Published in J Biol Chem on January 19, 2004
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov (2010) 5.55
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80
Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu Rev Immunol (2008) 2.86
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature (2009) 2.79
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med (2005) 2.57
FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system. Br J Pharmacol (2009) 2.49
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev (2010) 2.10
A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection. Proc Natl Acad Sci U S A (2009) 2.04
A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya). Discov Med (2011) 1.65
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules. Nat Rev Drug Discov (2009) 1.60
Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins. Biochem J (2011) 1.59
Retracted S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF. Proc Natl Acad Sci U S A (2005) 1.57
Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. Blood (2010) 1.56
Sphingosine-1-phosphate receptor signalling in the heart. Cardiovasc Res (2009) 1.53
Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circ Res (2008) 1.51
Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. Br J Pharmacol (2004) 1.48
Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza. Mol Pharmacol (2008) 1.48
The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. Curr Biol (2008) 1.47
Regulation and functional roles of sphingosine kinases. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.38
An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res (2014) 1.37
Fingolimod is a potential novel therapy for multiple sclerosis. Nat Rev Neurol (2010) 1.36
Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol (2008) 1.36
Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol (2011) 1.34
Insights into the pharmacological relevance of lysophospholipid receptors. Br J Pharmacol (2012) 1.31
The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate. Br J Pharmacol (2012) 1.30
Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chem Rev (2011) 1.29
Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. Am J Respir Cell Mol Biol (2010) 1.27
Sphingosine-1-phosphate and immune regulation: trafficking and beyond. Trends Pharmacol Sci (2010) 1.27
Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. J Clin Invest (2004) 1.26
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening. ACS Chem Biol (2008) 1.26
Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor. Cell Signal (2007) 1.24
Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol (2011) 1.24
A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). Prostaglandins Other Lipid Mediat (2007) 1.21
Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol (2014) 1.21
Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res (2010) 1.21
Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature. Am J Physiol Heart Circ Physiol (2008) 1.20
Identification of the hydrophobic ligand binding pocket of the S1P1 receptor. J Biol Chem (2006) 1.19
S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem (2008) 1.18
Cutting edge: Contact with secondary lymphoid organs drives postthymic T cell maturation. J Immunol (2008) 1.18
Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling. Am J Pathol (2007) 1.17
Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int (2008) 1.14
Sphingosine kinase and sphingosine 1-phosphate in cardioprotection. J Cardiovasc Pharmacol (2009) 1.10
High endothelial venules as traffic control points maintaining lymphocyte population homeostasis in lymph nodes. Blood (2011) 1.08
Lysophospholipid receptor activation of RhoA and lipid signaling pathways. Biochim Biophys Acta (2012) 1.07
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. J Biol Chem (2013) 1.07
Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. Lab Invest (2010) 1.06
Therapeutic effects of novel sphingosine-1-phosphate receptor agonist W-061 in murine DSS colitis. PLoS One (2011) 1.05
S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur J Immunol (2010) 1.04
Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells. Biochem J (2006) 1.03
S1P is associated with protection in human and experimental cerebral malaria. Mol Med (2011) 1.02
Lyase to live by: sphingosine phosphate lyase as a therapeutic target. Expert Opin Ther Targets (2009) 1.02
Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human study. Br J Clin Pharmacol (2013) 0.98
The role of sphingosine-1-phosphate and its receptors in asthma. Drug News Perspect (2008) 0.97
Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. Am J Physiol Heart Circ Physiol (2010) 0.97
FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology. Perspect Medicin Chem (2007) 0.97
The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells. Br J Pharmacol (2006) 0.95
Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. J Neurochem (2009) 0.94
The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons. J Neurophysiol (2010) 0.94
FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus. J Immunol (2011) 0.93
Sphingosine 1-phosphate chemical biology. Biochim Biophys Acta (2008) 0.93
S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. Am J Physiol Cell Physiol (2011) 0.93
Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. Biochim Biophys Acta (2012) 0.93
Ceramide signaling in cancer and stem cells. Future Lipidol (2008) 0.92
Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int (2012) 0.91
Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system. Br J Pharmacol (2011) 0.90
Molecular recognition in the sphingosine 1-phosphate receptor family. J Mol Graph Model (2007) 0.89
Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). Br J Pharmacol (2009) 0.89
Plasma gelsolin modulates cellular response to sphingosine 1-phosphate. Am J Physiol Cell Physiol (2010) 0.88
Immunosuppression: towards a logical approach in liver transplantation. Clin Exp Immunol (2005) 0.88
Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection. Virology (2009) 0.88
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem (2014) 0.87
Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. Stem Cells Dev (2013) 0.87
Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist. Kidney Int (2008) 0.87
Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J Pharmacol Exp Ther (2014) 0.86
Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Med Chem Lett (2013) 0.86
Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett (2011) 0.86
Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. Acta Pharmacol Sin (2010) 0.86
Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. Mediators Inflamm (2014) 0.85
Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorg Med Chem (2009) 0.85
The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue. J Cell Mol Med (2015) 0.85
Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. J Cell Mol Med (2010) 0.85
Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J Pharmacol Exp Ther (2011) 0.85
A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages. Immunology (2009) 0.85
Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs. Mol Pharmacol (2010) 0.85
Sphingosine 1-phosphate receptor modulators in multiple sclerosis. CNS Drugs (2015) 0.85
Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion. Br J Pharmacol (2010) 0.84
Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice. Clin Exp Immunol (2014) 0.84
FTY720, a sphingosine-1 phosphate receptor modulator, improves liver fibrosis in a mouse model by impairing the motility of bone marrow-derived mesenchymal stem cells. Inflammation (2014) 0.84
FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism. Br J Pharmacol (2007) 0.84
Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5. ACS Med Chem Lett (2010) 0.83
The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine. PLoS One (2013) 0.83
FTY720 regulates bone marrow egress of eosinophils and modulates late-phase skin reaction in mice. Am J Pathol (2010) 0.83
Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells. J Neurophysiol (2009) 0.82
Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator. PLoS One (2013) 0.82
Modulators of the Sphingosine 1-phosphate receptor 1. Bioorg Med Chem Lett (2013) 0.82
Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease. Mucosal Immunol (2016) 0.82
Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. ACS Med Chem Lett (2011) 0.81
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science (2002) 8.63
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med (2007) 5.06
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol (2006) 4.20
LPA receptors: subtypes and biological actions. Annu Rev Pharmacol Toxicol (2010) 3.91
Crystal structure of a lipid G protein-coupled receptor. Science (2012) 3.78
Lysophospholipid receptors: signaling and biology. Annu Rev Biochem (2004) 3.78
Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat Immunol (2005) 3.70
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors. Nat Rev Drug Discov (2009) 3.64
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat Immunol (2009) 3.44
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature (2005) 3.35
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc Natl Acad Sci U S A (2011) 3.20
Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature (2008) 3.14
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell (2011) 3.03
Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy. J Immunol (2005) 3.00
S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol (2005) 2.98
Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. Ann Neurol (2011) 2.85
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med (2004) 2.71
GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J Biol Chem (2006) 2.65
High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation (2006) 2.58
FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A (2010) 2.49
Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A (2003) 2.44
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest (2004) 2.36
Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nat Neurosci (2003) 2.36
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem (2003) 2.36
Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov (2012) 2.35
Roscovitine targets, protein kinases and pyridoxal kinase. J Biol Chem (2005) 2.31
Constitutional aneuploidy in the normal human brain. J Neurosci (2005) 2.28
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. J Biol Chem (2004) 2.17
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J (2006) 2.12
Response and acquired resistance to everolimus in anaplastic thyroid cancer. N Engl J Med (2014) 2.09
Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Mol Cell Biol (2002) 2.06
A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection. Proc Natl Acad Sci U S A (2009) 2.04
Emerging medicinal roles for lysophospholipid signaling. Trends Mol Med (2006) 2.01
Lysophospholipid G protein-coupled receptors. J Biol Chem (2004) 1.88
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med (2009) 1.86
Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nat Biotechnol (2009) 1.84
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance. Prostaglandins Other Lipid Mediat (2009) 1.81
Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. Arterioscler Thromb Vasc Biol (2006) 1.80
Lysophosphatidic acid signaling may initiate fetal hydrocephalus. Sci Transl Med (2011) 1.76
Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus. Proc Natl Acad Sci U S A (2011) 1.73
Lysophosphatidic acid (LPA) and its receptors. Curr Opin Pharmacol (2008) 1.70
Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol (2007) 1.70
Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells. Nat Biotechnol (2013) 1.69
Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem (2002) 1.68
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J Biol Chem (2007) 1.65
Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer. Blood (2008) 1.65
mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.63
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules. Nat Rev Drug Discov (2009) 1.60
Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Proc Natl Acad Sci U S A (2007) 1.58
Retracted S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF. Proc Natl Acad Sci U S A (2005) 1.57
The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology (2009) 1.56
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proc Natl Acad Sci U S A (2011) 1.52
Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metab (2011) 1.52
Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci (2013) 1.52
LPA1 receptor activation promotes renal interstitial fibrosis. J Am Soc Nephrol (2007) 1.51
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov (2012) 1.50
Cell surface receptors in lysophospholipid signaling. Semin Cell Dev Biol (2004) 1.49
Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza. Mol Pharmacol (2008) 1.48
FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML. Drug Resist Updat (2009) 1.47
A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol (2006) 1.47
A reevaluation of tetraploidy in the Alzheimer's disease brain. Neurodegener Dis (2009) 1.47
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem (2003) 1.47
Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. J Biol Chem (2007) 1.46
A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia. Blood (2013) 1.44
A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. Proc Natl Acad Sci U S A (2007) 1.43
Biological roles of lysophospholipid receptors revealed by genetic null mice: an update. Biochim Biophys Acta (2008) 1.43
Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. J Biol Chem (2007) 1.41
Chest compressions performed by ED staff: a randomized cross-over simulation study on the floor and on a stretcher. Am J Emerg Med (2012) 1.40
The end of a Chilean institute. Science (2005) 1.39
The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Mol Cell Biol (2005) 1.38
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J Neuroimmunol (2004) 1.37
Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol (2008) 1.36
Retracted Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood (2009) 1.36
Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology (2009) 1.33
Insights into the pharmacological relevance of lysophospholipid receptors. Br J Pharmacol (2012) 1.31
Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim Biophys Acta (2002) 1.30
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell (2009) 1.29
LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation. J Biol Chem (2006) 1.28
Alteration of gene expression by chromosome loss in the postnatal mouse brain. J Neurosci (2003) 1.28
Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. Am J Respir Cell Mol Biol (2010) 1.27
The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. PLoS One (2012) 1.27
A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem Biol (2010) 1.26
Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases. Curr Pharm Des (2006) 1.26
Regulation of immunity by lysosphingolipids and their G protein-coupled receptors. J Clin Invest (2004) 1.26
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening. ACS Chem Biol (2008) 1.26
The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J (2007) 1.25
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res (2009) 1.25
CD69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors. Eur J Immunol (2006) 1.25
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. J Am Chem Soc (2012) 1.24