Published in J Neurosci on January 21, 2004
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest (2008) 1.86
The adenosine kinase hypothesis of epileptogenesis. Prog Neurobiol (2007) 1.72
Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade. Purinergic Signal (2005) 1.58
Silk polymer-based adenosine release: therapeutic potential for epilepsy. Biomaterials (2008) 1.57
Targeting pannexin1 improves seizure outcome. PLoS One (2011) 1.43
Adenosine signaling and function in glial cells. Cell Death Differ (2009) 1.39
Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control. Exp Neurol (2007) 1.27
Adenosine kinase: exploitation for therapeutic gain. Pharmacol Rev (2013) 1.26
How do seizures stop? Epilepsia (2008) 1.25
Adenosine dysfunction in astrogliosis: cause for seizure generation? Neuron Glia Biol (2007) 1.23
Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies. Epilepsy Res (2009) 1.17
Candidate drug targets for prevention or modification of epilepsy. Annu Rev Pharmacol Toxicol (2014) 1.15
Adenosine dysfunction in epilepsy. Glia (2011) 1.14
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J Clin Invest (2013) 1.09
Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus. Exp Neurol (2006) 1.08
Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? Trends Neurosci (2008) 1.07
Cell and gene therapies for refractory epilepsy. Curr Neuropharmacol (2007) 1.06
Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity. Curr Neuropharmacol (2009) 1.04
Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation. Biochem Pharmacol (2009) 1.03
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. Epilepsia (2011) 1.01
Methylxanthines, seizures, and excitotoxicity. Handb Exp Pharmacol (2011) 0.99
Engineered adenosine-releasing cells for epilepsy therapy: human mesenchymal stem cells and human embryonic stem cells. Neurotherapeutics (2009) 0.98
Adenosine kinase as a target for therapeutic antisense strategies in epilepsy. Epilepsia (2011) 0.97
Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice. Neuron Glia Biol (2009) 0.96
Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex (2012) 0.95
Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection. J Neuroinflammation (2008) 0.93
Gene expression changes after seizure preconditioning in the three major hippocampal cell layers. Neurobiol Dis (2007) 0.93
Manipulation of adenosine kinase affects sleep regulation in mice. J Neurosci (2010) 0.91
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis? Glia (2011) 0.91
Caffeine prevents acute mortality after TBI in rats without increased morbidity. Exp Neurol (2011) 0.89
Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy. Epilepsia (2011) 0.88
Adenosine dysfunction and adenosine kinase in epileptogenesis. Open Neurosci J (2010) 0.88
Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia. J Clin Invest (2012) 0.87
Cortical interneurons from human pluripotent stem cells: prospects for neurological and psychiatric disease. Front Cell Neurosci (2013) 0.87
Gene therapy in epilepsy. Epilepsia (2008) 0.87
Adenosine and adenosine receptors: Newer therapeutic perspective. Indian J Pharmacol (2009) 0.86
Contributions of astrocytes to epileptogenesis following status epilepticus: opportunities for preventive therapy? Neurochem Int (2012) 0.85
Glial adenosine kinase--a neuropathological marker of the epileptic brain. Neurochem Int (2013) 0.84
Role of adenosine in status epilepticus: a potential new target? Epilepsia (2013) 0.84
Modulators of nucleoside metabolism in the therapy of brain diseases. Curr Top Med Chem (2011) 0.83
Adenosine and the auditory system. Curr Neuropharmacol (2009) 0.83
Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development. Epilepsia (2015) 0.83
The Biochemistry and Epigenetics of Epilepsy: Focus on Adenosine and Glycine. Front Mol Neurosci (2016) 0.82
The role of astroglia in the epileptic brain. Front Pharmacol (2012) 0.81
Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism. Pharmacol Res Perspect (2015) 0.81
Homeostatic control of brain function - new approaches to understand epileptogenesis. Front Cell Neurosci (2013) 0.81
Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss. Exp Gerontol (2011) 0.80
Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology (2015) 0.80
Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential. PLoS One (2013) 0.80
Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice. J Neurosurg (2013) 0.80
Comorbidities in Neurology: Is adenosine the common link? Neuropharmacology (2015) 0.80
From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy. Epilepsia (2016) 0.79
Role of adenosine kinase in cochlear development and response to noise. J Neurosci Res (2010) 0.78
Astrocytes derived from fetal neural progenitor cells as a novel source for therapeutic adenosine delivery. Seizure (2010) 0.78
Adenosinergic signaling in epilepsy. Neuropharmacology (2015) 0.78
Adenosine A1 receptors presynaptically modulate excitatory synaptic input onto subiculum neurons. Brain Res (2009) 0.77
Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury. J Mol Histol (2016) 0.77
Ginseng Rb fraction protects glia, neurons and cognitive function in a rat model of neurodegeneration. PLoS One (2014) 0.76
Adenosine kinase is a new therapeutic target to prevent ischemic neuronal death. Open Drug Discov J (2010) 0.76
Variations of ATP and its metabolites in the hippocampus of rats subjected to pilocarpine-induced temporal lobe epilepsy. Purinergic Signal (2016) 0.76
Faster flux of neurotransmitter glutamate during seizure - Evidence from 13C-enrichment of extracellular glutamate in kainate rat model. PLoS One (2017) 0.75
Adenosine kinase elevation increases activity in the kainic acid model of epilepsy. Epilepsy Curr (2005) 0.75
Upregulation of adenosine kinase in Rasmussen encephalitis. J Neuropathol Exp Neurol (2013) 0.75
Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity. J Neurosci (2016) 0.75
Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction. Front Mol Neurosci (2016) 0.75
Targeting the brain: focal delivery of natural anticonvulsant molecules. Epilepsy Curr (2005) 0.75
Specific GABAA circuits for visual cortical plasticity. Science (2004) 3.05
Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron (2006) 2.53
Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature (2008) 2.30
The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol Cell Neurosci (2003) 2.18
Neural bases for addictive properties of benzodiazepines. Nature (2010) 2.17
Intact sorting, targeting, and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro. J Comp Neurol (2002) 2.08
Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice. J Comp Neurol (2005) 2.05
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Invest (2008) 1.86
The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin. J Neurosci (2008) 1.83
A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors. J Clin Invest (2011) 1.79
Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia. Cereb Cortex (2002) 1.77
Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Proc Natl Acad Sci U S A (2002) 1.70
Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis. Eur J Neurosci (2011) 1.68
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J Neurosci (2004) 1.66
Silk polymer-based adenosine release: therapeutic potential for epilepsy. Biomaterials (2008) 1.57
Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons. Behav Neurosci (2007) 1.56
Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons. J Neurophysiol (2006) 1.55
Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation. Brain (2005) 1.51
Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain (2007) 1.50
Efficient transfection of DNA or shRNA vectors into neurons using magnetofection. Nat Protoc (2007) 1.49
Immunofluorescence in brain sections: simultaneous detection of presynaptic and postsynaptic proteins in identified neurons. Nat Protoc (2006) 1.44
Adenosine A1 receptors are crucial in keeping an epileptic focus localized. Exp Neurol (2006) 1.40
Inhibition of Adenosine Kinase Attenuates Acute Lung Injury. Crit Care Med (2016) 1.39
Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy. Epilepsia (2003) 1.38
Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci (2011) 1.35
Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice. J Comp Neurol (2006) 1.34
Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin. Proc Natl Acad Sci U S A (2010) 1.32
Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. J Cereb Blood Flow Metab (2006) 1.30
Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control. Exp Neurol (2007) 1.27
A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. J Neurosci (2008) 1.27
Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control. J Neurosci (2011) 1.26
Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. J Neurosci (2011) 1.25
Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells. J Physiol (2011) 1.25
Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging. Brain Res (2006) 1.24
Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile. J Neurosci (2006) 1.23
Adenosine dysfunction in astrogliosis: cause for seizure generation? Neuron Glia Biol (2007) 1.23
Disruption of the neurogenic potential of the dentate gyrus in a mouse model of temporal lobe epilepsy with focal seizures. Eur J Neurosci (2005) 1.21
Heterogeneity of glycinergic and gabaergic interneurons in the granule cell layer of mouse cerebellum. J Comp Neurol (2007) 1.20
Antiepileptic effects of silk-polymer based adenosine release in kindled rats. Exp Neurol (2009) 1.18
Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism. J Cereb Blood Flow Metab (2007) 1.18
Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus. Neuropharmacology (2008) 1.18
GABAergic inhibition at dendrodendritic synapses tunes gamma oscillations in the olfactory bulb. Proc Natl Acad Sci U S A (2007) 1.16
Early synapse formation in developing interneurons of the adult olfactory bulb. J Neurosci (2009) 1.16
Functional mapping of GABA A receptor subtypes in the amygdala. Eur J Neurosci (2004) 1.15
Vertebrate-specific sequences in the gephyrin E-domain regulate cytosolic aggregation and postsynaptic clustering. J Cell Sci (2007) 1.12
Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts. Exp Neurol (2005) 1.11
Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus. Exp Neurol (2005) 1.11
GABAergic terminals are required for postsynaptic clustering of dystrophin but not of GABA(A) receptors and gephyrin. J Neurosci (2002) 1.10
Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. J Physiol (2007) 1.10
Alteration of GABAergic synapses and gephyrin clusters in the thalamic reticular nucleus of GABAA receptor alpha3 subunit-null mice. Eur J Neurosci (2006) 1.10
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J Clin Invest (2013) 1.09
Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression. Neurosci Lett (2005) 1.09
Silk fibroin encapsulated powder reservoirs for sustained release of adenosine. J Control Release (2010) 1.09
Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors. Proc Natl Acad Sci U S A (2008) 1.08
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance. Epilepsia (2009) 1.07
Reporting statistical methods and statistical results in EJN. Eur J Neurosci (2008) 1.07
Rapid and long-term alterations of hippocampal GABAB receptors in a mouse model of temporal lobe epilepsy. Eur J Neurosci (2003) 1.07
Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants. J Cereb Blood Flow Metab (2006) 1.04
Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice. J Neurosci (2010) 1.04
Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses. J Cell Sci (2011) 1.03
Tonic inhibition in principal cells of the amygdala: a central role for α3 subunit-containing GABAA receptors. J Neurosci (2012) 1.03
Regional pattern of metabolic activation is reflected in the sleep EEG after sleep deprivation combined with unilateral whisker stimulation in mice. Eur J Neurosci (2004) 1.03
Engineering embryonic stem cell derived glia for adenosine delivery. Neurosci Lett (2004) 1.02
Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina. J Neurosci (2009) 1.02
GABA(A) receptors, gephyrin and homeostatic synaptic plasticity. J Physiol (2009) 1.02
Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning. Learn Mem (2011) 1.01
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. Epilepsia (2011) 1.01
Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs. Eur J Neurosci (2007) 1.00
Widespread and long-lasting alterations in GABA(A)-receptor subtypes after focal cortical infarcts in rats: mediation by NMDA-dependent processes. J Cereb Blood Flow Metab (2002) 1.00
Altered expression of alpha3-containing GABAA receptors in the neocortex of patients with focal epilepsy. Brain (2006) 0.99
Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: evidence from genetically modified mouse models and pharmacological inhibition. Biochem Pharmacol (2011) 0.98
Internalized GABA-receptor subunits are transferred to an intracellular pool associated with the postsynaptic density. Eur J Neurosci (2005) 0.97
Adenosine kinase as a target for therapeutic antisense strategies in epilepsy. Epilepsia (2011) 0.97
Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice. Neuron Glia Biol (2009) 0.96
The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice. PLoS Genet (2009) 0.95
Single particle tracking of alpha7 nicotinic AChR in hippocampal neurons reveals regulated confinement at glutamatergic and GABAergic perisynaptic sites. PLoS One (2010) 0.95
Glycine and GABA(A) receptor subunits on Renshaw cells: relationship with presynaptic neurotransmitters and postsynaptic gephyrin clusters. J Comp Neurol (2002) 0.95
Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex (2012) 0.95
Adenosine kinase determines the degree of brain injury after ischemic stroke in mice. J Cereb Blood Flow Metab (2011) 0.95
entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. J Biol Chem (2003) 0.94
Heterogeneity of gamma-aminobutyric acid type A receptors in mitral and tufted cells of the rat main olfactory bulb. J Comp Neurol (2005) 0.94
Suppression of kindled seizures by paracrine adenosine release from stem cell-derived brain implants. Epilepsia (2005) 0.94
ABCC1: a gateway for pharmacological compounds to the ischaemic brain. Brain (2008) 0.93
Matching of pre- and postsynaptic specializations during synaptogenesis. Neuroscientist (2007) 0.93
Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis. Epilepsy Res (2009) 0.93
Multimodal imaging in rats reveals impaired neurovascular coupling in sustained hypertension. Stroke (2013) 0.93
Regulation of cognition and symptoms of psychosis: focus on GABA(A) receptors and glycine transporter 1. Pharmacol Biochem Behav (2008) 0.93
Selective distribution of GABA(A) receptor subtypes in mouse spinal dorsal horn neurons and primary afferents. J Comp Neurol (2012) 0.92
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. J Biol Chem (2013) 0.92
Reorganization of GABAergic circuits maintains GABAA receptor-mediated transmission onto CA1 interneurons in alpha1-subunit-null mice. Eur J Neurosci (2007) 0.92
PICK1 interacts with alpha7 neuronal nicotinic acetylcholine receptors and controls their clustering. Mol Cell Neurosci (2007) 0.92
Impairment of dentate gyrus neuronal progenitor cell differentiation in a mouse model of temporal lobe epilepsy. Exp Neurol (2006) 0.91
Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis? Glia (2011) 0.91
Manipulation of adenosine kinase affects sleep regulation in mice. J Neurosci (2010) 0.91
Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One (2013) 0.90
The support of adenosine release from adenosine kinase deficient ES cells by silk substrates. Biomaterials (2006) 0.90
Hoxb8-Cre mice: A tool for brain-sparing conditional gene deletion. Genesis (2010) 0.89