Published in Int J Cancer on January 15, 2009
The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. J Carcinog (2011) 2.30
Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog (2009) 2.06
Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. Cancer Res (2009) 1.43
Antimicrobial activities of the rhizome extract of Zingiber zerumbet Linn. Asian Pac J Trop Biomed (2011) 1.12
Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. J Biomed Sci (2012) 1.04
Protein expression analysis of inflammation-related colon carcinogenesis. J Carcinog (2009) 0.98
Cancer prevention and therapy through the modulation of the tumor microenvironment. Semin Cancer Biol (2015) 0.97
Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation. Mol Vis (2011) 0.93
Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway. Evid Based Complement Alternat Med (2012) 0.93
Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer. Cancer Prev Res (Phila) (2011) 0.90
Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: review of current evidence. Int J Prev Med (2013) 0.84
Zerumbone attenuates the severity of acute necrotizing pancreatitis and pancreatitis-induced hepatic injury. Mediators Inflamm (2012) 0.83
Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo. Breast Cancer Res Treat (2012) 0.83
Non-specific protein modifications by a phytochemical induce heat shock response for self-defense. PLoS One (2013) 0.82
Heme oxygenase-1 system and gastrointestinal tumors. World J Gastroenterol (2010) 0.82
Inclusion Complex of Zerumbone with Hydroxypropyl- β -Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio. Evid Based Complement Alternat Med (2013) 0.80
Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse. Mol Vis (2011) 0.80
Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation. Cancer Med (2014) 0.80
Biomedical properties of a natural dietary plant metabolite, zerumbone, in cancer therapy and chemoprevention trials. Biomed Res Int (2014) 0.79
Targeting sonic hedgehog signaling by compounds and derivatives from natural products. Evid Based Complement Alternat Med (2013) 0.79
Notch2 activation is protective against anticancer effects of zerumbone in human breast cancer cells. Breast Cancer Res Treat (2014) 0.79
Preclinical cancer chemoprevention studies using animal model of inflammation-associated colorectal carcinogenesis. Cancers (Basel) (2012) 0.78
Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer. Mol Carcinog (2014) 0.78
Heme oxygenase-1 promotes tumor progression and metastasis of colorectal carcinoma cells by inhibiting antitumor immunity. Oncotarget (2015) 0.77
Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin. Cancer Biol Ther (2013) 0.77
Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. Cancer Prev Res (Phila) (2015) 0.76
Possible Anticancer Mechanisms of Some Costus speciosus Active Ingredients Concerning Drug Discovery. Curr Drug Discov Technol (2016) 0.75
Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1. PLoS One (2016) 0.75
Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions. Oncol Lett (2017) 0.75
A proteomic analysis of Curcuma comosa Roxb. rhizomes. Proteome Sci (2011) 0.75
Mouse models for the study of colon carcinogenesis. Carcinogenesis (2008) 2.10
Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer. Clin Cancer Res (2005) 1.99
Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J (2005) 1.83
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis (2007) 1.78
Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis (2005) 1.65
In vivo laser confocal microscopy findings and mutational analysis for Schnyder's crystalline corneal dystrophy. Ophthalmology (2009) 1.54
In vivo laser confocal microscopic findings of corneal stromal dystrophies. Arch Ophthalmol (2007) 1.49
Takotsubo (ampulla-shaped) cardiomyopathy associated with microscopic polyangiitis. Intern Med (2005) 1.47
Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. Chem Biol Interact (2009) 1.47
Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. Cancer Sci (2009) 1.44
Ursolic acid: an anti- and pro-inflammatory triterpenoid. Mol Nutr Food Res (2008) 1.43
Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS Lett (2004) 1.42
Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. BMC Cancer (2005) 1.39
[Towards the elimination of onchocerciasis at the global scale: history, challenges and future prospects]. Nippon Ganka Gakkai Zasshi (2012) 1.38
Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma. Invest Ophthalmol Vis Sci (2004) 1.28
Validation of HB-EGF and amphiregulin as targets for human cancer therapy. Biochem Biophys Res Commun (2007) 1.27
Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate. Cancer Sci (2004) 1.26
Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. Biochim Biophys Acta (2004) 1.23
Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway. Cancer Sci (2007) 1.18
Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition. Mol Cancer Ther (2008) 1.17
Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. Cancer Sci (2005) 1.17
International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles. Toxicol Pathol (2012) 1.17
Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci (2004) 1.16
Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice. Cancer Res (2002) 1.15
Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases. J Biol Chem (2003) 1.14
Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis. Biochem Biophys Res Commun (2005) 1.11
Production of Sry knockout mouse using TALEN via oocyte injection. Sci Rep (2013) 1.11
Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats. Int J Cancer (2002) 1.10
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression. Biochem Pharmacol (2004) 1.10
Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development. Cancer Res (2012) 1.09
Global inequality in eye health: country-level analysis from the Global Burden of Disease Study. Am J Public Health (2010) 1.09
Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway. Cancer Res (2007) 1.09
Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing. Invest Ophthalmol Vis Sci (2011) 1.08
Rapid oxidation of dichlorodihydrofluorescin with heme and hemoproteins: formation of the fluorescein is independent of the generation of reactive oxygen species. FEBS Lett (2002) 1.07
Lipoteichoic acid downregulates FcepsilonRI expression on human mast cells through Toll-like receptor 2. J Allergy Clin Immunol (2007) 1.07
Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. Prostaglandins Leukot Essent Fatty Acids (2005) 1.06
Analysis of COL8A2 gene mutation in Japanese patients with Fuchs' endothelial dystrophy and posterior polymorphous dystrophy. Jpn J Ophthalmol (2004) 1.06
Utility of fluorescence in situ hybridization to detect MDM2 amplification in liposarcomas and their morphological mimics. Int J Clin Exp Pathol (2013) 1.05
SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma. Invest Ophthalmol Vis Sci (2006) 1.05
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice. Int J Cancer (2004) 1.03
Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. Int J Cancer (2006) 1.03
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol (2005) 1.03
Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity. Cancer Prev Res (Phila) (2011) 1.03
Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice. Cancer Sci (2010) 1.02
Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat. Cancer Sci (2009) 1.02
Cigarette smoking, metabolic activation and carcinogenesis. Curr Drug Metab (2004) 1.02
Intestinal lineage commitment of embryonic stem cells. Differentiation (2010) 1.01
Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice. Cancer Prev Res (Phila) (2010) 1.01
Clinical significance of cell-free and concentrated ascites re-infusion therapy for advanced and recurrent gynecological cancer. Anticancer Res (2012) 1.00
Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures. J Cell Sci (2009) 1.00
Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats. Cancer Lett (2005) 1.00
A new model of retinal photoreceptor cell degeneration induced by a chemical hypoxia-mimicking agent, cobalt chloride. Brain Res (2006) 1.00
Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine. J Gastroenterol (2011) 1.00
Decoy-DNA against special AT-rich sequence binding protein 1 inhibits the growth and invasive ability of human breast cancer. Oligonucleotides (2011) 1.00
The role of interleukin-33 in chronic allergic conjunctivitis. Invest Ophthalmol Vis Sci (2009) 0.99
Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats. Jpn J Cancer Res (2002) 0.99
Evaluation of novel dry eye model: preganglionic parasympathetic denervation in rabbit. Invest Ophthalmol Vis Sci (2007) 0.99
Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation. Biochim Biophys Acta (2002) 0.99
(-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice. Cancer Prev Res (Phila) (2008) 0.99
In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. J Ethnopharmacol (2002) 0.99
Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament. Cytotechnology (2007) 0.99
Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer. Cancer Sci (2010) 0.98
A novel mutation of M1S1 gene found in a Vietnamese patient with gelatinous droplike corneal dystrophy. Am J Ophthalmol (2003) 0.98
Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate. BMC Cancer (2007) 0.98
Three-dimensional cell seeding and growth in radial-flow perfusion bioreactor for in vitro tissue reconstruction. Biotechnol Bioeng (2006) 0.98
Protein expression analysis of inflammation-related colon carcinogenesis. J Carcinog (2009) 0.98
Contact lens-induced infectious keratitis in Japan. Eye Contact Lens (2007) 0.98
Case of leiomyosarcoma of the renal pelvis. Int J Urol (2004) 0.97
Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. Clin Cancer Res (2009) 0.97
Mutagenicity of reactive oxygen and nitrogen species as detected by co-culture of activated inflammatory leukocytes and AS52 cells. Carcinogenesis (2003) 0.97
Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy. Am J Ophthalmol (2004) 0.97
Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice. Cancer Res (2009) 0.97
Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells. Diabetes (2003) 0.97
Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice. Carcinogenesis (2004) 0.97
Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. Biochem Pharmacol (2003) 0.96
Association between glaucoma and gene polymorphism of endothelin type A receptor. Mol Vis (2005) 0.96
Trends in microbial keratitis in Japan. Eye Contact Lens (2007) 0.96
Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. Cancer Lett (2003) 0.96
Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism. Carcinogenesis (2004) 0.96
Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2. Cancer Prev Res (Phila) (2011) 0.95
Heme and non-heme iron transporters in non-polarized and polarized cells. BMC Cell Biol (2010) 0.95
Nutraceutical approach for preventing obesity-related colorectal and liver carcinogenesis. Int J Mol Sci (2012) 0.95
Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis. Invest Ophthalmol Vis Sci (2009) 0.95
Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36. J Immunol (2007) 0.95
Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells. J Cancer Res Clin Oncol (2002) 0.94
Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment. Mol Carcinog (2010) 0.94
ATP-binding cassette superfamily transporter gene expression in human primary ovarian carcinoma. Clin Cancer Res (2002) 0.94
Dextran sulfate sodium enhances interleukin-1 beta release via activation of p38 MAPK and ERK1/2 pathways in murine peritoneal macrophages. Life Sci (2007) 0.93
Heterozygous Ala137Pro mutation in keratin 12 gene found in Japanese with Meesmann's corneal dystrophy. Jpn J Ophthalmol (2003) 0.93
Mutations in the CHST6 gene in patients with macular corneal dystrophy: immunohistochemical evidence of heterogeneity. Invest Ophthalmol Vis Sci (2003) 0.93
Trabeculectomy with mitomycin for open-angle glaucoma in phakic vs pseudophakic eyes after phacoemulsification. Arch Ophthalmol (2011) 0.93
Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats. Carcinogenesis (2002) 0.93