Published in Carcinogenesis on January 16, 2004
Guidelines for the welfare and use of animals in cancer research. Br J Cancer (2010) 6.97
Influence of obesity on the risk of developing colon cancer. Gut (2005) 1.93
Excess body weight and obesity--the link with gastrointestinal and hepatobiliary cancer. Nat Rev Gastroenterol Hepatol (2011) 1.18
Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes. Curr Diabetes Rev (2014) 1.12
Obesity and colorectal cancer: role of adipokines in tumor initiation and progression. World J Gastroenterol (2014) 1.11
Diverse roles of leptin in the gastrointestinal tract: modulation of motility, absorption, growth, and inflammation. Nutrition (2010) 1.00
Nutraceutical approach for preventing obesity-related colorectal and liver carcinogenesis. Int J Mol Sci (2012) 0.95
Insulin-like growth factor-1 promoter polymorphisms and colorectal cancer: a functional genomics approach. Gut (2008) 0.95
Obesity and cancer pathogenesis. Ann N Y Acad Sci (2014) 0.93
Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis. Semin Immunopathol (2012) 0.90
Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice. PLoS One (2013) 0.85
C57BL/KsJ-db/db-Apc mice exhibit an increased incidence of intestinal neoplasms. Int J Mol Sci (2011) 0.83
The leptin gene family and colorectal cancer: interaction with smoking behavior and family history of cancer. PLoS One (2013) 0.83
Microbial dysbiosis and colon carcinogenesis: could colon cancer be considered a bacteria-related disease? Therap Adv Gastroenterol (2013) 0.83
Combination of physical activity, nutrition, or other metabolic factors and vaccine response. Front Biosci (2007) 0.80
Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities. World J Gastroenterol (2014) 0.79
Obesity, adipocytokines and cancer. Transl Oncogenomics (2008) 0.78
The Activation of ERK1/2 and JNK MAPK Signaling by Insulin/IGF-1 Is Responsible for the Development of Colon Cancer with Type 2 Diabetes Mellitus. PLoS One (2016) 0.77
Inhibitory effects of astaxanthin on azoxymethane-induced colonic preneoplastic lesions in C57/BL/KsJ-db/db mice. BMC Gastroenterol (2014) 0.76
Preventive Effects of Pentoxifylline on the Development of Colonic Premalignant Lesions in Obese and Diabetic Mice. Int J Mol Sci (2017) 0.75
Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc. Carcinogenesis (2016) 0.75
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84
A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci (2003) 3.79
Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (2003) 3.18
Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012) 2.80
Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev (2004) 2.75
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer. Cancer Prev Res (Phila) (2008) 2.50
Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Res (2006) 2.49
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev (2007) 2.34
Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell (2005) 2.17
Mouse models for the study of colon carcinogenesis. Carcinogenesis (2008) 2.10
P2-type Na(x)[Fe(1/2)Mn(1/2)]O2 made from earth-abundant elements for rechargeable Na batteries. Nat Mater (2012) 1.99
PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells. Cell Stem Cell (2013) 1.96
Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J (2005) 1.83
Anomalous Hall effect governed by electron doping in a room-temperature transparent ferromagnetic semiconductor. Nat Mater (2004) 1.73
Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis (2005) 1.65
Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. Int J Cancer (2008) 1.63
Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci U S A (2004) 1.61
Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Res (2002) 1.56
Efficacy of a novel device for assessment of autonomic sensory function in the rat bladder. J Urol (2008) 1.49
Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms. Int J Cancer (2006) 1.48
Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. Chem Biol Interact (2009) 1.47
NSAIDs and chemoprevention. Curr Cancer Drug Targets (2004) 1.44
Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. Cancer Sci (2009) 1.44
Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice. Cancer Res (2006) 1.43
Biliary findings assist in predicting enlargement of intraductal papillary mucinous neoplasms of the pancreas. Clin Gastroenterol Hepatol (2012) 1.43
Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. BMC Cancer (2005) 1.39
Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. Clin Cancer Res (2004) 1.37
Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res (2007) 1.36
Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol Cell Biol (2006) 1.35
Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res (2007) 1.34
Evaluation of in vitro proliferative activity of human fetal neural stem/progenitor cells using indirect measurements of viable cells based on cellular metabolic activity. J Neurosci Res (2002) 1.33
Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells. Proc Natl Acad Sci U S A (2013) 1.32
Multistep carcinogenesis of the colon in Apc(Min/+) mouse. Cancer Sci (2007) 1.32
Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate. Cancer Sci (2004) 1.26
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci (2013) 1.26
Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-alpha. J Am Coll Cardiol (2002) 1.25
Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice. Int J Cancer (2009) 1.24
Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. Biochim Biophys Acta (2004) 1.23
VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells. Biochem Biophys Res Commun (2007) 1.20
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development (2013) 1.19
Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity. J Neurosci (2004) 1.19
Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. Cancer Sci (2005) 1.17
International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles. Toxicol Pathol (2012) 1.17
Mixed tocopherols inhibit N-methyl-N-nitrosourea-induced mammary tumor growth in rats. Nutr Cancer (2007) 1.16
Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci (2004) 1.16
Down-regulation of PU.1 by methylation of distal regulatory elements and the promoter is required for myeloma cell growth. Cancer Res (2007) 1.15
Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets. Mol Cancer Ther (2006) 1.15
Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice. Cancer Res (2002) 1.15
Functional expression of ABCG2 transporter in human neural stem/progenitor cells. Neurosci Res (2005) 1.14
Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice. Cytokine (2005) 1.12
Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells. Cancer Prev Res (Phila) (2009) 1.12
Reliable high-throughput method for inhibition assay of 8 cytochrome P450 isoforms using cocktail of probe substrates and stable isotope-labeled internal standards. Drug Metab Pharmacokinet (2012) 1.12
Atorvastatin and celecoxib inhibit prostate PC-3 tumors in immunodeficient mice. Clin Cancer Res (2007) 1.11
Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats. Int J Cancer (2002) 1.10
Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. Carcinogenesis (2007) 1.10
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression. Biochem Pharmacol (2004) 1.10
TNF-alpha contributes to the development of allergic rhinitis in mice. J Allergy Clin Immunol (2003) 1.09
Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development. Cancer Res (2012) 1.09
Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway. Cancer Res (2007) 1.09
Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats. Nutr Cancer (2006) 1.09
Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells. Proc Natl Acad Sci U S A (2011) 1.09
Adenocarcina of the mouse prostate growth inhibition by celecoxib: downregulation of transcription factors involved in COX-2 inhibition. Prostate (2006) 1.08
Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. Prostaglandins Leukot Essent Fatty Acids (2005) 1.06
Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Carcinogenesis (2002) 1.05
Retracted Suppression of N-methyl-N-nitrosourea/testosterone-induced rat prostate cancer growth by celecoxib: effects on cyclooxygenase-2, cell cycle regulation, and apoptosis mechanism(s). Clin Cancer Res (2003) 1.05
Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis. Development (2012) 1.04
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice. Int J Cancer (2004) 1.03
Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. Int J Cancer (2006) 1.03
Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells. Cancer Sci (2004) 1.03
Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity. Cancer Prev Res (Phila) (2011) 1.03
SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing. EMBO Mol Med (2011) 1.02
Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice. Cancer Sci (2010) 1.02
Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat. Cancer Sci (2009) 1.02
Cigarette smoking, metabolic activation and carcinogenesis. Curr Drug Metab (2004) 1.02
Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice. Cancer Prev Res (Phila) (2010) 1.01
Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes. Development (2009) 1.01
Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine. J Gastroenterol (2011) 1.00
A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent, cobalt chloride. Brain Res (2006) 1.00
Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats. Cancer Lett (2005) 1.00
Taurine in health and diseases: consistent evidence from experimental and epidemiological studies. J Biomed Sci (2010) 1.00
Perilesional hyperintense rim of malignant hepatic tumors on ferumoxide-enhanced T1-weighted gradient-echo MR images: correlation between MR imaging and histopathologic findings. J Magn Reson Imaging (2003) 0.99
External urethral sphincter activity in diabetic rats. Neurourol Urodyn (2008) 0.99
Lung toxicity of 16 fine particles on intratracheal instillation in a bioassay model using f344 male rats. Toxicol Pathol (2008) 0.99
Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC). Mol Carcinog (2008) 0.99
(-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice. Cancer Prev Res (Phila) (2008) 0.99
Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. Cancer Res (2003) 0.99