. Brain Res (1996) 0.92
State-dependent inhibition of L-type calcium channels: cell-based assay in high-throughput format. Anal Biochem (2004) 0.90
Blood pressure lowering efficacy of reserpine for primary hypertension. Cochrane Database Syst Rev (2009) 0.88
Verapamil blocks HERG channel by the helix residue Y652 and F656 in the S6 transmembrane domain. Acta Pharmacol Sin (2007) 0.86
Chlorinated pesticides: threats to health and importance of detection. Altern Med Rev (2009) 0.86
The roles of intracellular regions in the activation of voltage-dependent potassium channels. Eur Biophys J (2003) 0.86
Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.83
Topical fenticonazole in dermatology and gynaecology: current role in therapy. Drugs (2008) 0.78
Glove allergy due to 1,3-diphenylguanidine. Contact Dermatitis (2006) 0.78
Effect of oral administration of 1,3-diphenylguanidine on sperm morphology and male fertility in mice. Toxicology (1992) 0.77
Effects of econazole on receptor-operated and depolarization-induced contractions in rat isolated aorta. Life Sci (2000) 0.76
Prepublication data sharing. Nature (2009) 12.24
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A (2006) 9.92
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J Clin Invest (2002) 4.79
Influence of exercise, walking, cycling, and overall nonexercise physical activity on mortality in Chinese women. Am J Epidemiol (2007) 4.63
High-throughput screening assays for the identification of chemical probes. Nat Chem Biol (2007) 4.50
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet (2016) 4.49
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res (2011) 4.22
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci Transl Med (2011) 3.80
Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab (2004) 3.75
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Southern community cohort study: establishing a cohort to investigate health disparities. J Natl Med Assoc (2005) 3.67
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet (2010) 3.53
Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol (2010) 3.51
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol (2012) 3.40
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet (2011) 3.37
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science (2011) 3.30
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res (2010) 3.16
Soy food intake and breast cancer survival. JAMA (2009) 3.16
Compound cytotoxicity profiling using quantitative high-throughput screening. Environ Health Perspect (2008) 3.11
The landscape of recombination in African Americans. Nature (2011) 3.06
Directional water collection on wetted spider silk. Nature (2010) 3.06
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res (2008) 2.97
A high-throughput screen for aggregation-based inhibition in a large compound library. J Med Chem (2007) 2.97
Improving the human hazard characterization of chemicals: a Tox21 update. Environ Health Perspect (2013) 2.95
Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med (2008) 2.90
Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Lancet Oncol (2011) 2.85
Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts. Mol Cell (2006) 2.80
Abdominal adiposity and mortality in Chinese women. Arch Intern Med (2007) 2.75
Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays. Assay Drug Dev Technol (2004) 2.74
Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. J Steroid Biochem Mol Biol (2004) 2.73
Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proc Natl Acad Sci U S A (2005) 2.72
Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet (2012) 2.70
Effects of reproductive and demographic changes on breast cancer incidence in China: a modeling analysis. J Natl Cancer Inst (2008) 2.69
Identification of new genetic risk variants for type 2 diabetes. PLoS Genet (2010) 2.62
1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem (2007) 2.61
Manganese toxicity upon overexposure. NMR Biomed (2004) 2.61
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology (2012) 2.57
Fluorescence spectroscopic profiling of compound libraries. J Med Chem (2008) 2.53
Characterization of chemical libraries for luciferase inhibitory activity. J Med Chem (2008) 2.53
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A (2014) 2.50
Concerted assembly and cloning of multiple DNA segments using in vitro site-specific recombination: functional analysis of multi-segment expression clones. Genome Res (2004) 2.49
Night-shift work and breast cancer risk in a cohort of Chinese women. Am J Epidemiol (2010) 2.48
COPI complex is a regulator of lipid homeostasis. PLoS Biol (2008) 2.47
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet (2012) 2.45
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet (2003) 2.39
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol Biochem Parasitol (2006) 2.39
Dietary patterns and their correlates among middle-aged and elderly Chinese men: a report from the Shanghai Men's Health Study. Br J Nutr (2007) 2.35
Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women's Health Study. Am J Epidemiol (2013) 2.34
Chemical calcium indicators. Methods (2008) 2.33
Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women. Arch Intern Med (2007) 2.31
The analysis of large-scale gene expression correlated to the phase changes of the migratory locust. Proc Natl Acad Sci U S A (2004) 2.26
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Validity and reproducibility of the food-frequency questionnaire used in the Shanghai men's health study. Br J Nutr (2007) 2.26
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
dmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks. Bioinformatics (2010) 2.23
Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer Cell (2013) 2.22
Manganese: recent advances in understanding its transport and neurotoxicity. Toxicol Appl Pharmacol (2007) 2.17
Compound Management for Quantitative High-Throughput Screening. JALA Charlottesv Va (2008) 2.11
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol (2011) 2.09
A meta-analysis of bisphosphonates for periprosthetic bone loss after total joint arthroplasty. J Orthop Sci (2013) 2.09
The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites. Mol Biol Cell (2009) 2.09
Vanadium exposure-induced neurobehavioral alterations among Chinese workers. Neurotoxicology (2013) 2.08
Ovariectomy augments hypertension in aging female Dahl salt-sensitive rats. Hypertension (2004) 2.05
Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation. Proc Natl Acad Sci U S A (2008) 2.02
An automated, broad-based, near real-time public health surveillance system using presentations to hospital Emergency Departments in New South Wales, Australia. BMC Public Health (2005) 1.99
Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. PLoS Genet (2010) 1.98
Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor. Neurotoxicology (2007) 1.98
The choroid plexus removes beta-amyloid from brain cerebrospinal fluid. Exp Biol Med (Maywood) (2005) 1.97
Genome-wide association study of glioma and meta-analysis. Hum Genet (2012) 1.96
Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol (2010) 1.95
Reproducibility and validity of the Shanghai Women's Health Study physical activity questionnaire. Am J Epidemiol (2003) 1.95
Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet (2011) 1.94
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. PLoS Genet (2012) 1.91
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet (2012) 1.90
Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol (2010) 1.90
A robotic platform for quantitative high-throughput screening. Assay Drug Dev Technol (2008) 1.90
Race, gender, and information technology use: the new digital divide. Cyberpsychol Behav (2008) 1.90